CN103975786B - Using the method that even diformazan sodium sulfite improves radix scutellariae medicinal materials quality - Google Patents
Using the method that even diformazan sodium sulfite improves radix scutellariae medicinal materials quality Download PDFInfo
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- CN103975786B CN103975786B CN201410238771.4A CN201410238771A CN103975786B CN 103975786 B CN103975786 B CN 103975786B CN 201410238771 A CN201410238771 A CN 201410238771A CN 103975786 B CN103975786 B CN 103975786B
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Abstract
The invention discloses using the method that even diformazan sodium sulfite improves radix scutellariae medicinal materials quality, it is related to radix scutellariae medicinal materials technical field, and its preparation method is：Root of large-flowered skullcap fresh quench → clean → 20 25 DEG C dry in the shade 12 days → spray active oxygen carrier → 20 25 DEG C place 3 10 days → dry；To connect diformazan sodium sulfite, even the concentration of diformazan sodium sulfite is 0.4 μm of ol/L~40mmol/L to described active oxygen carrier；Its processing time period is 3~15 days；Temperature is 10 35 DEG C；The present invention plants Chinese medicine in plant optimum growth district or in main producing region, and can adopt various measures raising yield；According to the essence of radix scutellariae medicinal materials the form of quality, by the secondary metabolism of human intervention fresh medicinal material after medicinal material harvesting, the quality of medicinal material is increased substantially, so as to realize quality and yield bumper harvests.The invention improves the level of root of large-flowered skullcap secondary metabolism to greatest extent, the whole medicinal materials for being produced is met or exceeded the quality of genunie medicinal materials.
Description
Technical field：
The present invention relates to a kind of using the method that even diformazan sodium sulfite improves radix scutellariae medicinal materials quality, belong to radix scutellariae medicinal materials skill
Art field.
Background technology：
The quality of Chinese medicine has close relationship with environment；High temperature, low temperature, intense light irradiation, arid, nutritive water equality are not suitable for
The biological normal growth development of ambient influnence.Animal can move, and can actively find suitable environment existence, and plant can not
It is mobile, the change of physiological metabolism can only be relied on, new adverse environment is adapted to by producing secondary metabolite, and these are secondary
Metabolite be typically people required for medicinal ingredient.The distributed areas of plant are typically relatively broad, the weather of different regions
There is very big difference etc. environmental condition, therefore the quality of medicinal material of different regions there is also larger difference.Wherein a certain regional matter
Amount is preferable, has also occurred as soon as the concept of " genunie medicinal materials ".Genunie medicinal materials are the synonyms of high-quality medicinal material.The place of production of the root of large-flowered skullcap is throughout removing
Whole nation majority provinces and regions beyond south China, Tang and Song Dynasty time thinks that Shandong quality is good, with the continuous intensification recognized root of large-flowered skullcap quality, it is believed that
Produce Chengde root of large-flowered skullcap quality more preferably.Being not suitable for the environmental condition of growth can increase the secondary metabolite of plant, because
This quality of medicinal material in the secondary distributed area of non-suitable growth is preferable.Suitable growth area plant growth is rapid, and yield is higher, Er Feishi
Suitable production district plant growth is slow and secondary metabolite is higher, therefore for some Chinese medicines, is selected by planting area
Select and be difficult to reach taking into account for quality and yield.With continuing to develop for science and technology, a certain ecological ring in the place of production is recognized in the last few years
The relation of the border factor (such as arid, illumination) with radix scutellariae medicinal materials quality, and arid and high light are specify that in terms of molecular biology
According to etc. the synthesis of envirment factor and secondary metabolite some genes relation.For root of large-flowered skullcap cultivation, although arid promotes
The raising of quality, but the yield of medicinal material is also reduced, yield and quality are still present contradiction.
Many Chinese medicines are reduced because the change of environment under cultivation condition causes quality of medicinal material；The root of large-flowered skullcap is the large medicine of China
Material is, it is necessary to measure greatly, basic dependence is cultivated.The place of production of the root of large-flowered skullcap throughout in addition to south China the whole nation majority provinces and regions, so the root of large-flowered skullcap plant
Region is also very vast, so that having plantation in broad areas such as China northeast, North China, Central China, East China, causes quality of medicinal material to be joined
Difference is uneven.For all of crops, including medicinal material, growing and high yield measure is necessarily taken in the course of cultivation to improve yield, so
And these High-yielding Measures without exception be for plant growth provides optimal environment, with quality of medicinal material formed disagree.Even if
It is, in Genuine producing area, in order to improve the quality of medicinal material, the matter of medicinal material to be also resulted in by irrigation, measures of fertilizer well stimulation significantly
Amount is reduced.Therefore, for radix scutellariae medicinal materials cultivation, although solve the problems, such as that resource is nervous, but also result in quality of medicinal material
Decline, " medicine will not do a good job in, doctor might as well not " have also had a strong impact on the curative effect of Traditional Chinese Medicine.
The understanding of China's genunie medicinal materials starts from the Tang Dynasty before 1200, specify that quality of medicinal material has with the place of production (i.e. environment)
Close relationship, after the founding of the state, genunie medicinal materials modern study starts from the eighties in 20th century, is explored by the effort in more than 20 years, road
Although ground medicinal material research obtains some important achievements in terms of Crack cause and some specific environment factors, not yet take so far
Breakthrough is obtained, the ecological factor or rule to influenceing quality of medicinal material are substantially passive application, its reason can be summarized as two
Aspect：One is genunie medicinal materials complexity and objectivity in itself；Two is the limitation of Research Thinking and technical merit.To how to carry
Quality of medicinal material high is also the emphasis and difficult point of current natural resources of Chinese medicinal materials research.
The root of large-flowered skullcap is the conventional bulk medicinal materials of China, is acted on antipyretic, antibacterial, calm, step-down, transaminase lowering etc., scutelloside,
The chromocor compounds such as baicalein, wogonoside, wogonin are its main active.For this four kinds of chemical compositions, it
The intensity of pharmacodynamics effect be also different, baicalein ﹥ scutelloside ﹥ wogonin ﹥ wogonosides, the antibacterial activity of baicalein
It is scutelloside, wogonin, 2-5 times of wogonoside, active 1-3 times of suppression interleukin 1 B invertases.In addition, yellow
A kind of reed mentioned in ancient books element, because polarity is smaller, easily absorbs with wogonin in stomach, small intestine and colon, and absorptivity is 7 times of scutelloside, so that
Stronger activity is shown, scutelloside is quite different.Find out more than, root of large-flowered skullcap cellulose content improves 1% suitable content of baicalin and improves
More than 7%.At present, baicalein turns into the research focus for improving radix scutellariae medicinal materials quality, and scutelloside and the Chinese root of large-flowered skullcap can be made by conversion
Glycosides is reduced to original 1/70 and 1/13, and baicalein and wogonin improve 3.5 times and 3.1 times.By hydrolase the root of large-flowered skullcap
Glycosides and wogonoside conversion aglycon, increase antioxidation activity, significantly inhibit cancer cell growth.Therefore, the height of root of large-flowered skullcap cellulose content
It is that plant uses ability and influences the principal element of quality of medicinal material on environment.
The technical scheme of prior art one：Chinese medicine is planted in Genuine producing area.
The shortcoming of prior art one is：
First, high-quality medicinal material producing region is typically the secondary distributed area of plant, non-optimum growth district, therefore high-quality medicinal material institute
The adverse environment at place influences the raising of yield.I.e. high-quality producing region is generally not prolific area.
Secondly, under cultivation condition, obtain improving the growing environment of plant significantly by measures such as irrigation, fertilisings, it is this
Under the conditions of, the generation of unfavorable Secondary metabolites (the usually medicinal ingredient of the root of large-flowered skullcap), in Genuine producing area, cultivation will not be protected
Demonstrate,prove increasing substantially for quality of medicinal material.
3rd, in Genuine producing area due to being made the medicinal material in Genuine producing area by factors such as landform, fertilising, the differences of annual rainfall
Quality is uneven, is also difficult to ensure raising and the stabilization of the overall quality of medicinal material of card.
The technical scheme of prior art two：
China starts formally to implement with June, 2003《Good Agricultural Practices》(GAP), selected from kind
Select, planting area is selected, cultivation technique (Seed Treatment, site preparation, fertilising, irrigation, planting density, tillage and weeding, the prevention and control of plant diseases, pest control
Deng) links such as collecting time, process technology carry out specification to production, to ensure the stabilization of quality of medicinal material.
The shortcoming of prior art two：
First, arid is the principal element of the quality for improving the root of large-flowered skullcap, but reduces the yield of medicinal material.It is general under cultivation condition
All over measures such as the deep irrigations praised highly quality of medicinal material can not still be improved.
Second, the natural conditions of many influence quality of medicinal materials are difficult to manual control, many medicinal materials for producing Genuine producing area
Quality not high-quality.Even if under field conditions (factors), Secondary Metabolism of Plant level is determined by the unfavorable degree of external environment,
It is a process for quantitative change, not the root of large-flowered skullcap produces the highest level of secondary metabolism, therefore, influence of the Genuine producing area to quality of medicinal material
Not reach optimal level, that is to say, that although Genuine producing area is higher than non-Genuine producing area to the entire effect of quality of medicinal material,
Potentiality are not yet fully excavated.The high-quality potentiality of the root of large-flowered skullcap still can not be improved farthest, and increased quality is not notable.
Third, Chinese medicine standardization production process is complicated, the cycle is long, high cost, it is difficult to implement.
Current China has stopped the certification work of Chinese medicine standardization production base substantially.
The content of the invention：
Regarding to the issue above, the technical problem to be solved in the present invention is to provide a kind of yellow using even diformazan sodium sulfite raising
The method of a kind of reed mentioned in ancient books quality of medicinal material.
Of the invention a kind of using the method that even diformazan sodium sulfite improves radix scutellariae medicinal materials quality, its preparation method is：
Root of large-flowered skullcap fresh quench → clean → 20-25 DEG C dry in the shade 1-2 days → spray active oxygen carrier → 20-25 DEG C and place 3-10 days → drying；Institute
To connect diformazan sodium sulfite, even the concentration of diformazan sodium sulfite is 0.4 μm of ol/L~40mmol/L to the active oxygen carrier stated；At it
The reason time cycle is 3~15 days；Temperature is 10-35 DEG C.
Beneficial effects of the present invention are：
First, medicinal material more high-quality.Under field conditions (factors), Secondary Metabolism of Plant level is determined by the unfavorable degree of external environment
, it is that the process of a quantitative change artificially adjusts secondary metabolism, can fully excavate secondary metabolism potentiality.Huang can be made using proper treatment
The content of a kind of reed mentioned in ancient books element improves more than 10 times；
2nd, high yield and high quality is taken into account.In root of large-flowered skullcap cultivation, various High-yielding Measures are taken, improve the nascent metabolism of the root of large-flowered skullcap
Level, fully excavates the high yield potential of medicinal material；On this basis, improve secondary to greatest extent by the active oxygen amount of processing link
Metaboilic level, realizes that yield and quality in radix scutellariae medicinal materials production process get bumper harvests by Quality-Technology；
3rd, composition is pure natural.The process technology is the essence design influenceed on quality of medicinal material according to adverse environment, with life
Thing transformation technology is different, and the technology is that the altimeter for promoting secondary metabolism approach reaches, it is ensured that radix scutellariae medicinal materials ingredient is equal
For pure natural, the composition may with toxic and side effect will not be produced；
4th, medicinal material is remained without harmful chemicals.Active oxygen carrier used connects diformazan sodium sulfite (Na2S2O4) with stronger
Reproducibility, meets water and resolves into NaHSO3, further decompose into NaHSO4, without any murder by poisoning.Even diformazan sodium sulfite is not only
Municipal water use antichlor, the bactericide of beer bottle, but also be used as bleaching agent, preservative, raising agent for food industry and resist
It is used as reducing agent, cosmetics antioxidant when oxidant, dehydrated vegetables, therefore the toxic and side effect of medicinal material will not be caused.
Specific embodiment：
This specific embodiment uses following technical scheme：Its preparation method is：Root of large-flowered skullcap fresh quench → clean → 20-25 DEG C
Dry in the shade 1-2 days → spray active oxygen carrier → 20-25 DEG C and place 3-10 days → drying；Described active oxygen carrier is sub- to connect diformazan
Sodium sulphate, even the concentration of diformazan sodium sulfite is 0.4 μm of ol/L~40mmol/L；Its processing time period is 3~15 days；Temperature
It is 10-35 DEG C.
This specific embodiment plants Chinese medicine in plant optimum growth district or in main producing region, can take various arranging
Apply raising yield；According to the essence of radix scutellariae medicinal materials the form of quality, by the secondary of human intervention fresh medicinal material after medicinal material harvesting
Metabolism, increases substantially the quality of medicinal material, so as to realize quality and yield bumper harvests；It is secondary that the measure improves the root of large-flowered skullcap to greatest extent
The level of metabolism, fully excavates the potentiality that quality of medicinal material is improved, and the whole medicinal materials for being produced is met or exceeded genunie medicinal materials
Quality.
General principle of the invention and principal character and advantages of the present invention has been shown and described above.The technology of the industry
Personnel it should be appreciated that the present invention is not limited to the above embodiments, simply explanation described in above-described embodiment and specification this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and modifications of the present invention are possible, these changes
Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appending claims and its
Equivalent thereof.
Claims (1)
1., using the method that even diformazan sodium sulfite improves radix scutellariae medicinal materials quality, its preparation method is：Root of large-flowered skullcap fresh quench → clean
→ 20-25 DEG C dry in the shade 1-2 days → spray active oxygen carrier → 20-25 DEG C and place 3-10 days → drying；It is characterized in that：Described
To connect diformazan sodium sulfite, even the concentration of diformazan sodium sulfite is 0.4 μm of ol/L~40mmol/L to active oxygen carrier；During its treatment
Between the cycle be 3~15 days；Temperature is 10-35 DEG C.
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| CN104165498A (en) * | 2014-08-25 | 2014-11-26 | 济南康众医药科技开发有限公司 | Scutellaria baicalensis freeze-drying method |
| CN105878384A (en) * | 2016-04-14 | 2016-08-24 | 大兴安岭北极五味子科技开发有限公司 | Method for improving quality of Chinese magnoliavine fruits by adopting ROS (reactive oxygen species) |
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| CN102584918B (en) * | 2011-12-31 | 2014-09-10 | 沈阳药科大学 | Method for preparing high-purity baicalin |
| CN103081701B (en) * | 2013-02-06 | 2015-01-28 | 中国药材集团承德药材有限责任公司 | Scutellaria baicalensis sowing method |
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