CN103957878A - Dentifrice composition - Google Patents
Dentifrice composition Download PDFInfo
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- CN103957878A CN103957878A CN201280058734.4A CN201280058734A CN103957878A CN 103957878 A CN103957878 A CN 103957878A CN 201280058734 A CN201280058734 A CN 201280058734A CN 103957878 A CN103957878 A CN 103957878A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
Provided is a dentrifice composition that has a strong anti-staining effect and stain removing effect, low oral mucosa irritability, excellent properties such as taste and foaming when used, and good shelf life. The dentifrice composition is obtained by mixing (A) an acylamino acid salt, (B) an alkylsulfate, (C) a linear water-soluble polyphosphate represented by the following general formula (1) Mn+2PnO3n+1 (1) (where M is Na or K and n is an integer of 2 or 3), and (D) polyethylene glycol, and is characterized in that the amount of component (C) added is 0.3 to 1.5 mass% and the amount of component (D) added is 0.3 to 3 mass%. Furthermore, the dentifrice composition is obtained by mixing in (E) one or more water-soluble polymer compounds selected from carrageenan, xanthan gum, sodium polyacrylate, and hydroxyethyl cellulose sodium.
Description
Technical field
The present invention relates to a kind of Dentrifice composition, it can play high color stain and adhere to inhibition and color stain removal effect, and low to the stimulation of oral mucosa, and the use sense excellences such as taste and foaming, also have good storage stability.
Background technology
As a kind of color stain of tooth staining spot, it can be due to the formation such as the oral cavity such as tannin pigment, albumin internal protein, metal ion contained in coffee, tea etc.It is one of major subjects of stomatologic esthetics that the flank of tooth adheres to coloured stain.As solving the means of being steeped caused problem by this color, it is effective that removal color stain or inhibition color stain are adhered to.To steep caused problem in order solving by color, to have proposed up to now many Dentrifice compositions.
In order to remove color stain, remove by the mechanism of the grinding agent that mixes in compositions all the time.But, by grinding agent, cannot avoid the wearing and tearing of oral mucosa to being suitable for position, particularly soft neck portion etc.
Therefore, the various technology of removing color stain with chemical action have been proposed.
Up to now, applicant has proposed not rely on mechanism and the compositions (patent documentation 1: Japanese patent laid-open 9-12438 communique of removing flank of tooth spot by chemical action; Patent documentation 2: Japanese patent laid-open 11-343220 communique; Patent documentation 3: Japanese Patent Laid-Open 2002-47161 communique).In patent documentation 3; as the aqueous dentifrice of the phenoxyethanol containing geared surface, lingual surface chemically cleaning base, in embodiment 4, record the composition that is mixed with N-sodium lauroyl glutamate 0.2 quality %, lauroyl Glycine sodium 0.1 quality %, sodium lauryl sulfate 1.0 quality %, tetrasodium pyrophosphate 4.0 quality %, sodium tripolyphosphate 1.5 quality % and Polyethylene Glycol 1.0 quality %.But the use sense such as stimulation, foaming and the storage stability of this dentifrice to oral mucosa is difficult to say fully to also have room for improvement.
On the other hand, as the formation, safe and there is the composition of same effect that hinders tooth color stain, acyl amino hydrochlorate (patent documentation 4: Japanese patent laid-open 10-17444 communique) has been proposed.In this patent documentation 4, as embodiment 4, record the toothpaste that is mixed with lauroyl-methyl-Beta-alanine sodium 0.6 quality %, sodium lauryl sulfate 1.0 quality %, tetrasodium pyrophosphate 1.0 quality % and Polyethylene Glycol 5.0 quality %.But this toothpaste has problems aspect the use senses such as taste.In addition, there is fluid separation applications, thereby also aspect preparation storage stability, have problems.
In addition; known acyl amino hydrochlorate has unique abnormal flavour (bitterness), thereby has proposed to alleviate by mixing Palatinitol (Palatinit) compositions (patent documentation 5: Japanese Patent Laid-Open 2000-319148 communique) of bitterness.But in this technology, alleviating of bitterness is also insufficient.
Prior art document
Patent documentation
Patent documentation 1: Japanese patent laid-open 9-12438 communique
Patent documentation 2: Japanese patent laid-open 11-343220 communique
Patent documentation 3: Japanese Patent Laid-Open 2002-47161 communique
Patent documentation 4: Japanese patent laid-open 10-17444 communique
Patent documentation 5: Japanese Patent Laid-Open 2000-319148 communique
Summary of the invention
Invent problem to be solved
As mentioned above, tooth color stain is adhered in effective Dentrifice composition, there is the problem of the use senses such as stimulation, taste and foaming to oral mucosa and storage stability.Therefore, expect tooth color stain to adhere to effective new technique.
The present invention is In view of the foregoing and the invention of doing, its object is to provide a kind of Dentrifice composition, said composition can play high color stain and adhere to inhibition and color stain removal effect, and low to the stimulation of oral mucosa, the use sense such as taste and foaming excellence, also has good storage stability.
The means of dealing with problems
In order to achieve the above object, the inventor finds through wholwe-hearted result of study, by mixing (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) water-soluble poly-phosphate and (D) Polyethylene Glycol, and composition (C) and (D) be appropriate, can obtain following Dentrifice composition: said composition can play high color stain and adhere to inhibition and color stain removal effect, and low to the stimulation of oral mucosa, (taste is good for use sense excellence, foam number appropriateness), and storage stability is good, while being particularly prepared into toothpaste, can suppress fluid separation applications, give stable outward appearance.
Further find, except composition (A), (B), (C) with (D), be selected from one or more the water-soluble high-molecular compound in carrageenin, xanthan gum, sodium polyacrylate and sodium hydroxyethyl cellulose by further mixing (E), foam retentivity improves, and can further improve use sense.
If discussed more in detail; in order to address the above problem; the inventor conducts in-depth research; although known that it is effective that the color stain of water-soluble poly-phosphate and acylamino acid salt pair tooth is adhered to; even but blending constituent (A) and (B); color stain is adhered to inhibition and color stain poor removal effect, and produces the bitterness being caused by composition (A), and use sense is poor.In addition, if blending constituent (C) and (B), even if play color stain removal effect, but produce color stain adhere to inhibition poor, oral mucosa is produced stimulate, the low and poor such problem of use sense of foam number.Therefore, in order to address this problem, further be studied, it found that, if by composition (A), (B) and (C) combination, and the words of blending constituent (D), can all address the above problem unexpectedly, not only color stain is adhered to inhibition and color stain removal effect excellence, and the use sense such as oral mucosa stimulation, taste and foam number and storage stability also excellent, thereby given special action effect.In this case, by using ingredient (A), (B), (C) and (D), particularly color stain is adhered to inhibition and is especially improved, and the high color that has given cannot to obtain while lacking any essential condition of the present invention steeps and adheres to inhibition.In addition, by blending constituent (D), can suppress the unique abnormal flavour from composition (A), give the good use sense without bitterness.
As above, the newfound achievement of the inventor is as follows: by using ingredient (A), (B), (C) and (D), can obtain giving high color stain removal effect and color stain and adhere to inhibition, and the preparation of use sense and excellent storage stability, play above-mentioned special action effect.
Therefore, the invention provides following Dentrifice composition.
(1) a kind of Dentrifice composition; it is characterized in that; be mixed with the straight chain shape water-soluble poly-phosphate shown in (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) following general formula (1) and (D) Polyethylene Glycol
M
n+2P
nO
3n+1 (1)
(in formula, M represents Na or K, and n is 2 or 3 integer.)
And the combined amount of composition (C) is 0.3～1.5 quality %, the combined amount of composition (D) is 0.3～3 quality %.
(2) Dentrifice composition as described in (1), wherein, the mass ratio of composition (B)/composition (C) is 0.3～5.
(3) Dentrifice composition as described in (1) or (2), wherein, the acyl amino hydrochlorate of composition (A) is to be selected from more than one in acyl glutamate, acylaspartic acid salt and acylglycine salt.
(4) Dentrifice composition as described in (3), wherein, the acyl amino hydrochlorate of composition (A) is acyl glutamate.
(5) Dentrifice composition as described in any one in (1)～(4), wherein, the water-soluble poly-phosphate of composition (C) is sodium tripolyphosphate or tetrasodium pyrophosphate.
(6) Dentrifice composition as described in any one in (1)～(5), wherein, the Polyethylene Glycol of composition (D) is that mean molecule quantity is 200～6000 Polyethylene Glycol.
(7) Dentrifice composition as described in (1)～(6), wherein, is mixed with composition (A) 0.1～2 quality %, composition (B) 0.3～1.8 quality %.
(8) Dentrifice composition as described in any one in (1)～(7), is further mixed with (E) and is selected from one or more the water-soluble high-molecular compound in carrageenin, xanthan gum, sodium polyacrylate and sodium hydroxyethyl cellulose.
(9) a kind of Dentrifice composition; it is characterized in that; be mixed with (A) and be selected from more than one acyl amino hydrochlorate 0.1～2 quality %, (B) alkyl sulfate 0.3～1.8 quality %, (C) sodium tripolyphosphate or tetrasodium pyrophosphate 0.3～1.5 quality % and Polyethylene Glycol 0.3～3 quality % that (D) mean molecule quantity is 200～6000 in acyl glutamate, acylaspartic acid salt and acylglycine salt, and the mass ratio of composition (B)/composition (C) is 0.3～5.
Invention effect
The invention provides a kind of Dentrifice composition, it can play high color stain and adhere to inhibition and color stain removal effect, and low to the stimulation of oral mucosa, and the use sense excellences such as taste and foaming, also have good storage stability.Therefore, Dentrifice composition of the present invention adheres to very effective to the color stain of tooth.
Detailed description of the invention
Below, the present invention is discussed in further detail.Dentrifice composition of the present invention is mixed with (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) water-soluble poly-phosphate and (D) Polyethylene Glycol.
As the acyl amino hydrochlorate of composition (A), the carbon number of its acyl group is suitably 8～20, and suitable especially 12～16.In addition, for amino acid group, can enumerate glutamic acid, aspartic acid, glycine, sarcosine, alanine, methionine, phenylalanine, leucine and isoleucine etc., particularly preferably glutamic acid, aspartic acid and glycine, more preferably glutamic acid.For this salt, can enumerate the alkali metal salt such as sodium, potassium, alkali salt and organic amine salt etc.
As acyl amino hydrochlorate; for example; can enumerate the acyl glutamates such as N-lauroyl-Pidolidone sodium, N-myristoyl-Pidolidone sodium, N-coco-nut oil fatty acid acyl group-Monopotassium L-Glutamate; the acylaspartic acid salt such as N-lauroyl-L-Aspartic acid sodium, the acylglycine salt such as N-coco-nut oil fatty acid acylglycine potassium etc.These can be with a kind of or the mode of two or more combinations is mixed.
Specifically, can be called AminoSurfact ALMS-P1 (N-lauroyl-Pidolidone sodium by commodity in use, Asahi Chemical Corp (the ケ ミ カ of Asahi Chemical Industry Le ズ Co., Ltd.)), Amisoft LS-11 (N-lauroyl-Pidolidone sodium, aginomoto healthy supply Co., Ltd. (gourmet powder ヘ ル シ ー サ プ ラ イ Co., Ltd.)), AminoSurfact AMMS-P1 (N-myristoyl-Pidolidone sodium, Asahi Chemical Corp), Amisoft MS-11 (N-myristoyl-Pidolidone sodium, the healthy supply of aginomoto Co., Ltd.), AminoFoamer FLDS-L (N-lauroyl-L-Aspartic acid sodium, Asahi Chemical Corp) and Amilite GCK-12K (N-coco-nut oil fatty acid acylglycine potassium, the healthy supply of aginomoto Co., Ltd.) etc. commercial acyl amino hydrochlorate.
As acyl glutamates such as composition (A), particularly acyl glutamic acid sodium, compared with having the acylamino acid salt of other amino acid residue, its abnormal flavour (bitterness) is little, give aspect effect of the present invention more suitable.
The combined amount of composition (A) is preferably 0.1～2% (quality %, lower with) of whole composition, and more preferably 0.3～2%, more preferably 0.3～1.5%.Although combined amount is more, color stain is adhered to inhibition and the more raising of bubbling, if exceed 2%, occurs abnormal flavour, the situation that use sense declines.
As the alkyl sulfate of composition (B), can enumerate the alkali metal salt of the alkylsurfuric acid such as lauryl sulfate, myristyl sulphuric acid, can use separately one or use two or more.As alkyl sulfate, particularly sodium lauryl sulfate, it is easily mixed in Dentrifice composition, therefore suitable employing.
For alkyl sulfate, can use the commercially available prod of the manufactures such as Toho Chemical Industry Co., Ltd. (JP) Tokyo-To, Japan.
The combined amount of composition (B) is preferably 0.3～1.8% of whole composition, and more preferably 0.5～1.8%, more preferably 0.5～1.2%.Although combined amount is more, color stain adheres to inhibition and color stain is adhered to more raising of removal effect, and it is more excellent to bubble, if exceed 1.8%, having pair oral mucosa to produce stimulates, the situation that use sense declines.
As the water-soluble poly-phosphate of composition (C), can use one or more in the straight chain shape water-soluble poly-phosphate shown in following general formula (1).
M
n+2P
nO
3n+1 (1)
(in formula, M represents Na or K, and n is 2 or 3 integer.)
For example, can use the sodium tripolyphosphate etc. of the tetrasodium pyrophosphate of polymerization degree n=2 or potassium pyrophosphate, n=3.Especially, from color stain removal effect with to the irritating viewpoint of oral mucosa, more preferably sodium tripolyphosphate.
Specifically, can use the commercially available prod of the manufactures such as peaceful chemical Industry Co., Ltd.
The combined amount of composition (C) is whole composition 0.3～1.5%, is preferably 0.4～1.5%, more preferably 0.5～1.0%.While being less than 0.3%, color stain is adhered to inhibition and color stain poor removal effect, if exceed 1.5%, can oral mucosa be produced and be stimulated, and use sense declines.In addition, bubble and reduce, storage stability is poor.
In the present invention, can further improve effect with proper proportion blending constituent (B) and composition (C), therefore preferred, particularly suppress oral mucosa stimulate, bring into play high color stain adhere to suppress and removal effect aspect, it is more effective.
The blending ratio of composition (B) and composition (C) by quality ratio, (B)/(C) be preferably 0.3～5, more preferably 0.33～3.6, more preferably 0.5～3.Within the scope of this time, color stain adheres to inhibition and color stain removal effect improves, and is less than at 0.3 o'clock, has the situation about stimulating of cannot suppressing, also fluid separation applications poor stability sometimes.If exceed 5, there is pair mucous membrane irritation strong, the situation that use sense declines.
In the present invention; by further mixing (D) Polyethylene Glycol; can further improve the color stain being obtained by composition (A), (B) and also use (C) and adhere to inhibition; and can suppress the abnormal flavour from composition (A) acyl amino hydrochlorate, improve use sense.
As Polyethylene Glycol, although its mean molecule quantity is larger, effect embodies more effective, the Polyethylene Glycol that preferably mean molecule quantity is 200～6000, the Polyethylene Glycol that particularly preferably mean molecule quantity is 400～4000.If mean molecule quantity is in above-mentioned scope, color stain is adhered to inhibition and is improved, and mean molecule quantity is less than at 200 o'clock, has the situation that can not fully be inhibited from the effect of unique abnormal flavour of composition (A).If mean molecule quantity exceedes 6000, there is the abnormal flavour producing from Polyethylene Glycol, the situation of use sense variation.
In addition, mean molecule quantity herein represents the mean molecule quantity that medicine part outer article raw material specification 2006 is recorded, specifically, in pyridine, to make itself and phthalic anhydride form phthalic acid ester, and by excessive phthalic anhydride hydrolysis, the mean molecule quantity of obtaining with sodium hydroxide titration (lower same).
Specifically, can enumerate PEG400 (mean molecule quantity is 380～420), Macrogol 600 (mean molecule quantity is 570～630), Macrogol 4000 (mean molecule quantity is 2600～3800) etc.
Polyethylene Glycol for example can use the commercially available prod of the manufactures such as Sanyo Chemical Industries, Ltd..
The combined amount of composition (D) is whole composition 0.3～3%, is preferably 0.5～3%, more preferably 0.5～2%.While being less than 0.3%, can not suppress abnormal flavour.If exceed 3%, there is generation fluid separation applications, preparation stability is poor, produces in addition the abnormal flavour from Polyethylene Glycol, the situation that use sense is poor.
In the present invention, preferably further mix (E) and be selected from the water-soluble high-molecular compound in carrageenin, xanthan gum, sodium polyacrylate and sodium hydroxyethyl cellulose.By blending constituent (E), can improve intraoral foam retentivity, further improve use sense.In the present invention, as water-soluble high-molecular compound, composition (E) is effective especially aspect above-mentioned effect embodiment, uses composition (E) water-soluble high-molecular compound in addition can not obtain relevant effect.
As composition (E), can mix one or more in above-mentioned water-soluble high-molecular compound.Particularly two or more and use, especially xanthan gum and carrageenin and/or sodium polyacrylate use, can increase foam retentivity and the further use sense improving while brushing teeth, therefore more preferred.
As composition (E), can use commercially available prod.
When blending constituent (E), its combined amount is preferably 0.2～3% of whole composition, and more preferably 0.4～1.5%.If be less than 0.2%, there is the situation that can not get mixed effect.If exceed 3%, there is Dentrifice composition hardening, while brushing teeth, decline at intraoral dispersibility, be difficult to the situation of foaming and use sense variation.
Dentrifice composition of the present invention, the suitable especially toothpaste that is prepared into.In this case, can as required, not hindering in the scope of effect of the present invention, sneak into mentioned component known composition in addition.For example, grinding agent, adhesion agent, binding agent, surfactant be can sneak into, further as required, sweeting agent, antiseptic, coloring agent, spice, various effective ingredient etc. also can be sneaked into.
As grinding agent, can enumerate the silicon dioxide based abrasives such as silica gel, precipitability silicon dioxide, aluminium silicate, the series of calcium phosphate compounds such as dicalcium phosphate dihydrate and anhydride, tricalcium phosphate, tricresyl phosphate magnesium, tetracalcium phosphate, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, Zirconium orthosilicate., hydroxyapatite, synthetic resin based abrasive etc.
The combined amount of these grinding agents is generally 10～50% of whole composition, is preferably 10～30%.
As adhesion agent, can enumerate the sugar alcohol such as Sorbitol, xylitol, the polyhydric alcohol such as glycerol, propylene glycol.These combined amount is generally 5～50%, is in particular 20～45%.
As binding agent, not hindering in the scope of effect of the present invention, the known binding agent beyond can the water-soluble high-molecular compound of blending constituent (E).For example, can enumerate polyvinyl alcohol, guar gum, sodium alginate, Poise C-80M, tackifying silicon dioxide, Montmorillonitum, gelatin and sodium carboxymethyl cellulose etc.While mixing these binding agents, its combined amount preferably comprise composition (E) interior be 0.2～5% scope.
As surfactant, can blending constituent (A) and (B) the known surfactant such as anionic surfactant in addition, nonionic surfactant, cationic surfactant.Specifically, as anionic surfactant, can enumerate the N-acyl group sodium sarcosinate such as N-sodium N-lauroyl sarcosinate, N-myristoyl sodium sarcosinate.As nonionic surfactant, can use sucrose fatty acid ester, fatty ester of maltose, the sugar fatty acid esters such as milk sugar fats acid esters, maltitol fatty acid ester, the sugar alcohol fatty acid esters such as lactose fatty acid ester, polyoxyethylene sorbitan monolaurate, the polyoxyethylene sorbitan fatty acid esters such as polyethenoxy sorbitan monostearate, the polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated Oleum Ricini, lauric acid list or diglycollic amide, fatty acid esters of sorbitan, the senior alcohol ether of polyoxyethylene, poloxalkol, polyoxyethylene polyoxypropylene fatty acid ester etc.As cationic surfactant, can enumerate alkylammonium etc.
While mixing these surfactants, its combined amount comprises composition (A) and be (B) 1～5% in interior hope scope, particularly 1.5～4% scope.
As sweeting agent, can enumerate saccharin sodium etc.; As antiseptic, can enumerate p-Hydroxybenzoate, sodium benzoate etc.
As coloring agent, can enumerate blue No. 1, yellow No. 4, titanium dioxide etc.
As spice, the known spice material using in composition for oral cavity below use capable of being combined: Oleum menthae, Oleum Menthae Rotundifoliae, Oleum Anisi Stellati, Eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, thyme oil, sage oil, Fructus Citri Limoniae oil, orange oil, Oleum menthae (Ha ッ カ oil), Cardamom oil, Fructus Coriandri oil, tangerine oil, lime oil, Oleum lavandula angustifolia, oil of rosemary, bay oil, Flos Matricariae chamomillae oil, caraway oil, Majorana hortensis oil, laurel, Indian oil of verbena, Herba Origani oil, pinke needle oil, orange blossom oil, Oleum Rosae Rugosae, Jasmin oil, oil of grapefruit, Sweetie oil (ス ウ ィ ー テ ィ ー oil), grape-fruit seed oil, concrete of iris, Herba Menthae absolute oil, rose absolute, the natural perfume materials such as Orange Blossom, with processed (the front-end volatiles removal to these natural perfume materials, tails is removed, fractional distillation, liquid-liquid extraction, refine, powdered flavour etc.) after spice, and menthol, carvone, anethole, eucalyptole, methyl salicylate, cinnamic aldehyde, acetaminol, 3-L-menthoxypropane-1, 2-glycol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-replacement-to terpane-3-Methanamide, pinene, octanal, citral, pulegone, methyl acetate, anisaldehyde, ethyl acetate, ethyl n-butyrate., allyl cyclohexane propionic ester, methyl 2-aminobenzoate, ethyl methyl phenyl (+)-2,3-Epoxy-1-propanol, vanillin, undecalactone, hexanal, butanols, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, bran aldehyde, trimethylpyrazine, ethyl lactate, the single spice such as ethylenebis dithiocarbamate acetas, also have the mediation spice such as strawberry essence, apple essence, flavoring banana essence, flavoring pineapple essence, grape essence, Fructus Mangifera Indicae essence, butter essence, milk flavour, fruit mixing essence, tropical fruit (tree) essence etc.
As various effective ingredient, can enumerate sodium fluoride, the fluorides such as sodium monofluorophosphate, ortho-phosphoric potassium salt, the water-soluble phosphorus acid compounds such as sodium salt, glucanase, become the glucanase such as dextranase, allantoin chlorine hydroxy Al, chamenol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its esters, sodium chloride, tranexamic acid, episilon amino caproic acid, DL-tocopherol acetate, α-bisabolol, isopropyl methyl phenol, hibitane salt, cetylpyridinium chloride, azulene, enoxolone, chlorophyll copper sodium, the copper compounds such as copper gluconate, aluctyl., strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivant thereof, zeolite, amylase, methoxy-ethylene, copolymer-maleic anhydride, polyvinyl pyrrolidone, epidihydrocholesterol, benzethonium chloride, beta-cholestanol, trichlorocarbanilide, zinc citrate, the soft extract of Radix Angelicae Sinensis, Cortex Phellodendri extract, Flos Caryophylli, Herba Rosmarini Officinalis, Radix Scutellariae, the extracts such as Flos Carthami.In addition, above-mentioned effective ingredient can be not hinder the effective dose in the scope of effect of the present invention to mix.
Embodiment
Below, by enumerating embodiment and comparative example, the present invention is specifically described.But the present invention is not limited to following embodiment.In addition, in following example, if not otherwise specified, % all represents quality %.
[embodiment and comparative example] prepares the Dentrifice composition (toothpaste) of composition as shown in table 1～4 by the following method, and carries out following evaluation.Result is as shown in table 1～4.
The preparation of test Dentrifice composition:
(1) under room temperature, water soluble ingredient (except binding agent, propylene glycol etc.) mixed dissolution, after pure water, is added and mixes Sorbitol and tackifying silicon dioxide, preparation A phase.
(2) under room temperature, binding agent is scattered in propylene glycol, preparation B phase.
(3) the middle mixing B phase of adding mutually of the A in stirring, preparation C phase.
(4) under room temperature, use 1.5L kneader (tor work is made), C mutually in composition beyond the water soluble ingredient such as potpourri, grinding agent, surfactant, and carry out deaeration by reduce pressure (4kPa), obtain Dentrifice composition 1.2kg.
Use the details of raw material as described below.
(A) N-lauroyl-Pidolidone sodium:
Asahi Chemical Corp's (trade name: AminoSurfact ALMS-P1)
N-lauroyl-L-Aspartic acid sodium:
Asahi Chemical Corp's (trade name: AminoFoamer FLDS-L)
N-coco-nut oil fatty acid-cocos nucifera oil acyl glycine potassium:
Aginomoto healthy supply Co., Ltd. (trade name: Amilite GCK-12K)
(B) sodium lauryl sulfate: Toho Chemical Industry Co., Ltd. (JP) Tokyo-To, Japan
(C) sodium tripolyphosphate: peaceful chemical Industry Co., Ltd
Tetrasodium pyrophosphate: peaceful chemical Industry Co., Ltd
(D) PEG400: PEG400, Sanyo Chemical Industries, Ltd.
PEG4000: Macrogol 4000, Sanyo Chemical Industries, Ltd.
(E) carrageenin: three prosperous Co., Ltd.
Sodium polyacrylate: Toagosei Co., Ltd
Sodium hydroxyethyl cellulose: Daisel chemical industry Co., Ltd (ダ イ セ Le chemical industry Co., Ltd.)
Xanthan gum: DSP five assists food and KCC (DSP Wu Association フ ー De & ケ ミ カ Le Co., Ltd.)
For other composition, use the material that meets medicine part outer article raw material specification 2006.
<1> color stain is adhered to the evaluation of inhibition
<1-1> color stain is adhered to inhibition test
Untreated hydroapatite particles (HAP) surface (HOYA Corp. manufactures, diameter 7mm × thickness 3.5mm), after blasting treatment, cleaned with ultrasonic washing unit in neutral cleaners aqueous solution.Washing, after natural drying, is used beam splitting type colour difference meter (Japanese electricity Se Industrial Co., Ltd manufactures, model: SE-2000), measures the Δ E value (Δ E0) of the HAP before color stain is adhered to.
In addition, with the pure water dilution Dentrifice composition of 2 times of amounts, with 3000rpm centrifugalize 10 minutes, will obtain supernatant as the dispersion liquid that cleans the teeth.By above-mentioned HAP impregnated in be heated to 50 DEG C clean the teeth dispersion liquid after 10 minutes, clean with pure water, remove after surface moisture, according to the repeated impregnations operation in every 10 minutes at 50 DEG C of the order of 0.5% albumin solution → tannin extracting solution → 0.6% ferric citrate (III) ammonium salt solution.Tannin extracting solution is prepared by the following method: in the ion exchange water 1200mL of boiling, put into Japanese tea (trade mark: Lao Song) 50g, black tea (Amada Co., Ltd. of Uniliver manufacture, BRISK tea bag (Block リ ス Network テ ィ ー バ ッ Network)) 5 bags and instant coffee (trade name Nescafe, Amada Co., Ltd. of nest manufactures) 12g, place an evening, filter and remove Japanese tea and black tea.Repeat aforesaid operations 5 times, air-dry HAP surface, measures surperficial Δ E value (Δ E1) again.
The Δ E of initial stage HAP when replace the dispersion liquid that cleans the teeth to process equally with pure water is as Δ E0b, and Δ E after treatment is as Δ E1b.Calculate color stain by following formula and adhere to suppression ratio.
Color stain is adhered to suppression ratio (%)=[(Δ E1b-Δ E0b)-(Δ E1-Δ E0)]/(Δ E1b-Δ E0b) × 100
Adhere to suppression ratio and adhere to inhibition according to following standard evaluation color stain according to color stain.
Color stain is adhered to the evaluation criterion of inhibition
◎: it is more than 80% that color stain is adhered to suppression ratio
Zero: color stain is adhered to suppression ratio to be more than 70% and to be less than 80%
△: color stain is adhered to suppression ratio to be more than 60% and to be less than 70%
×: color stain is adhered to suppression ratio and is less than 60%
The evaluation of <2> color stain removal effect
<2-1> color steeps the manufacture method of adhering to HAP
Hydroapatite particles (HAP) surface (HOYA Corp. manufactures, diameter 7mm × thickness 3.5mm), after blasting treatment, cleaned with ultrasonic washing unit in neutral cleaners aqueous solution.With 30% phosphate aqueous solution etching surface (10 minutes), washing, after natural drying, (Japanese electricity Se Industrial Co., Ltd manufactures to use beam splitting type colour difference meter, model: SE-2000), measure the Lab value (L0) that color stain is adhered to front HAP.To above-mentioned HAP, with the repeated impregnations operation per hour of 0.5% albumin solution → tannin extracting solution → 0.6% ferric citrate (III) aqueous ammonium, repeat this dip operation 50 times, after air-dry one day at normal temperatures, with flowing water cleaning, more air-dry, make quality stain and adhere to HAP.In addition, tannin extracting solution is prepared by the following method: in the ion exchange water 1200mL of boiling, put into Japanese tea (trade mark: Lao Song) 50g, black tea (Amada Co., Ltd. of Uniliver manufacture, BRISK tea bag) 5 bags and instant coffee (trade name Nescafe, Amada Co., Ltd. of nest manufactures) 12g, place an evening, filter and remove Japanese tea and black tea.The color stain of making is adhered to the color on HAP surface and measure, be worth as L1.
<2-2> color stain is removed test
With the pure water dilution Dentrifice composition of 2 times of amounts, be made into the dispersion liquid that cleans the teeth.The color stain made from said method is adhered to HAP be impregnated in and clean the teeth in dispersion liquid, use is provided with flat brush toothbrush (PC Clinica toothbrush, Lion Corporation manufacture) automatic grinding testing machine (shop, river, Co., Ltd. palace manufacture, increase the weight of 200g, 37 DEG C of temperature) scrub 200 times, measure the Lab value (L2) of the HAP after scrubbing.
Calculate color stain clearance according to following formula.
Tannin ferrum color stain clearance (%)=[(L1-L2)/(L1-L0)] × 100
According to color stain clearance and according to following standard evaluation color stain removal effect.
The evaluation criterion of color stain removal effect
◎: color stain clearance is more than 50%
Zero: color stain clearance is more than 40% and is less than 50%
△: color stain clearance is more than 30% and is less than 40%
×: color stain clearance is less than 30%
The foaming evaluation of <3> dentifrice
, by 4 times of about 5g Dentrifice composition dilutions this 10mL aqueous solution is added in 100mL Epton (エ プ ト Application) pipe with Artificial saliva.Every 10 seconds up-down vibration 20 times, measure the foam height leaving standstill after 1 minute, and according to the foaming of following standard evaluation dentifrice.
The evaluation criterion of bubbling
◎: more than 20mm
Zero: 15mm is above and be less than 20mm
△: 10mm is above and be less than 15mm
×: be less than 10mm
The stimulation evaluation of <4> to oral mucosa
Adopt 10 special testers (paneler) to mucous membrane irritation sensitivity, stickyly on toothbrush get about 1g Dentrifice composition, the stimulation degree to oral mucosa when carrying out brushing teeth for 3 minutes, obtains the answer of 4 grades.In this answer, 4 points, " imperceptible stimulation " meter work, 3 points, " almost imperceptible stimulation " meter work, " feeling stimulates " 2 points, meter work, " strongly feeling stimulates " are counted and do 1 point, according to the average mark of 10 and according to following standard evaluation use sense.
The evaluation criterion stimulating
◎: more than being equally divided into 3.5 points, below 4.0 points
Zero: be equally divided into 3.0 points above and be less than 3.5 points
△: be equally divided into 2.0 points above and be less than 3.0 points
×: be equally divided into 1.0 points above and be less than 2.0 points
Bitter taste estimate when <5> brushes teeth
Adopt 10 special testers of dentist, stickyly on toothbrush get about 1g Dentrifice composition, brush teeth after approximately 3 minutes, the bitterness when brushing teeth, obtains the answer of 4 grades.In this answer, by " complete imperceptible bitterness " meter do 4 points, " almost imperceptible bitterness " meter do 3 points, " feeling a little bitterness " meter do 2 points, " feeling very bitter " meter do 1 point, according to the average mark of 10 and according to following standard evaluation use sense.
The evaluation criterion of bitterness
◎: more than being equally divided into 3.5 points, below 4.0 points
Zero: be equally divided into 3.0 points above and be less than 3.5 points
△: be equally divided into 2.0 points above and be less than 3.0 points
×: be equally divided into 1.0 points above and be less than 2.0 points
The storage stability evaluation of <6> preparation
3 tubular containers that accommodate Dentrifice composition are preserved after 1 month respectively under 40 DEG C of conditions, judged fluid separation applications stability according to following standards of grading, and evaluate according to following standard.
The standards of grading of fluid separation applications
4 points: no liquid separates completely.
3 points: confirm a little have fluid separation applications (degree out of question) at spout part.
2 points: a little obviously confirm to have fluid separation applications at spout part and mastic surface.
1 point: extrude Dentrifice composition from pipe time, confirm to have the separating medium of the degree of hanging down from spout part.
The evaluation criterion of storage stability
◎: 4.0 points
Zero: 3.0 point above and be less than 4.0 points
△: 2.0 points above and be less than 3.0 points
×: be less than 2.0 points
The intraoral foam retentivity of <7> is evaluated
Adopt 10 special testers of dentist, on toothbrush, glue and get about 1g Dentrifice composition, brush teeth approximately 3 minutes, to intraoral foam retentivity, obtain the answer of 4 grades.In this answer, to " from mouth, not hang down completely " meter do 4 points, " from mouth, hanging down hardly " meter do 3 points, " from mouth, hanging down a little " meter do 2 points, " from mouth, hanging down " meter do 1 point, according to the average mark of 10 and according to following standard evaluation use sense.
The evaluation criterion of foam retentivity
◎: more than being equally divided into 3.5 points, below 4.0 points
Zero: be equally divided into 3.0 points above and be less than 3.5 points
△: be equally divided into 2.0 points above and be less than 3.0 points
×: be equally divided into 1.0 points above and be less than 2.0 points
[table 1]
[table 2]
[table 3]
[table 4]
Claims (9)
1. a Dentrifice composition; it is characterized in that; be mixed with the straight chain shape water-soluble poly-phosphate shown in (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) following general formula (1) and (D) Polyethylene Glycol
M
n+2P
nO
3n+1 (1)
In formula, M represents Na or K, and n is 2 or 3 integer;
And the combined amount of composition (C) is 0.3～1.5 quality %, the combined amount of composition (D) is 0.3～3 quality %.
2. Dentrifice composition as claimed in claim 1, wherein, the mass ratio of composition (B)/composition (C) is 0.3～5.
3. Dentrifice composition as claimed in claim 1 or 2, wherein, the acyl amino hydrochlorate of composition (A) is to be selected from more than one in acyl glutamate, acylaspartic acid salt and acylglycine salt.
4. Dentrifice composition as claimed in claim 3, wherein, the acyl amino hydrochlorate of composition (A) is acyl glutamate.
5. the Dentrifice composition as described in any one in claim 1～4, wherein, the water-soluble poly-phosphate of composition (C) is sodium tripolyphosphate or tetrasodium pyrophosphate.
6. the Dentrifice composition as described in any one in claim 1～5, wherein, the Polyethylene Glycol of composition (D) is that mean molecule quantity is 200～6000 Polyethylene Glycol.
7. the Dentrifice composition as described in any one in claim 1～6, wherein, is mixed with composition (A) 0.1～2 quality %, composition (B) 0.3～1.8 quality %.
8. the Dentrifice composition as described in any one in claim 1～7, wherein, is also mixed with (E) and is selected from one or more the water-soluble high-molecular compound in carrageenin, xanthan gum, sodium polyacrylate and sodium hydroxyethyl cellulose.
9. a Dentrifice composition; it is characterized in that; be mixed with (A) and be selected from more than one acyl amino hydrochlorate 0.1～2 quality %, (B) alkyl sulfate 0.3～1.8 quality %, (C) sodium tripolyphosphate or tetrasodium pyrophosphate 0.3～1.5 quality % and Polyethylene Glycol 0.3～3 quality % that (D) mean molecule quantity is 200～6000 in acyl glutamate, acylaspartic acid salt and acylglycine salt, and the mass ratio of composition (B)/composition (C) is 0.3～5.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011261165A JP5891749B2 (en) | 2011-11-30 | 2011-11-30 | Dentifrice composition |
| JP2011-261165 | 2011-11-30 | ||
| PCT/JP2012/078848 WO2013080762A1 (en) | 2011-11-30 | 2012-11-07 | Dentifrice composition |
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| Publication Number | Publication Date |
|---|---|
| CN103957878A true CN103957878A (en) | 2014-07-30 |
| CN103957878B CN103957878B (en) | 2016-08-24 |
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|---|---|---|---|
| CN201280058734.4A Active CN103957878B (en) | 2011-11-30 | 2012-11-07 | Dentrifice composition |
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| JP (1) | JP5891749B2 (en) |
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| WO (1) | WO2013080762A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111031999A (en) * | 2017-12-07 | 2020-04-17 | 狮王株式会社 | Toothpaste composition |
| CN113038925A (en) * | 2018-12-26 | 2021-06-25 | 狮王株式会社 | Oral composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6055296B2 (en) * | 2012-06-08 | 2016-12-27 | 花王株式会社 | Oral composition |
| JP6334137B2 (en) * | 2013-11-05 | 2018-05-30 | 花王株式会社 | Dentifrice composition |
| JP6763725B2 (en) | 2016-09-06 | 2020-09-30 | 花王株式会社 | Oral composition |
| USD825741S1 (en) | 2016-12-15 | 2018-08-14 | Water Pik, Inc. | Oral irrigator handle |
| JP7565157B2 (en) | 2017-02-02 | 2024-10-10 | ウォーター ピック インコーポレイテッド | Tablets containing abrasives for cleaning teeth |
| CN114631908A (en) | 2017-03-16 | 2022-06-17 | 洁碧有限公司 | Oral irrigator handle for use with oral agents |
| JP7561478B2 (en) * | 2017-06-29 | 2024-10-04 | キリンホールディングス株式会社 | Oral cavity composition for inhibiting stain adhesion |
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| JP2002047161A (en) * | 2000-07-28 | 2002-02-12 | Lion Corp | Composition for oral cavity |
| CN1812760A (en) * | 2003-06-27 | 2006-08-02 | 狮王株式会社 | Dentifrice composition |
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| JPH0912438A (en) * | 1995-06-28 | 1997-01-14 | Lion Corp | Composition for oral cavity |
| JP4109727B2 (en) * | 1996-07-05 | 2008-07-02 | サンスター株式会社 | Composition for oral cavity containing amino acid surfactant |
| JP4147412B2 (en) * | 2003-12-24 | 2008-09-10 | ライオン株式会社 | Oral composition |
| JP4831948B2 (en) * | 2004-09-03 | 2011-12-07 | 花王株式会社 | Dentifrice composition |
| JP2006104101A (en) * | 2004-10-04 | 2006-04-20 | Lion Corp | Composition for oral cavity |
| JP5226986B2 (en) * | 2007-08-23 | 2013-07-03 | 花王株式会社 | Liquid oral composition |
| JP2010143843A (en) * | 2008-12-18 | 2010-07-01 | Lion Corp | Liquid composition for oral cavity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002047161A (en) * | 2000-07-28 | 2002-02-12 | Lion Corp | Composition for oral cavity |
| CN1812760A (en) * | 2003-06-27 | 2006-08-02 | 狮王株式会社 | Dentifrice composition |
| JP2010275272A (en) * | 2009-06-01 | 2010-12-09 | Lion Corp | Dentifrice composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111031999A (en) * | 2017-12-07 | 2020-04-17 | 狮王株式会社 | Toothpaste composition |
| CN111031999B (en) * | 2017-12-07 | 2023-03-28 | 狮王株式会社 | Toothpaste composition |
| CN113038925A (en) * | 2018-12-26 | 2021-06-25 | 狮王株式会社 | Oral composition |
| CN113038925B (en) * | 2018-12-26 | 2023-10-20 | 狮王株式会社 | Oral composition |
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| Publication number | Publication date |
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| WO2013080762A1 (en) | 2013-06-06 |
| CN103957878B (en) | 2016-08-24 |
| JP5891749B2 (en) | 2016-03-23 |
| JP2013112654A (en) | 2013-06-10 |
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