CN103948780B - A kind of medicine and capsule for constipation - Google Patents
A kind of medicine and capsule for constipation Download PDFInfo
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- CN103948780B CN103948780B CN201410168640.3A CN201410168640A CN103948780B CN 103948780 B CN103948780 B CN 103948780B CN 201410168640 A CN201410168640 A CN 201410168640A CN 103948780 B CN103948780 B CN 103948780B
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Abstract
The invention discloses a kind of medicine and capsule for constipation, it includes according to weight portion：10 parts 30 parts of prepared RADIX ET RHIZOMA RHEI, 5 parts 10 parts of stir-baked SEMEN PERSICAE and 5 parts 15 parts of lucid asparagus.Relax bowel, increase small intestine volume, improve the effect of excrement drainage rate in large intestine, Long term Animal toxicity research result shows：The general state of administration group animal during administration and after being discontinued, grow, diet etc. is showed no exception, the multinomial physiological and biochemical index such as blood routine, hepatic and renal function compares equal no significant difference with control group, is checked under the main organs sample mirror of pathological observation and censorship rat and is showed no the pathological change relevant with drug toxicity.Show that the medicine toxicity is relatively low, clinical dosage is orally safe.
Description
Technical field
The present invention relates to a kind of medicine and capsule for constipation.
Background technology
Constipation is clinical common complicated symptom, is primarily referred to as that defecation frequency is reduced, excrement amount is reduced, excrement is dry and hard, row
Just it is laborious etc..Not normal mainly due to large intestine conduction function, excrement is overstayed in enteral, and moisture is absorbed, and causes excrement to be done
Dry, it is scorching that the interpretation of the cause, onset and process of an illness is mainly stomach, and mechanism of qi is retarded by silt, body fluid being damaged.Constipation the lighter is little to body effect, and severe one can cause abdominal distension
Stomachache, poor food of receiving subtracts, and fissure in ano, thrombotic hemorrhoid, anal sinusitis is had blood in stool, and prolapse of the anus and face play acne, and dim complexion plays spot.
The current country there is no specific treatment medicine.
The content of the invention
In view of above-mentioned the deficiencies in the prior art, it is an object of the invention to provide a kind of medicine and capsule for constipation,
To provide a kind of Chinese medicine, the therapeutic effect to constipation is improved.
Technical scheme is as follows：
A kind of medicine for constipation, it includes according to weight portion：
10 parts -30 parts of prepared RADIX ET RHIZOMA RHEI, 5 parts -10 parts of stir-baked SEMEN PERSICAE and 5 parts -15 parts of lucid asparagus.
Described medicine, wherein, it includes according to weight portion：30 parts of prepared RADIX ET RHIZOMA RHEI, 5 parts of stir-baked SEMEN PERSICAE and 15 parts
Lucid asparagus.
It is a kind of to use the capsule that medicine is made as described.
A kind of medicine and capsule for constipation that the present invention is provided, adds using prepared RADIX ET RHIZOMA RHEI, stir-baked SEMEN PERSICAE and lucid asparagus are refined
Work is formed, and rheum officinale has attacks the functions such as stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances, stir-baked SEMEN PERSICAE have promoting blood circulation,
The function of relaxing bowel, lucid asparagus has the function of nourishing Yin and promoting production of body fluid, and the row of gastric content can be just promoted only with three taste Chinese medicines
Sky, relaxes bowel, and increases small intestine volume, improves the effect of excrement drainage rate in large intestine, Long term Animal toxicity research result
Show：The general state of administration group animal during administration and after being discontinued, grow, diet etc. is showed no exception, blood routine, liver
The multinomial physiological and biochemical index such as renal function compares equal no significant difference with control group, pathological observation and censorship rat it is main dirty
Checked under device sample mirror and be showed no the pathological change relevant with drug toxicity.Show that the medicine toxicity is relatively low, clinical dosage is orally pacified
Entirely.
Specific embodiment
The invention provides a kind of medicine and capsule for constipation, to make the purpose of the present invention, technical scheme and effect
Clearer, clear and definite, the present invention is described in more detail below.It should be appreciated that specific embodiment described herein is only
It is used to explain the present invention, is not intended to limit the present invention.
The invention provides a kind of medicine for constipation, it includes according to weight portion：10 parts -30 parts of prepared RADIX ET RHIZOMA RHEI, 5
The stir-baked SEMEN PERSICAE of -10 parts of part and 5 parts -15 parts of lucid asparagus.
Further, it includes according to weight portion：30 parts of prepared RADIX ET RHIZOMA RHEI, 5 parts of stir-baked SEMEN PERSICAE and 15 parts of Tianmen
Winter.
The formulations such as capsule, tablet, the water dispersion tablet that said medicine can be made.
In order to more description is of the invention in detail, more description in detail is below carried out.
Tablet is made using the lucid asparagus of the prepared RADIX ET RHIZOMA RHEI of 200g, the stir-baked SEMEN PERSICAE of 70g and 100g.
Animal toxicity test
Rat takes 80 and is randomly divided into 4 groups, every group of male and female half and half after animal observation ward raises 1 week.First group is
Control group, gavage gives 20ml/kg water, second and third, four groups be high, medium and low three dosage group, respectively gavage give rare treasure glue
Capsule powder 4.0,2.0,0.6g/kg（200,100,30 times equivalent to clinical application amount）, daily 1 time, generally upper
8.30~10.30 points of gastric infusions of noon, continuous 8 weeks.The daily behavioral activity for observing animal, diet, drinking-water and excrement etc.
Situation, weighs weekly 1 time.3 measure the ingesting of rat, amounts of drinking water weekly.24 hours, each group after last dose
10 rats are put to death respectively, are taken blood and are made that leucocyte (WBC) is counted and classification (LY, MO, GR), red blood cell count(RBC) (RBC), blood are small
Plate number (Pit), hemoglobin (Hb), mean corpuscular volume (MCV) (MCV), mean corpusular hemoglobin（MCH）Check, take
Blood is centrifuged, and with serum measure glutamic-pyruvic transaminase (enzyme process that ALT, IFCC recommend), (AST, IFCC recommend glutamic-oxalacetic transaminease
Enzyme process), total protein (TP, biuret method), albumin (ALB, Bromocresol green), creatinine (CR), urea (UREA, PAP enzyme
Method), blood sugar (GLU, enzymatic measurement), T-CHOL (CHOL, PAP enzyme process), total bilirubin (T-BLL, heavy nitrogen), alkalescence
Phosphatase (enzyme process that ALP, IFCC recommend).Dissect rat, visually observe the change of each internal organs of animal, and core, liver, spleen,
Lung, kidney, adrenal gland, thymus gland, testis, epididymis, prostate, thyroid gland, ovary and uterus are weighed, and are calculated organ index and are taken
State tissue and stomach, small intestine, large intestine make histopathological examination.After remaining rat is discontinued, continue to observe two weeks, convalescence terminates
Detected with the above method afterwards.Result of the test is processed through t inspections, is represented with X ± SD, the results are shown in Table 1~5.
Result of the test
1. continuous 8 weeks gastric infusions of the influence rare treasure capsule 4.0,2.0,0.6g/kg of pair rat outward appearance behavior etc.,
After administration 2 days, three administration group major part rats are soft stool, after 4 days, all soft stools, and high dose group has 2 in 8 weeks
Male rat, is upon administration semiliquid stool after 3 weeks, and by the 5th week, all soft stools, rat behavior activity was normal, hair color
Phenomenon bright, without exception occurs.After drug withdrawal, three administration groups are without secondary constipation phenomenon.
2. continuous 8 weeks gastric infusions of the influence rare treasure capsule 4.0,2.0,0.6g/kg of pair rat body weight, from second
Start middle dose group rat body weight growth rate week comparatively fast, a little higher than control group of average weight, high dose group male rat is being given
After medicine 6 weeks, body weight increase speed slows down, and body weight is slightly less than control group, high dose group female rats and low dose group rat body
Increase again, three dosage groups compare equal no significant difference with control group.The results are shown in Table 1.
3. pair rat ingests the continuous 8 weeks gastric infusions of influence rare treasure capsule 4.0,2.0,0.6g/kg of drinking-water, respectively
Ingest in administration group rat each week and compare no significant difference in week corresponding to control rats with amount of drinking water.The results are shown in Table 2.
4. the influence rare treasure capsule 4.0,2.0,0.6g/kg of pair Rats Organs and Tissues index is given for continuous 8 weeks to rat oral gavage
Medicine, high dose group heart, liver, kidney, adrenal gland, a little higher than control group of ovary organ index, but compare without group with control group
Between difference.In, the organ index that is determined of low dose group, compare no significant difference with control group.Convalescence lungs index
High, middle dose group is slightly less than control group, but compares without group difference with control group.Other organs index compares nothing with control group
Notable difference.Convalescence, three administration group Rats Organs and Tissues indexes compared no significant difference with control rats.The results are shown in Table 3,4.
5. the continuous 8 weeks gastric infusions of the influence rare treasure capsule 4.0,2.0,0.6g/kg of pair rat blood routine, three
RBC, WBC, Hgb, Pit, GR, LY, MO, MCV, MCH detected value of dosage group rat in normal range (NR), with control group
Compare no significant difference.Also no significant difference between convalescence each group rat blood routine.The results are shown in Table 5.
6. continuous 8 weeks gastric infusions of the influence rare treasure capsule 4.0,2.0,0.6g/kg of pair rat blood biochemical indicator
, three ALT, TP, ALB, UREA, CR, CHOL, ALP, AST, GLU, T-BIL detected value averages of dosage group rat are and right
Compare no significant difference according to group.High dose group ALP and AST averages are higher than control group after being administered 8 weeks, it may be possible to be administered
Dosage is big, caused by increase burden of liver.But compare without group difference with control group.Convalescence each group rat blood biochemical indicator
Also no significant difference.
Influence (X ± SD) of the table 1 to rat body weight
Table 2 is ingested the influence of amount of drinking water to rat
Continued 2
Influence of the table 3 to Rats Organs and Tissues index（8 weeks）（X±SD ）
Continued 3
Influence of the table 4 to Rats Organs and Tissues index（Convalescence）（X±SD ）
Continued 4
Influence of the table 5 to rat blood routine
It should be appreciated that application of the invention is not limited to above-mentioned citing, and for those of ordinary skills, can
To be improved according to the above description or converted, all these modifications and variations should all belong to the guarantor of appended claims of the present invention
Shield scope.
Claims (2)
1. a kind of medicine for constipation, it uses the lucid asparagus of the prepared RADIX ET RHIZOMA RHEI of 200g, the stir-baked SEMEN PERSICAE of 70g and 100g to be made；
The emptying of gastric content can just be promoted using three taste Chinese medicines, relaxed bowel, increase small intestine volume, raising excrement is in large intestine
Drainage rate.
2. a kind of medicine as claimed in claim 1, it is characterised in that the medicine is made tablet or capsule.
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| CN201410168640.3A CN103948780B (en) | 2014-04-23 | 2014-04-23 | A kind of medicine and capsule for constipation |
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| CN103948780B true CN103948780B (en) | 2017-06-16 |
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| US7482029B2 (en) * | 2005-04-01 | 2009-01-27 | Bionovo, Inc. | Composition for treatment of menopause |
| CN101129766A (en) * | 2007-09-24 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese medicine preparation for treating constipation |
| CN103223024B (en) * | 2013-04-09 | 2014-12-24 | 侯宪红 | Diabetes mellitus dialectical traditional Chinese medicine prescription |
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| 76 例损伤后便秘处理的临床体会;邢国平等;《中医药信息》;19981231(第3期);全文 * |
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