CN103933263A - External medicinal composition for treating chronic osteomyelitis and application thereof - Google Patents
External medicinal composition for treating chronic osteomyelitis and application thereof Download PDFInfo
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- CN103933263A CN103933263A CN201410197497.0A CN201410197497A CN103933263A CN 103933263 A CN103933263 A CN 103933263A CN 201410197497 A CN201410197497 A CN 201410197497A CN 103933263 A CN103933263 A CN 103933263A
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Abstract
The invention discloses an external medicinal composition for treating chronic osteomyelitis. The external medicinal composition for treating the chronic osteomyelitis is prepared from active ingredients and a pharmaceutic adjuvant, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight: 21-30 parts of Chinese violet, 15-26 parts of pagoda tree pod, 6-12 parts of szechwan lovage rhizome, 6-12 parts of stephania terandra and 18-30 parts of coptis chinensis. After the external medicinal composition disclosed by the invention is used for treating the chronic osteomyelitis, recovery of a bone structure of a sicken limb is in a progressive course, and combined action of the external medicinal composition for treating the chronic osteomyelitis for controlling infection and promoting bone regeneration is obviously better than pure anti-infection effect of antibiotic.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of externally-applied medicinal composition and application thereof for the treatment of chronic osteomyelitis.
Background technology
Chronic osteomyelitis is that high, the sick position of a kind of sickness rate is dark, the state of an illness weight, the course of disease length, weak curative effect, easy intractable orthopaedic disease of repeatedly showing effect, grievous injury patient's physical and mental health.Traditional treatment means is at least 4-6 week vein antibiotic application and facial debridement treatment, but because pathological tissues in chronic osteomyelitis is wrapped in infectious sequestrum, focus of infection is around held with the sclerotin of relative ischemia by sclerosis, and whole body application antibiotic is difficult to thoroughly eliminate and infect.
Summary of the invention
In view of the deficiencies in the prior art, the object of the invention is to by folk prescription among the people is furtherd investigate, thereby a kind of externally-applied medicinal composition and application thereof for the treatment of chronic osteomyelitis is provided.Adopt the determined curative effect of this Drug therapy chronic osteomyelitis, can thoroughly eliminate infection, be better than antibiotic therapeutic effect.
The object of the present invention is achieved like this:
A kind of externally-applied medicinal composition for the treatment of chronic osteomyelitis, by active component and pharmaceutically acceptable auxiliaries, be prepared from, by weight, described active component is prepared from through decoction and alcohol sedimentation technique by following traditional Chinese medicinal material raw materials: Herba Violae 21-30 part, Fructus Sophorae 15-26 part, Rhizoma Chuanxiong 6-12 part, Radix Stephaniae Tetrandrae 6-12 part, Rhizoma Coptidis 18-30 part.
Preferably, treat as mentioned above the externally-applied medicinal composition of chronic osteomyelitis, by weight, described active component is prepared from through decoction and alcohol sedimentation technique by following traditional Chinese medicinal material raw materials: Herba Violae 24-26 part, Fructus Sophorae 19-21 part, Rhizoma Chuanxiong 8-10 part, Radix Stephaniae Tetrandrae 8-10 part, Rhizoma Coptidis 22-25 part.
Further preferably, treat as mentioned above the externally-applied medicinal composition of chronic osteomyelitis, by weight, described active component is prepared from through decoction and alcohol sedimentation technique by following traditional Chinese medicinal material raw materials: 25 parts of Herba Violaes, 20 parts of the Fructuss Sophorae, 9 parts of Rhizoma Chuanxiongs, 9 parts of Radixs Stephaniae Tetrandrae, 23 parts of Rhizoma Coptidis.
The externally-applied medicinal composition for the treatment of chronic osteomyelitis of the present invention can be prepared as gel, ointment.
X-ray inspection is the basic diagnostic method of chronic osteomyelitis, can know bone marrow hyperosteogeny, the sclerosis situation of reflection chronic osteomyelitis, for key shape, periosteal proliferation degree imaging clearly.By animal experiment, study discovery, adopt after externally-applied medicinal composition treatment of the present invention, the x-ray performance of rabbit model is along with the prolongation for the treatment of time improves gradually, x-ray typing be take after the 40th day and is cured recovery type as main in treatment, and this points out externally-applied medicinal composition of the present invention can play the effect for the treatment of chronic osteomyelitis.Therefore, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of externally-applied medicinal composition as above in the medicine of preparation treatment chronic osteomyelitis.
Compared with prior art, pharmaceutical composition of the present invention reaches the object of curing chronic osteomyelitis by improving body's immunity, control local infection and improving tissue repair.This medicine is used for the treatment of after chronic osteomyelitis, and the recovery of suffering limb bone structure is carries out sexual development, and the comprehensive function of its infection control and promotion osteanagenesis is obviously better than antibiotic simple infection effect.
The specific embodiment
It should be noted that, the traditional Chinese medicinal material raw materials that various embodiments of the present invention adopt has following source: Herba Violae is selected the dry herb of Violaceae Chinese violet Viola yedoensis Makino.The Fructus Sophorae is selected the dry mature fruit of leguminous plant Chinese scholartree Sophora japonica L..Rhizoma Chuanxiong is selected samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Radix Stephaniae Tetrandrae is selected the dry root of menispermaceous plants Radix stephaniae tetrandrae Stephania tetrandra S. Moore.Rhizoma Coptidis is selected the dry rhizome of the plant Rhizoma Coptidis Coptis chinensis Franch. of gelsemium section.
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Take Herba Violae 0.25kg, Fructus Sophorae 0.20kg, Rhizoma Chuanxiong 0.09kg, Radix Stephaniae Tetrandrae 0.09kg and Rhizoma Coptidis 0.23kg merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃, relative density is 1.15g/mL, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dry cream, pulverize, 10g carbomer is slowly joined in the distilled water of 500ml left and right, limit edged stirs until form transparent gel-type vehicle, 1.5g dried cream powder is dissolved in suitable quantity of water, add again in gel-type vehicle, stir, add 60ml propylene glycol, 60ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, obtains Chinese medicine gel.
Embodiment 2
Take Herba Violae 0.21kg, Fructus Sophorae 0.20kg, Rhizoma Chuanxiong 0.12kg, Radix Stephaniae Tetrandrae 0.06kg and Rhizoma Coptidis 0.20kg merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 85% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃, relative density is 1.15g/mL, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dry cream, pulverize, 10g carbomer is slowly joined in the distilled water of 500ml left and right, limit edged stirs until form transparent gel-type vehicle, 1.5g dried cream powder is dissolved in suitable quantity of water, add again in gel-type vehicle, stir, add 60ml propylene glycol, 60ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, obtains Chinese medicine gel.
Embodiment 3
Take Herba Violae 0.28kg, Fructus Sophorae 0.26kg, Rhizoma Chuanxiong 0.08kg, Radix Stephaniae Tetrandrae 0.10kg and Rhizoma Coptidis 0.30kg merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing over night, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃, relative density is 1.15g/m, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dry cream, pulverize, 10g carbomer is slowly joined in the distilled water of 500ml left and right, limit edged stirs until form transparent gel-type vehicle, 1.5g dried cream powder is dissolved in suitable quantity of water, add again in gel-type vehicle, stir, add 60ml propylene glycol, 60ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, obtains Chinese medicine gel.
The therapeutic test of embodiment 4 Chinese medicine externals to chronic osteomyelitis model
The preparation of blank gel: 10g carbomer is slowly joined in the distilled water of 500ml left and right, limit edged stirs until form transparent gel-type vehicle, add 60ml propylene glycol, 60ml glycerol, purified water to 1000ml, triethanolamine regulates pH value to neutral, the white gel agent of having leisure.
30 of healthy rabbits, male and female half and half, body weight 1.8-2.2 kg.Prepare as follows chronic osteomyelitis model: under aseptic condition, rabbit right tibial medial longitudinal incision 3cm, cut skin, subcutaneous tissue, appear right proximal tibia inner side, after peeling off local periosteum, with 3mm drill bit hand drill, bore 3 longitudinally connected, partly overlapping bone holes, strike off spongy bone, make the rectangle bone window of 0.5cm * 1.0crn.In bone window, inject sodium morrhuate 0.5ml, after placement 15 min, inject 5 * 10
6the staphylococcus aureus ATCC 29213 suspension 0.5ml of CFU/ml, bone wax sealing bone is damaged.Povidone iodine wiping after normal saline flushing, sew up wound.The 3rd day rabbit sick lower limb vein is red and swollen, heating.Tunnel after 3 weeks, suppurate.X-ray inspection shows middle tibia soft tissue swelling, and the visible cortical bone density in outside reduces, the destructive focus of molten bone, and periosteal proliferation, mottled osteoclasias etc., illustrate chronic osteomyelitis molding success.
Rabbits Models is divided into following two groups at random: model control group, treatment by Chinese herbs group, 15 every group.Two groups of capable suffering limb clearance of focal lesions of chronic osteomyelitis rabbit model, postoperative treatment by Chinese herbs group rabbit sticks by the Chinese medicine gel of the embodiment of the present invention 1 preparation, stick front first that affected part is cleanly with aseptic change dressing, after wound nature airing, osteomyelitis gel is spread out on sterile gauze, stick in affected part.Model control group rabbit sticks with above-mentioned blank gel, sticks front first that affected part is cleanly with aseptic change dressing, after wound nature airing, osteomyelitis gel is spread out on sterile gauze, sticks in affected part.
Latter the 20th, 40,60 days for the treatment of, after Animal Anesthesia, row trouble bone x-ray is taken the photograph sheet.Conditions of exposure: 50kV, 50mA, 0.06s.According to document (Liu Zongyi, Xie Jinglong, Xie Zhengping. the discussion of chronic suppurative osteomyelisis x-ray diagnosis typing. doctor studies magazine, 1993,16 (11): chronic suppurative osteomyelisis x-ray diagnosis typing standard 41-43), by rabbit suffer from X-ray of bone be divided into gently, in, 3 grades of severes, slight for curing recovery type, moderate is proliferous type and x-ray stable type, and severe is for destroying Advancement Type and sequestrum formation type.The relatively variation of different time rabbit suffering limb x-ray diagnosis typing after treatment.The results are shown in Table 1.
The variation (only) of table 1 liang group rabbit pathological changes limbs x-ray diagnosis typing
Result of the test by table 1 can find out, at each of point, the x-ray diagnosis typing of model control group be take severe as main observing time, and treatment by Chinese herbs group take slight and moderate as main at the 40th day, take slightly as main after the 60th day, had obvious therapeutic effect.
Claims (5)
1. an externally-applied medicinal composition for the treatment of chronic osteomyelitis, by active component and pharmaceutically acceptable auxiliaries, be prepared from, it is characterized in that: by weight, described active component is prepared from through decoction and alcohol sedimentation technique by following traditional Chinese medicinal material raw materials: Herba Violae 21-30 part, Fructus Sophorae 15-26 part, Rhizoma Chuanxiong 6-12 part, Radix Stephaniae Tetrandrae 6-12 part, Rhizoma Coptidis 18-30 part.
2. treat as claimed in claim 1 the externally-applied medicinal composition of chronic osteomyelitis, it is characterized in that: by weight, described active component is prepared from through decoction and alcohol sedimentation technique by following traditional Chinese medicinal material raw materials: Herba Violae 24-26 part, Fructus Sophorae 19-21 part, Rhizoma Chuanxiong 8-10 part, Radix Stephaniae Tetrandrae 8-10 part, Rhizoma Coptidis 22-25 part.
3. treat as claimed in claim 2 the externally-applied medicinal composition of chronic osteomyelitis, it is characterized in that: by weight, described active component is prepared from through decoction and alcohol sedimentation technique by following traditional Chinese medicinal material raw materials: 25 parts of Herba Violaes, 20 parts of the Fructuss Sophorae, 9 parts of Rhizoma Chuanxiongs, 9 parts of Radixs Stephaniae Tetrandrae, 23 parts of Rhizoma Coptidis.
4. as described in claim 1 or 2 or 3, treat the externally-applied medicinal composition of chronic osteomyelitis, it is characterized in that: described externally-applied medicinal composition is gel, ointment.
5. the application of the externally-applied medicinal composition described in claim 1 or 2 or 3 in the medicine of preparation treatment chronic osteomyelitis.
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| CN201410197497.0A CN103933263A (en) | 2014-05-12 | 2014-05-12 | External medicinal composition for treating chronic osteomyelitis and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721561A (en) * | 2015-02-28 | 2015-06-24 | 朱海颖 | Traditional Chinese medicine for treating heat-toxin accumulation type traumatic chronic osteomyelitis and preparation method thereof |
| CN104940541A (en) * | 2015-06-19 | 2015-09-30 | 张士海 | Preparation for chronic osteomyelitis treating and preparation method |
| CN104940629A (en) * | 2015-06-19 | 2015-09-30 | 张士海 | External-use paste for treating chronic osteomyelitis and preparation method |
-
2014
- 2014-05-12 CN CN201410197497.0A patent/CN103933263A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| 华浩明等: "《中医骨伤科处方手册》", 30 November 2006, 科学技术文献出版社 * |
| 第七冶金建设会司职工医院中草药小组: "草药治愈慢性骨髓炎一例", 《新医学》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721561A (en) * | 2015-02-28 | 2015-06-24 | 朱海颖 | Traditional Chinese medicine for treating heat-toxin accumulation type traumatic chronic osteomyelitis and preparation method thereof |
| CN104940541A (en) * | 2015-06-19 | 2015-09-30 | 张士海 | Preparation for chronic osteomyelitis treating and preparation method |
| CN104940629A (en) * | 2015-06-19 | 2015-09-30 | 张士海 | External-use paste for treating chronic osteomyelitis and preparation method |
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Application publication date: 20140723 |