CN103930125B - 具有失活rgd域的修饰的骨桥蛋白肽及其用途 - Google Patents

具有失活rgd域的修饰的骨桥蛋白肽及其用途 Download PDF

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CN103930125B
CN103930125B CN201280049850.XA CN201280049850A CN103930125B CN 103930125 B CN103930125 B CN 103930125B CN 201280049850 A CN201280049850 A CN 201280049850A CN 103930125 B CN103930125 B CN 103930125B
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alopecia
use according
hair
polypeptide
seq
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CN103930125A (zh
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J.艾伦法尔
P.杜纳
A.赫特嘉思尼尔森
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Follicum AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
CN201280049850.XA 2011-08-10 2012-08-10 具有失活rgd域的修饰的骨桥蛋白肽及其用途 Active CN103930125B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1113770.0A GB2493540A (en) 2011-08-10 2011-08-10 Agents for stimulating hair growth in mammals
GB1113770.0 2011-08-10
PCT/GB2012/051955 WO2013021212A2 (en) 2011-08-10 2012-08-10 Novel compositions and uses thereof

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CN103930125A CN103930125A (zh) 2014-07-16
CN103930125B true CN103930125B (zh) 2017-11-03

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US (3) US9381149B2 (https=)
EP (2) EP3087999B1 (https=)
JP (1) JP6049718B2 (https=)
KR (1) KR101992282B1 (https=)
CN (1) CN103930125B (https=)
AU (1) AU2012293448B2 (https=)
BR (1) BR112014003051B1 (https=)
CA (1) CA2844749C (https=)
DK (2) DK2741761T3 (https=)
ES (2) ES2740826T3 (https=)
GB (1) GB2493540A (https=)
PL (2) PL3087999T3 (https=)
RU (1) RU2604797C2 (https=)
TR (1) TR201910685T4 (https=)
WO (1) WO2013021212A2 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2493540A (en) 2011-08-10 2013-02-13 Follicum Ab Agents for stimulating hair growth in mammals
GB201406989D0 (en) * 2014-04-17 2014-06-04 Follicum Ab Novel treatments
JP6548126B2 (ja) * 2014-11-27 2019-07-24 国立大学法人大阪大学 Ｉｉｉ型コラーゲン産生促進剤
KR101906557B1 (ko) 2015-08-06 2018-10-11 서울대학교산학협력단 합성 펩타이드를 이용한 유도만능줄기세포의 제조방법
JP2020514395A (ja) * 2017-03-23 2020-05-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 老化細胞および細胞老化関連分泌形質による発毛の刺激
DK3618845T3 (da) * 2017-05-04 2021-04-19 Follicum Ab Peptider til behandling af diabetes
KR102091567B1 (ko) * 2018-06-15 2020-03-20 인하대학교 산학협력단 오스테오폰틴 단백질 단편을 유효성분으로 함유하는 뇌손상 예방 또는 치료용 약학 조성물
KR20210088583A (ko) * 2018-11-07 2021-07-14 폴리쿰 에이비 당뇨병 치료를 위한 펩타이드 단편
US20220273765A1 (en) * 2019-04-24 2022-09-01 Follicum Ab Topical formulation
CN115397458B (zh) * 2020-02-25 2024-09-13 安普力菲卡控股集团公司 用于刺激毛发生长的组合物和方法
IL311053A (en) * 2021-08-25 2024-04-01 Amplifica Holdings Group Inc Compositions and methods for stimulating hair growth
WO2023218095A1 (en) * 2022-05-13 2023-11-16 Coegin Pharma Ab Agents for stimulating tissue regeneration
CA3251755A1 (en) * 2022-05-13 2023-11-16 Coegin Pharma Ab VASCULARIZING AGENTS
WO2024263662A2 (en) * 2023-06-20 2024-12-26 Amplifica Holdings Group, Inc. Compositions and methods for stimulating hair growth

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032961A1 (en) * 1995-04-20 1996-10-24 The Trustees Of The University Of Pennsylvania Compositions and methods for regulating hair growth
WO2001084159A2 (en) * 2000-05-01 2001-11-08 Board Of Regents, The University Of Texas System Ldl receptor signaling pathways
CN1513000A (zh) * 2001-04-05 2004-07-14 ��ʽ���������о��� 抗骨桥蛋白抗体及其用途
CN1930295A (zh) * 2004-03-05 2007-03-14 拜尔作物科学有限公司 多种淀粉磷酸化酶活性增加的植物
WO2008086449A2 (en) * 2007-01-09 2008-07-17 Oregon Health & Science University Synthetic osteopontin peptides and methods of use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5643872A (en) 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5756094A (en) 1991-03-27 1998-05-26 Trustees Of The University Of Pennsylvania Methods for stimulating follicular growth
US5753612A (en) 1992-10-27 1998-05-19 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Pharmaceutical composition and method for inhibiting hair growth by administration of activin or activin agonists
US6008058A (en) 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
WO2001028509A1 (en) 1999-10-21 2001-04-26 Kao Corporation Depilatories and agents for external use
DE60131525T2 (de) 2000-03-23 2008-09-25 Glaxo Group Ltd., Greenford Verfahren zum screening von inhibitoren für osteopontin
WO2002046465A2 (en) * 2000-12-08 2002-06-13 Oxford Biomedica (Uk) Limited Method for identification of genes involved in specific diseases
MXPA03010327A (es) * 2001-05-17 2004-02-17 Applied Research Systems USO DE OSTEOPONTINA PARA TRATAMIENTO Y/O PREVENCIoN DE ENFERMEDADES NEUROLoGICAS.
JP2007537142A (ja) 2003-12-18 2007-12-20 ノボ　ノルディスク　アクティーゼルスカブ アルブミン様物質に結合した新規のｇｌｐ−１類似物
WO2005066339A2 (en) 2004-01-06 2005-07-21 Novozymes A/S Polypeptides of alicyclobacillus sp.
RU2309730C2 (ru) * 2006-04-18 2007-11-10 Леонид Юрьевич Брежнев Средство для стимуляции роста волос, его варианты и способ его получения
GB2493540A (en) 2011-08-10 2013-02-13 Follicum Ab Agents for stimulating hair growth in mammals

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996032961A1 (en) * 1995-04-20 1996-10-24 The Trustees Of The University Of Pennsylvania Compositions and methods for regulating hair growth
WO2001084159A2 (en) * 2000-05-01 2001-11-08 Board Of Regents, The University Of Texas System Ldl receptor signaling pathways
CN1513000A (zh) * 2001-04-05 2004-07-14 ��ʽ���������о��� 抗骨桥蛋白抗体及其用途
CN1930295A (zh) * 2004-03-05 2007-03-14 拜尔作物科学有限公司 多种淀粉磷酸化酶活性增加的植物
WO2008086449A2 (en) * 2007-01-09 2008-07-17 Oregon Health & Science University Synthetic osteopontin peptides and methods of use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Non-RGD domains of osteopontin promote cell adhesion without involving alpha v integrins;Katagiri YU,et al;《J Cell Biochem》;19960731;第62卷(第1期);123-131 *
Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent mannerOsteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner;Yu DW,et al;《J Invest Dermatol》;20011231;第117卷(第6期);1554-1558 *
Osteopontin gene is upregulated during the catagen phase of the hair cylce;Yu DW,et al;《Journal of Investigative Dermatology》;19970430;第108卷(第4期);692 *
The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways;Courter D,et al;《PLoS One》;20100310;第5卷(第3期);e9633 *
大鼠皮肤及毛囊骨桥蛋白研究;杨恬等;《中国医学科学院学报》;20000630;第22卷(第3期);296-299 *

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EP3087999B1 (en) 2019-05-08
AU2012293448A1 (en) 2014-02-27
WO2013021212A3 (en) 2014-04-17
CA2844749A1 (en) 2013-02-14
DK3087999T3 (da) 2019-07-29
US20150018273A1 (en) 2015-01-15
BR112014003051A2 (pt) 2019-04-02
US10517932B2 (en) 2019-12-31
US10137169B2 (en) 2018-11-27
PL3087999T3 (pl) 2019-09-30
KR20140083977A (ko) 2014-07-04
ES2576299T3 (es) 2016-07-06
EP3087999A1 (en) 2016-11-02
EP2741761A2 (en) 2014-06-18
DK2741761T3 (en) 2016-08-15
BR112014003051B1 (pt) 2022-01-04
US20190192631A1 (en) 2019-06-27
CA2844749C (en) 2020-07-14
GB201113770D0 (en) 2011-09-21
PL2741761T3 (pl) 2017-01-31
GB2493540A (en) 2013-02-13
AU2012293448B2 (en) 2016-04-07
WO2013021212A2 (en) 2013-02-14
KR101992282B1 (ko) 2019-06-24
HK1197540A1 (zh) 2015-01-23
TR201910685T4 (tr) 2019-08-21
EP2741761B1 (en) 2016-05-18
US9381149B2 (en) 2016-07-05
JP2014525394A (ja) 2014-09-29
RU2604797C2 (ru) 2016-12-10
JP6049718B2 (ja) 2016-12-21
ES2740826T3 (es) 2020-02-06
US20160317620A1 (en) 2016-11-03
RU2014108819A (ru) 2015-09-20
CN103930125A (zh) 2014-07-16

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