CN103919137B - 一种增强免疫力的保健食品 - Google Patents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
本发明公开了一种增强免疫力的保健食品。它由下述原料药制成其有效成分：阿胶粉、大枣、熟地黄、刺五加、酸枣仁、佛手、陈皮、刀豆、山药、火麻仁、当归、延胡索、丹参、鸡血藤、怀牛膝、杜仲、甘草和珍珠粉。该保健食品以阿胶、大枣为主要原料，经动物功能试验证明，具有增强免疫力的保健功能。
Description
技术领域
本发明涉及一种增强免疫力的保健食品，属于保健品技术领域。
背景技术
随着生活节奏的加快，人们的工作、学习压力的加大，同时由于多数人长期缺乏体育锻炼，因此处于亚健康状态的人群越来越多，增强免疫力已刻不容缓。免疫力是人体自身的防御机制，是人体识别和消灭外来侵入的任何异物(病毒、细菌等)；处理衰老、损伤、死亡、变性的自身细胞以及识别和处理体内突变细胞和病毒感染细胞的能力。免疫力低下的人群一般有体质虚弱、营养不良、精神萎糜、疲乏无力、食欲降低、睡眠障碍等表现，生病、打针吃药便成了家常便饭。每次生病都要很长时间才能恢复，而且常常反复发作。长此以往会导致身体和智力发育不良，还易诱发重大疾病。通过体育锻炼有助于增强免疫力，但是体育锻炼的同时也结合适当的保健食品才能更好的提高人体的免疫力。
发明内容
本发明提供了一种增强免疫力的保健食品。该保健食品以阿胶、大枣为主要原料，经动物功能试验证明，具有增强免疫力的保健功能。
本发明的技术方案是：一种增强免疫力的保健食品，其特征是，由下述重量份的原料药制成其有效成分：阿胶粉15-20、大枣40-50、熟地黄10-15、刺五加10-15、酸枣仁12-18、佛手8-12、陈皮10-15、刀豆8-12、山药8-10、火麻仁8-12、当归15-20、延胡索10-15、丹参10-15、鸡血藤10-15、怀牛膝10-15、杜仲8-12、甘草5-8和珍珠粉3-5。
优选配比：阿胶粉20、大枣50、熟地黄12、刺五加12、酸枣仁15、佛手10、陈皮12、刀豆10、山药9、火麻仁10、当归20、延胡索12、丹参12、鸡血藤15、怀牛膝12、杜仲10、甘草5和珍珠粉3。
制备方法：将阿胶粉、珍珠粉以外的原料药水煎煮，经浓缩干燥(至含水量≦5％)，研磨成过100-200目筛的浸膏粉；然后将浸膏粉、阿胶粉和珍珠粉加入辅料制成各种制剂，如颗粒剂、片剂及胶囊剂。优选为胶囊剂。
胶囊剂生产工艺：将浸膏粉、阿胶粉、珍珠粉和辅料淀粉(按质量比，主料：辅料＝65：35)混合均匀；然后加入90％的乙醇制软材；然后经制粒、干燥(含水量≤5％)后灌装入空胶囊中，每粒重0.5g/粒，得胶囊制剂。
服用方法：
适宜人群：免疫力低下者，不适于少年儿童、孕妇及乳母服用。
食用量及食用方法：每日2次，每次3-5粒；口服。
规格：0.5g/粒。
各原料的药理作用：
阿胶：甘，平。归肺、肝、肾经。功能与主治：补血滋阴，润燥，止血。用于血虚萎黄，眩晕心悸，肌痿无力，心烦不眠，虚风内动，肺燥咳嗽，劳嗽咯血，吐血尿血，便血崩漏，妊娠胎漏。
大枣：甘，温。归脾、胃、心经。功能与主治：补中益气，养血安神。用于脾虚食少，乏力便溏。
熟地黄：甘，微温。归肝、肾经。功能与主治：补血滋阴，益精填髓。用于血虚萎黄，心悸怔忡，月经不调，崩漏下血，肝肾阴虚，腰膝酸软，骨蒸潮热，盗汗遗精，内热消渴，眩晕，耳鸣，须发早白。
刺五加：辛、微苦，温。归脾、肾、心经。功能与主治：益气健脾，补肾安神。用于脾肺气虚，体虚乏力，食欲不振，肺肾两虚，久咳虚喘，肾虚腰膝酸痛，心脾不足，失眠多梦。
酸枣仁：甘、酸，平。归肝、胆、心经。功能与主治：养心补肝，宁心安神，敛汗，生津。用于虚烦不眠，惊悸多梦，体虚多汗，津伤口渴。
珍珠粉：甘、咸，寒。归心、肝经。功能与主治：安神定惊，明目消翳，解毒生肌，润肤祛斑。用于惊悸失眠，惊风癫痫，目赤翳障，疮疡不敛，皮肤色斑。
佛手：辛、苦、酸，温。归肝、脾、胃、肺经。功能与主治：疏肝理气，和胃止痛，燥湿化痰。用于肝胃气滞，胸胁胀痛，胃脘痞满，食少呕吐，咳嗽痰多。
陈皮：苦、辛，温。归肺、脾经。功能与主治：理气健脾，燥湿化痰。用于脘腹胀满，食少吐泻，咳嗽痰多。
刀豆：甘，温。归胃、肾经。功能与主治：温中，下气，止呃。用于虚寒呃逆，呕吐。
沙棘：酸、涩，温。归脾、胃、肺、心经。功能与主治：健脾消食，止咳祛痰。活血散瘀。用于脾虚食少，食积腹痛，咳嗽痰多，胸痹心痛，瘀血经闭，跌扑瘀肿。
山药：甘，平。归脾、肺、肾经。补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。
火麻仁：甘、平。归脾、胃、大肠经。功效及应用：润肠通便。用于肠燥便秘，润燥、杀虫：发落不生；疮癞。
当归：甘、辛，温。归肝、心、脾经。功能与主治：补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，风湿痹痛，跌扑损伤，痈疽疮疡，肠燥便秘。
延胡索：辛、苦，温。归肝、脾经。功能与主治：活血，行气，止痛。用于胸胁、脘腹疼痛，胸痹心痛，经闭痛经，产后瘀阻，跌扑肿痛。
丹参：活血祛瘀，通经止痛，清心除烦，凉血消痈。用于胸痹心痛，脘腹胁痛，瘾瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
鸡血藤：苦、甘，温。归肝、肾经。功能与主治：活血补血，调经止痛，舒筋活络。用于月经不调，痛经.经闭，风湿痹痛，麻木瘫痪，血虚萎黄。
怀牛膝：逐瘀通经，补肝肾，强筋骨，利尿通淋，引血下行。用于经闭，痛经，腰膝酸痛，筋骨无力，淋证，水肿，头痛，眩晕，牙痛，日疮，吐血，衄血。
杜仲：甘，温。归肝、肾经。功能与主治：补肝肾，强筋骨，安胎。用于肝肾不足，腰膝酸痛，筋骨无力，头晕目眩，妊娠漏血，胎动不安。
甘草：甘，平。归心、肺、脾、胃经。功能与主治：补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
本发明以上述原料药组方，调养气血、改善睡眠、活血通络、改善食欲和润肠通便，从而改善了人们的亚健康状态，增强了免疫力。
本发明的有益效果是：本发明的保健食品经动物功能试验证明，具有增强免疫力的保健功能。以下结合功能试验来进一步说明其有益效果。
1.材料
1.1试验动物：清洁型昆明种雌性小鼠60只，体重18-22克，按体重随机分为4组，每组15只。
1.2试验条件：屏障环境，温度22-24℃，湿度54-56％。
1.3剂量分组及受试样品给予时间：本发明保健食品(配方见实施例1)推荐量4克/人(60kg)·日(66.6mg/kgBW)。实验设三个剂量组和一个空白对照组，以人体推荐量的5倍为低剂量组(333mg/kgBW)，10倍为中剂量组(666mg/kgBW)，30倍为高剂量组(2000mg/kgBW)。受试物加蒸馏水定容至200ml，分别给予受试小鼠灌胃，每天灌胃一次，灌胃体积为0.2ml/10g鼠重，对照组灌以等体积的蒸馏水，时间为30天。
2.实验方法
按卫生部《保健食品检验与评价技术规范》(2003版)，进行小鼠脏器/体重比值测定、淋巴细胞增殖能力OD差值、足跖肿胀度、半数溶血值(HC50)和小鼠碳廓清试验(吞噬指数a)进行功能评价。试验结果见表1。
表1本发明保健食品对小鼠免疫功能的影响总体评价表
注：*与对照组相比有显著性差异(P﹤0.05)，**与空白对照组相比有较显著性差异(P﹤0.01)
试验结果表明：经口给予小鼠各剂量的本发明保健品30天，小鼠脏器/体重比值均无明显影响。中剂量组能显著提高小鼠单核一巨噬细胞碳廓清的能力(P＜0.05)、小鼠足跖肿胀度(P＜0.05)和淋巴细胞增殖能力(P﹤0.05)；高剂量组能明显增强小鼠单核一巨噬细胞碳廓清的能力(P＜0.05)、小鼠足跖肿胀度(P＜0.01)和淋巴细胞增殖能力(P﹤0.01)和提高小鼠的半数溶血值(P＜0.05)。试验表明本发明保健品具有增强免疫力的保健功能。
具体实施方式
实施例1：
配比(重量份)：阿胶粉20、大枣50、熟地黄12、刺五加12、酸枣仁15、佛手10、陈皮12、刀豆10、山药9、火麻仁10、当归20、延胡索12、丹参12、鸡血藤15、怀牛膝12、杜仲10、甘草5和珍珠粉3。
制备方法：
(1)将阿胶粉和珍珠粉均研末成过100目筛的粉末；
(2)其余原料药水煎煮2次，每次40分钟；合并两次的煎煮液，经45-50℃浓缩干燥至含水量≦5％，研磨成过200目筛的浸膏粉；
(3)将浸膏粉、阿胶粉、珍珠粉和辅料淀粉按质量比，浸膏粉+阿胶粉+珍珠粉：辅料＝65：35的比例称取后混合均匀；然后加入90％的乙醇制软材；然后经制粒、40-50℃干燥至含水量≤5％后灌装入空胶囊中，每粒重0.5g/粒。
实施例2：
配比(重量份)：阿胶粉20、大枣50、熟地黄15、刺五加15、酸枣仁18、佛手12、陈皮15、刀豆12、山药10、火麻仁12、当归20、延胡索15、丹参15、鸡血藤15、怀牛膝15、杜仲12、甘草8和珍珠粉5。
制备方法：同实施例1。
实施例3：
配比(重量份)：阿胶粉15、大枣40、熟地黄10、刺五加10、酸枣仁12、佛手8、陈皮10、刀豆8、山药8、火麻仁8、当归15、延胡索10、丹参10、鸡血藤10、怀牛膝10、杜仲8、甘草5和珍珠粉3。
制备方法：同实施例1。
Claims (4)
1.一种增强免疫力的保健食品，其特征是，由下述重量份的原料药制成其有效成分：阿胶粉20、大枣50、熟地黄12、刺五加12、酸枣仁15、佛手10、陈皮12、刀豆10、山药9、火麻仁10、当归20、延胡索12、丹参12、鸡血藤15、怀牛膝12、杜仲10、甘草5和珍珠粉3。
2.一种制备权利要求1所述的保健食品的方法，其特征是，将阿胶粉、珍珠粉以外的原料药水煎煮，经浓缩干燥，研磨成过100-200目筛的浸膏粉；然后将浸膏粉、阿胶粉和珍珠粉加入辅料制成各种制剂。
3.如权利要求2所述的制备保健食品的方法，其特征是，将浸膏粉、阿胶粉、珍珠粉和辅料淀粉混合均匀；然后加入90%的乙醇制软材；然后经制粒、干燥后灌装入空胶囊中，制成胶囊制剂。
4.如权利要求4所述的制备保健食品的方法，其特征是，所述按质量比计，浸膏粉+阿胶粉+珍珠粉：淀粉=65：35。
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