CN103908642A - Drug for treating rheumatic arthralgia and preparation method thereof - Google Patents
Drug for treating rheumatic arthralgia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a drug for treating rheumatic arthralgia. The drug is composed of the following raw material drugs in parts by weight: 5-7 parts of moutan bark, 9-12 parts of pine nut, 1-3 parts of coix, 3-5 parts of fructus forsythiae, 7-11 parts of walnut, 6-9 parts of rhizoma curcumae, 11-12 parts of caulis trachelospermi, 3-4 parts of monkshood, 11-16 parts of evening primrose oil, 3-5 parts of allicin, 6-9 parts of sodium alginate and 10-12 parts of celecoxib. The preparation method includes the following steps: a. milling the moutan bark, the pine nut, the fructus forsythiae, the rhizoma curcumae and the caulis trachelospermi into powder, adding the powder into 80-100 parts of 75% alcohol, soaking for a month, and extracting filtrate; b. adding the walnut, the coix and the monkshood into the filtrate obtained in step a, heating and decocting the mixture into paste, drying to obtain 300-500 meshes powder; c. preparing the allicin, the sodium alginate and the celecoxib into 300-500 meshes powder, adding the mixture in step b and the evening primrose oil into an agitato, and stirring uniformly.
Description
Technical field
The invention belongs to field of medicaments, be specially a kind of medicine for the treatment of cold rheumatoid joint pain and preparation method thereof.
Background technology
The disease take muscle, arthralgia as main manifestations that cold rheumatoid joint pain refers to that human feeling's rheumatism cold-evil causes, belongs to Chinese medicine " arthromyodynia " category.Its morbidity is human body weakness, yang-energy weakened defensive QI, and wet the taking advantage of a weak point in opponent's defence of wind and cold and people stays in meridians, muscle, joint causes that QI and blood impatency, circulation are not smooth, and the diseases such as pain, tingle, heavy, joint stuffiness occur.Western medicine is still not clear the pathogenic factor of primary disease, clinically rheumatalgia, benign arthritis, the chronic lambago and skelalgia of claiming more.
Acetyl ammonia phenol: be to process the First Line medication of pain, only have analgesic effect and without anti-inflammatory effect, but side effect is slighter.Oral or external on-steroidal anti-inflammation analgesic (NSAID): the most conventional, comprising: Naproxen, Salsalate, Ibuprofen, Diclofenac, can alleviate pain and reduce inflammation; Approximately there is 30% patient to take on-steroidal anti-inflammation analgesic and can produce upper digestive tract malaise symptoms, comprise dyspepsia, abdominal distention, feel sick, digestive tract hemorrhage, ulcer; In addition, likely can cause edema or affect renal function at fraction patient NSAID.Clinical research result shows, the slightly poor but various side effect much less of the effect of external NSAID, but still have the possibility of chafe.
Summary of the invention
The object of this invention is to provide a kind of medicine for the treatment of cold rheumatoid joint pain and preparation method thereof.
The medicine for the treatment of cold rheumatoid joint pain of the present invention; Crude drug by following parts by weight: 10～12 parts of 5～7 parts of Cortex Moutans, 9～12 parts, Semen Pini, 1～3 part of Semen Coicis, 3～5 parts of Fructus Forsythiaes, 7～11 parts of Semen Juglandiss, 6～9 parts of Rhizoma Curcumae, 11～12 parts of Caulis Trachelospermis, 3～4 parts of Radix Aconiti Lateralis Preparatas, 11～16 parts of Radix Oenotherae erythrosepalae oil, 3～5 parts of garlicins, 6～9 parts of sodium alginates, celecoxib are made.
As optimization, the medicine of this treatment cold rheumatoid joint pain is by the crude drug of following parts by weight: 11 parts of 6 parts of Cortex Moutans, 10 parts, Semen Pini, 2 parts of Semen Coiciss, 4 parts of Fructus Forsythiaes, 9 parts of Semen Juglandiss, 7 parts of Rhizoma Curcumae, 11 parts of Caulis Trachelospermis, 3 parts of Radix Aconiti Lateralis Preparatas, 13 parts of Radix Oenotherae erythrosepalae oil, 3 parts of garlicins, 7 parts of sodium alginates, celecoxib are made.
The preparation method of the medicine for the treatment of cold rheumatoid joint pain, comprises the following steps:
A, be in 75% ethanol of 80～100 parts by joining weight fraction after the Cortex Moutan of described weight fraction, Semen Pini, Fructus Forsythiae, Rhizoma Curcumae, Caulis Trachelospermi pulverizing, brewed one month, get its filtrate;
B, the Semen Juglandis of described weight fraction, Semen Coicis, Radix Aconiti Lateralis Preparata are joined in the filtrate in step a, heating is brewed into pasty state, makes 300～500 order powder after oven dry;
C, the garlicin of described parts by weight, sodium alginate, celecoxib are made to 300～500 order powder; Together with the mixture in step b, the Radix Oenotherae erythrosepalae oil of described parts by weight joins in blender and stirs;
D, by the medicated powder in step c, in incapsulating according to 0.58 gram every.
The present invention treats in the medicine of cold rheumatoid joint pain, Cortex Moutan, and nourishing YIN to lower pathogenic fire, separates speckle poison, throat, diuresis stasis.Modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has inhibition Platelet; Paeonol has the effects such as the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolytic and atherosclerosis, diuresis, antiulcer.
Semen Pini cures mainly osteoarthrosis rheumatism, dizziness, wind-damp dispelling, and moistening five ZANG-organs, allays one's hunger, by migratory arthralgia cold, body void, skin care.Clothes for a long time, making light of one's life by commiting suicide, it is not old to prolong life.Separately there is lung moistening function, control dryness accumulated in the stomach and intestine cough.
Semen Coicis has invigorating spleen to remove dampness, clearing away heat and discharging pus function.For diseases such as diarrhea due to hypofunction of the spleen edema beriberi, leucorrhea, wet, arthralgia, acute appendicitis, consumptive lung diseases.Still for cancer and multiple warts such as gastric cancer, cervical cancer, chorionic epithelioma.
The pharmacological action such as that Fructus Forsythiae has is antibacterial, heart tonifying, diuresis, town are told, is the Chinese medicine of heat-clearing and toxic substances removing, cures mainly calentura from the beginning of symptom, its bacteriostasis and Flos Lonicerae broadly similars such as, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.
Semen Juglandis sweet in the mouth, warm in nature, enters kidney, lung, large intestine channel.Can the kidney invigorating, the strong waist of controlling nocturnal emission with astringent drugs, warming the lung Dingchuan, loosening bowel to relieve constipation.Cure mainly: suffer from a deficiency of the kidney breathe heavily cough, lumbago; (wooden interlayer in core) bitter in the mouth, warm in nature; The kidney invigorating, arresting seminal emission.
Rhizoma Curcumae is Zingiberaceae, and fragrance as tool Camphora is faint yellow or white; Elongated or the end of root enlarges into tuber.There is the effect of removing blood stasis promoting the circulation of QI to relieve pain, long-pending eliminating stagnation, removing blood stasis, promoting the circulation of QI to relieve pain.
Caulis Trachelospermi has expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, and clearing away heat and cooling blood, effect of removing toxic substances and promoting subsidence of swelling, cures mainly dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence.For rheumatism pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.
Radix Aconiti Lateralis Preparata has recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by effect of wind-cold damp pathogen.Cure mainly YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, arthralgia due to cold-dampnes etc.
Garlicin (Allicin) is a kind of organosulfur compound extracting from the bulb (Bulbus Allii head) of Herba Alii fistulosi section allium Bulbus Allii (Allium Sativum), is also present in Bulbus Allii Cepae and other Herba Alii fistulosi section plants.Formal name used at school GIUCOSinoate.
Radix Oenotherae erythrosepalae oil wind-damp dispelling, bone and muscle strengthening, promoting blood circulation to remove obstruction in the collateral; Endogenous wind stopping suppressing the hyperactive liver; Detumescence sore.Main obstruction of qi in the chest and cardialgia; Apoplectic hemiplegia; Stirring-up of pathogenic wind in the interior resulting from deficiency; How moving children's is; Wind dampness rheumatic anesthesia pain; Stomachache is had loose bowels; Dysmenorrhea; Oral-anal-genital ulcer syndrome; Skin infection; Eczema.
Sodium alginate, a kind of natural polysaccharide, has the required stability of pharmaceutical preparation adjuvant, dissolubility, viscosity and safety.1881, first Englishize scholar E.C.Stanford carried out scientific research to the alginate extract in brown seaweed.He finds that this alignic extract has several very interesting characteristics, and it has concentrated solution, forms the ability of gel and film forming.
Celecoxib is non_steroidal anti_inflammatory drug of new generation; suppress Cycloxygenase-2(COX-2 by selectivity) suppress prostaglandin generate; reach anti-inflammatory, analgesic effect; because it can not suppress to have physiology enzyme---the Cycloxygenase-1(COX-1 of pipe intestinal protection effect), its gastrointestinal side effect risk is starkly lower than traditional non_steroidal anti_inflammatory drug.All recurrence due to taking drug close, and expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, anti-inflammatory and antalgic nourish joint, are easy to absorb; Treatment cold rheumatoid joint pain effect is remarkable.
Physical data: cold rheumatoid joint pain patient 390 examples, wherein male 142 examples, female's 248 examples; 22～63 years old age, average 40 years old; The course of disease 6 months～11 years, average 3.9 years.390 routine patient's Syndrome Differentiation of Traditional Chinese Medicines comprise heavy 86 examples of wind, weight in wet base type 76 examples, cold heavy 68 examples, rheumatism type 78 examples, cold-dampness type 82 examples.
Diagnosis basis: cold rheumatoid joint pain is diagnosed according to first standard that national combination of Chinese and Western medicine rheumatism academic conference is formulated in 1988: 1. have wind-cold damp pathogen invasion and attack history; 2. show as that joint or muscle are miserable, numb, pain, movable difficulty, meets cold rnning weight; 3. how get involved joint without swelling, without joint deformity; 4. how normal erythrocyte sedimentation rate (ESR) is, and c reactive protein (CRP), rheumatoid factor (RF), routine blood test are all normal; 5. x-ray is generally without sclerotin change.Syndrome Differentiation of Traditional Chinese Medicine: 1. wind heavy type: the each joint of whole body, muscle migration walk to alter pain (aching), pale tongue, white and thin fur; 2. weight in wet base type: patient part is heavy, miserable or apathetic, joint joint stuffiness, has bony crepitus (cartilage friction) when movable more, pale tongue, tongue is white greasy or micro-Huang is greasy, and how slow arteries and veins is or moisten; 3. cold heavy: the local muscle of patient, joint skin are sent out cool, stationarity severe pain or contracture contracture.Pale tongue, Tai Bai or whiten, stringy and tense pulse or heavy tight; 4. rheumatism type: pain is altered in patient's muscle, the existing migration in joint, has again sense of heaviness, and when climate change, pain increases the weight of, arteries and veins is how floating slow, and body of the tongue is light red, and the micro-Huang of tongue is greasy; 5. cold-dampness type: patient is local to be sent out cool (being in a cold sweat), stationarity severe pain, and heavy stiff, the movable difficulty of severe patient, even state of paralysis, loses work capacity.Pale tongue, moist and slippery fur or greasy in vain. how deep and slow arteries and veins is or heavy tight.
Therapeutic Method: adopt capsule in the embodiment of the present invention 1,4 tablets/time, 3 times/d 1 month is 1 course for the treatment of, is used in conjunction 3～6 courses for the treatment of.
Efficacy evaluation: reference " traditional Chinese medical science disease Standardization of diagnosis and curative effect ": cure: the joint of getting involved, myalgia disappear, and joint function recovery is normal; Effective: the joint of getting involved, the large portion of myalgia disappear or obviously alleviate; Effective: the arthralgia of getting involved take a favorable turn; Invalid: to treat 2 courses for the treatment of and get involved joint symptom without improvement.The results are shown in Table 1
The specific embodiment
The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; according to the present invention, content, to nonessential improvement and adjustment more of the present invention, still belongs to protection scope of the present invention to those skilled in the art.
Embodiment 1, a, is in 75% ethanol of 82 grams by joining weight fraction after 6 grams of the Cortex Moutans of described weight fraction, 10 grams, Semen Pini, 4 grams of Fructus Forsythiaes, 7 grams of Rhizoma Curcumae, 11 grams of pulverizing of Caulis Trachelospermi, brewed one month, gets its filtrate; B, by 9 grams of the Semen Juglandiss of described weight fraction, 2 grams of Semen Coiciss, 3 grams of filtrates that join in step a of Radix Aconiti Lateralis Preparata, heating be brewed into pasty state, after oven dry, make 300～500 order powder; C, 3 grams of the garlicins of described parts by weight, 7 grams of sodium alginates, celecoxib 11 are restrained into 300～500 order powder; Together with the mixture in step b, 13 grams of the Radix Oenotherae erythrosepalae oil of described parts by weight join in blender and stir; D, by the medicated powder in step c, in incapsulating according to 0.58 gram every.
Embodiment 2, a, is in 75% ethanol of 80 grams by joining weight fraction after 5 grams of the Cortex Moutans of described weight fraction, 9 grams, Semen Pini, 3 grams of Fructus Forsythiaes, 6 grams of Rhizoma Curcumae, 11 grams of pulverizing of Caulis Trachelospermi, brewed one month, gets its filtrate; B, by 7 grams of the Semen Juglandiss of described weight fraction, 1 gram of Semen Coicis, 3 grams of filtrates that join in step a of Radix Aconiti Lateralis Preparata, heating be brewed into pasty state, after oven dry, make 300～500 order powder; C, 3 grams of the garlicins of described parts by weight, 6 grams of sodium alginates, celecoxib 10 are restrained into 300～500 order powder; Together with the mixture in step b, 11 grams of the Radix Oenotherae erythrosepalae oil of described parts by weight join in blender and stir; D, by the medicated powder in step c, in incapsulating according to 0.58 gram every.
Embodiment 3, a, is in 75% ethanol of 100 grams by joining weight fraction after 7 grams of the Cortex Moutans of described weight fraction, 12 grams, Semen Pini, 5 grams of Fructus Forsythiaes, 9 grams of Rhizoma Curcumae, 12 grams of pulverizing of Caulis Trachelospermi, brewed one month, gets its filtrate; B, by 11 grams of the Semen Juglandiss of described weight fraction, 3 grams of Semen Coiciss, 4 grams of filtrates that join in step a of Radix Aconiti Lateralis Preparata, heating be brewed into pasty state, after oven dry, make 300～500 order powder; C, 5 grams of the garlicins of described parts by weight, 9 grams of sodium alginates, celecoxib 12 are restrained into 300～500 order powder; Together with the mixture in step b, 16 grams of the Radix Oenotherae erythrosepalae oil of described parts by weight join in blender and stir; D, by the medicated powder in step c, in incapsulating according to 0.58 gram every.
Claims (3)
1. treat the medicine of cold rheumatoid joint pain for one kind; It is characterized in that the crude drug by following parts by weight: 10～12 parts of 5～7 parts of Cortex Moutans, 9～12 parts, Semen Pini, 1～3 part of Semen Coicis, 3～5 parts of Fructus Forsythiaes, 7～11 parts of Semen Juglandiss, 6～9 parts of Rhizoma Curcumae, 11～12 parts of Caulis Trachelospermis, 3～4 parts of Radix Aconiti Lateralis Preparatas, 11～16 parts of Radix Oenotherae erythrosepalae oil, 3～5 parts of garlicins, 6～9 parts of sodium alginates, celecoxib are made.
2. the medicine for the treatment of cold rheumatoid joint pain according to claim 1, it is characterized in that the crude drug by following parts by weight: 11 parts of 6 parts of Cortex Moutans, 10 parts, Semen Pini, 2 parts of Semen Coiciss, 4 parts of Fructus Forsythiaes, 9 parts of Semen Juglandiss, 7 parts of Rhizoma Curcumae, 11 parts of Caulis Trachelospermis, 3 parts of Radix Aconiti Lateralis Preparatas, 13 parts of Radix Oenotherae erythrosepalae oil, 3 parts of garlicins, 7 parts of sodium alginates, celecoxib are made.
3. prepare a method for the treatment of the medicine of cold rheumatoid joint pain described in claim 1, it is characterized in that comprising the following steps:
A, be in 75% ethanol of 80～100 parts by joining weight fraction after the Cortex Moutan of described weight fraction, Semen Pini, Fructus Forsythiae, Rhizoma Curcumae, Caulis Trachelospermi pulverizing, brewed one month, get its filtrate;
B, the Semen Juglandis of described weight fraction, Semen Coicis, Radix Aconiti Lateralis Preparata are joined in the filtrate in step a, heating is brewed into pasty state, makes 300～500 order powder after oven dry;
C, the garlicin of described parts by weight, sodium alginate, celecoxib are made to 300～500 order powder; Together with the mixture in step b, the Radix Oenotherae erythrosepalae oil of described parts by weight joins in blender and stirs;
D, by the medicated powder in step c, in incapsulating according to 0.58 gram every.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106620315A (en) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | Medicinal composition for treating rheumatism |
| WO2021042276A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Combination drug for treating osteoarthritis |
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| CN1528386A (en) * | 2003-09-25 | 2004-09-15 | 张利民 | Chinese medicine composition for treating rheumatism, rheumatoid, hyperosteogeny and fracture and preparing method thereof |
| CN101085304A (en) * | 2007-06-18 | 2007-12-12 | 付先进 | Plaster mainly for curing cervical vertebra and lumbar vertebra disease |
| CN102451428A (en) * | 2010-10-14 | 2012-05-16 | 中国中医科学院广安门医院 | Chinese medicinal composition for treating rheumatoid arthritis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528386A (en) * | 2003-09-25 | 2004-09-15 | 张利民 | Chinese medicine composition for treating rheumatism, rheumatoid, hyperosteogeny and fracture and preparing method thereof |
| CN101085304A (en) * | 2007-06-18 | 2007-12-12 | 付先进 | Plaster mainly for curing cervical vertebra and lumbar vertebra disease |
| CN102451428A (en) * | 2010-10-14 | 2012-05-16 | 中国中医科学院广安门医院 | Chinese medicinal composition for treating rheumatoid arthritis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106620315A (en) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | Medicinal composition for treating rheumatism |
| WO2021042276A1 (en) * | 2019-09-03 | 2021-03-11 | 鲁南制药集团股份有限公司 | Combination drug for treating osteoarthritis |
| CN114340650A (en) * | 2019-09-03 | 2022-04-12 | 鲁南制药集团股份有限公司 | Combined medicine for treating osteoarthritis |
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