CN103893634B - Traditional Chinese medicine for treating infantile cholestasis - Google Patents
Traditional Chinese medicine for treating infantile cholestasis Download PDFInfo
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- CN103893634B CN103893634B CN201410159431.2A CN201410159431A CN103893634B CN 103893634 B CN103893634 B CN 103893634B CN 201410159431 A CN201410159431 A CN 201410159431A CN 103893634 B CN103893634 B CN 103893634B
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Abstract
The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine for treating infantile cholestasis. The traditional Chinese medicine comprises the following components in parts by weight: 25-35 parts of oriental wormwood, 25-35 parts of rhizoma atractylodis nacrocephalae, 5-12 parts of peach kernels, 15-25 parts of lysimachia christinae hance, 16-25 parts of golden cypress, 14-26 parts of oldenlandia diffusa, 18-26 parts of semen litchi, 26-35 parts of raw malt, 0.5-1.5 parts of amber, 0.5-1.5 parts of indigo naturalis and 0.5-1.5 parts of resina draconis. In the formula, oriental wormwood which is a monarch drug has the effects of clearing heat, promoting diuresis and removing jaundice; lysimachia christinae hance, oldenlandia diffusa and golden cypress which are ministerial drugs assist oriental wormwood to enhance the effects of promoting diuresis and removing jaundice; peach kernels, semen litchi and resina draconis which are ministerial drugs assist oriental wormwood to enhance the effect of promoting blood circulation to remove blood stasis; amber and indigo naturalis which are guide drugs enter into the liver channel and have the effects of relieving convulsion and soothing the nerves; rhizoma atractylodis nacrocephalae and raw malt which are assistant drugs have the effects of invigorating spleen to promote digestion and restricting side effects of the above medicines. All the medicines are used together to take the effects of promoting blood circulation to remove blood stasis, promoting diuresis and removing jaundice. The traditional Chinese medicine decoction is good in compliance, small in dosage, fast in effect, free of toxic and side effects and high in curative effect rate.
Description
Technical field
The invention belongs to lunar physics technique field, particularly to a kind of Chinese medicine treating baby's cholestasis.
Background technology
Baby's Intrahepatic Cholestasis refer to that baby leads to normal bile flow to reduce because of certain reason, increase with bilirubin direct
And cause a kind of syndrome being clinically main performance with jaundice, it is infantile common disease, treatment difficulty is big, be baby
One of lethal, major reason of disabling.Baby's Intrahepatic Cholestasis cause of disease is complicated, its occur may with biliary tract inflammation, developmental disorder,
The factors such as viral infection, dealed with medicine went, hereditary metabolic disorders and immunity are relevant, diagnosis and treatment not in time, often lead to seek
Support bad, growth retardation, or even biliary cirrhosiss, have a strong impact on the life quality of infant, or even threat to life.Mesh
Before, the method for the treatment of baby's cholestasis is less and curative effect is not affirmed, the no Therapeutic Method of specially good effect both at home and abroad.
Content of the invention
Pointed out according to above-mentioned deficiency, it is an object of the invention to provide a kind of prepare treatment baby's gallbladder simple, evident in efficacy
The Chinese medicine of juice alluvial.
For achieving the above object, the technical scheme is that a kind of Chinese medicine treating baby's cholestasis, according to weight
Number meter, it includes following component, Herba Artemisiae Scopariae 25-35 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Semen Persicae 5-12 part, Herba Lysimachiae 15-25 part, Cortex Phellodendri
16-25 part, Herba Hedyotidis Diffusae 14-26 part, Semen Litchi 18-26 part, Fructus Hordei Germinatus 26-35 part, succinum 0.5-1.5 part, Indigo Naturaliss 0.5-
1.5 parts, Sanguis Draxonis 0.5-1.5 part.
Preferably: in parts by weight, it includes following component, Herba Artemisiae Scopariae 27-33 part, Rhizoma Atractylodis Macrocephalae 27-33 part, Semen Persicae 7-
10 parts, Herba Lysimachiae 17-23 part, Cortex Phellodendri 18-23 part, Herba Hedyotidis Diffusae 16-24 part, Semen Litchi 20-24 part, Fructus Hordei Germinatus 28-33 part,
Succinum 0.7-1.3 part, Indigo Naturaliss 0.7-1.3 part, Sanguis Draxonis 0.7-1.3 part.
Preferably: in parts by weight, it includes following component, Herba Artemisiae Scopariae 29-31 part, Rhizoma Atractylodis Macrocephalae 29-31 part, Semen Persicae 8-
9 parts, Herba Lysimachiae 19-21 part, Cortex Phellodendri 20-21 part, Herba Hedyotidis Diffusae 18-22 part, Semen Litchi 21-23 part, Fructus Hordei Germinatus 30-31 part,
Succinum 0.9-1.1 part, Indigo Naturaliss 0.9-1.1 part, Sanguis Draxonis 0.9-1.1 part.
Preferably: in parts by weight, it includes following component, 30 parts of Herba Artemisiae Scopariae, 30 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Semen Persicae, gold
20 parts of money grass, 20 parts of Cortex Phellodendri, 20 parts of Herba Hedyotidis Diffusae, 20 parts of Semen Litchi, 30 parts of Fructus Hordei Germinatus, 1 part of succinum, 1 part of Indigo Naturaliss, Sanguis Draxonis 1
Part.
Preferably: described Chinese medicine is decoction.
The beneficial effects of the present invention is: the pharmaceutical characteristic of each activated feedstock is:
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis, jaundice eliminating subcutaneous ulcer.For cold-damp, jaundice due to damp-heat.
Herba Lysimachiae: relieving stranguria by diuresis, dehumidify jaundice eliminating, removing toxic substances and promoting subsidence of swelling.For diseases such as pyretic stranguria, sand Stranguria, stranguria caused by urinary stone, jaundice.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication.For diseases such as damp-heat dysentery, jaundice.
Herba Hedyotidis Diffusae: clearing away heat-damp and promoting diuresis, removing toxicity for eliminating carbuncles.For diseases such as carbuncle sore tumefacting virus, pyretic stranguria, dysuria.
Semen Persicae: blood circulation promoting and blood stasis dispelling.Disease for dysmenorrhea, stasis blocking pain.
Semen Litchi: regulating QI to relieve pain, cold relieving dissipates stagnant.For diseases such as the colic caused by Liver Channel QI stagnated by cold and qi depressions to blood stasis.
Sanguis Draxonis: promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation.For ecchymoma due to internal injury, the disease such as traumatic injury.
Succinum: tranquillizing the mind by relieving convulsion, promoting blood circulation to remove blood stasis, inducing diuresis for treating stranguria syndrome.For malaise, infantile convulsion epilepsy, stagnation of blood stasis disease, drench
Disease, the disease such as difficulty in urination.
Indigo Naturaliss: heat-clearing and toxic substances removing, removing heat from blood dissipates swollen.This product is apt to clearing away liver-fire, sends out the disease of speckle, infantile convulsion for pyretic toxicity.
The Rhizoma Atractylodis Macrocephalae: air making-up and spleen enlivening, eliminate dampness and have diuretic effect.Disease for deficiency-weakness of spleen-QI.
Fructus Hordei Germinatus: help digestion and in, soothing the liver.For the disease of stagnation of QI due to depression of the liver, as adjuvant.
In formula, Herba Artemisiae Scopariae heat-clearing and dampness-resolving, is monarch.Herba Lysimachiae, Herba Hedyotidis Diffusae, Cortex Phellodendri auxiliary Herba Artemisiae Scopariae strengthen dampness removing and move back
Yellow effect；Semen Persicae, Semen Litchi, Sanguis Draxonis auxiliary Herba Artemisiae Scopariae strengthen blood circulation promoting and blood stasis dispelling effect, are ministerial drug.Succinum, Indigo Naturaliss enter Liver Channel, shake
Shy and calm the nerves, for making medicine.The Rhizoma Atractylodis Macrocephalae, Fructus Hordei Germinatus strengthening the spleen to promote digestion, restrict above side effects of pharmaceutical drugs, are adjuvant drug.All medicines share, and play and live
Blood and dissolving stasis, the effect of removing dampness through diuresis and removing jaundice.The compliance of this Chinese medicine decoction is good, and consumption is few, instant effect, and has no toxic side effect, treated
Efficiency high.
Specific embodiment
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese medicine treating baby's cholestasis, in parts by weight, it includes following component, 25 parts of Herba Artemisiae Scopariae, in vain
25 parts of art, 5 parts of Semen Persicae, 15 parts of Herba Lysimachiae, 16 parts of Cortex Phellodendri, 14 parts of Herba Hedyotidis Diffusae, 18 parts of Semen Litchi, 26 parts of Fructus Hordei Germinatus, succinum
0.5 part, 0.5 part of Indigo Naturaliss, 0.5 part of Sanguis Draxonis.Above-mentioned raw materials are cleaned up, is brewed into decoction, quantitatively takes.Usage and dosage: mouth
Clothes, two times a day, each 5ml/kg, one after each meal.
Embodiment 2
A kind of Chinese medicine treating baby's cholestasis, in parts by weight, it includes following component, 35 parts of Herba Artemisiae Scopariae, in vain
35 parts of art, 12 parts of Semen Persicae, 25 parts of Herba Lysimachiae, 25 parts of Cortex Phellodendri, 26 parts of Herba Hedyotidis Diffusae, 26 parts of Semen Litchi, 35 parts of Fructus Hordei Germinatus, succinum
1.5 parts, 1.5 parts of Indigo Naturaliss, 1.5 parts of Sanguis Draxonis.Above-mentioned raw materials are cleaned up, is brewed into decoction, quantitatively takes.Usage and dosage: mouth
Clothes, two times a day, each 5ml/kg, one after each meal.
Embodiment 3
A kind of Chinese medicine treating baby's cholestasis, in parts by weight, it includes following component, 30 parts of Herba Artemisiae Scopariae, in vain
30 parts of art, 10 parts of Semen Persicae, 20 parts of Herba Lysimachiae, 20 parts of Cortex Phellodendri, 20 parts of Herba Hedyotidis Diffusae, 20 parts of Semen Litchi, 30 parts of Fructus Hordei Germinatus, succinum
1 part, 1 part of Indigo Naturaliss, 1 part of Sanguis Draxonis.Above-mentioned raw materials are cleaned up, is brewed into decoction, quantitatively takes.Usage and dosage: oral, one day
Secondary, each 5ml/kg, one after each meal.
Embodiment 4
A kind of Chinese medicine treating baby's cholestasis, in parts by weight, it includes following component, 32 parts of Herba Artemisiae Scopariae, in vain
28 parts of art, 11 parts of Semen Persicae, 24 parts of Herba Lysimachiae, 17 parts of Cortex Phellodendri, 23 parts of Herba Hedyotidis Diffusae, 19 parts of Semen Litchi, 34 parts of Fructus Hordei Germinatus, succinum
0.8 part, 1.2 parts of Indigo Naturaliss, 0.9 part of Sanguis Draxonis.Above-mentioned raw materials are cleaned up, is brewed into decoction, quantitatively takes.Usage and dosage: mouth
Clothes, two times a day, each 5ml/kg, one after each meal.
Embodiment 5
A kind of Chinese medicine treating baby's cholestasis it is characterised in that: in parts by weight, it includes following component,
19 parts of Herba Artemisiae Scopariae, 26 parts of the Rhizoma Atractylodis Macrocephalae, 8 parts of Semen Persicae, 19 parts of Herba Lysimachiae, 24 parts of Cortex Phellodendri, 19 parts of Herba Hedyotidis Diffusae, 25 parts of Semen Litchi, raw wheat
29 parts of bud, 1.4 parts of succinum, 0.9 part of Indigo Naturaliss, 1.3 parts of Sanguis Draxonis.Above-mentioned raw materials are cleaned up, is brewed into decoction, quantitatively takes.
Usage and dosage: oral, two times a day, and each 5ml/kg, one after each meal.
Embodiment 6
A kind of Chinese medicine treating baby's cholestasis it is characterised in that: in parts by weight, it includes following component,
31 parts of Herba Artemisiae Scopariae, 31 parts of the Rhizoma Atractylodis Macrocephalae, 11 parts of Semen Persicae, 21 parts of Herba Lysimachiae, 21 parts of Cortex Phellodendri, 21 parts of Herba Hedyotidis Diffusae, 21 parts of Semen Litchi, raw wheat
31 parts of bud, 1.2 parts of succinum, 1.2 parts of Indigo Naturaliss, 1.2 parts of Sanguis Draxonis.Above-mentioned raw materials are cleaned up, is brewed into decoction, quantitatively takes.
Usage and dosage: oral, two times a day, and each 5ml/kg, one after each meal.
Clinical observation on the therapeutic effect
1 clinical data: the infant that hospital neonates section of Qingdao City is met cholestasis is randomly divided into experimental group (Chinese medicine
Decoction group) 50 carry out Comparison of therapeutic to observe Chinese medicine decoction of the present invention for baby's bile with matched group (Yin Zhi Huang group) 90
The curative effect of alluvial disease；The each group age is the 0-3 month；Wherein experimental group male 29, women 21, mean age (1.97 soil
0.59 month)；Male 51 in matched group, women 39, the mean age (2.02 soil 1.12 months)；Two groups of situation no significant difference (p
＞ 0.05), there is comparability.
2 diagnostic criterias: " the Infantile hepatitis syndrome diagnosis and treatment rhetoric feature " worked out with reference to 2004, in conjunction with following index:
1. serum total bilirubin tbil >=85.5 μm ol/l；2. serum direct bilirubin dbil >=34.2 μm ol/l；3. stool color is
Light yellow to white；4. hepatosplenomegaly >=3cm or quality change；5. alanine aminotransferase alt, glutamic oxaloacetic transaminase, GOT ast normal or
Increase.
3 Therapeutic Method: experimental group uses oral Chinese medicine of the present invention, usage and dosage: oral, two times a day, each 5ml/kg；
Matched group adopts Yinzhihuang oral liquid, usage and dosage: oral, 1 twice-daily, each 5ml/kg.It is within 14 days a course for the treatment of.Wherein, mattress
The manufacturer of Cape jasmine Huang oral liquid is Beijing Huarun High-Tech Natural Pharmaceutical Co., Ltd..
4 curative effect determinate standards
Cure: infant xanthochromia disappears, biochemical indicator (tbil, dbil) and liver function (alt, ast) index are just recovered
Often, liver spleen no enlargement.
Effective: infant xanthochromia substantially mitigates, biochemical indicator (tbil, dbil) tends to normal, liver function (alt, ast)
Substantially recover, hepatosplenomegaly is obviously reduced.
Effective: the clinical symptoms of patient are obviously improved, biochemical indicator (tbil, dbil) has a certain degree of recovery, liver function
Can (alt, ast) recover.
Invalid: the clinical symptoms of patient are no improved, biochemical indicator (tbil, dbil) no recovers, and liver function (alt, ast) is no
Recover, the state of an illness is in gradually to increase trend.
5 the results are shown in Table 1.
Table 1 experimental group and the comparison of matched group curative effect
Note: statistics education spss17.0 statistical software, using ridit analysis, p ＜ 0.05 represents has statistics meaning
Justice.
(1) 95% credibility interval of experimental group population mean ridit value is [0.644,0.808], and two groups of differences have statistics
Meaning (p ＜ 0.05), result proves that experimental group treats the curative effect of baby's cholestasis better than matched group.
(2) this result of study confirms, rapid-action using this Chinese medicine preparation, can obviously reduce Infant with Jaundice index, and infant is treated
Effect is notable, and effective percentage is 92.0%.The compliance of this Chinese medicine preparation is good, and consumption is few, instant effect, and has no toxic side effect, treats effectively
Rate is high.
Claims (5)
1. a kind of Chinese medicine treating baby's cholestasis it is characterised in that: in parts by weight, it is made up of following component:
Herba Artemisiae Scopariae 25-35 part, Rhizoma Atractylodis Macrocephalae 25-35 part, Semen Persicae 5-12 part, Herba Lysimachiae 15-25 part, Cortex Phellodendri 16-25 part, Herba Hedyotidis Diffusae 14-26
Part, Semen Litchi 18-26 part, Fructus Hordei Germinatus 26-35 part, succinum 0.5-1.5 part, Indigo Naturaliss 0.5-1.5 part, Sanguis Draxonis 0.5-1.5 part.
2. according to described in claim 1 treatment baby's cholestasis Chinese medicine it is characterised in that: in parts by weight, it
It is made up of following component: Herba Artemisiae Scopariae 27-33 part, Rhizoma Atractylodis Macrocephalae 27-33 part, Semen Persicae 7-10 part, Herba Lysimachiae 17-23 part, Cortex Phellodendri 18-23 part,
Herba Hedyotidis Diffusae 16-24 part, Semen Litchi 20-24 part, Fructus Hordei Germinatus 28-33 part, succinum 0.7-1.3 part, Indigo Naturaliss 0.7-1.3 part, blood
Exhaust 0.7-1.3 part.
3. according to described in claim 1 treatment baby's cholestasis Chinese medicine it is characterised in that: in parts by weight, it
It is made up of following component: Herba Artemisiae Scopariae 29-31 part, Rhizoma Atractylodis Macrocephalae 29-31 part, Semen Persicae 8-9 part, Herba Lysimachiae 19-21 part, Cortex Phellodendri 20-21 part, in vain
Serpentis SHECAO 18-22 part, Semen Litchi 21-23 part, Fructus Hordei Germinatus 30-31 part, succinum 0.9-1.1 part, Indigo Naturaliss 0.9-1.1 part, Sanguis Draxonis
0.9-1.1 part.
4. according to described in claim 1 treatment baby's cholestasis Chinese medicine it is characterised in that: in parts by weight, it
It is made up of following component: 30 parts of Herba Artemisiae Scopariae, 30 parts of the Rhizoma Atractylodis Macrocephalae, 10 parts of Semen Persicae, 20 parts of Herba Lysimachiae, 20 parts of Cortex Phellodendri, 20 parts of Herba Hedyotidis Diffusae,
20 parts of Semen Litchi, 30 parts of Fructus Hordei Germinatus, 1 part of succinum, 1 part of Indigo Naturaliss, 1 part of Sanguis Draxonis.
5. according to claim 1-4 any one treatment baby's cholestasis Chinese medicine it is characterised in that: in described
Medicine is decoction.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104288691A (en) * | 2014-10-20 | 2015-01-21 | 济南高达信息技术有限公司 | Traditional Chinese medicine decoction for treating cholestasis syndrome |
| CN107837307A (en) * | 2017-11-13 | 2018-03-27 | 鄢素琪 | A kind of Chinese medicine cholagogic composition for treating baby's cholestasis and purposes |
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2014
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Non-Patent Citations (4)
| Title |
|---|
| 1月龄婴儿黄疸持续不退;王建设等;《中国循证儿科杂志》;20080930;第3卷(第5期);388-396 * |
| 成秋宸等.荔枝核总黄酮对胆汁淤积性肝纤维化大鼠抗肝纤维化的机制探讨.《医药论坛杂志》.2013,第34卷(第12期),11-14. * |
| 胡艳等.裴学义治疗婴儿肝炎综合症经验.《中国中医药信息杂志》.2012,第19卷(第2期),87. * |
| 裴学义教授治疗难治型乳儿黄疸一则;孙淑芬等;《北京中医药大学学报》;19990930;第22卷(第5期);79 * |
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