CN103893356B - A kind of pharmaceutical composition and application thereof promoting cesarean postoperate restoration of gastrointestinal function - Google Patents
A kind of pharmaceutical composition and application thereof promoting cesarean postoperate restoration of gastrointestinal function Download PDFInfo
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- CN103893356B CN103893356B CN201410173886.XA CN201410173886A CN103893356B CN 103893356 B CN103893356 B CN 103893356B CN 201410173886 A CN201410173886 A CN 201410173886A CN 103893356 B CN103893356 B CN 103893356B
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Abstract
The invention discloses a kind of pharmaceutical composition and the application thereof that promote cesarean postoperate restoration of gastrointestinal function, said composition is prepared from by active component and pharmaceutic adjuvant, and described active component is extracted by the traditional Chinese medicinal material raw materials of following weight portion and forms after decocting: Semen Litchi 70-100 part, Herba sopubiae Trifidae 31-40 part, Radix Polygalae 15-23 part, Radix Aconiti Lateralis Preparata 7-14 part.Pharmaceutical composition of the present invention spreads on SHENQUE acupoint by external, and the excited intestinal tube of energy, promotes enterokinesia, shorten micturition time, thus play relieving distension except stagnant effect, the time of recovery of parturient normal diet is significantly shifted to an earlier date, thus promotes the early recovery of cesarean postoperate gastrointestinal function.
Description
Technical field
The invention belongs to medical art, in particular to a kind of pharmaceutical composition and the application thereof that promote cesarean postoperate restoration of gastrointestinal function.
Background technology
In recent years, Cesarean esction has just like become the main flow mode of production in China, and the post-operative complication problem brought thus is also in ascendant trend year by year.Wherein abdominal distention is one of common complication of cesarean postoperate, many because of factors such as tractives in psychentonia, anesthesia, art, make the intestinal of body occur temporary dysfunction, cause enterokinesia to weaken and even disappear, passage of gas by anus is postponed, affects feed and the physical rehabilitation of puerpera.Therefore the recovery as early as possible of postoperative enterokinesia how is promoted, slack except enteroparalysis and abdominal distention, also become in clinical obstetrics nursery work one of problem needing to solve.
Puerpera is due to pain, the uterine contraction pain of abdominal incision, and position limited etc., makes its comfort reduce, psychentonia, poor sleeping quality, impact feed, lactation amount minimizing.The traditional Chinese medical science thinks that cesarean postoperate is due to hematozemia of feeling frustrated, the blood deficiency stagnation of QI, simulataneous insufficiency and excessive, causes the mechanism of qi of intestinal internal organs to run and falls and do not rise, dynamic and not quiet; Pathogenesis is dysfunction of the spleen in transportation, stomach-QI being unable to descend normally, conduction dereliction of duty, venation are impaired, qi depression to blood stasis, middle Jiao is obstructed and body void, deficiency of kidney-QI, gas can not promote caused by enterokinesia.Umbilical part is SHENQUE acupoint, is the master point of conception vessel, is connected with the twelve regular channels, also communicates with internal organs and whole body, and for the logical tune whole body is through point, the deep of umbilicus is directly connected with large intestine, therefore SHENQUE acupoint wants cave for recovery of having one's ideas straightened out.Applying umbilicus to treat also known as umbilicus, be mediate a settlement viscera theory for theoretical basis with science of arteries and veins, select corresponding medicine according to the needs of different syndromes, be a kind of through cave external treatment, belong to percutaneous dosing category, is the third generation dose regimen that WHO recommends.Absorbed by topical remedy, acupuncture points on the human body meridians transmit, the effect of system fading margin, the wet effect such as long-pending of the logical Yuanyang of temperature, strengthening the body resistance, the smooth meridians of tune, invigorating the spleen and stomach, change plug can be reached.
Summary of the invention
Applying Chinese medicine to the umbilicus is the nursing means of the feature therapies patients in remission using Chinese medicine.Given this, the object of the present invention is to provide a kind of pharmaceutical composition and the application thereof that adopt umbilical compress therapy promotion cesarean postoperate restoration of gastrointestinal function.
The object of the present invention is achieved like this:
A kind of pharmaceutical composition promoting cesarean postoperate restoration of gastrointestinal function, be prepared from by active component and pharmaceutic adjuvant, wherein said active component is extracted by the traditional Chinese medicinal material raw materials of following weight portion and forms after decocting: Semen Litchi 70-100 part, Herba sopubiae Trifidae 31-40 part, Radix Polygalae 15-23 part, Radix Aconiti Lateralis Preparata 7-14 part.
Preferably, the pharmaceutical composition of promotion cesarean postoperate restoration of gastrointestinal function described above, wherein said active component is extracted by the traditional Chinese medicinal material raw materials of following weight portion and forms after decocting: Semen Litchi 75-90 part, Herba sopubiae Trifidae 34-36 part, Radix Polygalae 17-20 part, Radix Aconiti Lateralis Preparata 9-11 part.
Further preferably, the pharmaceutical composition of promotion cesarean postoperate restoration of gastrointestinal function described above, wherein said active component is extracted by the traditional Chinese medicinal material raw materials of following weight portion and forms after decocting: Semen Litchi 80 parts, Herba sopubiae Trifidae 35 parts, Radix Polygalae 18 parts, Radix Aconiti Lateralis Preparata 10 parts.
It should be noted that, traditional Chinese medicinal material raw materials of the present invention has following source: Semen Litchi selects the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Herba sopubiae Trifidae selects the dry herb of the short hat grass of goatweed.Radix Polygalae selects the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd..The daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx. selected by Radix Aconiti Lateralis Preparata.
The present inventor is found by a large amount of clinical practice, and pharmaceutical composition of the present invention spreads on the excited intestinal tube of SHENQUE acupoint energy, promotes enterokinesia, shortens micturition time, thus plays relieving distension except stagnant effect, and the time of recovery of parturient normal diet is significantly shifted to an earlier date.Therefore, present invention also offers a kind of new pharmaceutical use, that is: above-mentioned active component promotes the application in the medicine of cesarean postoperate restoration of gastrointestinal function in preparation.Preferably, above-mentioned active component promotes the application in the external used medicine of cesarean postoperate restoration of gastrointestinal function in preparation.
Before applying Chinese medicine to the umbilicus, the object, method, points for attention etc. of medication will be described to puerpera, and cold season will be noted warming.Nursing staff's action wants skilled, and dosage is wanted accurately.During operation, sufficiently sterilised umbilical part be noted, also will conscientiously clean after medication, keep umbilical part dry.During clean umbilicus, wiping of can not exerting oneself, prevents skin injury.When applying umbilicus with oil preparation, paste and powder, to apply with plastic foil or immobilization with adhesive tape firm when sticking medicine, to keep drug effect, prevent drug wastage or pollute clothing.After applying Chinese medicine to the umbilicus, close observation patient with or without discomfort, if any inadaptable drug withdrawal immediately.Notice that skin is with or without phenomenons such as allergy, erythra and blisters, avoid the gauze of covering or adhesive plaster humidity, pollute, prevent skin infection.Must guard against with stopping, in order to avoid affect the treatment.Umbilicus has inflammation, breakage or forbids drug allergy person.
The preparation method of pharmaceutical composition of the present invention comprises the steps: to take Semen Litchi 70-100 part, Herba sopubiae Trifidae 31-40 part, Radix Polygalae 15-23 part, Radix Aconiti Lateralis Preparata 7-14 part, clean roguing, dry, be ground into granule, then the soak by water 1-1.5h of medical material weight 10-15 times amount is added, filter, collect filtrate; The soak by water 0.5-1h of medical material weight 10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate merged, be concentrated into liquor capacity: the drug extract of medical material weight=0.5-1: 1, by extractum spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), pulverize 100 mesh sieves, obtain clear paste powder; By clear paste powder and adjuvant conveniently technique be prepared as various external preparation, as gel, ointment, ointment, liniment, cataplasma, etc.
Pharmaceutical composition of the present invention spreads on SHENQUE acupoint by external, and the excited intestinal tube of energy, promotes enterokinesia, shorten micturition time, thus play relieving distension except stagnant effect, the time of recovery of parturient normal diet is significantly shifted to an earlier date, thus promotes the early recovery of cesarean postoperate gastrointestinal function.This medicine is in deposited umbilicus use procedure, and puerpera's no pain, patient medication interdependence is high.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Take Semen Litchi 7.5kg, Herba sopubiae Trifidae 3.1kg, Radix Polygalae 1.5kg, Radix Aconiti Lateralis Preparata 1.4kg, clean roguing, dry, be ground into granule, then add the soak by water 1h of medical material weight 12 times amount, filter, collect filtrate; The soak by water 1h of medical material weight 10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 1, by extractum spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), pulverize 100 mesh sieves, obtain clear paste powder.
Embodiment 2
Take Semen Litchi 9.0kg, Herba sopubiae Trifidae 3.6kg, Radix Polygalae 2.3kg, Radix Aconiti Lateralis Preparata 1.1kg, clean roguing, dry, be ground into granule, then add the soak by water 1.5h of medical material weight 10 times amount, filter, collect filtrate; The soak by water 0.5h of medical material weight 10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 1, by extractum spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), pulverize 80 mesh sieves, obtain clear paste powder.
Embodiment 3
Take Semen Litchi 8.0kg, Herba sopubiae Trifidae 3.5kg, Radix Polygalae 1.8kg, Radix Aconiti Lateralis Preparata 1.0kg, clean roguing, dry, be ground into granule, then add the soak by water 1h of medical material weight 15 times amount, filter, collect filtrate; The soak by water 1h of medical material weight 10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 1, by extractum spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), pulverize 100 mesh sieves, obtain clear paste powder.
Embodiment 4
Take Semen Litchi 10.0kg, Herba sopubiae Trifidae 4.0kg, Radix Polygalae 1.8kg, Radix Aconiti Lateralis Preparata 0.7kg, clean roguing, dry, be ground into granule, then add the soak by water 1h of medical material weight 12 times amount, filter, collect filtrate; The soak by water 1h of medical material weight 10 times amount is added again in medicinal residues, filter, collect filtrate, twice filtrate merged, be concentrated into liquor capacity: medical material weight=1: the drug extract of 1, by extractum spraying dry, (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, and atomizing pressure is 0.2 MPa, and spray velocity is 5ml/s.), pulverize 100 mesh sieves, obtain clear paste powder.
Clinical practice example
Single tire full-term pregnancy primipara 76 example of row cesarean section delivery first, age 21-33 year, in pregnant all 38-41 weeks, without pregnancy complication, all at the descending low cesarean section of subarachnoid anesthesia, postoperatively leave analgesia pump.According to random packet principle, 76 routine puerperas are divided at random matched group and each 38 examples of test group, two groups of puerperas compare there was no significant difference in situations such as age, pregnant week, modus operandi, operating times, have comparability.
After the postoperative peace of matched group puerpera returns ward, carry out antiinflammatory fluid-supplement therapy, nursing staff also gives routine care: remove flat sleeping, the fasting taboo water 6h of pillow, the laggard high heat of 6h, few slag, digestible light diet, as gruel etc., bring out gastrointestinal peristalsis by the chewing of diet.Meanwhile, start to follow colon upwards run from puerpera's lower abdomen ileocecum portion, massage downwards left pushes away and rubs, and maneuver from slow to fast, grows from weak to strong, each 20min, every day 2 times.Postoperative 8h starts every 2h and stands up 1 time, leaves the bed and carries out simple activities, and add large amount of exercise in time and extend the activity time after 24h.
On the basis of test group puerpera routine care after surgery, the clear paste powder starting to adopt the embodiment of the present invention 3 to prepare in postoperative 6h carries out umbilical dressing, every day 1 time, external application 3d, and one to paste be 1 course for the treatment of.Implementation method: after dipping in 75% alcohol disinfecting umbilicus with cotton swab, be with glove by antiseptic gauze one piece (10cm × 10cm), qinghuo reagent powder 5-8g, reconciles into pasty state with a little Mel, is applied on gauze, gauze is laid on umbilicus, opened by another block gauze above covering, suitably fix with adhesive plaster, the drug of topical application time is 60min again, note warming, drug of topical application Final finishing puerpera's clothes and Bed unit.Observed by nursing staff and record micturition time and first defecation time first.After treatment terminates, statistical results, two groups of primipara's cesarean postoperate evacuation times and defecation time relatively in table 1.
The comparison (h) of table 1 liang group primipara cesarean postoperate evacuation time and defecation time first
Compare with matched group, *
p< 0.05, * *
p< 0.01.
Can be found out by the efficacy result of table 1, adopt the test group operation in patients final vacuum of medicine composite for curing of the present invention, defecation time is significantly shorter than matched group (
p< 0.01).This demonstrate pharmaceutical composition of the present invention and spread on the excited intestinal tube of SHENQUE acupoint energy, promote enterokinesia, shorten micturition time, thus play relieving distension except stagnant effect, the time of recovery of parturient normal diet is significantly shifted to an earlier date.
Claims (2)
1. one kind promotes the pharmaceutical composition of cesarean postoperate restoration of gastrointestinal function, be prepared from by active component and pharmaceutic adjuvant, it is characterized in that: described active component is extracted by the traditional Chinese medicinal material raw materials of following weight portion and forms after decocting: Semen Litchi 80 parts, Herba sopubiae Trifidae 35 parts, Radix Polygalae 18 parts, Radix Aconiti Lateralis Preparata 10 parts; Described pharmaceutical composition is external used medicine, and external spreads on SHENQUE acupoint.
2. active component according to claim 1 promotes the application in the medicine of cesarean postoperate restoration of gastrointestinal function in preparation.
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| CN201410173886.XA CN103893356B (en) | 2014-04-29 | 2014-04-29 | A kind of pharmaceutical composition and application thereof promoting cesarean postoperate restoration of gastrointestinal function |
| CN201510743481.XA CN105194057A (en) | 2014-04-29 | 2014-04-29 | Method for preparing externally-used medicine for promoting recovery of gastrointestinal functions after cesarean section |
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| CN104306527A (en) * | 2014-10-15 | 2015-01-28 | 青岛申达高新技术开发有限公司 | Medicine composition for treating chronic superficial gastritis and application thereof |
| CN105168712A (en) * | 2015-09-15 | 2015-12-23 | 陈红 | Drug for promoting gastrointestinal function recovery after abdominal operation realized through epidural anesthesia |
| CN105232848A (en) * | 2015-11-06 | 2016-01-13 | 强红艳 | Medicine for post-hysterectomy intestine function rehabilitation, and application thereof |
| CN105412664A (en) * | 2015-12-18 | 2016-03-23 | 于景荣 | Medicine for postoperative cesarean delivery |
| CN105687789A (en) * | 2016-03-11 | 2016-06-22 | 陈洁 | Pharmaceutical composition for promoting intestinal function recovery after abdominal operation and application of pharmaceutical composition |
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| CN103142898A (en) * | 2013-03-31 | 2013-06-12 | 张朋飞 | Preparation method of medicine used after esophageal achalasia operation |
| CN103638384A (en) * | 2013-12-10 | 2014-03-19 | 高峰 | Pharmaceutical composition for enema treatment of abdominal distension after colon cancer surgery and application thereof |
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| CN103142898A (en) * | 2013-03-31 | 2013-06-12 | 张朋飞 | Preparation method of medicine used after esophageal achalasia operation |
| CN103638384A (en) * | 2013-12-10 | 2014-03-19 | 高峰 | Pharmaceutical composition for enema treatment of abdominal distension after colon cancer surgery and application thereof |
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