CN103889438B - 心血管疗法 - Google Patents

心血管疗法 Download PDF

Info

Publication number
CN103889438B
CN103889438B CN201280050843.1A CN201280050843A CN103889438B CN 103889438 B CN103889438 B CN 103889438B CN 201280050843 A CN201280050843 A CN 201280050843A CN 103889438 B CN103889438 B CN 103889438B
Authority
CN
China
Prior art keywords
signal peptide
type
peptide fragment
natriuretic signal
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280050843.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN103889438A (zh
Inventor
C·J·彭伯顿
A·M·理查德
C·J·查尔斯
M·西里瓦德纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otago Innovation Ltd
Original Assignee
Otago Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otago Innovation Ltd filed Critical Otago Innovation Ltd
Publication of CN103889438A publication Critical patent/CN103889438A/zh
Application granted granted Critical
Publication of CN103889438B publication Critical patent/CN103889438B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201280050843.1A 2011-08-18 2012-08-17 心血管疗法 Expired - Fee Related CN103889438B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161525140P 2011-08-18 2011-08-18
US61/525,140 2011-08-18
PCT/IB2012/002117 WO2013024362A2 (en) 2011-08-18 2012-08-17 Cardiovascular therapeutics

Publications (2)

Publication Number Publication Date
CN103889438A CN103889438A (zh) 2014-06-25
CN103889438B true CN103889438B (zh) 2016-08-24

Family

ID=47715527

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280050843.1A Expired - Fee Related CN103889438B (zh) 2011-08-18 2012-08-17 心血管疗法

Country Status (8)

Country Link
US (2) US9783574B2 (https=)
EP (1) EP2744506B1 (https=)
JP (1) JP6222779B2 (https=)
CN (1) CN103889438B (https=)
AU (1) AU2012296266B2 (https=)
CA (1) CA2845617A1 (https=)
SG (2) SG11201400067TA (https=)
WO (1) WO2013024362A2 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001017617A1 (en) * 1999-09-03 2001-03-15 Callaway Golf Company A golf club head with a polymer insert
WO2008030122A1 (en) * 2006-09-07 2008-03-13 University Of Otago Biomarkers

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155590A (en) 1962-08-02 1964-11-03 Ncr Co Encapsulation process and its product
US3488418A (en) 1965-11-18 1970-01-06 Sterling Drug Inc Sustained relief analgesic composition
US3391416A (en) 1966-07-14 1968-07-09 Wollard Aircraft Service Equip Conveyance loader system
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
JP4181232B2 (ja) 1997-07-18 2008-11-12 帝國製薬株式会社 ジクロフェナクナトリウム含有油性外用貼付製剤
US6193996B1 (en) 1998-04-02 2001-02-27 3M Innovative Properties Company Device for the transdermal delivery of diclofenac
US6410041B1 (en) 1998-04-28 2002-06-25 Trustees Of Tufts College Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine
WO2000018352A2 (en) 1998-09-28 2000-04-06 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
US20050171021A1 (en) * 1998-11-12 2005-08-04 Cormier Michel J. Buffered drug formulations for transdermal
US6309380B1 (en) 1999-01-27 2001-10-30 Marian L. Larson Drug delivery via conformal film
GB9917165D0 (en) * 1999-07-22 1999-09-22 Knoll Ag Polypeptides polynuclcotides and uses thereof
WO2005052593A1 (en) 2003-10-29 2005-06-09 The University Of Leicester Detection
CA2554599A1 (en) * 2004-01-27 2005-08-11 Compugen Usa, Inc. Novel brain natriuretic peptide variants and methods of use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001017617A1 (en) * 1999-09-03 2001-03-15 Callaway Golf Company A golf club head with a polymer insert
WO2008030122A1 (en) * 2006-09-07 2008-03-13 University Of Otago Biomarkers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
《 Antioxidative properties of tripeptide libraries prepared by the combinattorial chemistry》;SAITO,K. et al;《Journal of agricultrual and food chemistry》;20031231;第51卷;3668-3674 *
《Utilizing reversible copper(II) peptide coordination in a sequence-selective luminescent receptor》;STADLBAUER,S,et al;《Chemistry: A European Journal》;20081231;第14卷;2536-2541 *

Also Published As

Publication number Publication date
JP2014524435A (ja) 2014-09-22
SG11201400067TA (en) 2014-04-28
EP2744506A4 (en) 2015-06-03
US20180148475A1 (en) 2018-05-31
WO2013024362A3 (en) 2013-07-25
US9783574B2 (en) 2017-10-10
WO2013024362A2 (en) 2013-02-21
SG10201601086WA (en) 2016-03-30
CN103889438A (zh) 2014-06-25
EP2744506B1 (en) 2019-10-09
US20130072431A1 (en) 2013-03-21
EP2744506A2 (en) 2014-06-25
JP6222779B2 (ja) 2017-11-01
AU2012296266A1 (en) 2014-03-13
CA2845617A1 (en) 2013-02-21
AU2012296266B2 (en) 2017-08-31
NZ621790A (en) 2017-09-29

Similar Documents

Publication Publication Date Title
RU2332229C2 (ru) Способ введения молекул glp-1
US5641744A (en) Treatment of diabetes mellitus
US5175145A (en) Treatment of diabetes mellitus with amylin agonists
EP4043010A1 (en) Elp fusion proteins for controlled and sustained release
JP2019104768A (ja) 代謝性症候群を予防し又は治療するための方法
CN103764159A (zh) 芳香族阳离子肽及其用途
US20220023390A1 (en) Methods and compositions for treating cystic fibrosis
EP2440231B1 (en) Co-administration of an agent linked to a tat-internalization peptide with a mast cell degranulation inhibitor
ES2563489T3 (es) Administración oral de péptidos mejorada
CN102791280A (zh) 用于预防或治疗血管阻塞损伤的方法
CN104324360A (zh) 用于减少cd36表达的方法
JP2018500291A (ja) 制御放出および持続的放出のためのｅｌｐ融合タンパク質
KR20160009008A (ko) 심부전과 관련된 위험 및 이와 관련된 인자를 감소시키는 방법
KR20210093958A (ko) 미토콘드리아 질환을 표적으로 하는 유사체
US20240299552A1 (en) Pharmaceutical Composition of GLP-1/GLP-2 Dual Agonists
WO2013192238A2 (en) Compositions and methods for treatment of diabetes
CN103889438B (zh) 心血管疗法
JP2019522041A (ja) 新規のペプチド及びペプチド模倣体
NZ621790B2 (en) Cardiovascular therapeutics
US9670250B2 (en) Alpha-helical peptidomimetic inhibitors and methods using same
CN100508957C (zh) 肽经口输递的改进
JP2009516711A (ja) 糖尿病の処置のための組成物および方法
WO2025123051A1 (en) Non-naturally occurring melanocortin analogs and uses thereof for modulating weight gain

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160824

Termination date: 20200817

CF01 Termination of patent right due to non-payment of annual fee