CN103877231B - A kind of seven tastes nourish heart the preparation method of spleen-invigorating granula - Google Patents
A kind of seven tastes nourish heart the preparation method of spleen-invigorating granula Download PDFInfo
- Publication number
- CN103877231B CN103877231B CN201410145740.4A CN201410145740A CN103877231B CN 103877231 B CN103877231 B CN 103877231B CN 201410145740 A CN201410145740 A CN 201410145740A CN 103877231 B CN103877231 B CN 103877231B
- Authority
- CN
- China
- Prior art keywords
- invigorating
- granula
- tastes
- spleen
- mass parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of seven tastes to nourish heart the preparation method of spleen-invigorating granula, first Fructus Schisandrae Chinensis, Herba Menthae, Cortex Cinnamomi and Semen Platycladi mixed and pulverize to obtain coarse powder; Gained coarse powder is carried out supercritical carbon dioxide extraction and obtains total oil extract, medicinal residues are for subsequent use; Total oil extract and beta-schardinger dextrin-are mixed and stir enclose and obtains clathrate; Medicinal residues and Radix Glycyrrhizae, the Radix Astragali and Poria are mixed to get compound, add water in described compound, supersound extraction 2-3 time under room temperature, merge extractive liquid, concentrating under reduced pressure also obtains dry extract after vacuum drying; Dry extract, starch and dextrin are mixed, using alcoholic solution as wetting agent soft material, by soft material and clathrate mix homogeneously, granulate, granulate namely obtain seven tastes after drying and to nourish heart spleen-invigorating granula.Show according to pharmacological research, seven tastes of the present invention nourish heart spleen-invigorating granula display sedative-hypnotic effect, improve the oxygen deficit tolerance ability of mice, extend the time-to-live, extend mice swimming continuance time.
Description
One, technical field
The present invention relates to a kind of preparation method of existing medicine, specifically a kind of seven tastes nourish heart the preparation method of spleen-invigorating granula.
Two, background technology
Qiwei yangxin jianpi capsules is because offspring doctor of medicine Zhang Xutong donates prescription by Chinese American, clearly court of a feudal ruler imperial physician Cui Guo, within 2003, be listed in national torch science and technology item, the research continuing 12 years by University of Anhui and Anhui Guo Zheng Pharmaceutical limited company succeeded in developing listing in 2004.The party is made up of Fructus Schisandrae Chinensis, Radix Glycyrrhizae, the Radix Astragali, Poria, Herba Menthae, Semen Platycladi, Cortex Cinnamomi seven taste Chinese medicine.Fructus Schisandrae Chinensis mind tranquilizing and the heart calming in side, in prescription, consumption is maximum, for main symptom, therefore is monarch drug; The Radix Astragali, Radix Glycyrrhizae function invigorating the spleen and replenishing QI, help Fructus Schisandrae Chinensis for the severe palpitation of deficiency of vital energy deficiency of heart-blood; Poria function spleen-benefiting mind-tranquilizing; Three taste medicines assist principal agent for main symptom, therefore are ministerial drug; The clear sharp head of Herba Menthae fragrance energy, Semen Platycladi function tranquilizing by nourishing the heart; Cortex Cinnamomi temperature can transport yang-energy, inspires QI and blood growth; Three medicines can treat accompanied symptoms, promote that major-minor medicine better plays a role, therefore are adjuvant.There is effect of benefiting vital QI for tranquillizing, spleen reinforcing brain-strengthening.For syndrome of deficiency of both heart and spleen (being equivalent to modern's sub-health state).
When qiwei yangxin jianpi capsules is produced, capsule 's content is each medical material micropowder, does not have that the other side's Chinese medicine effectively extracts, purification, and cause medicine dose large, take often, drug effect is slow; After oral, the fine powder sloughing softgel shell easily produces sensation of fullness at stomach, and laxative belch waits malaise symptoms.
Three, summary of the invention
The present invention aims to provide a kind of seven tastes and to nourish heart the preparation method of spleen-invigorating granula, adopts supercritical carbon dioxide and ultrasonic wave extraction, is extracted by qiwei yangxin jianpi capsules agent Chinese medicine, dry, adds adjuvant and is prepared into granule.The present invention changes qiwei yangxin jianpi capsules agent into granule, reduces and directly takes the discomfort reaction that medicated powder causes, reduce taking dose, have storage, carry, convenient transportation, child, old people garment use advantage easily.
The nourish heart preparation method of spleen-invigorating granula of the present invention seven taste is as follows:
1) Semen Platycladi of the Herba Menthae of the Fructus Schisandrae Chinensis of 45 mass parts, 32 mass parts, the Cortex Cinnamomi of 35 mass parts and 25 mass parts mixed and pulverizes, crossing 24 mesh sieves and obtain coarse powder (being no more than 40% by 65 mesh sieves);
2) step 1) gained coarse powder is carried out supercritical carbon dioxide extraction and obtain total oil extract, medicinal residues are for subsequent use; The technological parameter of supercritical carbon dioxide extraction is: extraction time 90-100min, extraction temperature 40-50 DEG C, CO
2flow is 18-22L/h, and separating pressure is 5MPa, and separation temperature is 40 DEG C;
3) by step 2) total oil extract of obtaining and beta-schardinger dextrin-mix with the mass ratio of 1:10-12 and stir enclose and obtain clathrate, and enclose temperature is 65-75 DEG C, enclose time 1.5-2 hour;
4) by step 2) medicinal residues that obtain and the Radix Glycyrrhizae of 15 mass parts, the Radix Astragali of 15 mass parts and 12 mass parts Poria be mixed to get compound, add water by the solid-liquid ratio of 1g:20-40mL in described compound, supersound extraction 2-3 time under room temperature, each 30-50min, merge extractive liquid, concentrating under reduced pressure also obtains dry extract after vacuum drying;
5) dry extract step 4) obtained, starch and dextrin (or extractum, dextrin and Icing Sugar) mix by the mass ratio of 1:2:1, using the alcoholic solution of 70-80vt% as wetting agent soft material, the clathrate described soft material and step 3) obtained compares mix homogeneously according to the quality of 50-60:1, cross 14 mesh sieves to granulate, after 16 mesh sieve granulate, be dried to constant weight in 60 DEG C, obtain seven tastes and to nourish heart spleen-invigorating granula.
Show according to pharmacological research, seven tastes of the present invention nourish heart spleen-invigorating granula display sedative-hypnotic effect, improve the oxygen deficit tolerance ability of mice, extend the time-to-live, extend mice swimming continuance time.Compared with the technique prepared with traditional extraction technique, the incubation period of mice sleep and the time effects of sleep are caused to pentobarbital sodium, on the impact of mice swimming time, has significant difference.Display the present invention has stronger hypnosis and improves the effect of body endurance.
Four, detailed description of the invention
Embodiment 1:
1) Semen Platycladi of the Herba Menthae of the Fructus Schisandrae Chinensis of 45 mass parts, 32 mass parts, the Cortex Cinnamomi of 35 mass parts and 25 mass parts mixed and pulverizes, crossing 24 mesh sieves and obtain coarse powder (being no more than 40% by 65 mesh sieves);
2) step 1) gained coarse powder is carried out supercritical carbon dioxide extraction and obtain total oil extract, medicinal residues are for subsequent use; The technological parameter of supercritical carbon dioxide extraction is: extraction time 90min, extraction temperature 40 DEG C, CO
2flow is 18L/h, and separating pressure is 5MPa, and separation temperature is 40 DEG C;
3) by step 2) total oil extract of obtaining and beta-schardinger dextrin-mix with the mass ratio of 1:10 and stir enclose and obtain clathrate, and enclose temperature is 65 DEG C, 1.5 hours enclose time;
4) by step 2) medicinal residues that obtain and the Radix Glycyrrhizae of 15 mass parts, the Radix Astragali of 15 mass parts and 12 mass parts Poria be mixed to get compound, add water by the solid-liquid ratio of 1g:20mL in described compound, supersound extraction 2 times under room temperature, each 30min, merge extractive liquid, concentrating under reduced pressure also obtains dry extract after vacuum drying;
5) dry extract step 4) obtained, starch and dextrin mix by the mass ratio of 1:2:1, using the alcoholic solution of 70vt% as wetting agent soft material, the clathrate described soft material and step 3) obtained compares mix homogeneously according to the quality of 50:1, cross 14 mesh sieves to granulate, after 16 mesh sieve granulate, be dried to constant weight in 60 DEG C, obtain seven tastes and to nourish heart spleen-invigorating granula.
Embodiment 2:
1) Semen Platycladi of the Herba Menthae of the Fructus Schisandrae Chinensis of 45 mass parts, 32 mass parts, the Cortex Cinnamomi of 35 mass parts and 25 mass parts mixed and pulverizes, crossing 24 mesh sieves and obtain coarse powder (being no more than 40% by 65 mesh sieves);
2) step 1) gained coarse powder is carried out supercritical carbon dioxide extraction and obtain total oil extract, medicinal residues are for subsequent use; The technological parameter of supercritical carbon dioxide extraction is: extraction time 95min, extraction temperature 45 DEG C, CO
2flow is 20L/h, and separating pressure is 5MPa, and separation temperature is 40 DEG C;
3) by step 2) total oil extract of obtaining and beta-schardinger dextrin-mix with the mass ratio of 1:11 and stir enclose and obtain clathrate, and enclose temperature is 70 DEG C, enclose time 2 h;
4) by step 2) medicinal residues that obtain and the Radix Glycyrrhizae of 15 mass parts, the Radix Astragali of 15 mass parts and 12 mass parts Poria be mixed to get compound, add water by the solid-liquid ratio of 1g:30mL in described compound, supersound extraction 3 times under room temperature, each 30min, merge extractive liquid, concentrating under reduced pressure also obtains dry extract after vacuum drying;
5) dry extract step 4) obtained, dextrin and Icing Sugar mix by the mass ratio of 1:2:1, using the alcoholic solution of 75vt% as wetting agent soft material, the clathrate described soft material and step 3) obtained compares mix homogeneously according to the quality of 55:1, cross 14 mesh sieves to granulate, after 16 mesh sieve granulate, be dried to constant weight in 60 DEG C, obtain seven tastes and to nourish heart spleen-invigorating granula.
Embodiment 3:
1) Semen Platycladi of the Herba Menthae of the Fructus Schisandrae Chinensis of 45 mass parts, 32 mass parts, the Cortex Cinnamomi of 35 mass parts and 25 mass parts mixed and pulverizes, crossing 24 mesh sieves and obtain coarse powder (being no more than 40% by 65 mesh sieves);
2) step 1) gained coarse powder is carried out supercritical carbon dioxide extraction and obtain total oil extract, medicinal residues are for subsequent use; The technological parameter of supercritical carbon dioxide extraction is: extraction time 100min, extraction temperature 50 DEG C, CO
2flow is 22L/h, and separating pressure is 5MPa, and separation temperature is 40 DEG C;
3) by step 2) total oil extract of obtaining and beta-schardinger dextrin-mix with the mass ratio of 1:12 and stir enclose and obtain clathrate, and enclose temperature is 75 DEG C, enclose time 2 h;
4) by step 2) medicinal residues that obtain and the Radix Glycyrrhizae of 15 mass parts, the Radix Astragali of 15 mass parts and 12 mass parts Poria be mixed to get compound, add water by the solid-liquid ratio of 1g:40mL in described compound, supersound extraction 3 times under room temperature, each 30min, merge extractive liquid, concentrating under reduced pressure also obtains dry extract after vacuum drying;
5) dry extract step 4) obtained, starch and dextrin mix by the mass ratio of 1:2:1, using the alcoholic solution of 80vt% as wetting agent soft material, the clathrate described soft material and step 3) obtained compares mix homogeneously according to the quality of 60:1, cross 14 mesh sieves to granulate, after 16 mesh sieve granulate, be dried to constant weight in 60 DEG C, obtain seven tastes and to nourish heart spleen-invigorating granula.
[pharmacological experiment study of spleen-invigorating granula that seven tastes of different extraction process are nourished heart]
1 experiment material
1.1 test medicine: seven tastes prepared by the present invention nourish heart spleen-invigorating granula (hereinafter referred to as " seven taste granules (newly) "), and preparation method is shown in embodiment 3.Add water the suspension of furnishing 35.94 crude drugs/kg and 17.56g crude drug/kg.
1.2 contrast medicines: seven tastes spleen-invigorating granula (hereinafter referred to as " seven taste granules (tradition) ") preparation method that nourishes heart that traditional handicraft is extracted is: get the drug dose that the spleen-invigorating granula (newly) that to nourish heart with seven tastes is equal to, to add water reflux, extract, 3 times with the ratio of solid-liquid ratio 1g:40mL, sucking filtration, merging filtrate, concentrating under reduced pressure, vacuum drying, obtains dry extract.Dry extract, dextrin and Icing Sugar are pressed the mass ratio mixing of 1:2:1, using 80vt% ethanol as wetting agent soft material, cross 14 mesh sieves and granulate, 14 mesh sieves are granulated, 16 mesh sieve granulate, and 60 DEG C are dried to constant weight, obtained granule.Add water the suspension of furnishing 35.94 crude drugs/kg and 17.56g crude drug/kg.
1.3 animals: Kunming mouse, Wistar Mus is provided by Anhui Chinese Medicine College Animal House
1.4 key instruments: YLS-1A Multifunctional mouse autonomic activities monitor, Shandong Academy of Medical Sciences's equipment station.
1.5 laboratory environments: temperature 18-28 DEG C, relative humidity 60-80%, natural lighting.
2 experimental techniques and result
2.1 statistical method
Table 1 experimental data χ
2exact method method in inspection, other experimental data Cochran & Cox is similar to t inspection.
2.2 experiment of pentobarbital sodium subliminal hypnosis and sleep experiments
Pentobarbital sodium subliminal hypnosis is tested: get mice 60, the administration of each group mouse stomach, 2 times/d, continuous 15d, each mouse peritoneal injection 3.5mg/ml pentobarbital sodium after last administration 1h, sleep mice number in record 30min.
Pentobarbital sodium sleep experiments: get mice 60, each group of mouse stomach administration, 1 time/d, continuous 21d, each mouse peritoneal injection 5.0mg/ml pentobarbital sodium after last administration 1h, record dropping asleep latency (from injection pentobarbital sodium to time for falling asleep) and the length of one's sleep (righting reflex loss occurs to righting reflex).
Seven tastes of table 1 two kinds of techniques nourish heart the impact of spleen-invigorating granula on pentobarbital sodium subliminal hypnosis
Note: compared with blank group,
bp<0.01; Seven taste granule high and low dose group (newly) are corresponding with seven taste granule high and low dose group (tradition) to be compared,
△ △p<0.01
Seven tastes of table 2 two kinds of techniques nourish heart the impact of spleen-invigorating granula on the pentobarbital sodium hypnosis time
Note: compared with blank group,
ap<0.05,
bp<0.01; Seven taste granule high and low dose group (newly) are corresponding with seven taste granule high and low dose group (tradition) to be compared,
△p<0.05,
△ △p<0.01
As shown in Table 1, compare with blank group, seven taste granules (newly) and seven taste granules (tradition) all significantly can increase pentobarbital sodium sub-threshold dose and cause mice sleep number (P<0.01), and the high dose group of both variable grains there were significant differences (P<0.01) using.
As shown in Table 2, compared with blank group, seven taste granules (newly) are to the incubation period that pentobarbital sodium causes mice sleep, there were significant differences (P<0.01 or P<0.05), and there were significant differences (P<0.01 or P<0.05) using for both variable grains.Compared with blank group, seven taste granules (newly) cause the time effects of mice sleep to pentobarbital sodium, and there were significant differences (P<0.01 or P<0.05), and there were significant differences (P<0.05) using for the granule low dose group of both techniques.
2.2 anti-stress effect
2.2.1 hydrocortisone is caused to the impact of YIN-deficiency type mice anoxia enduring
Get mice 72, body weight 20-26g, male and female half and half, be divided into 6 groups.By dosed administration in table 3, dosage 0.3ml/10g, continuous 7d, matched group and hydrocortisone deficiency of YIN group give the normal saline of same volume.Within 3rd day, rise, except matched group intramuscular injection 0.2ml/ normal saline, all the other respectively organize every mice intramuscular injection hydrocortisone 5mg/d, are used in conjunction 4d.Mice is placed in the 250ml wide mouthed bottle filling 10g sodica calx by 7d respectively, sealing bottleneck, observed and recorded each Mus time-to-live.The results are shown in Table 3.
Seven tastes of table 3 two kinds of techniques nourish heart the impact of spleen-invigorating granula on hydrocortisone YIN-deficiency type mice anoxia enduring
Note: compared with model control group,
ap<0.05,
bp<0.01; Seven taste granule high and low dose group (newly) are corresponding with seven taste granule high and low dose group (tradition) to be compared,
△p<0.05,
△ △p<0.01
As shown in Table 3, seven tastes of the two kinds of techniques spleen-invigorating granula that nourishes heart causes the time-to-live of YIN-deficiency type mice all higher than model group to hydrocortisone, compared with model group, blank group, seven taste granule high and low dose group (newly) and seven taste granule high dose group (tradition) all have significant difference (P<0.05), but seven tastes of two kinds of techniques nourish heart between spleen-invigorating granula effect and do not have significant difference.
2.2.2 on the impact of mice swimming time
Get mice 60, body weight 20-22g, male and female half and half, be divided into 5 groups, by dosed administration in table 4, dosage is 0.3ml/10g, continuous medicine-filling 8d.After last administration after 40min, bear a heavy burden 10% by afterbody, put into the glass jar be filled with water, depth of water 30cm, water temperature 20 ± 1 DEG C.Observing and recording mice from such as water, to the time of being drowned, is every mice swimming continuance time.The results are shown in Table 4.
Seven tastes of table 4 two kinds of techniques nourish heart the impact of spleen-invigorating granula on mice swimming time
Note: compared with blank group,
ap<0.05,
bp<0.01; Seven taste granule high and low dose group (newly) are corresponding with seven taste granule high and low dose group (tradition) to be compared,
△p<0.05
As shown in Table 4, seven tastes of two kinds of techniques nourish heart spleen-invigorating granula to mice swimming time all higher than blank group, and compared with blank, seven taste granule high and low dose group (newly) have significant difference (P<0.01); Seven tastes of two kinds of techniques nourish heart between spleen-invigorating granula effect and have significant difference (P<0.05).
3 conclusions
Seven tastes prepared by the 3.1 supercritical extractions spleen-invigorating granula that nourishes heart can significantly reduce mice autonomic activities, increases pentobarbital sodium sub-threshold dose and causes mice sleep number, extends pentobarbital sodium and causes mouse sleep time, display sedative-hypnotic effect.The oxygen deficit tolerance ability that hydrocortisone causes YIN-deficiency type mice can be significantly improved, extend the time-to-live.Mice swimming continuance time can be extended.
Seven tastes prepared by the 3.2 supercritical extractions spleen-invigorating granula high and low dose group that nourishes heart causes the preclinical impact of mice sleep to nourish heart compared with spleen-invigorating granula with causing the time effects of mice sleep and seven tastes of traditional extraction to pentobarbital sodium on pentobarbital sodium, has significant difference.Seven tastes prepared by the supercritical extraction spleen-invigorating granula low dose group that nourishes heart is extracted on the impact of mice swimming time and tradition seven tastes prepared and is nourished heart compared with spleen-invigorating granula, has significant difference.
Claims (2)
1. seven tastes nourish heart a preparation method for spleen-invigorating granula, it is characterized in that operating according to the following steps:
1) Semen Platycladi of the Herba Menthae of the Fructus Schisandrae Chinensis of 45 mass parts, 32 mass parts, the Cortex Cinnamomi of 35 mass parts and 25 mass parts mixed and pulverizes, crossing 24 mesh sieves and obtain coarse powder;
2) step 1) gained coarse powder is carried out supercritical carbon dioxide extraction and obtain total oil extract, medicinal residues are for subsequent use; The technological parameter of supercritical carbon dioxide extraction is: extraction time 90-100min, extraction temperature 40-50 DEG C, CO
2flow is 18-22L/h, and separating pressure is 5MPa, and separation temperature is 40 DEG C;
3) by step 2) total oil extract of obtaining and beta-schardinger dextrin-mix with the mass ratio of 1:10-12 and stir enclose and obtain clathrate, and enclose temperature is 65-75 DEG C, enclose time 1.5-2 hour;
4) by step 2) medicinal residues that obtain and the Radix Glycyrrhizae of 15 mass parts, the Radix Astragali of 15 mass parts and 12 mass parts Poria be mixed to get compound, add water by the solid-liquid ratio of 1g:20-40mL in described compound, supersound extraction 2-3 time under room temperature, each 30-50min, merge extractive liquid, concentrating under reduced pressure also obtains dry extract after vacuum drying;
5) dry extract step 4) obtained, starch and dextrin mix by the mass ratio of 1:2:1, using the alcoholic solution of 70-80vt% as wetting agent soft material, clathrate gained soft material and step 3) obtained compares mix homogeneously according to the quality of 50-60:1, cross 14 mesh sieves to granulate, after 16 mesh sieve granulate, be dried to constant weight in 60 DEG C, obtain seven tastes and to nourish heart spleen-invigorating granula.
2. preparation method according to claim 1, is characterized in that:
5) dry extract step 4) obtained, dextrin and Icing Sugar mix by the mass ratio of 1:2:1, using the alcoholic solution of 70-80vt% as wetting agent soft material, clathrate gained soft material and step 3) obtained compares mix homogeneously according to the quality of 50-60:1, cross 14 mesh sieves to granulate, after 16 mesh sieve granulate, be dried to constant weight in 60 DEG C, obtain seven tastes and to nourish heart spleen-invigorating granula.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410145740.4A CN103877231B (en) | 2014-04-11 | 2014-04-11 | A kind of seven tastes nourish heart the preparation method of spleen-invigorating granula |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410145740.4A CN103877231B (en) | 2014-04-11 | 2014-04-11 | A kind of seven tastes nourish heart the preparation method of spleen-invigorating granula |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103877231A CN103877231A (en) | 2014-06-25 |
| CN103877231B true CN103877231B (en) | 2015-11-18 |
Family
ID=50946567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410145740.4A Expired - Fee Related CN103877231B (en) | 2014-04-11 | 2014-04-11 | A kind of seven tastes nourish heart the preparation method of spleen-invigorating granula |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103877231B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115227755B (en) * | 2022-07-29 | 2023-10-13 | 重庆希尔安药业有限公司 | Industrial process of seven-ingredient heart-nourishing spleen-strengthening composition capsules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618113A (en) * | 2008-06-30 | 2010-01-06 | 广州白云山和记黄埔中药有限公司 | Traditional Chinese medicine and western medicine composition containing fine powder and preparation method thereof |
-
2014
- 2014-04-11 CN CN201410145740.4A patent/CN103877231B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101618113A (en) * | 2008-06-30 | 2010-01-06 | 广州白云山和记黄埔中药有限公司 | Traditional Chinese medicine and western medicine composition containing fine powder and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 薄荷_肉桂中挥发油提取及_环糊精包合工艺研究;卫强;《中兽医医药杂志》;20111231(第5期);第49-52页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103877231A (en) | 2014-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107569612B (en) | Medicine for improving sleep and preparation method thereof | |
| CN102600358B (en) | Traditional Chinese laxative medicine and product thereof | |
| CN102416071B (en) | Medicinal composition with effect of treating insomnia, preparation method and application of medicinal composition | |
| CN101690755B (en) | Antivirus extract and preparation method thereof | |
| CN103877231B (en) | A kind of seven tastes nourish heart the preparation method of spleen-invigorating granula | |
| CN100477984C (en) | Infant Kechuanling Chinese medicine prepn for treating dyspneic cough and its prepn | |
| CN102600312A (en) | Medicine composition with effect of preventing influenza | |
| CN105456818A (en) | Traditional Chinese medicine composition containing folium artemisiae argyi and being capable of treating insomnia and preparation method of traditional Chinese medicine composition | |
| CN102178792B (en) | Shiqi exogenous Chinese medicinal buccal tablets | |
| CN104435567A (en) | Traditional Chinese medicinal composition containing gynostemma pentaphyllum for treating gout | |
| CN103948896A (en) | Composition for resisting altitude stress and application of composition | |
| CN103432386B (en) | A kind of Chinese medicine preparation for the treatment of cough and preparation method thereof | |
| CN100998787B (en) | Traditional Chinese medicine effervescent tablets for treating gastrointestinal disease and its preparing method | |
| CN1660260A (en) | Effervescence grains of reducing fever and relieving a cough for infant and preparation method | |
| CN106581236A (en) | Medicinal composition for promoting gastric motility, and preparation method and application thereof | |
| CN103372071B (en) | A kind of pharmaceutical composition for the treatment of of insomnia patients | |
| CN101991722B (en) | Shiqi exogenous disease-treating traditional Chinese medicinal capsules | |
| CN105106547A (en) | Pharmaceutic preparation for treating neurasthenia | |
| CN107753628B (en) | Traditional Chinese medicine composition for treating insomnia and preparation method thereof | |
| CN100998776B (en) | Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method | |
| CN104435079A (en) | Traditional Chinese medicinal composition for treating gout | |
| CN104623352B (en) | A kind of pharmaceutical composition for improving sleep | |
| CN110101753A (en) | A kind of preparation method and purposes of compound ganoderma extractive composition | |
| CN101991721B (en) | Shiqi expathy traditional Chinese medicine sugar-free granule | |
| CN103393782A (en) | Traditional Chinese medicine composition with function of resolving stagnation for tranquilization, preparation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151118 Termination date: 20200411 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |