CN1038753C - The preparation method of Iron-Dextrin Complex - Google Patents
The preparation method of Iron-Dextrin Complex Download PDFInfo
- Publication number
- CN1038753C CN1038753C CN 88107217 CN88107217A CN1038753C CN 1038753 C CN1038753 C CN 1038753C CN 88107217 CN88107217 CN 88107217 CN 88107217 A CN88107217 A CN 88107217A CN 1038753 C CN1038753 C CN 1038753C
- Authority
- CN
- China
- Prior art keywords
- iron
- sample
- complexing
- dextran
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to and utilizing molecular weight is the method that 10000～15000 dextran prepares Iron-Dextrin Complex.After passing through alkalization, complexing, make with extra care, prepare and sterilizing.Make the medicine that obtains prevention, treatment piglet and livestock hypoferric anemia that iron level is 150mg/ml, the effect of tangible anti-anaemia and promotion growth is arranged through the pharmacological testing proof, be used for piglet, can make weight gain of piglets 10～25%, survival rate improves more than 7%, modest viscosity, and foreign matter content is few, the preparation method is simple, and production cost is low.
Description
The preparation method of the medicine Iron-Dextrin Complex of a kind of prophylactic treatment piglet and livestock hypoferric anemia.
As everyone knows, short rectangular of domestic animal.Iron-Dextrin Complex is effective especially to piglet.The too little iron at large because piglet one is born.The iron that obtains from breast milk can not satisfy the needs of growth, and iron deficiency can cause piglet weak and sickly, poor growth.Therefore both at home and abroad all nascent piglet is replenished the injection of irony, but at the Iron-Dextrin Complex that is used for livestock at present because molecular-weight average (100,000～200,000), and iron-holder is low, injection capacity is big, causes multiple injection and interference colony.Often there is bad color spot the injection site; Heavy metal content height in the product that has, toxicity is big.Adopting dextran (dextran) according to the introduction of U.S4180567 patent is raw material.Form through degraded, complexing, refining, preparation, packing, sterilization.But it is raw material that this method is utilized the dextran of special scintilla (molecular weight is 4000～6000).Thereby the production cost height, raw material is rare, and iron-holder is low, less than 100mg/ml.No. 1088829 patents of Britain have proposed to prepare the method for Iron-Dextrin Complex, but this method needs repeatedly complexing, fractionation precipitation, complex process.Though Britain produces the product of iron-holder up to 200mg/ml.But heavy metal content is higher, and the product costliness.Therefore, all urgent wish to prepare a kind ofly contain the concentration of iron height, viscosity is low, toxicity is little, production cost is low, effective product is to satisfy needs of society.
The present inventor is in order to overcome above-mentioned deficiency, through conscientiously research repeatedly, proposed molecular weight in 10000～15000 dextran through alkalization, complexing, refining, preparation and sterilize and just obtain Iron-Dextrin Complex proposed by the invention.
According to the present invention, said alkalization is exactly that the high-molecular weight dextran is degraded to 4000～6000 molecular weight, because molecular weight is too high or cross the low satisfied complex compound that all can not obtain.The present invention proposes under stirring state, add dextran in the reactor that distilled water is housed, its add-on is 0.5～0.8: 1 (by weight, down together) to be warmed up to 70～85 ℃, gelatinization, half an hour with the ratio of distilled water.Alkalization temperature is preferably 55～65 ℃, stirs 0.5～1 hour, drips basic solution again, as this class solution Na (OH), Na is arranged
2CO
3, KOH, NH
4(OH), K
2CO
3Deng solution, its working concentration is 30～40%, and its add-on is 0.5～0.7: 1 with the ratio of dextran, add alkali lye after, continue constant temperature half an hour, reduce to room temperature again.With the neutralization of the hydrochloric acid of 6N, making and obtaining pH is about 5 alkalization dextran liquid.
Said complexing is alkalization dextran liquid to be joined in the reactor carry out complexing with water-soluble molysite according to the present invention.As these molysite iron trichloride, ferric sulfate, iron nitrate, Iron triperchlorate, ferric trichloroacetate, iron acetate, ironic citrate, ferric ammonium citrate, ferric ammonium nitrate, iron glycerophosphate are arranged; Its add-on is 0.6～0.8: 1 with the ratio of iron and dextran.Because being form and the glucan with ironic hydroxide, ferric iron carries out complexing.The complex compound that forms is a non-ionic type, water-soluble formation colloidal solution.It or not true solution.Have only under suitable condition and could stablize.Therefore, the present inventor has proposed also to add 20% sodium hydroxide solution when alkalization dextran liquid adds iron salt solutions, and the pH in the complexing process is progressively improved.Finally be 7～8.With water-bath control complexing temperature, at 70～100 ℃, be preferably 70～90 ℃ simultaneously, the complexing time is 4～8 hours, is preferably 5～7 hours.Complexing is carried out under condition of stirring.After complexing finishes, be warming up to the water-bath boiling again, keep half an hour, in half an hour, reduce to again under 50 ℃, after the standing over night, just obtain complex liquid.
According to the present invention, said refining be meant the further impurity elimination of resultant complex liquid after the complex reaction, since complex reaction except that obtaining Iron-Dextrin Complex.Also has the precipitation of hydroxide of the small amounts of iron of unreacted intact dextran, molysite and generation.If do not remove, product toxicity is increased.The present inventor proposes.Complex liquid after leaving standstill is filtered, use the alcohol of 2～3 times of (volume) filtrates to carry out precipitate and separate then, refilter, and throw out is pressed dry, press dry thing and add in the beaker and add dissolved in distilled water again.Add the distillation water yield to former complex liquid capacity, treat dissolving fully after, repeat aforesaid operations more once, the gained throw out is Iron-Dextrin Complex proposed by the invention through drying under 65～80 ℃ of left and right sides temperature.
Said preparation and sterilization are meant that Iron-Dextrin Complex packs in the container after grinding according to the present invention, add a certain amount of phenol, salt and water for injection mixed solution.After dissolving fully at a certain temperature, being made into iron-holder is the Iron-Dextrin Complex injection liquid of 150mg/ml, packs after filtration, in 110～120 ℃ of (about 1kg/cm again
2Vapour pressure) under, steam sterilizing was product proposed by the invention in 30 minutes.
According to the prepared product that goes out of preparation method proposed by the invention have the iron-holder height, heavy metal content is few, viscosity is low, toxicity is little, product is stable, preparation cost is low.Be used for piggy injection, can increase the number of heads of livestock for sale more than 7% rate of body weight gain 10～25%.
Embodiment 1
Alkalization: in having the 500ml there-necked flask of agitator and heating in water bath, add distilled water 200ml, start agitator, add 125g dextran (molecular weight 10000～15000 is crossed 80 orders), be warmed up to 80 ℃, gelatinization 30 minutes, Dropwise 5 0ml, 40% sodium hydroxide solution then.After adding alkali lye, constant temperature alkalization 30 minutes promptly obtains dark-brown solution.Reduce the temperature to room temperature again, be neutralized to pH=4.0 with 6N hydrochloric acid, gained solution is alkalization dextran liquid.
Complexing: in the 2000ml there-necked flask, add alkalization dextran liquid, stir on the limit, and 75 ℃ of warming-in-water drip 40% liquor ferri trichloridi 873.8ml and 20% NaOH solution 807ml simultaneously and carry out complex reaction.After dropwising, transfer pH=7.5 with 20%NaOH solution again, be warming up to the water boiling then.Kept 30 minutes, and in half an hour, reaction solution was reduced under 50 ℃ standing over night again.
Refining: as, to use earlier the filter paper suction filtration with the complex liquid of standing over night.Use the sintered glass funnel suction filtration again No. 3, pour in the beaker after the filtrate metering, and make the liquid level mark; Use the alcohol of 2.5 times (volumes) to precipitate again, cloth filter.Be pressed on to such an extent that throw out is poured in the former beaker.Adding distil water dissolves throw out to former mark fully, repeats top process redeposition once, and the gained precipitation is purer Iron-Dextrin Complex through 70 ℃ of oven dry.
Preparation and sterilization: Iron-Dextrin Complex is through grinding, and in the bottle of packing into, the phenol water 357ml of adding 1% is after dissolving fully under 85 ℃ of temperature, and being made into iron-holder is the colloid dextran injection liquid of 150mg/ml.Refilter, packing was sample 1 in 30 minutes in 110～120 ℃ of following boiling sterilizations.
Embodiment 2
Preparation process and example 1 with, but bath temperature is 80 ℃ during complexing, 40% liquor ferri trichloridi of adding is 800ml, products obtained therefrom is a sample 2.
Embodiment 3
Preparation process and example 1 with, but bath temperature is 85 ℃ during complexing, 40% liquor ferri trichloridi of adding is 950ml, products obtained therefrom is a sample 3.
Embodiment 4
Other method and 1 is mixed with the preparation that iron-holder is 100mg/ml together, is sample 4.
With complexing iron, free iron, sodium-chlor and the foreign matter content in the chemical method analysed preparation, measure pH value and viscosity, it the results are shown in table 1, and contrasts with the numerous living company of Britain product " blood is how plain " and Canadian De Shilong product " richness is come blood iron pin ".(Table I is seen the literary composition back)
By Table I as can be seen, to have viscosity suitable for the product of preparing by method proposed by the invention.Meet features such as injection standard, lead, arsenic content are low, iron-holder height.
Application examples 1
The piglet of birth after 2～3 days, every at random nest piglet is divided into two groups.Promptly test for one group.One group of contrast, 1 one milliliters of every injected sample of test group.Control group is not injected.Each group is all measured its blood content of hemoglobin (g/dl) in test blood sampling in back 20 days.It is all heavy from breast time-division another name in when test and 45 ages in days that each organizes piglet.And add up its weightening finish and survival condition.It the results are shown in Table II and Table III.(Table II is seen the literary composition back)
Can find out that from Table II injection product proposed by the invention compares control group, oxyphorase increases by 77.47%.(Table III, IV see the literary composition back)
From Table III and Table IV as can be known, injected sample 1 back comparison increases weight 18.7% respectively according to group, and survival rate improves 6.76%.
Comparative example
Experimental technique is identical with detection means and application examples.Produce " richness is come blood iron pin " with Canada and compare, it the results are shown in Table V, Table VI.(Table V is seen the literary composition back)
Sample 1 comes the oxyphorase of blood, sample 4 to improve 5.73% and 2.85% respectively than richness as can be seen from the above table, and sample 4 comes blood to improve 7.45% than richness.(Table VI is seen the literary composition back)
From Table VI as can be seen.After the injected sample 1, the weightening finish of piglet comes blood to improve 7.72% and 3.65% than sample 4, richness respectively, and sample 4 comes blood to improve 3.09% than richness.(Table VII is seen the literary composition back)
As can be seen, after the injected sample 1, the piglet survival rate comes blood to improve 3.17% and 1.91% than injected sample 4, richness respectively from Table VII, and sample 4 comes blood to improve 1.07% than richness.
Pharmacological research
1) provide protection of mouse hemolytic anemia
It is 30 of Kunming hybrid mouse that many elements of the blood of selecting for use sample 1 and the numerous living company of Britain (FISONS) to produce and physiological saline contrast the fortune thing, and body weight 20～25g evenly is divided into three groups.The iHqd of dosage shown in the according to the form below * 4, iH0.3ml after the last administration, 0.5% phenylhydrazine hydrochloride solution.1 time totally 2 times every other day, after, the administration preceding, poisoned back 4 days and 8 days respectively at poisoning.Measure mouse RBC and Hb, it the results are shown in following table: (table is seen the literary composition back)
2) to the influence of mouse body weight
Get 32 of mouse, body weight 15～18g, male and female half and half evenly are divided into three groups, 12 of salt solution groups, all the other every group 10, administration is 2 times altogether.Experimental session was weighed once in per three days, and it the results are shown in following table: (table is seen the literary composition back)
3) to the influence of Mouse Liver, spleen
Get 1 poisoned 8 days after mouse spleen weigh, fix, conventional film-making, liver is film-making by the same method also, it the results are shown in following table: (table is seen the literary composition back)
Show that from above-mentioned test-results sample 1 can increase normal mouse RBC, the RBC minimizing that phenylhydrazine hydrochloride is caused also has tangible antagonistic action, and mouse is had tangible anti-anaemia and promotes the growth effect.Compare no significant difference with Britain many elements of blood.
With small white mouse vein intramuscular injection sample 1,2,3, adopt the Horn method to measure the LD50 size 2400mg/kg body weight of small white mouse, with the acute toxicity classification, the nontoxic level in true border.
Table V is injected different iron preparation piglet blood content of hemoglobin tables
| Title | Iron level (mg/ml) | Injection volume (ml) | The test fate (my god) | Nest number (nest) | Total number (head) | A group number (head) | Oxyphorase (g/dl) | Contrast (%) | ||
| Total content | Average content | Increase and decrease | ||||||||
| Sample 1 | ??150 | ??1 | ??20 | ??8 | ??81 | ??40 | ??374.00 | ??8.66 | ??+0.24 | ??102.85 |
| Sample 4 | ??100 | ??1 | ??20 | ??41 | ??345.10 | ??8.42 | ??0 | ??100 | ||
| Sample 1 | ??150 | ??1 | ??20 | ??7 | ??63 | ??33 | ??316.88 | ??9.60 | ??0.52 | ??105.73 |
| Richness is come blood | ??100 | ??1 | ??20 | ??30 | ??272.34 | ??9.08 | ??0 | ??100 | ||
| Sample 4 | ??100 | ??1 | ??35 | ??8 | ??71 | ??35 | ??318.36 | ??9.09 | ??0.63 | ??107.45 |
| Richness is come blood | ??100 | ??1 | ??36 | ??36 | ??304.64 | ??8.46 | ??0 | ??100 | ||
Table VI is injected different iron preparation weight gain of piglets tables
| Title | Iron level (mg/ml) | Injection volume (ml) | Nest number (nest) | Total number (head) | A group number (head) | Body weight (kg) before the medicine | From newborn body weight (kg) | Total augment weight (kg) | Average weight gain (kg) | Increase and decrease (kg) | Contrast (%) |
| Sample 1 | ????150 | ??1 | ??15 | ??128 | ????65 | 89.40 | ?760.20 | ?670.20 | ?10.32 | ?+0.70 | 107.70 |
| Sample 4 | ????100 | ??1 | ????63 | 85.80 | ?689.55 | ?603.75 | ?9.58 | ?0 | 100 | ||
| Sample 1 | ????150 | ??1 | ??12 | ??110 | ????56 | 107.03 | ?727.00 | ?619.97 | ?11.07 | ?0.39 | 103.65 |
| Richness is come blood | ????100 | ??1 | ????54 | 99.4 | ?676.00 | ?576.00 | ?10.68 | ?0 | 100 | ||
| Sample 4 | ????100 | ??1 | ??20 | ??189 | ????95 | 151.36 | ?1324.75 | ?1173.39 | ?12.35 | ?0.37 | 103.09 |
| Richness is come blood | ????100 | ??1 | ????94 | 147.65 | ?1273.75 | ?1126.10 | ?11.98 | ?0 | 100 |
Table VII is injected different iron preparation piglet survival tables
| Title | Iron level (mg/ml) | Injection volume (ml) | The test fate (my god) | Nest number (nest) | Total number (head) | Medicine front number (head) | Survival number (head) | Survival rate (%) | Increase and decrease (%) | Contrast (%) |
| Sample 1 | ????150 | ??1 | ???45 | ???15 | ???146 | ????73 | ????65 | ????89.04 | +2.74 | ?103.17 |
| Sample 4 | ????100 | ??1 | ???45 | ????73 | ????63 | ????86.30 | 0 | ?100 | ||
| Sample 1 | ????150 | ??1 | ???45 | ???12 | ???115 | ????58 | ????56 | ????96.55 | +1.81 | ?101.91 |
| Richness is come blood | ????100 | ??1 | ???45 | ????57 | ????54 | ????94.74 | 0 | ?100 | ||
| Sample 4 | ????100 | ??1 | ???45 | ???20 | ???190 | ????95 | ????95 | ????100 | +1.06 | ?101.07 |
| Richness is come blood | ????100 | ??1 | ???45 | ????95 | ????94 | ????98.94 | 0 | ?100 |
Table I
| Sample | Complexing iron (mg/ml) | Free iron (mg/ml) | ??NaCl ?(mg/ml) | Viscosity (μ pool) | ????pH | Foreign matter content | |||
| ????Pb ???(PPM) | ?????As ????(PPM) | ?????Cd ????(PPM) | ??Cu ?(PPM) | ||||||
| Sample 1 | ??160.2 | ??2.04 | ??5.93 | ???30 | ????5.5 | ???≤1.2 | Do not detect | ????＜0.2 | ???34 |
| Sample 2 | ??155.1 | ??2.4 | ??11.74 | ???20 | ????5.6 | ???≤1.8 | Do not detect | ????＜0.2 | ???33 |
| Sample 3 | ??203.7 | ??4.72 | ??7.85 | ???25 | ????5.6 | ???≤1.6 | Do not detect | ????＜0.2 | ???34 |
| How plain blood is | ??188.3 | ??3.95 | ??28.48 | ???30 | ????6.0 | ?????2.2 | ????6 | ????0.66 | ???80 |
| Richness is come blood iron pin | ??93.74 | ??5.17 | ??19.48 | ???10 | ????6.4 | ||||
Table II piggy injection sample I blood content of hemoglobin table
| Group | Dosage (ml) | The test fate | Nest number (head) | Total number (head) | A group number (head) | Oxyphorase (g/dl) | Contrast % | ||
| Total content | Average content | Increase and decrease | |||||||
| Sample 1 | ????1 | ???20 | ???12 | ???94 | ????47 | ??448.12 | ???9.53 | ??+4.16 | 177.47 |
| Control group | ????0 | ???20 | ???12 | ????47 | ??252.67 | ???5.37 | ????0 | ??100 | |
Table III piggy injection sample 1 weightening finish information slip
| Group | Dosage (ml) | The test fate (my god) | Nest number (nest) | Total number (head) | Every group of number (head) | Body weight (kg) before the medicine | From newborn body weight (kg) | Total augment weight (kg) | Average weight gain (kg) | Increase and decrease (kg) | Contrast (%) |
| Sample 1 | ???1 | ???45 | ??18 | ??142 | ???77 | ???118.18 | ???794.60 | ??676.42 | ??8.78 | ±1.35 | ?118.7 |
| Control group | ???0 | ???45 | ???65 | ???109.66 | ???592.75 | ??483.09 | ??7.43 | ???0 | ?100 |
Table IV injected sample I piglet survival table
| Group | Dosage (ml) | The test fate (my god) | Nest number (nest) | Total number (head) | Medicine front number (head) | A survival number (head) | Survival rate (%) | Increase and decrease (%) | Contrast (%) |
| Sample 1 | ???1 | ???45 | ???18 | ???154 | ???81 | ???77 | ???95.06 | ????+6.02 | ??106.76 |
| Control group | ???0 | ???45 | ???73 | ???65 | ???89.04 | ??????0 | ???100 |
| Medicine | Dosage (ml/ mouse) | RBC (x+SD ten thousand/mm 3) | |||
| Before the administration | Administration 4 days | Poisoned 4 days | Poisoned 8 days | ||
| 50% sample 1 | ????0.1 | ??528±45 | ??????*?* ????701±132 | ????410±56 | ????575±114 |
| How plain 50% blood is | ????0.1 | ??520±57 | ??????*??* ????680±109 | ????431±43 | ????501±81 |
| Salt solution | ????0.1 | ??602±99 | ????525±98 | ????381±50 | ????422±69 |
| Medicine | Dosage (ml/ mouse) | ??????????????????????Hb(x±SD.g/100ml) | |||
| Before the administration | Administration 4 days | Poisoned 4 days | Poisoned 8 days | ||
| The same table | ????0.1 | 11.5±1.0 | ????12.8±0.9 | ????11.0±0.7 | ????11.6±0.6 |
| ????0.1 | 11.2±1.2 | ????12.6±1.1 | ????10.9±0.6 | ????10.9±1.0 | |
| ????0.1 | 11.4±1.1 | ????11.5±1.7 | ????10.8±0.6 | ????10.2±0.5 | |
| Medicine | Dosage (ml/ mouse) | Before the administration (x ± SD.g) | After the administration (x ± SD.g) | ||||||
| 3 days | 6 days | 9 days | |||||||
| Salt solution | ??0.05 | ????16.3±1.0 | ????16.9±1.5 | ????16.9±1.8 | ????18.0±1.4 | ||||
| Sample 1 | ??0.05 | ????16.9±1.0 | ????17.0±1.3 | ????17.2±1.5 | ????20.0±1.6 | ||||
| How plain blood is | ??0.05 | ????16.2±1.5 | ????16.8±1.9 | ????18.0±2.1 | ????20.6±2.1 | ||||
| Medicine | Dosage (ml/ mouse) | Before the administration (x ± SD.g) | After the administration (x ± SD.g) | ||||||
| 12 days | 15 days | 18 days | 21 days | ||||||
| Salt solution | ??0.05 | ????16.3±1.0 | 20.8±2.0 | ??23.7±2.5 | ??25.8±2.6 | ??29.8±3.1 | |||
| Sample 1 | ??0.05 | ????16.9±1.0 | 23.7±1.8 | ??25.7±2.0 | ??27?7±1.0 | ??30.8±3.2 | |||
| How plain blood is | ??0.05 | ????16.2±1.5 | 22.8±2.3 | ??24.7±2.6 | ??26.8±2.9 | ??29.3±1.7 | |||
| Medicine | Dosage (ml/ mouse) | The spleen weight (mg/20 gram mouse x ± SD) |
| Salt solution | ?????0.1 | ?????????281±55 |
| 50% sample 1 | ?????0.1 | ?????????408±64** |
| How plain 50% blood is | ?????0.1 | ?????????571±257 |
Claims (2)
1. a method for preparing Iron-Dextrin Complex comprises alkalization, complexing, makes with extra care, prepares and sterilization, and wherein 55-65 ℃ of alkalization 0.5-1 hour, the alkaline concentration of adding was 30-40%, and alkaline solution is 0.5-0.7 with the ratio of dextran: 1, neutralize with hydrochloric acid then; The complexing temperature is 5-7 hour 70-100 ℃ of complexing time.
It is characterized in that the final pH value that alkalizes is 4.0; In conjunction with the time add molysite and NaOH solution simultaneously, and complexing final pH value is 7～8, iron is 0.6-0.8 with the ratio of dextran: 1;
2. according to the method for claim 1, it is characterized in that refining is alcohol with 2-3 times of complex liquid, carries out precipitate and separate, after the filtration throw out is depressed, and adds distilled water to the complex liquid consumption, and dissolving separates with 2-3 times of alcohol precipitation again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88107217 CN1038753C (en) | 1988-10-14 | 1988-10-14 | The preparation method of Iron-Dextrin Complex |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88107217 CN1038753C (en) | 1988-10-14 | 1988-10-14 | The preparation method of Iron-Dextrin Complex |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| CN1041762A CN1041762A (en) | 1990-05-02 |
| CN1026182C CN1026182C (en) | 1994-10-12 |
| CN1038753C true CN1038753C (en) | 1998-06-17 |
Family
ID=4834567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88107217 Expired - Lifetime CN1038753C (en) | 1988-10-14 | 1988-10-14 | The preparation method of Iron-Dextrin Complex |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1038753C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043303C (en) * | 1993-11-23 | 1999-05-12 | 广西南宁市桃源兽药厂 | Ferric selenium injection for animal |
| CN1059321C (en) * | 1994-06-28 | 2000-12-13 | 张晓频 | Iron, cobalt, selenophene, copper, arsenic injection |
| CN101215338B (en) * | 2007-01-05 | 2010-09-15 | 庄茅 | Iron isomaltum oligosaccharide and preparing method thereof |
| CN101967205B (en) * | 2010-10-12 | 2013-04-17 | 滨州学院 | Beta-dextriferron composite and preparation method thereof |
| CN103044571A (en) * | 2011-10-13 | 2013-04-17 | 天津中敖生物科技有限公司 | Iron dextran bulk drug and preparation method thereof |
| CN104829745B (en) * | 2015-04-29 | 2017-03-08 | 江西华太药业有限公司 | A kind of iron-dextrin and preparation method thereof |
| CN105708805A (en) * | 2016-01-28 | 2016-06-29 | 山西普德药业股份有限公司 | Reduced carboxy alkyl dextriferron and preparation method thereof |
| CN105708792A (en) * | 2016-01-28 | 2016-06-29 | 山西普德药业股份有限公司 | Reduced carboxy alkyl dextriferron injection and preparation method thereof |
| CN105616372A (en) * | 2016-01-28 | 2016-06-01 | 山西普德药业股份有限公司 | Reduced-type carboxyl alkyl dextriferron tablet |
-
1988
- 1988-10-14 CN CN 88107217 patent/CN1038753C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1041762A (en) | 1990-05-02 |
| CN1026182C (en) | 1994-10-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE4239442C2 (en) | Use of an adsorbent material modified with polynuclear metal oxide hydroxides for the selective elimination of inorganic phosphate from protein-containing liquids | |
| JP3665345B2 (en) | Adsorbents for phosphates from aqueous media, their manufacture and use | |
| CN1038753C (en) | The preparation method of Iron-Dextrin Complex | |
| CN110105460B (en) | Selenylation carboxymethyl pachyman and preparation method and application thereof | |
| CN1147322C (en) | Iron-dextran compound for use as component in therapeutical composition for prophylaxis or treatment of iron-deficiency, process for producing said iron-dextran compound and use of said compound for p | |
| CN101671373A (en) | Preparation method for iron sucrose bulk drug and injection thereof | |
| JP4520748B2 (en) | Iron dextrin compounds for the treatment of iron deficiency anemia | |
| CN101215338B (en) | Iron isomaltum oligosaccharide and preparing method thereof | |
| CN1287687C (en) | Lead-removing health care food and preparation method thereof | |
| CN1122212A (en) | Peanut skin and jujube tea and its producing method | |
| CN1039571C (en) | Calcium L-threonate for food additives and preparing process and use thereof | |
| CN1087610C (en) | Lentinus edodes polysaccharide injecta and its preparation | |
| CN112552422B (en) | Preparation method and application of maca polysaccharide-zinc (II) complex | |
| CN110183548A (en) | A kind of preparation method and applications of low molecular weight dextran iron | |
| RU2374430C2 (en) | Aloe base deposit formation inhibitor | |
| CN1397567A (en) | Spiruline polyose, its extraction process and it medical application in increasing white cells and treating cancer | |
| CN1043303C (en) | Ferric selenium injection for animal | |
| CN112300299A (en) | Preparation method and application of zinc and calcium polysaccharide complex | |
| CN110628557A (en) | Compound wine containing small molecular okra peptide and production method thereof | |
| CN106631848B (en) | It is a kind of using bay scallop shell as the L-Lysine Ca of Chelate preparation method of calcium source | |
| CN1830426A (en) | New houttuynine sodium bisulfite injection and its preparation method and use | |
| CN1059321C (en) | Iron, cobalt, selenophene, copper, arsenic injection | |
| CN1572802A (en) | Chinese yam polysaccharide and ferrum compound and preparation process | |
| CN101940552B (en) | Chinese medicament shikimic acid powder injection | |
| JPH05310802A (en) | Polysaccharide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C26 | Partial revocation of patent right or utility model | ||
| RP01 | Partial revocation of patent right | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
| OR01 | Other related matters | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |