CN1059321C - Iron, cobalt, selenophene, copper, arsenic injection - Google Patents
Iron, cobalt, selenophene, copper, arsenic injection Download PDFInfo
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- CN1059321C CN1059321C CN94107777A CN94107777A CN1059321C CN 1059321 C CN1059321 C CN 1059321C CN 94107777 A CN94107777 A CN 94107777A CN 94107777 A CN94107777 A CN 94107777A CN 1059321 C CN1059321 C CN 1059321C
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Abstract
The present invention relates to an injection and a growth-promoting agent for controlling various diseases caused by lack of iron, selenium, cobalt, copper and arsenic of piglets, livestock and fowl, which overcomes the defects of single utility and tiny effects of past products, and can simultaneously meet requirements for iron, cobalt, selenium, copper and arsenic of livestock and fowl, especially piglets. The injection with stable performance is prepared through the processes of degradation, complexing, refining, preparation and high-temperature sterilization; each milliliter of injection contains 150 mg (+/-) 5 mg of complex iron, 1 mg (+/-) 0.5 mg of complex cobalt, 1 mg (+/-) 0.2 mg of selenium compounds, 2 mg (+/-) 0.5 mg of complex copper and 50 (+/-) 10 mg/ml of organic arsenic.
Description
The invention relates to control piglet and fowl poultry because of iron deficiency, lack selenium, lack cobalt, lack copper, lack the injection and the short long agent of the various diseases that arsenic causes.
The present invention is the development of No. 92114411.3 patent applications.
As everyone knows, because the influence of environment and the restriction of physiological condition, domestic animal, poultry all can produce various because of lacking the caused condition of illness of some trace element, can cause as the piglet iron deficiency and draw Hakuri, dysplasia, severe patient even death; Scarce selenium can cause white muscle disease; Horse lacks selenium can cause the disease of sitting; Lamb lacks selenium can cause diarrhoea, draws dysentery; Cattle, sheep lack cobalt and can cause " dry-sickness ", loss of appetite, and reproductivity descends or the like.And the scarce copper of animal can cause anemia, osteoporosis, gastrointestinal function disorder etc.; Scarce arsenic can cause malnutrition, and premunition is not strong or the like.In the past, people adopt the chemical compound that adds ferrum, cobalt, selenium, copper, arsenic in feedstuff in order to solve the problem of poultry iron deficiency, cobalt, selenium, copper, arsenic, but there is significantly deficiency in this method, the one, the chemical compound poultry that add absorb not exclusively, thereby poor effect; The 2nd, this method is not suitable for young stock, and the piglet that resembles firm birth only absorbs nutrition from breast milk, thereby can't be replenished from feedstuff.For trace element supplement, people have adopted the method for intramuscular injection, and as injection iron supplement injection in the piglet birth three days, injection contains the selenium injection, the arsenic compound of feeding after the wean in seven days.But there is significant disadvantages in this method: multiple injection, can produce repeatedly stress, and delay animal growth.Therefore, press for the injection of a kind of iron supplement simultaneously, benefit cobalt, selenium supplement, benefit copper, benefit arsenic.But, replenish these trace element simultaneously, must understand that can these elements be absorbed by the fowl poultry, whether element can produce antagonism each other, add how many amounts and could not cause injury the fowl poultry, these elements under what process conditions, the mutual uniform mixing of meeting, do not produce precipitation, reach poultry and use the use standard.
The present inventor has prepared a kind of easily the poultry by fowl and has absorbed through research in earnest repeatedly, adopts the optimum content that does not produce antagonism, and it is long to help the fowl dirty swine, and mix homogeneously does not produce precipitation, meets " iron, cobalt, selenophene, copper, arsenic injection " that poultry is used the use standard.
92114411.3 number patent application has been proposed the preparation method of ferrum cobalt selenium injection by the present inventor, but an injection iron content, cobalt, selenium with this method preparation, poultry supplementation with copper and arsenic can not be given simultaneously, thereby the needs of poultry can not be satisfied ferrum, cobalt, selenium, copper, arsenic.
The present inventor is through research in earnest repeatedly, a kind of preparation method of iron, cobalt, selenophene, copper, arsenic injection has been proposed, promptly high-molecular weight dextran being degraded to molecular weight after through alkalization is 4000～6000 low-molecular-weight dextran, then with contain cobalt, cupric, ferruginous chemical compound complexation, refining, in process for preparation, add and contain selenium and arsenical chemical compound, fully behind the mix homogeneously, sterilization just obtains poultry proposed by the invention and uses iron, cobalt, selenophene, copper, arsenic injection again.
Said iron containing compounds is meant iron sulfate, ferric nitrate, ferric perchlorate, ferric chloride, ferric citrate calcium, iron acetate according to the present invention, the weight ratio of its addition and dextran is 0.5～0.7: 1, and said cobalt compound is meant cobaltous chloride, cobaltous sulfate and pin acid cobalt.Said copper-containing compound is meant copper sulfate, curpic carbonate, copper chloride, Schweinfurt green.Because these chemical compounds are soluble in water, and cobalt, ferrum, copper have similar outer electronic structure and physicochemical characteristics, so easily and the dextran complexation, forms corresponding complex, easily absorbed by poultry.In the present invention, the weight ratio of the amount of the cobalt compound of adding and dextran is 0.8～1: 10; The amount of the copper compound that adds and the weight ratio of dextran are 0.6～0.8: 12.Said selenium compound is meant sodium selenite, sodium selenate, selenic chloride and fulvic acid selenium according to the present invention, and the weight ratio of its addition and injection proposed by the invention is 0.8～1: 1000.According to the present invention, said arsenic compound is meant arsanilic acid, 3-nitro-4-hydroxy benzenes arsenic acid, Arsanilic acid sodium salt., 3-nitro-4-hydroxy benzenes natrium arsenicum.Its addition is 40～60 mcg/ml of injection proposed by the invention.
According to alkalization proposed by the invention, it is the dextran that macromolecular dextran is degraded into 4000～6000 molecular weight through alkalization, be that macromolecular dextran is joined in the distilled water, its addition is 0.6～0.8: 1 with the ratio of distilled water, be warmed up to 60～80 ℃, be preferably 65～75 ℃, stir, slowly add concentration again and be 20～30% NaOH solution, the weight ratio of its addition and dextran is 6.6～0.8: 1, added behind the alkali liquor constant temperature 0.5～1 hour again, and reduced to room temperature again, just obtaining pH value with the hydrochloric acid neutralization is about 4 alkaline solution.
According to complexation proposed by the invention, be to join the solution of iron content, cobalt, copper in the alkaline solution respectively, the concentration of cobalt-carrying solution is 35～50%, be preferably 40～45%, under stirring state, slowly join in the alkaline solution, the control temperature adds concentration and is 40～45% copper solution again at 80～110 ℃ after adding.The complexation of copper excessive concentration is incomplete, causes waste, causes the antagonism between the element; Cross low to not reaching the preparation requirement.Add the copper solution method and to add cobalt liquor the same.After adding, adding concentration again is 45～60%, is preferably 50～60% ferrous solution, slowly add, stir while dripping, the control temperature is preferably 90～95 ℃ at 80～110 ℃, add 25% NaOH solution simultaneously, the pH value of solution in the complexation process is raise gradually, reach 7～9.5, dropwise back constant temperature at 100 ℃, continue reaction 30 minutes, just obtain the said complex liquid of the present invention.
What propose according to the present invention is refining, is meant complex liquid is carried out purification, removes wherein impurity and unreacted reactant.Because except the complex that generates ferrum, cobalt, copper, the small amount of impurities that also has a small amount of unreacted dextran, iron salt, mantoquita, cobalt salt and brought by raw material if do not remove, can make the quality of product reduce in complex reaction.The present inventor proposes, with the complex liquid isolated by filtration after leaving standstill, under stirring state, 95% the ethanol that adds the filtrate triplication is in filtrate, stirred 10 minutes, left standstill again 30 minutes, isolated by filtration adds distilled water again in filter cake, adds distilled water to former complexation liquid measure, after filter cake dissolves fully, stirred 30 minutes, and slowly added simultaneously 95% ethanol of the long-pending amount of triploid, precipitation separation, the gained precipitate is dried under 65～80 ℃ of left and right sides temperature, is the mixed complex of iron dextran proposed by the invention, DEXTRAN COBALT COMPLEX, DEXTRAN COPPER COMPLEX.
The preparation that proposes according to the present invention is after pulverizing through purified dry complex, adds a certain amount of distilled water and selenium compound, arsenic compound again, perhaps adds the solution of respective compound.Add phenol again, be mixed with that to contain complexation ferrum amount be 150～200mg/ml, containing the complex cobalt amount is 0.5～1.2mg/ml, containing the complex copper amount is 2～2.5mg/ml, and selenium-containing compound is 1～1.5mg/ml, and arsenical is the iron, cobalt, selenophene, copper arsenic solution of 40～60 mcg/ml, again after filtration, encapsulation 110～120 ℃ of following steam sterilizations 30 minutes, just obtains iron, cobalt, selenophene, copper, arsenic injection proposed by the invention.
The prepared product that goes out of the preparation method that proposes according to the present invention, contain the concentration of iron height, mix homogeneously, do not produce precipitation, be easy to the fowl poultry and absorb, viscosity is low, and toxic and side effects is little, satisfied the fowl poultry simultaneously, particularly the young stock growth is to ferrum, cobalt, selenium, copper, the needs of arsenic have improved resistance against diseases and the survival rate of fowl poultry, have alleviated people and have been control fowl poultry iron deficiency, selenium, cobalt, copper, the labor intensity of arsenic disease, reduced the control cost, reduce the young stock stress, especially can significantly promote growth in piglets to grow, improved survival rate, reach more than 96%, more favourable to the growth behind the weaned piglet, general than the piglet of not injecting this product, when piglet goes out nest, weightening finish improves 2～3 kilograms, and is healthy active.And every piglet of expenses for medicine cost has only 0.3 yuan.
Embodiment 1
Alkalization: in the there-necked flask of the 1000ml that has agitator and water-soluble heating, add distilled water 300ml, start agitator, slowly add dextran (molecular weight is 10000～15000, crosses 80 orders) 200g, be warmed up to 75 ℃, stirred 30 minutes, and dripped 20% sodium hydroxide solution 80ml then, be cooled to room temperature after dripping off again, hydrochloric acid with 6mol/L is neutralized to pH=4.0, just obtains alkaline solution.
Complexation: in the there-necked flask of 2000ml, add alkaline solution, stir on the limit, be warmed up to 93 ℃, the cobalt chloride solution 5ml of adding 40% adds 20%NaOH solution 10ml simultaneously, adds 40% copper-bath 10ml then, add 20% NaoH20ml simultaneously, drip 40% liquor ferri trichloridi 120ml and 20% NaOH solution 110ml then simultaneously, constant temperature half an hour again after dropwising, add 20% NaoH solution again, transfer pH value of solution=8.0, be warming up to the water boiling then, kept 30 minutes, reduce to room temperature again, left standstill 20 hours, and just obtained complex liquid.
Refining: with the complex liquid of standing over night, use earlier the filter paper sucking filtration, No. two sintered glass filters of reuse filter, filtrate metering back example is gone in the beaker and is made the liquid level labelling, filtrate is joined in the beaker, 95% the ethanol that adds the long-pending amount of triploid again precipitates, precipitation separation, press dry through squeezer, put in the former beaker, adding distil water is to former labelled amount again, and the process redeposition once above repeating, the gained precipitation is the mixed complex of iron dextran, DEXTRAN COBALT COMPLEX, DEXTRAN COPPER COMPLEX through 70 ℃ of oven dry.
Preparation and sterilization: measure the amount that contains iron dextran, DEXTRAN COBALT COMPLEX and glucosan acid anhydride copper in the mixed complex, add a certain amount of content and be sodium selenite, the arsanilic acid more than 98%, phenol, water for injection more than 97% and be mixed with that to contain complexation ferrum be that 150mg/ml, sodium selenite are that 1mg/ml, complex cobalt 0.5mg/ml, complex copper are that 2mg/ml, arsanilic acid are the iron, cobalt, selenophene, copper, arsenic injection of 50 micrograms/ml.After filtration, sterilizing 30 minutes down in 110～120 ℃ in the encapsulation back, just is sample 1.
Embodiment 2
Preparation process and example 1 with, but the complexation temperature is 90 ℃, 40% cobalt chloride solution of adding is 8ml, 40% copper-bath is 15ml, 45% liquor ferri trichloridi is 120ml, adds Arsanilic acid sodium salt. and selenic chloride during preparation.Products obtained therefrom sample 2.
Embodiment 3
Preparation process and example 1 are same, but the water solution temperature of complexation is 105 ℃, and the concentration of the ferric chloride of adding is 50%, and products obtained therefrom is a sample 3.
With complexation ferrum, complex cobalt, complex copper, selenium compound, arsenic compound and impurity content, pH value and the viscosity in the chemical analysis method mensuration product.
Application examples 1
Test with sample 1, injection is one milliliter in piglet birth three days, adopts brood random packet, compares with blank, weighs in three ages in days, and 45 ages in days are checked and accepted, and it the results are shown in table 1.
Table 1 sample 1 result of the test list position: kilogram
| Group | Number | Age in days | Compare % with matched group | |||||
| 3 | 10 | 20 | 30 | 50 | 60 | |||
| Sample | 54 | 1.57 | 2.81 | 4.45 | 6.65 | 13.12 | 17.4 | +11.53 |
| Blank | 54 | 1.48 | 2.67 | 4.25 | 5.85 | 11.83 | 15.6 | 0 |
Through variance analysis (F＜0.01), it is extremely remarkable that difference reaches, and as can be seen from Table 1, along with the time is long more, difference is more remarkable, and the later stage of 1 pair of piglet of interpret sample grows favourable.
Compare with blank, test with sample 1, inject a ml sample 1 to test group when three ages in days, respectively at 10,20,30,40,50,60 ages in days, measure hematochrome content, get their meansigma methods, it the results are shown in table 2.
Table 2 sample 1 hematochrome relatively
| Group | Number | Hematochrome content during three ages in days | Record meansigma methods six times | Variance analysis |
| Sample 1 | 6 | 5.68g±0.19 | 7.24g±0.35 | F＜0.01 |
| Blank | 6 | 5.9g±0.36 | 6.68g±0.26 |
Can find out from table 2, through the piglet of injected sample 1 and injection not to compare hematochrome content difference heteropole remarkable.
Application examples 2
Test with sample 2, injection is one milliliter in piglet birth three days, adopts random packet in every nest, and half is tested, and half compares, and matched group is not injected, and other management condition is identical, the results are shown in table 3
Table 3 sample 2 result of the tests
| Group | Number | Body weight (kilogram) | Rate of body weight gain % | Survival rate % | Hematochrome content (mg/100ml) | ||||
| Nascent | 20 ages in days | 45 ages in days | Nascent | 20 ages in days | Variance analysis | ||||
| Sample 2 | 80 | 1.12 | 4.92 | 16.30 | 128.6 | 96.3 | 8.53 | 9.72 | F＜0.01 |
| Contrast | 128 | 1.08 | 4.04 | 12.67 | 100 | 87.5 | 8.55 | 5.68 | Difference is extremely remarkable |
Application examples 3
Test with sample 3, compare on 64 piglets of 7 nests with " ferrum selenium injection " and " iron dextran " and blank and carry out, inject one milliliter in the Yu Sanri respectively, it the results are shown in table 4.
Table 4 sample 3 result of the tests
| Group | Weightening finish (kilogram) | / 100 milliliters of hematochrome content grams | Survival rate % | |
| Starting weight | Daily gain | |||
| Sample 3 | 1.75 | 0.2006 | 9.25±0.5978 | 100 |
| Ferrum selenium injection | 1.72 | 0.1797 | 9.1375±0.4882 | 93.75 |
| Iron dextran | 1.63 | 0.1564 | 8.50±0.4082 | 81.25 |
| Blank | 1.67 | 0.1399 | 8.00±0.3333 | 81.25 |
Through variance analysis, aspect weightening finish, sample 3 and iron dextran compare with blank that to reach F＜0.01 extremely remarkable, compare with ferrum selenium injection to reach significantly, obviously are better than other on survival rate, also obviously are better than other on hematochrome content.
Claims (3)
1, a breeding stock iron, cobalt, selenophene, copper, arsenic injection, it is characterized in that: high molecular dextran is degraded into low molecular dextran, carry out complexation with ferrum, cobalt, copper then, refining complex adds selenium compound, organoarsenium compound again, is mixed with every milliliter and contains complexation ferrum 150～200mg, complex cobalt 0.5～1.2mg, complex copper 2～2.5mg, selenium compound 1～1.5mg, the injection of arsenic compound 40～60 micrograms.
2, the preparation method of iron, cobalt, selenophene, copper, arsenic injection according to claim 1, it is characterized in that: high molecular dextran is degraded into low molecular dextran, carry out complexation with ferrum, cobalt, copper then, refining complex, complexation is to carry out under 80～110 ℃ of temperature, adds cobalt liquor, copper solution and ferrous solution respectively, and stir on the limit, add NaOH solution simultaneously, transfer pH value to 7～9.5.
3, preparation method according to claim 2 is characterized in that: the cobalt liquor concentration that adds during complexation is 35～50%, and copper solution concentration is 40～45%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94107777A CN1059321C (en) | 1994-06-28 | 1994-06-28 | Iron, cobalt, selenophene, copper, arsenic injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94107777A CN1059321C (en) | 1994-06-28 | 1994-06-28 | Iron, cobalt, selenophene, copper, arsenic injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1104090A CN1104090A (en) | 1995-06-28 |
| CN1059321C true CN1059321C (en) | 2000-12-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94107777A Expired - Fee Related CN1059321C (en) | 1994-06-28 | 1994-06-28 | Iron, cobalt, selenophene, copper, arsenic injection |
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| CN (1) | CN1059321C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258535B (en) * | 2011-05-13 | 2012-12-05 | 山东德州神牛药业有限公司 | Method for preparing veterinary compound iron dextran injection and influence of veterinary compound iron dextran injection on growth of mice |
| CN105326856B (en) * | 2015-10-23 | 2018-03-13 | 四川农业大学 | The preparation method and its Animal nutrition purposes of a kind of animal anti-anemia action micro-capsule |
| CN107929318A (en) * | 2017-12-19 | 2018-04-20 | 上海申亚动物保健品阜阳有限公司 | A kind of preparation method of iron-dextrin selenium parenteral solution |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041762A (en) * | 1988-10-14 | 1990-05-02 | 广西化工研究所 | The preparation method of Iron-Dextrin Complex |
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1994
- 1994-06-28 CN CN94107777A patent/CN1059321C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041762A (en) * | 1988-10-14 | 1990-05-02 | 广西化工研究所 | The preparation method of Iron-Dextrin Complex |
Non-Patent Citations (1)
| Title |
|---|
| 《畜牧与兽医》19(3) 1987.3.1 尤自光等，国产和进口铁制剂对提高子猪 * |
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| Publication number | Publication date |
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| CN1104090A (en) | 1995-06-28 |
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