Summary of the invention
The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment acute mastitis, thereby has completed the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment acute mastitis.
Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Herba Taraxaci, Herba Lycopi, Pericarpium Trichosanthis, Flos Lonicerae, Herba Violae, Radix Sophorae Flavescentis, the Radix Angelicae Dahuricae, Semen Vaccariae, Herba Violae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Folium Isatidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Rubiae, Radix Rhapontici, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Trichosanthis, Herba Solani Lyrati, Squama Manis, Flos Chrysanthemi Indici, Radix Notoginseng, Herba Plantaginis, Rhizoma Paridis, the Radix Pulsatillae, Rhizoma Cyperi, Rhizoma Bolbostematis, Fructus Arctii medicine to combine preparation, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat acute mastitis.Wherein select Herba Taraxaci to be because its property bitter but sweet flavor is cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Selecting Herba Lycopi is that tepor, enters liver, spleen channel, invigorates blood circulation because of its nature and flavor toil, and the function of row water, controls amenorrhea , mass in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, body and face edema, injury from falling down, incised wound, carbuncle.Select Pericarpium Trichosanthis to be because its nature and flavor are sweet, cold, attach to the lung and stomach meridians, there is removing heat-phlegm, the function of promoting the circulation of QI the chest stuffiness relieving, controls phlegm-heat cough, hypochondriac pain uncomfortable in chest.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, there is heat clearing away, the function of removing toxic substances, controls epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Herba Violae to be because its nature and flavor hardship is cold, enter the heart, Liver Channel, have clearing away heat-damp and promoting diuresis, the function of removing toxic substances and promoting subsidence of swelling, controls furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.Select Radix Sophorae Flavescentis to be because its nature and flavor hardship is cold, enter liver, kidney, large intestine, small intestine meridian, have heat clearing away, dampness, the function of parasite killing, controls toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, erosion of vulva pruritus due to damp pathogen, scrofula, scalds.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Select Semen Vaccariae to be because its nature and flavor are bitter flat, enter liver, stomach warp, have promoting the circulation of blood to stimulate the menstrual flow, expedite the emergence of stimulating milk secretion, the function of detumescence sore, controls women's amenorrhea, galactostasis, and difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.Selecting Herba Violae is that GUIXIN, Liver Channel, have heat-clearing and toxic substances removing because of its nature and flavor bitter, acrid, cold, and the function of removing heat from blood detumescence, controls furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Select Fructus Hordei Germinatus to be because its nature and flavor are sweet, tepor, enters spleen, stomach warp, and have and help digestion, and in, the function of the therapeutic method to keep the adverse QI flowing downwards, controls food stagnation and does not disappear, swollen distention and fullness in the abdomen, and inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Selecting Pericarpium Citri Reticulatae is that temperature, returns lung, spleen channel, has regulating qi-flowing for strengthening spleen because of its nature and flavor hardship, pungent, and the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Select Folium Isatidis to be because its nature and flavor hardship is cold, enter liver, the heart, stomach warp, have heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.Select Herba Ephedrae to be because its nature and flavor are arduous, temperature, enters lung, urinary bladder channel, has diaphoresis, relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Radix Rubiae to be because its nature and flavor hardship is cold, enter the heart, Liver Channel, have promoting the circulation of blood hemostasis, dredge the meridian passage, eliminating phlegm and stopping cough, controls haematemesis, epistaxis, hematuria, has blood in stool, metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood is stagnant to swell and ache, jaundice, property tracheitis.Select Radix Rhapontici to be because its nature and flavor hardship is salty, cold, enter stomach, large intestine channel, there is heat-clearing and toxic substances removing, detumescence and apocenosis, stimulating milk secretion, the function of logical muscle arteries and veins, controls carbuncle carbuncle on the back, breast swell and pain, galactostasis, scrofula malignant boil, the contracture of arthralgia chiefly caused by damp pathogen muscle arteries and veins, arthralgia, toxic-heat and blood stasis, bleeding hemorrhoids.Select Radix Paeoniae Rubra to be because its nature and flavor hardship is slightly cold, return Liver Channel, have clearing away heat and cooling blood, the function of eliminating stasis to stop pain, controls warm poison and goes mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea , Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Caulis Lonicerae to be because its nature and flavor are sweet, cold, enter the heart, lung meridian, there is heat clearing away, removing toxic substances, the function of dredging collateral, controls epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.Select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness acid is cool, enter lung, stomach warp, have and promote the production of body fluid, quench the thirst, pathogenic fire reducing, moisturizes, evacuation of pus, and the function of detumescence, controls calentura thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Select Herba Solani Lyrati to be because its nature and flavor sweetness and bitterness is cold, have heat clearing away, dampness removing, dispels the wind, the function of removing toxic substances, treating malaria disease, jaundice, edema, gonorrhea, rheumatic arthritis, erysipelas, furuncle.Select Squama Manis to be because its nature and flavor are salty, cool, enter liver, stomach warp, have the routed carbuncle of detumescence, search wind active, the function of the stimulating milk secretion of stimulating the menstrual flow, controls carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Flos Chrysanthemi Indici to be because its nature and flavor toil is cool, enter lung, Liver Channel, have wind and heat dispersing, the function of subduing swelling and detoxicating, controls anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furuncle, carbuncle, aphtha, erysipelas, eczema, epidemic blisters.Selecting Radix Notoginseng is that temperature, enters liver, stomach, large intestine channel, has hemostasis because of its property sweet and slightly bitter taste, dissipating blood stasis, and detumescence, the function of analgesic therapy, controls haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.Select Herba Plantaginis to be because its nature and flavor are sweet, cold, enter liver, spleen two warps, there is diuretic, heat clearing away, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, jaundice, edema, hematodiarrhoea, has loose bowels, epistaxis, conjunctival congestion and swelling pain, sore throat tonsillitis, cough, skin ulcer.Select Rhizoma Paridis to be because its nature and flavor hardship is slightly cold, slightly poisonous, return Liver Channel, there is heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the function of cool liver arresting convulsion, controls furuncle carbuncle, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, convulsion with spasms.Select the Radix Pulsatillae to be because its nature and flavor hardship is cold, enter large intestine, liver, stomach warp, have clearing away heat and cooling blood, the function of removing toxic substances, controls toxic-heat and blood stasis, pyrexial malaria cold and heat, epistaxis, internal hemorrhoid with bleeding.Select Rhizoma Cyperi to be because the pungent micro-hard work of its nature and flavor is flat, enter liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Rhizoma Bolbostematis to be because its nature and flavor hardship is cool, have eliminating stagnation poison, the function of subduing inflammation, controls acute mastitis, scrofula sucutaneous nodule, sore swollen toxin and snakeworm poison.Select Fructus Arctii to be because its nature and flavor are arduous, cool, enter lung, stomach warp, have dispelling wind and heat pathogens, lung qi dispersing rash, the function of subduing swelling and detoxicating, controls cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule is not saturating, and rubella is had an itch, carbuncle sore tumefacting virus.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight.
Herba Taraxaci 10-20 gram of Herba Lycopi 25-35 gram of Pericarpium Trichosanthis 10-20 gram
Flos Lonicerae 10-20 gram of Herba Violae 25-35 gram of Radix Sophorae Flavescentis 15-25 gram
Radix Angelicae Dahuricae 8-18 gram of Semen Vaccariae 10-20 gram of Herba Violae 10-18 gram
Fructus Hordei Germinatus 16-25 gram of Pericarpium Citri Reticulatae 20-30 gram of Folium Isatidis 18-26 gram
Herba Ephedrae 4-9 gram of Radix Angelicae Sinensis 12-20 gram of Radix Rubiae 6-15 gram
Radix Rhapontici 10-20 gram of Radix Paeoniae Rubra 10-20 gram of Caulis Lonicerae 15-25 gram
Radix Trichosanthis 8-16 gram of Herba Solani Lyrati 15-22 gram of Squama Manis 1-4 gram
Flos Chrysanthemi Indici 8-15 gram of Radix Notoginseng 16-22 gram of Herba Plantaginis 8-15 gram
Rhizoma Paridis 10-20 gram of Radix Pulsatillae 25-35 gram of Rhizoma Cyperi 6-12 gram
Rhizoma Bolbostematis 10-20 gram of Fructus Arctii 8-16 gram.
Be preferably:
12 grams of 30 grams of Pericarpium Trichosanthiss of 15 grams of Herba Lycopi of Herba Taraxaci
20 grams of 30 grams of Radix Sophorae Flavescentiss of 15 grams of Herba Violaes of Flos Lonicerae
15 grams of 13 grams of Herba Violaes of 10 grams of Semen Vaccariae of the Radix Angelicae Dahuricae
20 grams of 25 grams of Folium Isatidiss of 20 grams of Pericarpium Citri Reticulataes of Fructus Hordei Germinatus
9 grams of 15 grams of Radix Rubiae of 5 grams of Radix Angelicae Sinensis of Herba Ephedrae
20 grams of 15 grams of Caulis Loniceraes of 15 grams of Radix Paeoniae Rubra of Radix Rhapontici
2 grams of 18 grams of Squama Maniss of 10 grams of Herba Solani Lyratis of Radix Trichosanthis
10 grams of 20 grams of Herba Plantaginiss of 10 grams of Radix Notoginseng of Flos Chrysanthemi Indici
9 grams of 30 grams of Rhizoma Cyperis of 15 grams of Radix Pulsatillaes of Rhizoma Paridis
10 grams of 15 grams of Fructus Arctiis of Rhizoma Bolbostematis.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Taraxaci: choose decontamination, clean earth, cutting, dries;
2, Herba Lycopi: choose decontamination, remove undesirable root, water spray is profit slightly, and cutting is dried;
3, Pericarpium Trichosanthis: get crude drug, remove fruit stem and impurity, wash quickly is clean, runs through, and shredding is dry, and sieve removes chip;
4, Flos Lonicerae: sieve removes silt, chooses clean impurity;
5, Herba Violae: choose clean impurity, water washes away earth, cutting is dried;
6, Radix Sophorae Flavescentis: choose clean impurity, remove residual stem, clean earth, be soaked in water, pull out, run through, section, dries;
7, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;
8, Semen Vaccariae: the clean impurity of winnowing with a dustpan, put in pot, fry with slow fire and spend six to popping in vain, take out seventy percent time, cool;
9, Herba Violae: get crude drug, remove impurity, clean, slightly dry in the air, cutting, dry;
10, Fructus Hordei Germinatus: get Fructus Hordei Germinatus and put pot interior micro-stir-fry to yellow, taking-up cools;
11, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, clean, soften, shredding, dries or cold drying, sieve dedust bits;
12, Folium Isatidis: choose decontamination and dead leaf, clean, slightly profit, cutting, dries;
13, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after micro-profit, is drying to obtain;
14, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air, and section is dried;
15, Radix Rubiae: choose clean impurity, remove Lu Miao, clean, run through rear timely section, dry;
16, Radix Rhapontici: choose clean impurity, unhairing is cleaned, and runs through, and section, dries;
17, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping, cleans, runs through, shave, and dry, sieve removes chip;
18, Caulis Lonicerae: choose decontamination, be soaked in water, run through, section, dries;
19, Radix Trichosanthis: choose decontamination, size block separately, saturating with blister approximately sixty percent, pulls out, and moistening is even to inside and outside humidity, and section, dries; Or wash, pull out, shine extremely dryly, smash into fritter;
20, Herba Solani Lyrati: get crude drug, remove impurity, clean, slightly profit, cutting, dry;
21, Squama Manis: get the Squama Manis sheet of choosing clean, separately size, separately puts sand in pot and make popular, adds Squama Manis sheet, fries to heaving while being golden yellow, takes out, and sieve shakeout, cools;
22, Flos Chrysanthemi Indici: spend autumn while blooming and gather, dry;
23, Radix Notoginseng: choose clean impurity, smash to pieces, grind or run through rear section into powder and dry;
24, Herba Plantaginis: remove most earth, dry;
25, Rhizoma Paridis: remove fibrous root, cleaning, drying;
26, the Radix Pulsatillae: choose clean impurity, clean, run through rear section, dry;
27, Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;
28, Rhizoma Bolbostematis: clean, break into two with one's hands, boil to without the white heart, take out, dry;
29, Fructus Arctii: choose decontamination, sieve removes spare.
Two, preparation
1, the Herba Taraxaci of described weight, Herba Lycopi, Pericarpium Trichosanthis, Flos Lonicerae, Herba Violae, Radix Sophorae Flavescentis, the Radix Angelicae Dahuricae, Semen Vaccariae, Herba Violae, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Folium Isatidis, Herba Ephedrae, Radix Angelicae Sinensis, Radix Rubiae, Radix Rhapontici, Radix Paeoniae Rubra, Caulis Lonicerae, Radix Trichosanthis, Herba Solani Lyrati, Squama Manis, Flos Chrysanthemi Indici, Radix Notoginseng, Herba Plantaginis, Rhizoma Paridis, the Radix Pulsatillae, Rhizoma Cyperi, Rhizoma Bolbostematis, Fructus Arctii are decocted with water twice, 6 times of amounts for the first time add water, intense fire decocts boiling 10 minutes, use again slow fire boiling 25 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal residues after filtering are for the first time added water 4 times and measured, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time.
3, merge twice decoction liquor, intense fire boils, then with slow fire boiling 10 minutes and get final product, medicinal liquid is divided into 4 doses and takes.
Medicine of the present invention has heat-clearing and toxic substances removing, promoting the circulation of QI the chest stuffiness relieving, and the function of reducing swelling and alleviating pain, is used for the treatment of acute mastitis instant effect, good effect.
Further set forth below the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 100 examples for medical treatment.
2, diagnostic criteria
(1) Ipsilateral mastalgia, inflammation part (multidigit is in the LOQ of breast) redness, hardening, tenderness form abscess later.Abscess is often positioned under mammary areola, after latex dust, mammary gland or mammary gland, deep abscess fluctuation is not remarkable.
(2) local red, swollen, burning pain, touches pain property lump, after abscess forms, can have fluctuation.
(3) homonymy axillary gland enlargement, suppurated in a couple of days of being everlasting.Tenderness.
(4) can there be shiver with cold, high heat, asthenia and a symptom such as be off one's feed.Blood leukocytes increases.Great majority have nipple damage, chap or long-pending newborn medical history.
(5) ultrasound investigation has the flat section of liquid, and pus is extracted in puncture out.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, every day 2 times, each 1 dose 10 days is a course for the treatment of, takes continuously 3 courses for the treatment of.
4, efficacy assessment standard
Effective: the recovery from illness of acute mastitis symptom;
Take a turn for the better: acute mastitis symptom alleviates, progressively take a turn for the better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy acute mastitis patient of the present invention 100 examples, effective 80 examples of result, obvious effective rate is 80%, 12 examples that take a turn for the better, and improvement rate is 12%, invalid 8 examples, total effective rate is 92%.