CN103827667B - 评估造血毒性的工具和方法 - Google Patents

评估造血毒性的工具和方法 Download PDF

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Publication number
CN103827667B
CN103827667B CN201280044690.XA CN201280044690A CN103827667B CN 103827667 B CN103827667 B CN 103827667B CN 201280044690 A CN201280044690 A CN 201280044690A CN 103827667 B CN103827667 B CN 103827667B
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CN
China
Prior art keywords
biomarker
hematopoietic toxicity
toxicity
amount
compound
Prior art date
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Expired - Fee Related
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CN201280044690.XA
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English (en)
Chinese (zh)
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CN103827667A (zh
Inventor
T·B·沃克
B·范拉文兹韦
W·梅勒特
E·法比安
V·施特劳斯
H·坎普
J·C·维默尔
R·洛塞
M·M·赫罗尔德
A·普奥考汀
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BASF SE
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BASF SE
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Priority to CN201610422742.2A priority Critical patent/CN106053832A/zh
Publication of CN103827667A publication Critical patent/CN103827667A/zh
Application granted granted Critical
Publication of CN103827667B publication Critical patent/CN103827667B/zh
Expired - Fee Related legal-status Critical Current
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/709—Toxin induced

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280044690.XA 2011-09-13 2012-09-12 评估造血毒性的工具和方法 Expired - Fee Related CN103827667B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610422742.2A CN106053832A (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161533867P 2011-09-13 2011-09-13
EP11181156 2011-09-13
EP11181156.8 2011-09-13
US61/533,867 2011-09-13
PCT/IB2012/054731 WO2013038341A1 (en) 2011-09-13 2012-09-12 Means and methods for assessing hematopoietic toxicity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610422742.2A Division CN106053832A (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

Publications (2)

Publication Number Publication Date
CN103827667A CN103827667A (zh) 2014-05-28
CN103827667B true CN103827667B (zh) 2016-07-13

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CN201280044690.XA Expired - Fee Related CN103827667B (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法
CN201610422742.2A Pending CN106053832A (zh) 2011-09-13 2012-09-12 评估造血毒性的工具和方法

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Country Link
US (1) US20150037825A1 (enExample)
EP (1) EP2756301A4 (enExample)
JP (1) JP2014526681A (enExample)
KR (1) KR20140059805A (enExample)
CN (2) CN103827667B (enExample)
AU (1) AU2012310147A1 (enExample)
BR (1) BR112014005472A2 (enExample)
CA (1) CA2845621A1 (enExample)
IL (1) IL231007A0 (enExample)
WO (1) WO2013038341A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114594192A (zh) * 2022-03-07 2022-06-07 山东大学 一种泊沙康唑起始物料中氯苯胺和氯硝基苯胺同分异构体的检测方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112409B2 (en) * 1999-01-29 2006-09-26 Center For Molecular Medicine And Immunology Method of determining cytokine dosage for myelosuppressive state
JP2003245076A (ja) * 2001-01-30 2003-09-02 Takeda Chem Ind Ltd 新規タンパク質およびそのｄｎａ
EP1539997A4 (en) * 2002-08-21 2007-04-25 Ivan N Rich HIGH-PERFORMANCE PROLIFERATION ASSAY OF HEMATOPOIETIC STRAINS AND PROGENITOR CELLS
US20040121305A1 (en) * 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US8034613B2 (en) * 2005-06-01 2011-10-11 Wisconsin Alumni Research Foundation Multipotent lymphohematopoietic progenitor cells
EP2059809B1 (en) * 2006-08-30 2014-07-23 Metanomics GmbH Means and method for diagnosing hemolytic anemia
US7689187B2 (en) * 2007-03-01 2010-03-30 Motorola, Inc. Dual input low noise amplifier for multi-band operation
US8062222B2 (en) * 2007-06-13 2011-11-22 Litron Laboratories, Ltd. Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment
CN102105792A (zh) * 2008-05-28 2011-06-22 巴斯夫欧洲公司 评估肝毒性的工具和方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
三聚氰胺污染饲料致大鼠肾毒性的代谢组学研究;窦春艳等;《中国药理学与毒理学杂志》;20110228;第25卷(第1期);88-92 *

Also Published As

Publication number Publication date
CN106053832A (zh) 2016-10-26
WO2013038341A1 (en) 2013-03-21
AU2012310147A1 (en) 2014-03-13
EP2756301A1 (en) 2014-07-23
CN103827667A (zh) 2014-05-28
BR112014005472A2 (pt) 2017-03-28
KR20140059805A (ko) 2014-05-16
EP2756301A4 (en) 2015-08-12
IL231007A0 (en) 2014-03-31
CA2845621A1 (en) 2013-03-21
US20150037825A1 (en) 2015-02-05
JP2014526681A (ja) 2014-10-06

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Granted publication date: 20160713

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CF01 Termination of patent right due to non-payment of annual fee