CN103827107A - 作为α2肾上腺素能受体的调节剂的N-(咪唑烷-2-亚基)喹啉衍生物 - Google Patents

作为α2肾上腺素能受体的调节剂的N-(咪唑烷-2-亚基)喹啉衍生物 Download PDF

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Publication number
CN103827107A
CN103827107A CN201280046305.5A CN201280046305A CN103827107A CN 103827107 A CN103827107 A CN 103827107A CN 201280046305 A CN201280046305 A CN 201280046305A CN 103827107 A CN103827107 A CN 103827107A
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CN
China
Prior art keywords
ylidene
amine
compound
imidazolidin
quinolin
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Pending
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CN201280046305.5A
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English (en)
Chinese (zh)
Inventor
S·C·辛哈
王黎明
周健雄
M·I·蒂巴斯
M·E·贾斯特
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Allergan Inc
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Allergan Inc
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Publication of CN103827107A publication Critical patent/CN103827107A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201280046305.5A 2011-07-25 2012-07-20 作为α2肾上腺素能受体的调节剂的N-(咪唑烷-2-亚基)喹啉衍生物 Pending CN103827107A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161511298P 2011-07-25 2011-07-25
US61/511,298 2011-07-25
PCT/US2012/047570 WO2013016178A1 (en) 2011-07-25 2012-07-20 N-(imidazolidin-2-ylidene)quinoline derivatives as modulators of alpha 2 adrenergic receptors

Publications (1)

Publication Number Publication Date
CN103827107A true CN103827107A (zh) 2014-05-28

Family

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CN201280046305.5A Pending CN103827107A (zh) 2011-07-25 2012-07-20 作为α2肾上腺素能受体的调节剂的N-(咪唑烷-2-亚基)喹啉衍生物

Country Status (11)

Country Link
US (3) US8815861B2 (https=)
EP (1) EP2736902A1 (https=)
JP (1) JP6031719B2 (https=)
KR (1) KR20140062471A (https=)
CN (1) CN103827107A (https=)
AU (1) AU2012287164A1 (https=)
BR (1) BR112014001938A2 (https=)
CA (1) CA2843251A1 (https=)
HK (1) HK1198762A1 (https=)
RU (1) RU2014106364A (https=)
WO (1) WO2013016178A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8941159B2 (en) 2013-01-30 2015-01-27 Omnivision Technologies, Inc. Color filter including clear pixel and hard mask

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552403A (en) * 1993-10-13 1996-09-03 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
CN1137793A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α2肾上腺素能受体兴奋剂的6-(2-咪唑啉基氨基)喹啉化合物
CN1137755A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α-2肾上腺素能受体兴奋剂的6-(2-咪唑啉基氨基)喹喔啉化合物
CN1137754A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α2肾上腺素能受体兴奋剂的7-(2-咪唑啉基氨基)喹啉化合物
US6087361A (en) * 1995-05-12 2000-07-11 Allergan Sales, Inc. Aryl-imidazolines and aryl-imidazoles useful as α-2 adrenergic agonists without cardiovascular side effects

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB889282A (en) 1957-05-07 1962-02-14 Air Reduction Preparation of hexafluorodiethyl ether and medicinal compositions containing it
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
EP0775134A4 (en) 1994-08-04 1997-08-13 Synaptic Pharma Corp NEW BENZIMIDAZOLE DERIVATIVES
AU715350B2 (en) * 1995-05-12 2000-01-20 Allergan, Inc. Aryl-imidazolines and aryl-imidazoles useful as alpha-2 adrenergic agonists without cardiovascular side effects
US5677321A (en) 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
ES2756499T3 (es) * 2009-10-06 2020-04-27 Allergan Inc Derivados de 2H-pirrol-5-amina como moduladores de receptor alfa adrenérgico

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552403A (en) * 1993-10-13 1996-09-03 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
CN1137793A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α2肾上腺素能受体兴奋剂的6-(2-咪唑啉基氨基)喹啉化合物
CN1137755A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α-2肾上腺素能受体兴奋剂的6-(2-咪唑啉基氨基)喹喔啉化合物
CN1137754A (zh) * 1993-12-17 1996-12-11 普罗克特和甘保尔公司 用作α2肾上腺素能受体兴奋剂的7-(2-咪唑啉基氨基)喹啉化合物
US6087361A (en) * 1995-05-12 2000-07-11 Allergan Sales, Inc. Aryl-imidazolines and aryl-imidazoles useful as α-2 adrenergic agonists without cardiovascular side effects

Also Published As

Publication number Publication date
JP6031719B2 (ja) 2016-11-24
WO2013016178A1 (en) 2013-01-31
BR112014001938A2 (pt) 2017-02-21
AU2012287164A1 (en) 2014-02-20
US20160045489A1 (en) 2016-02-18
KR20140062471A (ko) 2014-05-23
US20130029994A1 (en) 2013-01-31
EP2736902A1 (en) 2014-06-04
RU2014106364A (ru) 2015-08-27
HK1198762A1 (en) 2015-06-05
US9199989B2 (en) 2015-12-01
US20140329852A1 (en) 2014-11-06
CA2843251A1 (en) 2013-01-31
JP2014521647A (ja) 2014-08-28
US8815861B2 (en) 2014-08-26

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Application publication date: 20140528