CN103826658A - 具有氢氧化铝纳米颗粒的疫苗组合物 - Google Patents

具有氢氧化铝纳米颗粒的疫苗组合物 Download PDF

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Publication number
CN103826658A
CN103826658A CN201280034602.8A CN201280034602A CN103826658A CN 103826658 A CN103826658 A CN 103826658A CN 201280034602 A CN201280034602 A CN 201280034602A CN 103826658 A CN103826658 A CN 103826658A
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China
Prior art keywords
nanoparticles
vaccine composition
aluminum
polyacrylate
pseudoboehmite
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Pending
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CN201280034602.8A
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English (en)
Chinese (zh)
Inventor
Y.马蒂厄
B.勒博
V.瓦尔谢夫
J.帕塔兰
M.加里诺
J.安斯勒
E.索佐
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Sanofi Pasteur Inc
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Sanofi Pasteur Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201280034602.8A 2011-07-13 2012-07-12 具有氢氧化铝纳米颗粒的疫苗组合物 Pending CN103826658A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1156398 2011-07-13
FR1156398A FR2977800B1 (fr) 2011-07-13 2011-07-13 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium
PCT/FR2012/051648 WO2013007956A1 (fr) 2011-07-13 2012-07-12 Composition vaccinale avec des nanoparticules d'hydroxyde d'aluminium

Publications (1)

Publication Number Publication Date
CN103826658A true CN103826658A (zh) 2014-05-28

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ID=46639612

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CN201280034602.8A Pending CN103826658A (zh) 2011-07-13 2012-07-12 具有氢氧化铝纳米颗粒的疫苗组合物

Country Status (9)

Country Link
US (1) US9770505B2 (https=)
EP (1) EP2731622B1 (https=)
JP (1) JP6111245B2 (https=)
CN (1) CN103826658A (https=)
CA (1) CA2838817A1 (https=)
ES (1) ES2650740T3 (https=)
FR (1) FR2977800B1 (https=)
NO (1) NO2731622T3 (https=)
WO (1) WO2013007956A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587464A (zh) * 2015-01-23 2015-05-06 四川大学 一种基于氢氧化铝纳米粒的疫苗载体
CN106177939A (zh) * 2015-06-01 2016-12-07 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106421775A (zh) * 2015-08-12 2017-02-22 普莱柯生物工程股份有限公司 一种疫苗用佐剂及含该佐剂的疫苗组合物和其应用
CN107041952A (zh) * 2016-02-05 2017-08-15 中国人民解放军军事医学科学院微生物流行病研究所 表面修饰有氧化铝的疫苗及其制备方法和疫苗组合物
CN109195587A (zh) * 2016-06-01 2019-01-11 传染病研究所 含上胶剂的纳米明矾颗粒
CN114522241A (zh) * 2022-02-18 2022-05-24 广东粤港澳大湾区国家纳米科技创新研究院 一种铝纳米晶复合免疫药物及其制备方法和应用
CN115944723A (zh) * 2022-12-22 2023-04-11 中国人民解放军陆军军医大学 基于纳米铝盐与纳米乳的复合物在制备疫苗佐剂中的应用及其产品

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017053594A1 (en) * 2015-09-23 2017-03-30 The Regents Of The University Of California Compositions and methods of using the same for decontamination of skin
CN113666404B (zh) * 2021-09-23 2023-07-28 北京智飞绿竹生物制药有限公司 一种适合规模化生产的高浓度纳米级氢氧化铝佐剂配制方法
GB202215072D0 (en) * 2022-10-13 2022-11-30 Glaxosmithkline Biologicals Sa Process for production of aluminium hydroxide particles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158334A1 (en) * 2001-07-26 2005-07-21 Mario Contorni Vaccines comprising aluminium adjuvants and histidine
CN101370515A (zh) * 2005-11-04 2009-02-18 诺华疫苗和诊断有限公司 包含颗粒佐剂和免疫增强剂组合的流感疫苗

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK143689C (da) * 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4836948A (en) * 1987-12-30 1989-06-06 Lever Brothers Company Viscoelastic gel detergent compositions
NZ259285A (en) * 1993-01-08 1996-07-26 Csl Ltd Vaccine preparations in stable particulate form comprising an immunogen absorbed to an aluminium salt adjuvant or biodegradable polymer matrix
KR100629028B1 (ko) * 1998-10-16 2006-09-26 글락소스미스클라인 바이오로지칼즈 에스.에이. 애쥬번트 시스템 및 백신
NZ568211A (en) * 2005-11-04 2011-11-25 Novartis Vaccines & Diagnostic Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
CN101678090B (zh) * 2007-03-07 2012-04-11 乌第有限合伙公司 用于预防和治疗自身免疫病的组合物和方法
CA2694083A1 (en) * 2007-07-26 2009-01-29 Sanofi Pasteur Limited Antigen-adjuvant compositions and methods
EP3263128A3 (en) 2009-04-14 2018-01-24 GlaxoSmithKline Biologicals S.A. Compositions for immunising against staphylococcus aureus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050158334A1 (en) * 2001-07-26 2005-07-21 Mario Contorni Vaccines comprising aluminium adjuvants and histidine
CN101370515A (zh) * 2005-11-04 2009-02-18 诺华疫苗和诊断有限公司 包含颗粒佐剂和免疫增强剂组合的流感疫苗

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KWOK PAN YAU ET AL: "Aluminum Hydroxide Adjuvant Produced under constant Reactant Concentration", 《J.PHARM.SCI》 *
YANNICK MATHIEU ET AL: "Control of the Morphology and Particle Size of Boehmite Nanoparticles Synthesized under Hydrothermal Conditons", 《LANGMUIR》 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587464A (zh) * 2015-01-23 2015-05-06 四川大学 一种基于氢氧化铝纳米粒的疫苗载体
CN106177939A (zh) * 2015-06-01 2016-12-07 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
CN106421775A (zh) * 2015-08-12 2017-02-22 普莱柯生物工程股份有限公司 一种疫苗用佐剂及含该佐剂的疫苗组合物和其应用
CN107041952A (zh) * 2016-02-05 2017-08-15 中国人民解放军军事医学科学院微生物流行病研究所 表面修饰有氧化铝的疫苗及其制备方法和疫苗组合物
CN107041952B (zh) * 2016-02-05 2020-11-10 中国人民解放军军事医学科学院微生物流行病研究所 表面修饰有氧化铝的疫苗及其制备方法和疫苗组合物
CN109195587A (zh) * 2016-06-01 2019-01-11 传染病研究所 含上胶剂的纳米明矾颗粒
US11173126B2 (en) * 2016-06-01 2021-11-16 Infectious Disease Research Institute Nanoalum particles comprising a PAA sizing agent
US20220016042A1 (en) * 2016-06-01 2022-01-20 Infectious Disease Research Institute Nanoalum particles containing a pegylated lipid sizing agent
US12427116B2 (en) * 2016-06-01 2025-09-30 Access To Advanced Health Institute Nanoalum particles containing a pegylated lipid sizing agent
CN114522241A (zh) * 2022-02-18 2022-05-24 广东粤港澳大湾区国家纳米科技创新研究院 一种铝纳米晶复合免疫药物及其制备方法和应用
CN115944723A (zh) * 2022-12-22 2023-04-11 中国人民解放军陆军军医大学 基于纳米铝盐与纳米乳的复合物在制备疫苗佐剂中的应用及其产品

Also Published As

Publication number Publication date
US9770505B2 (en) 2017-09-26
JP6111245B2 (ja) 2017-04-05
FR2977800B1 (fr) 2014-03-14
ES2650740T3 (es) 2018-01-22
EP2731622A1 (fr) 2014-05-21
NO2731622T3 (https=) 2018-03-10
EP2731622B1 (fr) 2017-10-11
CA2838817A1 (fr) 2013-01-17
FR2977800A1 (fr) 2013-01-18
JP2014520836A (ja) 2014-08-25
US20140234422A1 (en) 2014-08-21
WO2013007956A1 (fr) 2013-01-17

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