CN103819907B - A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability - Google Patents
A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability Download PDFInfo
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- CN103819907B CN103819907B CN201410084364.2A CN201410084364A CN103819907B CN 103819907 B CN103819907 B CN 103819907B CN 201410084364 A CN201410084364 A CN 201410084364A CN 103819907 B CN103819907 B CN 103819907B
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- polypropylene glycol
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Abstract
The present invention discloses a kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability, adopt following steps: the 1) synthesis of poly-peptide-polypropylene glycol graft copolymer: add poly-peptide homopolymer, polypropylene glycol monobutyl ether, solvent and catalyzer in dry reactor, under inert atmosphere, in 55 ~ 58 DEG C of stirring reactions after 3 ~ 4 days, by filtration, dialysis, dry obtained target compound; 2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification: add poly-peptide-polypropylene glycol graft copolymer, polyethylene alcohol and solvent in dry reactor, under inert atmosphere, after being uniformly mixed 50 ~ 70 minutes in 40 ~ 50 DEG C, also dry by casting method film forming, obtain target compound of the present invention.Preparation technology of the present invention is simple, be easy to grasp, and gained modified membrane wetting ability is greatly improved.
Description
Technical field
The present invention relates to a kind of method that poly-peptide film wetting ability is improved, belong to field of polymer film preparing technology.
Background technology
Poly-peptide a kind ofly has good biocompatibility and the biomaterial of biodegradability, and poly-peptide film can be used as artificial skin etc., but poly-peptide film lacks good wetting ability, thus limit its application to a certain extent.Polypropylene glycol has good biocompatibility and biodegradability, and has good blended property with polyvinyl alcohol.Polyvinyl alcohol has good biocompatibility and biodegradability, and has excellent wetting ability.First polypropylene glycol segment is introduced poly-peptide segment and form poly-peptide-polypropylene glycol graft copolymer to improve the blended property of poly-peptide, and then polyvinyl alcohol segments is added poly-peptide-polypropylene glycol graft copolymer formation blend, obtained modification gathers peptide film, thus drastically increases the wetting ability of poly-peptide film.
Summary of the invention
The object of the present invention is to provide a kind of simple to operate and effect preferably to the method that poly-peptide film wetting ability is improved.Its technical scheme is:
A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability, it is characterized in that: in modified membrane, the molecular weight of poly-peptide segment is 60000 ~ 80000, the molecular weight of polypropylene glycol segment is 1000 ~ 2000, and the molecular weight of polyvinyl alcohol segments is 4000 ~ 5000; Its method of modifying adopts following steps:
1) synthesis of poly-peptide-polypropylene glycol graft copolymer: add poly-peptide homopolymer, polypropylene glycol monobutyl ether, solvent and catalyzer in dry reactor, under inert atmosphere, in 55 ~ 58 DEG C of stirring reactions after 3 ~ 4 days, by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification: add poly-peptide-polypropylene glycol graft copolymer, polyethylene alcohol and solvent in dry reactor, under inert atmosphere, after being uniformly mixed 50 ~ 70 minutes in 40 ~ 50 DEG C, also dry by casting method film forming, obtain target compound.
The method that described a kind of polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability, in step 1), poly-peptide homopolymer adopts poly-(r-phenmethyl-Pidolidone ester), poly-(r-ethyl-L-glutamate ester) or poly-(r-methyl-Pidolidone ester), and the mol ratio of polypropylene glycol monobutyl ether and poly-peptide homopolymer is 15 ~ 25:1.
The method that described a kind of polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability, in step 1), catalyzer adopts tosic acid, and the mol ratio of catalyzer and poly-peptide homopolymer is 25 ~ 45:1, solvent adopts dimethyl sulfoxide (DMSO), and reactant solution concentration is 5 ~ 15g:100ml.
The method that described a kind of polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability, step 2) in, the mass percent of polyvinyl alcohol in modified membrane is 1 ~ 3%, and solvent adopts dimethyl sulfoxide (DMSO), and mixture solution concentration is 25 ~ 30g:100ml.
Compared with prior art, its advantage is in the present invention:
1, described polypropylene glycol and polyvinyl alcohol improve the poly-hydrophilic method of peptide film, adopt graft copolymerization and blended two kinds of means, simple to operate, be easy to grasp;
2, described poly-peptide modified membrane wetting ability is greatly improved.
Embodiment
embodiment 1
1) synthesis of poly-peptide-polypropylene glycol graft copolymer:
12 gram molecular weights are 60000 poly-(r-phenmethyl-Pidolidone esters), 3.1 gram molecular weights are 1000 polypropylene glycol monobutyl ether, 0.9 gram of tosic acid is added in dry reactor, add 260 milliliters of dimethyl sulfoxide solvents again, under inert atmosphere, in 55 DEG C of stirring reactions after 3 days, termination reaction, then by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification:
10 grams of poly-peptide-polypropylene glycol graft copolymers and 38 milliliters of dimethyl sulfoxide solvents are added in dry reactor, separately add the polyvinyl alcohol (molecular weight is 4000) accounting for modified membrane gross weight 1%, under inert atmosphere, after being uniformly mixed 50 minutes in 40 DEG C, use casting method film forming, in 50 DEG C of vacuum drying ovens, drying obtains target compound.
After tested: the hydrophilic rate of target compound of the present invention is than improve 12.9% before modified.
embodiment 2
1) synthesis of poly-peptide-polypropylene glycol graft copolymer:
12 gram molecular weights are 70000 poly-(r-ethyl-L-glutamate esters), 5.3 gram molecular weights are 1500 polypropylene glycol monobutyl ether, 0.91 gram of tosic acid is added in dry reactor, add 230 milliliters of dimethyl sulfoxide solvents again, under inert atmosphere, in 56 DEG C of stirring reactions after 4 days, termination reaction, then by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification:
10 grams of poly-peptide-polypropylene glycol graft copolymers and 36 milliliters of dimethyl sulfoxide solvents are added in dry reactor, separately add the polyvinyl alcohol (molecular weight is 4500) accounting for modified membrane gross weight 2%, under inert atmosphere, after being uniformly mixed 60 minutes in 45 DEG C, use casting method film forming, in 50 DEG C of vacuum drying ovens, drying obtains target compound.
After tested: the hydrophilic rate of target compound of the present invention is than improve 14.9% before modified.
embodiment 3
1) synthesis of poly-peptide-polypropylene glycol graft copolymer:
12 gram molecular weights are 80000 poly-(r-methyl-Pidolidone esters), 7.2 gram molecular weights are 2000 polypropylene glycol monobutyl ether, 1.03 grams of tosic acid are added in dry reactor, add 177 milliliters of dimethyl sulfoxide (DMSO) again, under inert atmosphere, in 58 DEG C of stirring reactions after 3 days, termination reaction, then by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification:
10 grams of poly-peptide-polypropylene glycol graft copolymers and 35.5 milliliters of dimethyl sulfoxide (DMSO) are added in dry reactor, separately add the polyvinyl alcohol (molecular weight is 5000) accounting for modified membrane gross weight 3%, under inert atmosphere, after being uniformly mixed 70 minutes in 50 DEG C, use casting method film forming, in 50 DEG C of vacuum drying ovens, drying obtains target compound.
After tested: the hydrophilic rate of target compound of the present invention is than improve 16.8% before modified.
Claims (4)
1. the method poly-peptide film wetting ability improved with polypropylene glycol and polyvinyl alcohol, it is characterized in that: in modified membrane, the molecular weight of poly-peptide segment is 60000 ~ 80000, the molecular weight of polypropylene glycol segment is 1000 ~ 2000, and the molecular weight of polyvinyl alcohol segments is 4000 ~ 5000; Its method of modifying adopts following steps:
1) synthesis of poly-peptide-polypropylene glycol graft copolymer: add poly-peptide homopolymer, polypropylene glycol monobutyl ether, solvent and catalyzer in dry reactor, under inert atmosphere, in 55 ~ 58 DEG C of stirring reactions after 3 ~ 4 days, by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification: add poly-peptide-polypropylene glycol graft copolymer, polyethylene alcohol and solvent in dry reactor, under inert atmosphere, after being uniformly mixed 50 ~ 70 minutes in 40 ~ 50 DEG C, also dry by casting method film forming, obtain target compound.
2. a kind of polypropylene glycol according to claim 1 and polyvinyl alcohol method that poly-peptide film wetting ability is improved, it is characterized in that: in step 1), poly-peptide homopolymer adopts poly-(γ-phenmethyl-Pidolidone ester), poly-(γ-ethyl-L-glutamate ester) or poly-(γ-methyl-Pidolidone ester), and the mol ratio of polypropylene glycol monobutyl ether and poly-peptide homopolymer is 15 ~ 25:1.
3. a kind of polypropylene glycol according to claim 1 and polyvinyl alcohol method that poly-peptide film wetting ability is improved, it is characterized in that: in step 1), catalyzer adopts tosic acid, the mol ratio of catalyzer and poly-peptide homopolymer is 25 ~ 45:1, solvent adopts dimethyl sulfoxide (DMSO), and reactant solution concentration is 5 ~ 15g:100ml.
4. a kind of polypropylene glycol according to claim 1 and polyvinyl alcohol method that poly-peptide film wetting ability is improved, it is characterized in that: step 2) in, the mass percent of polyvinyl alcohol in modified membrane is 1 ~ 3%, solvent adopts dimethyl sulfoxide (DMSO), and mixture solution concentration is 25 ~ 30g:100ml.
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| CN201410084364.2A CN103819907B (en) | 2014-03-10 | 2014-03-10 | A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability |
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| CN201410084364.2A CN103819907B (en) | 2014-03-10 | 2014-03-10 | A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability |
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| CN103819907A CN103819907A (en) | 2014-05-28 |
| CN103819907B true CN103819907B (en) | 2016-04-06 |
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| CN104559214B (en) * | 2015-01-06 | 2017-02-08 | 山东理工大学 | Method for improving hydrophily and flexibility of polypeptide membrane by polypropylene glycol and polyacrylic acid |
| CN105622951A (en) * | 2016-03-03 | 2016-06-01 | 山东理工大学 | Method for preparing polyvinyl alcohol-polytrimethylene carbonate-polypeptide double grafted copolymer |
| CN105542207A (en) * | 2016-03-07 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol film through polypropylene glycol and polypeptide-polyvinylpyrrolidone |
| CN105542178A (en) * | 2016-03-07 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol film through poly(trimethylene carbonate) and polypeptide |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012159084A1 (en) * | 2011-05-18 | 2012-11-22 | Baxter International, Inc. | Modification-dependent activity assays |
| CN103242536A (en) * | 2013-05-09 | 2013-08-14 | 山东理工大学 | Method for preparing polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012159084A1 (en) * | 2011-05-18 | 2012-11-22 | Baxter International, Inc. | Modification-dependent activity assays |
| CN103242536A (en) * | 2013-05-09 | 2013-08-14 | 山东理工大学 | Method for preparing polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer |
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