CN103819905B - A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability - Google Patents
A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability Download PDFInfo
- Publication number
- CN103819905B CN103819905B CN201410080716.7A CN201410080716A CN103819905B CN 103819905 B CN103819905 B CN 103819905B CN 201410080716 A CN201410080716 A CN 201410080716A CN 103819905 B CN103819905 B CN 103819905B
- Authority
- CN
- China
- Prior art keywords
- poly
- ptmc
- peptide
- polyvinylpyrrolidone
- wetting ability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The present invention discloses a kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability, adopt following steps: the 1) synthesis of poly-peptide-PTMC graft copolymer: add poly-peptide homopolymer, PTMC monododecyl ether, solvent and catalyzer in dry reactor, under inert atmosphere, in 55 ~ 58 DEG C of stirring reactions after 3 ~ 4 days, by filtration, dialysis, dry obtained target compound; 2) preparation of the poly-peptide film of PTMC and polyvinyl pyrrolidone modified: add poly-peptide-PTMC graft copolymer, polyvinylpyrrolidone and solvent in dry reactor, under inert atmosphere, after being uniformly mixed 50 ~ 70 minutes in 40 ~ 50 DEG C, also dry by casting method film forming, obtain target compound of the present invention.Preparation technology of the present invention is simple, be easy to grasp, and gained modified membrane wetting ability is greatly improved.
Description
Technical field
The present invention relates to a kind of method that poly-peptide film wetting ability is improved, belong to field of polymer film preparing technology.
Background technology
Poly-peptide a kind ofly has good biocompatibility and the biomaterial of biodegradability, and poly-peptide film can be used as artificial skin etc., but poly-peptide film lacks good wetting ability, thus limit its application to a certain extent.PTMC has good biocompatibility and biodegradability, and has good blended property with polyvinylpyrrolidone.Polyvinylpyrrolidone has good biocompatibility and biodegradability, and has excellent wetting ability.First PTMC segment is introduced poly-peptide segment and form poly-peptide-PTMC graft copolymer to improve the blended property of poly-peptide, and then polyvinylpyrrolidone segment is added poly-peptide-PTMC graft copolymer formation blend, obtained modification gathers peptide film, thus drastically increases the wetting ability of poly-peptide film.
Summary of the invention
The object of the present invention is to provide a kind of simple to operate and effect preferably to the method that poly-peptide film wetting ability is improved.Its technical scheme is:
A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability, it is characterized in that: in modified membrane, the molecular weight of poly-peptide segment is 60000 ~ 80000, the molecular weight of PTMC segment is 1000 ~ 2000, and the molecular weight of polyvinylpyrrolidone segment is 4000 ~ 5000; Its method of modifying adopts following steps:
1) synthesis of poly-peptide-PTMC graft copolymer: add poly-peptide homopolymer, PTMC monododecyl ether, solvent and catalyzer in dry reactor, under inert atmosphere, in 55 ~ 58 DEG C of stirring reactions after 3 ~ 4 days, by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of PTMC and polyvinyl pyrrolidone modified: add poly-peptide-PTMC graft copolymer, polyvinylpyrrolidone and solvent in dry reactor, under inert atmosphere, after being uniformly mixed 50 ~ 70 minutes in 40 ~ 50 DEG C, also dry by casting method film forming, obtain target compound.
The method that described a kind of PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability, in step 1), poly-peptide homopolymer adopts poly-(r-phenmethyl-Pidolidone ester), poly-(r-ethyl-L-glutamate ester) or poly-(r-methyl-Pidolidone ester), and the mol ratio of PTMC monododecyl ether and poly-peptide homopolymer is 15 ~ 25:1.
The method that described a kind of PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability, in step 1), catalyzer adopts tosic acid, the mol ratio of catalyzer and poly-peptide homopolymer is 25 ~ 45:1, solvent adopts dimethyl sulfoxide (DMSO), and reactant solution concentration is 5 ~ 15g:100ml.
The method that described a kind of PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability, step 2) in, the mass percent of polyvinylpyrrolidone in modified membrane is 1 ~ 3%, and solvent adopts dimethyl sulfoxide (DMSO), and mixture solution concentration is 25 ~ 30g:100ml.
Compared with prior art, its advantage is in the present invention:
1, described PTMC and polyvinylpyrrolidone improve the poly-hydrophilic method of peptide film, adopt graft copolymerization and blended two kinds of means, simple to operate, be easy to grasp;
2, described poly-peptide modified membrane wetting ability is greatly improved.
Embodiment
embodiment 1
1) synthesis of poly-peptide-PTMC graft copolymer:
12 gram molecular weights are 60000 poly-(r-phenmethyl-Pidolidone esters), 3.1 gram molecular weights are 1000 PTMC monododecyl ether, 0.9 gram of tosic acid is added in dry reactor, add 260 milliliters of dimethyl sulfoxide solvents again, under inert atmosphere, in 55 DEG C of stirring reactions after 3 days, termination reaction, then by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of PTMC and polyvinyl pyrrolidone modified:
10 grams of poly-peptide-PTMC graft copolymers and 38 milliliters of dimethyl sulfoxide solvents are added in dry reactor, separately add the polyvinylpyrrolidone (molecular weight is 4000) accounting for modified membrane gross weight 1%, under inert atmosphere, after being uniformly mixed 50 minutes in 40 DEG C, use casting method film forming, in 50 DEG C of vacuum drying ovens, drying obtains target compound.
After tested: the hydrophilic rate of target compound of the present invention is than improve 12.8% before modified.
embodiment 2
1) synthesis of poly-peptide-PTMC graft copolymer:
12 gram molecular weights are 70000 poly-(r-ethyl-L-glutamate esters), 5.3 gram molecular weights are 1500 PTMC monododecyl ether, 0.91 gram of tosic acid is added in dry reactor, add 230 milliliters of dimethyl sulfoxide solvents again, under inert atmosphere, in 56 DEG C of stirring reactions after 4 days, termination reaction, then by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of PTMC and polyvinyl pyrrolidone modified:
10 grams of poly-peptide-PTMC graft copolymers and 36 milliliters of dimethyl sulfoxide solvents are added in dry reactor, separately add the polyvinylpyrrolidone (molecular weight is 4500) accounting for modified membrane gross weight 2%, under inert atmosphere, after being uniformly mixed 60 minutes in 45 DEG C, use casting method film forming, in 50 DEG C of vacuum drying ovens, drying obtains target compound.
After tested: the hydrophilic rate of target compound of the present invention is than improve 13.9% before modified.
embodiment 3
1) synthesis of poly-peptide-PTMC graft copolymer:
12 gram molecular weights are 80000 poly-(r-methyl-Pidolidone esters), 7.2 gram molecular weights are 2000 PTMC monododecyl ether, 1.03 grams of tosic acid are added in dry reactor, add 177 milliliters of dimethyl sulfoxide (DMSO) again, under inert atmosphere, in 58 DEG C of stirring reactions after 3 days, termination reaction, then by filtration, dialysis, dry obtained target compound;
2) preparation of the poly-peptide film of PTMC and polyvinyl pyrrolidone modified:
10 grams of poly-peptide-PTMC graft copolymers and 35.5 milliliters of dimethyl sulfoxide (DMSO) are added in dry reactor, separately add the polyvinylpyrrolidone (molecular weight is 5000) accounting for modified membrane gross weight 3%, under inert atmosphere, after being uniformly mixed 70 minutes in 50 DEG C, use casting method film forming, in 50 DEG C of vacuum drying ovens, drying obtains target compound.
After tested: the hydrophilic rate of target compound of the present invention is than improve 15.8% before modified.
Claims (4)
1. the method poly-peptide film wetting ability improved with PTMC and polyvinylpyrrolidone, it is characterized in that: in modified membrane, the molecular weight of poly-peptide segment is 60000 ~ 80000, the molecular weight of PTMC segment is 1000 ~ 2000, and the molecular weight of polyvinylpyrrolidone segment is 4000 ~ 5000; Its method of modifying adopts following steps:
1) synthesis of poly-peptide-PTMC graft copolymer: add poly-peptide homopolymer, PTMC monododecyl ether, solvent and catalyzer in dry reactor, under inert atmosphere, in 55 ~ 58 DEG C of stirring reactions after 3 ~ 4 days, by filtration, dialysis, dry obtained target compound, wherein, poly-peptide homopolymer adopts poly-(γ-phenmethyl-Pidolidone ester), poly-(γ-ethyl-L-glutamate ester) or poly-(γ-methyl-Pidolidone ester);
2) preparation of the poly-peptide film of PTMC and polyvinyl pyrrolidone modified: add poly-peptide-PTMC graft copolymer, polyvinylpyrrolidone and solvent in dry reactor, under inert atmosphere, after being uniformly mixed 50 ~ 70 minutes in 40 ~ 50 DEG C, also dry by casting method film forming, obtain target compound.
2. a kind of PTMC according to claim 1 and polyvinylpyrrolidone method that poly-peptide film wetting ability is improved, it is characterized in that: in step 1), the mol ratio of PTMC monododecyl ether and poly-peptide homopolymer is 15 ~ 25:1.
3. a kind of PTMC according to claim 1 and polyvinylpyrrolidone method that poly-peptide film wetting ability is improved, it is characterized in that: in step 1), catalyzer adopts tosic acid, the mol ratio of catalyzer and poly-peptide homopolymer is 25 ~ 45:1, solvent adopts dimethyl sulfoxide (DMSO), and reactant solution concentration is 5 ~ 15g:100mL.
4. a kind of PTMC according to claim 1 and polyvinylpyrrolidone method that poly-peptide film wetting ability is improved, it is characterized in that: step 2) in, the mass percent of polyvinylpyrrolidone in modified membrane is 1 ~ 3%, solvent adopts dimethyl sulfoxide (DMSO), and mixture solution concentration is 25 ~ 30g:100mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410080716.7A CN103819905B (en) | 2014-03-07 | 2014-03-07 | A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410080716.7A CN103819905B (en) | 2014-03-07 | 2014-03-07 | A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103819905A CN103819905A (en) | 2014-05-28 |
| CN103819905B true CN103819905B (en) | 2016-01-20 |
Family
ID=50755211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410080716.7A Expired - Fee Related CN103819905B (en) | 2014-03-07 | 2014-03-07 | A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103819905B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104497593B (en) * | 2015-01-05 | 2017-02-08 | 山东理工大学 | Method for improving hydrophilicity and flexibility of polyurethane and polyvinylpyrrolidone improved polypeptide film |
| CN104559225A (en) * | 2015-01-12 | 2015-04-29 | 山东理工大学 | Method for improving hydrophilicity and flexibility of polypeptide film by polytrimethylene carbonate and waterborne polyurethane |
| CN104559226B (en) * | 2015-01-12 | 2017-02-22 | 山东理工大学 | Method for improving hydrophilicity and flexibility of polypeptide film by polytrimethylene carbonate and carboxymethyl chitosan |
| CN105622954A (en) * | 2016-03-03 | 2016-06-01 | 山东理工大学 | Preparation method of polyvinyl alcohol-polypeptide-poly(trimethylene carbonate)-poly(lactic acid-glycolic acid) tri-grafted copolymer |
| CN105542486A (en) * | 2016-03-16 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyving akohol membrane by polycaprolactone and polypeptide-polyvinylpyrrolidone |
| CN105778522A (en) * | 2016-03-16 | 2016-07-20 | 山东理工大学 | Method for improving water tolerance and flexibility of polyvinyl alcohol membrane with poly (trimethylene carbonate) and polypeptide-polyvinyl pyrrolidone |
| CN105647198A (en) * | 2016-03-16 | 2016-06-08 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol membrane by using polycaprolactone and P(CPP-SA)-polyvinylpyrrolidone |
| CN105670307A (en) * | 2016-03-16 | 2016-06-15 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol membrane through polycaprolactone and poly(trimethylene carbonate)-polyvinylpyrrolidone |
| CN106987132A (en) * | 2017-05-22 | 2017-07-28 | 山东理工大学 | A kind of method that MPEGPLA improves polypropylene sorrel water resistance and compliance with PTMC |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282345A (en) * | 1997-10-03 | 2001-01-31 | 麦克罗梅德公司 | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| CN1324374A (en) * | 1998-10-01 | 2001-11-28 | 麦克罗梅德公司 | Biodegradable low molecular weight triblock polyester polyethylene glocol copolymers having reverse thermal gelation properties |
-
2014
- 2014-03-07 CN CN201410080716.7A patent/CN103819905B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282345A (en) * | 1997-10-03 | 2001-01-31 | 麦克罗梅德公司 | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| CN1324374A (en) * | 1998-10-01 | 2001-11-28 | 麦克罗梅德公司 | Biodegradable low molecular weight triblock polyester polyethylene glocol copolymers having reverse thermal gelation properties |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103819905A (en) | 2014-05-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103819905B (en) | A kind of method that PTMC and polyvinylpyrrolidone improve poly-peptide film wetting ability | |
| CN103865087B (en) | A kind of method that poly-peptide film kindliness is improved by poly(lactic acid) and PPDO | |
| CN103834180B (en) | A kind of method that polycaprolactone and polypropylene glycol improve poly-peptide film kindliness | |
| CN103865275B (en) | A kind of poly(lactic acid) and polypropylene glycol improve the method for polyvinyl alcohol film water tolerance | |
| CN103881398A (en) | Method for improving water resistance of polyvinyl alcohol film by using poly(trimethylene carbonate) and poly(p-dioxanone) | |
| CN103865089B (en) | A kind of poly(lactic acid) and PPDO improve the method for poly-peptide film kindliness | |
| CN103937269A (en) | Method for modifying water proofness of polyvinyl alcohol membrane by polypeptide and polycaprolactone | |
| CN103804865B (en) | A kind of method that PPDO and aqueous polyurethane improve poly-peptide film wetting ability | |
| CN103865085B (en) | A kind of PTMC and polyvinylpyrrolidone improve the poly-hydrophilic method of peptide film | |
| CN105542482A (en) | Method for modifying water resistance and flexibility of polyvinyl alcohol membrane through poly(p-dioxanone) and poly(lactic acid-glycolic acid) | |
| CN105542479A (en) | Method for improving water resistance and flexibility of polyvinyl alcohol film through poly(p-dioxanone) and poly lactic acid-glycolic acid | |
| CN103865090B (en) | A kind of method that polycaprolactone and polyoxyethylene glycol improve poly-peptide film wetting ability | |
| CN104448841A (en) | Method for improving hydrophilia and flexibility of poly peptide film through poly (lactic acid-glycolic acid) (PLGA) and polyacrylic acid | |
| CN105542483A (en) | Method for modifying water resistance and flexibility of polyvinyl alcohol membrane through poly(trimethylene carbonate) and poly(p-dioxanone) | |
| CN105542208A (en) | Method for improving water resistance and flexibility of polyvinyl alcohol film through polycaprolactone and poly(p-dioxanone) | |
| CN103819906B (en) | A kind of method that polypropylene glycol and PTMC are improved poly-peptide film kindliness | |
| CN103865088A (en) | Method for improving hydrophilia of polypeptide membrane by polycaprolactone and polyethylene glycol | |
| CN103865086B (en) | A kind of polycaprolactone and polypropylene glycol improve the method for poly-peptide film kindliness | |
| CN105566663A (en) | Method for improving water resistance and compliance of polyvinyl alcohol film with poly (p-dioxanone) and P (CPP-SA)-polyethylene glycol | |
| CN103819907B (en) | A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability | |
| CN103819908B (en) | A kind of method that PPDO and urethane improve poly-peptide film kindliness | |
| CN103804914B (en) | A kind of polypropylene glycol and polyvinyl alcohol improve the poly-hydrophilic method of peptide film | |
| CN103937270B (en) | A kind of polypropylene glycol and poly-(caprolactone-rac-Lactide) improve the method for polyvinyl alcohol film water tolerance | |
| CN105566922A (en) | Method for improving water resistance and compliance of polyvinyl alcohol film with poly trimethylene carbonate and P (CPP-SA)-polyethylene glycol | |
| CN103819701B (en) | A kind of method that PTMC and PTMG are improved poly-peptide film kindliness |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160120 Termination date: 20180307 |