CN103819907A - Method for improving polypeptide membrane hydrophilicity by adopting polypropylene glycol and polyvinyl alcohol - Google Patents
Method for improving polypeptide membrane hydrophilicity by adopting polypropylene glycol and polyvinyl alcohol Download PDFInfo
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- CN103819907A CN103819907A CN201410084364.2A CN201410084364A CN103819907A CN 103819907 A CN103819907 A CN 103819907A CN 201410084364 A CN201410084364 A CN 201410084364A CN 103819907 A CN103819907 A CN 103819907A
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Abstract
The invention discloses a method for improving polypeptide membrane hydrophilicity by adopting polypropylene glycol and polyvinyl alcohol. The method comprises the following steps: (1) synthesis of the polypeptide-polypropylene glycol graft copolymer: adding polypeptide homopolymer, polypropylene glycol monobutyl ether, a solvent and a catalyst into a dry reactor, under the inert atmosphere, and stirring and reacting for 3-4 days at the temperature of 55-58 DEG C, so that the target product is obtained through filtering, dialyzing and drying; (2) preparation for the polypeptide membrane modified by the polypropylene glycol and the polyvinyl alcohol: adding the polypeptide-polypropylene glycol graft copolymer, polyvinyl alcohol and a solvent into the dry reactor, under the inert atmosphere, stirring and mixing for 50-70 min at the temperature of 45-50 DEG C, forming the membrane through tape casting, and drying, so that the target product is obtained. The method has the advantages that the preparation technology is simple and easy to master, and the hydrophilicity of the modified membrane is improved greatly.
Description
Technical field
The present invention relates to one poly-peptide film wetting ability is carried out to improved method, belong to field of polymer film preparing technology.
Background technology
Poly-peptide is a kind of have good biocompatibility and biomaterial of biodegradability, and poly-peptide film can be used as artificial skin etc., but poly-peptide film lacks good wetting ability, thereby has limited to a certain extent its application.Polypropylene glycol has good biocompatibility and biodegradability, and has good blend with polyvinyl alcohol.Polyvinyl alcohol has good biocompatibility and biodegradability, and has good wetting ability.First polypropylene glycol segment is introduced to poly-peptide segment and formed poly-peptide-polypropylene glycol graft copolymer to improve the blend of poly-peptide, and then add poly-peptide-polypropylene glycol graft copolymer to form blend polyvinyl alcohol segments, make the poly-peptide film of modification, thereby greatly improved the wetting ability of poly-peptide film.
Summary of the invention
The object of the present invention is to provide a kind of simple to operate and effect preferably poly-peptide film wetting ability to be carried out to improved method.Its technical scheme is:
One is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, it is characterized in that: in modified membrane, the molecular weight of poly-peptide segment is 60000～80000, the molecular weight of polypropylene glycol segment is 1000～2000, and the molecular weight of polyvinyl alcohol segments is 4000～5000; Its method of modifying adopts following steps:
1) poly-peptide-polypropylene glycol graft copolymer is synthetic: in dry reactor, add poly-peptide homopolymer, polypropylene glycol monobutyl ether, solvent and catalyzer, under inert atmosphere, after 3～4 days, make target compound by filtering, dialyse, being dried in 55～58 ℃ of stirring reactions;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification: add poly-peptide-polypropylene glycol graft copolymer, polyethylene alcohol and solvent in dry reactor, under inert atmosphere, be uniformly mixed after 50～70 minutes in 40～50 ℃, by casting method film forming dry, obtain target compound.
Described one is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, in step 1), poly-peptide homopolymer adopts poly-(r-phenmethyl-Pidolidone ester), poly-(r-ethyl-Pidolidone ester) or poly-(r-methyl-Pidolidone ester), and the mol ratio of polypropylene glycol monobutyl ether and poly-peptide homopolymer is 15～25:1.
Described one is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, in step 1), catalyzer adopts tosic acid, and the mol ratio of catalyzer and poly-peptide homopolymer is 25～45:1, solvent adopts dimethyl sulfoxide (DMSO), and reactant solution concentration is 5～15 g:100 ml.
Described one is carried out improved method, step 2 with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability) in, the mass percent of polyvinyl alcohol in modified membrane is 1～3%, and solvent adopts dimethyl sulfoxide (DMSO), and mixture solution concentration is 25～30 g:100 ml.
Compared with prior art, its advantage is in the present invention:
1, described polypropylene glycol and polyvinyl alcohol improve the poly-hydrophilic method of peptide film, adopt graft copolymerization and two kinds of means of blend, simple to operate, be easy to grasp;
2, described poly-peptide modified membrane wetting ability is greatly improved.
Embodiment
embodiment 1
1) poly-peptide-polypropylene glycol graft copolymer is synthetic:
In dry reactor, adding 12 gram molecular weights is polypropylene glycol monobutyl ether, the 0.9 gram of tosic acid that 60000 poly-(r-phenmethyl-Pidolidone esters), 3.1 gram molecular weights are 1000, add again 260 milliliters of dimethyl sulfoxide solvents, under inert atmosphere, in 55 ℃ of stirring reactions after 3 days, termination reaction, then make target compound by filtering, dialyse, being dried;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification:
In dry reactor, add 10 grams of poly-peptide-polypropylene glycol graft copolymers and 38 milliliters of dimethyl sulfoxide solvents, separately add the polyvinyl alcohol (molecular weight is 4000) that accounts for modified membrane gross weight 1%, under inert atmosphere, be uniformly mixed after 50 minutes in 40 ℃, use casting method film forming, the dry target compound that obtains in 50 ℃ of vacuum drying ovens.
After tested: the hydrophilic rate of target compound of the present invention has improved 12.9% before than modification.
embodiment 2
1) poly-peptide-polypropylene glycol graft copolymer is synthetic:
In dry reactor, adding 12 gram molecular weights is polypropylene glycol monobutyl ether, the 0.91 gram of tosic acid that 70000 poly-(r-ethyl-Pidolidone esters), 5.3 gram molecular weights are 1500, add again 230 milliliters of dimethyl sulfoxide solvents, under inert atmosphere, in 56 ℃ of stirring reactions after 4 days, termination reaction, then make target compound by filtering, dialyse, being dried;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification:
In dry reactor, add 10 grams of poly-peptide-polypropylene glycol graft copolymers and 36 milliliters of dimethyl sulfoxide solvents, separately add the polyvinyl alcohol (molecular weight is 4500) that accounts for modified membrane gross weight 2%, under inert atmosphere, be uniformly mixed after 60 minutes in 45 ℃, use casting method film forming, the dry target compound that obtains in 50 ℃ of vacuum drying ovens.
After tested: the hydrophilic rate of target compound of the present invention has improved 14.9% before than modification.
embodiment 3
1) poly-peptide-polypropylene glycol graft copolymer is synthetic:
In dry reactor, adding 12 gram molecular weights is polypropylene glycol monobutyl ether, the 1.03 grams of tosic acid that 80000 poly-(r-methyl-Pidolidone esters), 7.2 gram molecular weights are 2000, add again 177 milliliters of dimethyl sulfoxide (DMSO), under inert atmosphere, in 58 ℃ of stirring reactions after 3 days, termination reaction, then make target compound by filtering, dialyse, being dried;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification:
In dry reactor, add 10 grams of poly-peptide-polypropylene glycol graft copolymers and 35.5 milliliters of dimethyl sulfoxide (DMSO), separately add the polyvinyl alcohol (molecular weight is 5000) that accounts for modified membrane gross weight 3%, under inert atmosphere, be uniformly mixed after 70 minutes in 50 ℃, use casting method film forming, the dry target compound that obtains in 50 ℃ of vacuum drying ovens.
After tested: the hydrophilic rate of target compound of the present invention has improved 16.8% before than modification.
Claims (4)
1. one kind is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, it is characterized in that: in modified membrane, the molecular weight of poly-peptide segment is 60000～80000, the molecular weight of polypropylene glycol segment is 1000～2000, and the molecular weight of polyvinyl alcohol segments is 4000～5000; Its method of modifying adopts following steps:
1) poly-peptide-polypropylene glycol graft copolymer is synthetic: in dry reactor, add poly-peptide homopolymer, polypropylene glycol monobutyl ether, solvent and catalyzer, under inert atmosphere, after 3～4 days, make target compound by filtering, dialyse, being dried in 55～58 ℃ of stirring reactions;
2) preparation of the poly-peptide film of polypropylene glycol and polyvinyl alcohol modification: add poly-peptide-polypropylene glycol graft copolymer, polyethylene alcohol and solvent in dry reactor, under inert atmosphere, be uniformly mixed after 50～70 minutes in 40～50 ℃, by casting method film forming dry, obtain target compound.
2. one according to claim 1 is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, it is characterized in that: in step 1), poly-peptide homopolymer adopts poly-(r-phenmethyl-Pidolidone ester), poly-(r-ethyl-Pidolidone ester) or poly-(r-methyl-Pidolidone ester), and the mol ratio of polypropylene glycol monobutyl ether and poly-peptide homopolymer is 15～25:1.
3. one according to claim 1 is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, it is characterized in that: in step 1), catalyzer adopts tosic acid, the mol ratio of catalyzer and poly-peptide homopolymer is 25～45:1, solvent adopts dimethyl sulfoxide (DMSO), and reactant solution concentration is 5～15 g:100 ml.
4. one according to claim 1 is carried out improved method with polypropylene glycol and polyvinyl alcohol to poly-peptide film wetting ability, it is characterized in that: step 2) in, the mass percent of polyvinyl alcohol in modified membrane is 1～3%, solvent adopts dimethyl sulfoxide (DMSO), and mixture solution concentration is 25～30 g:100 ml.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410084364.2A CN103819907B (en) | 2014-03-10 | 2014-03-10 | A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability |
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| CN201410084364.2A CN103819907B (en) | 2014-03-10 | 2014-03-10 | A kind of method that polypropylene glycol and polyvinyl alcohol improve poly-peptide film wetting ability |
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| CN103819907A true CN103819907A (en) | 2014-05-28 |
| CN103819907B CN103819907B (en) | 2016-04-06 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104559214A (en) * | 2015-01-06 | 2015-04-29 | 山东理工大学 | Method for improving hydrophily and flexibility of polypeptide membrane by polypropylene glycol and polyacrylic acid |
| CN105542207A (en) * | 2016-03-07 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol film through polypropylene glycol and polypeptide-polyvinylpyrrolidone |
| CN105542178A (en) * | 2016-03-07 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol film through poly(trimethylene carbonate) and polypeptide |
| CN105622951A (en) * | 2016-03-03 | 2016-06-01 | 山东理工大学 | Method for preparing polyvinyl alcohol-polytrimethylene carbonate-polypeptide double grafted copolymer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012159084A1 (en) * | 2011-05-18 | 2012-11-22 | Baxter International, Inc. | Modification-dependent activity assays |
| CN103242536A (en) * | 2013-05-09 | 2013-08-14 | 山东理工大学 | Method for preparing polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer |
-
2014
- 2014-03-10 CN CN201410084364.2A patent/CN103819907B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012159084A1 (en) * | 2011-05-18 | 2012-11-22 | Baxter International, Inc. | Modification-dependent activity assays |
| CN103242536A (en) * | 2013-05-09 | 2013-08-14 | 山东理工大学 | Method for preparing polypeptide-polylactic acid-polyethyleneglycol dual-graft copolymer |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104559214A (en) * | 2015-01-06 | 2015-04-29 | 山东理工大学 | Method for improving hydrophily and flexibility of polypeptide membrane by polypropylene glycol and polyacrylic acid |
| CN104559214B (en) * | 2015-01-06 | 2017-02-08 | 山东理工大学 | Method for improving hydrophily and flexibility of polypeptide membrane by polypropylene glycol and polyacrylic acid |
| CN105622951A (en) * | 2016-03-03 | 2016-06-01 | 山东理工大学 | Method for preparing polyvinyl alcohol-polytrimethylene carbonate-polypeptide double grafted copolymer |
| CN105542207A (en) * | 2016-03-07 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol film through polypropylene glycol and polypeptide-polyvinylpyrrolidone |
| CN105542178A (en) * | 2016-03-07 | 2016-05-04 | 山东理工大学 | Method for improving water resistance and flexibility of polyvinyl alcohol film through poly(trimethylene carbonate) and polypeptide |
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| CN103819907B (en) | 2016-04-06 |
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