CN103816086A - Whitening traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Whitening traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a whitening traditional Chinese medicine composition as well as a preparation method and application thereof. The preparation method comprises the steps as follows: raw materials comprising safflower, notoginseng, sanguis draconis and persimmon leaf are weighed; the safflower is taken, crushed and then subjected to heating, reflux extraction is performed through an alcohol aqueous solution, and an extraction solution is filtered, and pressure-reduction concentration is performed to obtain a thick paste; the notoginseng is taken and crushed, heating reflux extraction is performed through petroleum ether, chloroform or acetidin, and an extraction solution is filtrated, and pressure-reduction concentration is performed to obtain another thick paste; the sanguis draconis is taken and crushed, pressure-reduction concentration is performed through a 95-percent alcohol aqueous solution, an extraction solution is filtrated, pressure-reduction concentration is performed through to remove alcohol, so that a concentrated solution is obtained, the concentrated solution is placed in water, uniformly agitated, filtrated, extracted by the petroleum ether and then extracted through acetidin to obtain a third thick paste; the persimmon leaf is taken, and crushed, heating reflux extraction is performed through the alcohol aqueous solution, an extraction solution is filtered, and pressure-reduction concentration is performed to obtain a fourth thick paste; all the thick pastes are uniformly mixed. Experiment results show that the whitening traditional Chinese medicine composition disclosed by the invention can resist the activity of tyrosinase, and enables the skin to keep healthy and white for a long time.
Description
Technical field
The present invention relates to a kind of Chinese medicine lightening compositions and its preparation method and application.
Background technology
Because the traditional view of " a white screening hundred is ugly ", Asia women is with Bai Weimei; And western countries due to Exposure to Sunlight in recent years cause a series of skin problems, whitening also becomes a kind of trend, therefore the demand of whitening product increases day by day.
At present, the whitening product kind on market, most whitening product poor effect, and some product is in skin whitening, band is served hidden danger, therefore, needs the one can be safe and effective, the whitening product of stable curative effect.
The color of human skin is mainly determined by melanic content in skin and concentration, tryrosinase is in organism, to participate in the synthetic key enzyme of melanin, be many subunits of the cupric oxidoreductase that is extensively present in occurring in nature, extremely increase with chloasma, melanin, the pigmentation disease such as vitiligo is closely related.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of preparation method of Chinese medicine lightening compositions is provided.
Second object of the present invention is to provide a kind of Chinese medicine lightening compositions.
The 3rd object of the present invention is to provide a kind of application of Chinese medicine lightening compositions.
Technical scheme of the present invention is summarized as follows:
A preparation method for Chinese medicine lightening compositions, comprises the steps:
(1) take by weight following raw material: Flos Carthami 20-50 part, Radix Notoginseng 20-50 part, Sanguis Draxonis 10-30 part, Folium Kaki 10-30 part;
(2) get Flos Carthami, pulverize, the ethanol water heating and refluxing extraction that is 50%-95% by described Flos Carthami weight 6-10 volume fraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL;
(3) get Radix Notoginseng, pulverize, by petroleum ether doubly of described three seven weight 6-10, chloroform or ethyl acetate heating and refluxing extraction 1-3 time, 2-4 hour at every turn, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by described Sanguis Draxonis weight 6-10 volume fraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 1-3 volume water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:1-2 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:1-2 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 1-2g/mL;
(5) get Folium Kaki, pulverize, the ethanol water heating and refluxing extraction that is 30%-50% by described Folium Kaki weight 6-10 volume fraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
Step (1) is preferably and takes by weight following raw material: Flos Carthami 25-35 part, Radix Notoginseng 25-35 part, Sanguis Draxonis 15-25 part, Folium Kaki 15-25 part.
Chinese medicine lightening compositions prepared by the preparation method of above-mentioned a kind of Chinese medicine lightening compositions.
Above-mentioned Chinese medicine lightening compositions is in the application of preparing in skin-lightening cosmetic.
Experimental results show that the activity that a kind of Chinese medicine lightening compositions of the present invention can restraint of tyrosinase, can make the skin pale state of keeping fit for a long time.
In the present composition, Flos Carthami has promoting blood circulation to restore menstrual flow, and effect of stasis-dispelling and pain-killing can blood circulation promoting, promotes melanin to decompose, and has very strong beauty functions; In Radix Notoginseng, be rich in the effective ingredient such as arasaponin, Radix Notoginseng polysaccharide, dencichine, flavone, there is the effect such as blood circulation promoting and enriching, blood circulation promoting, Radix Notoginseng total arasaponins and flavones ingredient can also improve serum superoxide dismutases, reduced glutathion and catalatic level, have stronger free radical resisting, antioxidation; Sanguis Draxonis has effect of dissipating blood stasis analgesic therapy, hemostasis, promoting tissue regeneration and ulcer healing, can brighten by evacuation of pus granulation promoting ， Qu über, moist skin; In Folium Kaki, contain the effective ingredient such as abundant vitamin C, rutin, choline, flavonoid glycoside, carotene, aminoacid, can lower peroxide content in serum, improve superoxide dismutase content, remove free radical, there is antioxidative effect, vitamin C, aminoacid and the carotene etc. that are rich in Folium Kaki can skin care, keeps skin fitness, has good beauty functions.
Accompanying drawing explanation
Fig. 1 is the OD value of Chinese medicine lightening compositions of the present invention to tyrosinase inhibitory action, wherein: * and relatively P<0.05** and relatively P<0.01 of blank group of blank group.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
A preparation method for Chinese medicine lightening compositions, comprises the steps:
(1) take by weight following raw material: 30 parts, Flos Carthami, 30 parts of Radix Notoginseng, 20 parts of Sanguis Draxonis, 20 parts of Folium Kaki;
(2) get Flos Carthami, pulverize, the ethanol water that is 75% by the volume fraction of 8 times of Flos Carthami weight, heating and refluxing extraction 2 times, each 3 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1.5g/mL;
(3) get Radix Notoginseng, pulverize, by the ethyl acetate of 8 times of three seven weight, heating and refluxing extraction 2 times, each 3 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1.5g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by the volume fraction of 8 times of Sanguis Draxonis weight 2 times, each 3 hours, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 2 volumes water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:1.5 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:1.5 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 1.5g/mL;
(5) get Folium Kaki, pulverize, the ethanol water that is 40% by the volume fraction of 8 times of described Folium Kaki weight, heating and refluxing extraction 2 times, each 3 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1.5g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
Embodiment 2
A preparation method for Chinese medicine lightening compositions, comprises the steps:
(1) take by weight following raw material: 25 parts, Flos Carthami, 35 parts of Radix Notoginseng, 15 parts of Sanguis Draxonis, 25 parts of Folium Kaki;
(2) get Flos Carthami, pulverize, the ethanol water that is 50% by the volume fraction of 10 times of Flos Carthami weight, heating and refluxing extraction 1 time, each 4 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1g/mL;
(3) get Radix Notoginseng, pulverize, by the chloroform of 10 times of three seven weight, heating and refluxing extraction 1 time, each 4 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by the volume fraction of 10 times of Sanguis Draxonis weight 1 time, each 4 hours, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 1 volume water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:1 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:1 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 1g/mL;
(5) get Folium Kaki, pulverize, the ethanol water heating and refluxing extraction that is 30% by the volume fraction of 10 times of Folium Kaki weight 1 time, each 4 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
Embodiment 3
A preparation method for Chinese medicine lightening compositions, comprises the steps:
(1) take by weight following raw material: 35 parts, Flos Carthami, 25 parts of Radix Notoginseng, 25 parts of Sanguis Draxonis, 15 parts of Folium Kaki;
(2) get Flos Carthami, pulverize, the ethanol water that is 95% by the volume fraction of 6 times of Flos Carthami weight, heating and refluxing extraction 3 times, each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 2g/mL;
(3) get Radix Notoginseng, pulverize, by the petroleum ether of 6 times of three seven weight, heating and refluxing extraction 3 times, each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 2g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by the volume fraction of 6 times of Sanguis Draxonis weight 3 times, each 2 hours, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 3 volumes water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:2 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:2 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 2g/mL;
(5) get Folium Kaki, pulverize, the ethanol water heating and refluxing extraction that is 50% by the volume fraction of 6 times of Folium Kaki weight 3 times, each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 2g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
Embodiment 4
A preparation method for Chinese medicine lightening compositions, comprises the steps:
(1) take by weight following raw material: 20 parts, Flos Carthami, 50 parts of Radix Notoginseng, 10 parts of Sanguis Draxonis, 30 parts of Folium Kaki;
(2) get Flos Carthami, pulverize, the ethanol water that is 50% by the volume fraction of 10 times of Flos Carthami weight, heating and refluxing extraction 1 time, each 4 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1g/mL;
(3) get Radix Notoginseng, pulverize, by the chloroform of 10 times of three seven weight, heating and refluxing extraction 1 time, each 4 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by the volume fraction of 10 times of Sanguis Draxonis weight 1 time, each 4 hours, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 1 volume water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:1 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:1 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 1g/mL;
(5) get Folium Kaki, pulverize, the ethanol water heating and refluxing extraction that is 30% by the volume fraction of 10 times of Folium Kaki weight 1 time, each 4 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 1g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
Embodiment 5
A preparation method for Chinese medicine lightening compositions, comprises the steps:
(1) take by weight following raw material: 50 parts, Flos Carthami, 20 parts of Radix Notoginseng, 30 parts of Sanguis Draxonis, 10 parts of Folium Kaki;
(2) get Flos Carthami, pulverize, the ethanol water that is 95% by the volume fraction of 6 times of Flos Carthami weight, heating and refluxing extraction 3 times, each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 2g/mL;
(3) get Radix Notoginseng, pulverize, by the petroleum ether of 6 times of three seven weight, heating and refluxing extraction 3 times, each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 2g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by the volume fraction of 6 times of Sanguis Draxonis weight 3 times, each 2 hours, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 3 volumes water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:2 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:2 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 2g/mL;
(5) get Folium Kaki, pulverize, the ethanol water heating and refluxing extraction that is 50% by the volume fraction of 6 times of Folium Kaki weight 3 times, each 2 hours, extracting liquid filtering, filtrate decompression is concentrated into the thick paste that density is 2g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
Embodiment 6
Tyrosinase activity suppression ratio is measured
(1) preparation of phosphate buffer (pH=6.8):
Sodium hydrogen phosphate and sodium dihydrogen phosphate are made into respectively to the solution of 0.1mol/L, get disodium phosphate soln 231.5mL, add sodium dihydrogen phosphate 268.5mL, be diluted with water to 750mL, shake up, to obtain final product.
(2) preparation of tryrosinase solution:
Get the tryrosinase that unit of activity is 1881U/mg, be made into the solution of 0.8mg/mL with phosphate buffer (pH=6.8), to obtain final product.
(3) preparation of L-3,4 dihydroxyphenylalanine solution:
It is 0.005% solution that phosphate buffer for L-3,4 dihydroxyphenylalanine (pH=6.8) is mixed with concentration, to obtain final product.
(4) Chinese medicine lightening compositions embodiment 1,2,3,4 and 5 being prepared, the Flos Carthami extract thick paste that embodiment 1 step (2) obtains, the Radix Notoginseng extract thick paste that embodiment 1 step (3) obtains, the Sanguis Draxonis extract thick paste that embodiment 1 step (4) obtains, the persimmon leaf extract thick paste that embodiment 1 step (5) obtains; Be made into dmso solution the solution that concentration is 1mg/ml respectively, then use phosphate buffer (pH=6.8) to prepare respectively the sample diluting liquid of 10 μ g/mL, in 4 degree Refrigerator stores, for subsequent use;
Before mensuration, accurately prepare with micropipettor:
C1 test specimens: add 50 μ L-Tyr enzymatic solution in 100 μ L phosphate buffered solution (pH=6.8);
C2 test specimens: 150 μ L phosphate buffered solution (pH=6.8);
T1 test specimens: 100 μ L sample diluting liquids add 50 μ L-Tyr enzymatic solution;
T2 test specimens: 50 μ L phosphate buffered solution (pH=6.8) add 100 μ L sample diluting liquids;
Add respectively in 96 orifice plates, after 25 ℃ of constant temperature water bath reaction 10min, add 50 μ L L-3,4 dihydroxyphenylalanine solution, continue isothermal reaction 1h 25 ℃ of water-baths, after reaction finishes, measure respectively immediately the absorbance A of the T2 of the T1 of C1, C2,9 samples, 9 samples in 490nm place
c1, A
c2, A
t1, A
t2, select kojic acid as positive control, detect the inhibitory action to tryrosinase, represent the inhibitory action to tryrosinase with the suppression ratio of tryrosinase.Suppression ratio=[1-(the A of tryrosinase
t1-A
t2)/(A
c1-A
c2)] × 100%.
(5) result of the test shows that the compositions of embodiment 1,2,3,4 and 5 has significance inhibitory action to tryrosinase.See Fig. 1.
Embodiment 7
The preparation of Chinese medicine lightening compositions solution
Table 1 Chinese medicine lightening compositions solution formula
1, accurately weigh every in mutually of A, put it in water tank and heat, while being heated to 85 ℃, the B of mix homogeneously is added to, keep after 20 minutes, in suction emulsion tank, opening cooling water circulation cooling;
2, be cooled to 40 ℃ and be added to weighing C accurately, stir discharging after 20 minutes, make the solution of Chinese medicine lightening compositions.
Embodiment 8
The preparation of Chinese medicine lightening compositions Emulsion
Table 2 Chinese medicine lightening compositions emulsion formulations
1, accurately weigh A every in mutually, joined in oil phase heating tank, be heated to 80 ℃, be incubated sterilizing in 20 minutes, for subsequent use; 2, accurately weigh in B everyly, joined in water heating tank, be heated to 80 ℃, be incubated sterilizing in 20 minutes, for subsequent use; 3, by B phase suction emulsion tank, keep emulsion tank temperature at 80 ℃, open homogenizing and stirring, mixing speed is 20 revs/min, by A slowly join mutually B mutually in, add rear homogenizing completely 300 seconds, after homogenizing finishes, continue to stir 15 minutes, open cooling water, rotating speed is reduced to 12 revs/min;
4, be cooled to 40 ℃, C is added in emulsion tank, continue to stir discharging after 30 minutes, make the Emulsion of Chinese medicine lightening compositions.
Embodiment 9
The preparation of Chinese medicine lightening compositions cream
Table 3 Chinese medicine lightening compositions cream formula
1, accurately weigh A every in mutually, joined in oil phase heating tank, be heated to 80 ℃, be incubated sterilizing in 20 minutes, for subsequent use; 2, accurately weigh in B everyly, joined in water heating tank, be heated to 80 ℃, be incubated sterilizing in 20 minutes, for subsequent use; 3, by B phase suction emulsion tank, keep emulsion tank temperature at 80 ℃, open homogenizing and stirring, mixing speed is 20 revs/min, by A slowly join mutually B mutually in, add rear homogenizing completely 300 seconds, after homogenizing finishes, continue to stir 15 minutes, open cooling water, rotating speed is reduced to 12 revs/min;
4, while being cooled to 40 ℃, C is added in emulsion tank, continues to stir discharging after 30 minutes, make Chinese medicine lightening compositions cream.
Embodiment 10
Embodiment 7,8,9 is carried out to clinic trial observation.
Number of cases on probation: choosing face has the crowd of pigementation, dark yellow skin problem, age 25-45 year, wherein women's 60 examples, are divided into three groups at random, and male's 60 examples are divided into three groups at random.
Using method: after sooner or later clean face, the product of getting appropriate embodiment 7,8,9 preparations is evenly applied in face, pats and absorbs gently, and massage gently 3-5 minute, allows skin fully absorb; It within 28 days, is a course for the treatment of.
Criterion of therapeutical effect: (1) is effective: pigment is dark yellow to disappear more than 90%; (2) effective: pigment is dark yellow to disappear more than 50%; (3) invalid: the dark yellow nothing of pigment disappears.
It is that the effective percentage of 92.5%, embodiment 8 is that the effective percentage of 95%, embodiment 9 is 95% that result on trial shows to use the effective percentage of embodiment 7 after 42 days, and total effective rate is 94%.
Compositions of the present invention can also be prepared corresponding spray, gel, membrane, unguentum and suspensoid.
Claims (4)
1. a preparation method for Chinese medicine lightening compositions, is characterized in that comprising the steps:
(1) take by weight following raw material: Flos Carthami 20-50 part, Radix Notoginseng 20-50 part, Sanguis Draxonis 10-30 part, Folium Kaki 10-30 part;
(2) get Flos Carthami, pulverize, the ethanol water heating and refluxing extraction that is 50%-95% by described Flos Carthami weight 6-10 volume fraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL;
(3) get Radix Notoginseng, pulverize, by petroleum ether doubly of described three seven weight 6-10, chloroform or ethyl acetate heating and refluxing extraction 1-3 time, 2-4 hour at every turn, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL;
(4) get Sanguis Draxonis, pulverize, the ethanol water heating and refluxing extraction that is 95% by described Sanguis Draxonis weight 6-10 volume fraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, concentrating under reduced pressure is removed ethanol and is obtained concentrated solution, concentrated solution is put into 1-3 volume water doubly, stir, remove by filter and precipitate to obtain filtrate, be the ratio of 1:1-2 by volume, by filtrate petroleum ether extraction; Be the ratio of 1:1-2 by volume again, the filtrate after petroleum ether extraction is extracted with ethyl acetate, acetic acid ethyl acetate extract is evaporated to the thick paste that density is 1-2g/mL;
(5) get Folium Kaki, pulverize, the ethanol water heating and refluxing extraction that is 30%-50% by described Folium Kaki weight 6-10 volume fraction doubly 1-3 time, each 2-4 hour, extracting liquid filtering, is evaporated to the thick paste that density is 1-2g/mL;
(6) thick paste mix homogeneously step (2), (3), (4) and (5) being obtained, obtains a kind of Chinese medicine lightening compositions.
2. the preparation method of a kind of Chinese medicine lightening compositions according to claim 1, is characterized in that described step (1) is for taking by weight following raw material: Flos Carthami 25-35 part, Radix Notoginseng 25-35 part, Sanguis Draxonis 15-25 part, Folium Kaki 15-25 part.
3. the Chinese medicine lightening compositions that prepared by the preparation method of a kind of Chinese medicine lightening compositions of claim 1 or 2.
4. the Chinese medicine lightening compositions of claim 3 is in the application of preparing in skin-lightening cosmetic.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104288039A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Method for preparing traditional Chinese medicine ointment for skin whitening |
| CN104522876A (en) * | 2014-11-25 | 2015-04-22 | 云南中烟工业有限责任公司 | Persimmon extract for cigarettes and application of persimmon extract for cigarettes |
| CN107467969A (en) * | 2017-08-28 | 2017-12-15 | 安吉万昌家具有限公司 | A kind of safe and healthy antibiotic bed mattress and preparation method thereof |
| CN113693974A (en) * | 2020-09-26 | 2021-11-26 | 北京御本堂控股集团有限公司 | Persimmon leaf clear paste and preparation method thereof, freckle removing composition and application thereof, freckle removing preparation and preparation method of freckle removing paste |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288039A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Method for preparing traditional Chinese medicine ointment for skin whitening |
| CN104522876A (en) * | 2014-11-25 | 2015-04-22 | 云南中烟工业有限责任公司 | Persimmon extract for cigarettes and application of persimmon extract for cigarettes |
| CN107467969A (en) * | 2017-08-28 | 2017-12-15 | 安吉万昌家具有限公司 | A kind of safe and healthy antibiotic bed mattress and preparation method thereof |
| CN113693974A (en) * | 2020-09-26 | 2021-11-26 | 北京御本堂控股集团有限公司 | Persimmon leaf clear paste and preparation method thereof, freckle removing composition and application thereof, freckle removing preparation and preparation method of freckle removing paste |
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| CN103816086B (en) | 2015-12-30 |
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