Summary of the invention
The technical problem to be solved in the present invention is for above deficiency, a kind of medicine and preparation method for the treatment of intractable acne is provided, overcome the poor defect of therapeutic effect in prior art, adopted after medicine of the present invention, had advantages of that therapeutic effect is good, have no side effect, do not stay scar, not repeatedly.
For solving above technical problem, the present invention is by the following technical solutions: a kind of medicine for the treatment of intractable acne, it is characterized in that: its effective ingredient and weight portion are: 18~21 parts of Folium Eriobotryaes, 17~20 parts, Folium Mori, 18~22 parts of Cortex Mori, 20~24 parts of Flos Loniceraes, 15~20 parts of Herba Taraxaci, 10~15 parts of Fructus Forsythiaes, 8~12 parts of Cortex Phellodendris, 20~25 parts of Radix Angelicae Sinensis, 10~12 parts of Rhizoma Chuanxiongs, 8~12 parts of Radix Paeoniae Rubra, 9~13 parts of Cortex Moutans, 8~11 parts, Flos Carthami, 9~12 parts of eupolyphaga, 17~20 parts of Herba Artemisiae Scopariaes, 18~20 parts of Semen Coiciss, 8~10 parts of Herba Eupatoriis, 14~16 parts of Radix Et Rhizoma Rhei, 15~17 parts of Herba Hedyotidis Diffusaes, 10~18 parts of Spina Gleditsiae, 10~16 parts of Flos Chrysanthemi Indicis, 20~25 parts of Herba Violaes, 12~15 parts of the Flos Sophorae Immaturus, 12~15 parts of 14~20 parts of Rhizoma Alismatis and Fructus Crataegi.
A kind of prioritization scheme, the effective ingredient of described medicine and weight portion are: 15 parts of 20 parts of Folium Eriobotryaes, 20 parts, Folium Mori, 20 parts of Cortex Mori, 20 parts of Flos Loniceraes, 20 parts of Herba Taraxaci, 10 parts of Fructus Forsythiaes, 10 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Radix Paeoniae Rubra, 10 parts of Cortex Moutans, 10 parts, Flos Carthami, 10 parts of eupolyphaga, 20 parts of Herba Artemisiae Scopariaes, 20 parts of Semen Coiciss, 10 parts of Herba Eupatoriis, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Hedyotidis Diffusaes, 15 parts of Spina Gleditsiae, 15 parts of Flos Chrysanthemi Indicis, 20 parts of Herba Violaes, 15 parts of the Flos Sophorae Immaturus, 15 parts of Rhizoma Alismatis and Fructus Crataegi.
In above raw material:
Folium Eriobotryae, bitter in the mouth, cold nature, attaches to the lung and stomach meridians, and has effect of clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI, cures mainly cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup, can treat that xerostomia is quenched one's thirst, lung-wind syndrome acne vulgaris, acne.
Folium Mori, bitter in the mouth, sweet, cold in nature, return lung, Liver Channel, there is effect of anti-inflammation, heat-clearing and toxic substances removing, loose wind heat extraction, liver heat removing and eyesight improving, YIN nourishing and the production of body fluid promoting, the eyes that cures mainly anemopyretic cold, dryness-heat impairing the lung, excessive rising of liver-YANG and wind heat or liver-fire conjunctival congestion flu, dryness-heat impairing the lung, excessive rising of liver-YANG and wind heat or liver-fire conjunctival congestion and swelling pain, deficiecny of liver-YIN is dim-sighted, in addition, and can also cooling blood for hemostasis.
Cortex Mori, sweet in the mouth, pungent, cold in nature, return lung, spleen channel, there is effect of eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, cure mainly lung-heat cough with asthma, the edema of the face, dysuria.
Flos Lonicerae, sweet in the mouth, cold in nature, GUIXIN, lung, stomach, large intestine channel, have effect of heat-clearing and toxic substances removing, wind-heat dissipating, cures mainly carbuncle furuncle, sore throat, erysipelas, warm blood fulminant dysentery, anemopyretic cold, epidemic febrile disease heating.
Herba Taraxaci, have another name called Herba Taraxaci, bitter in the mouth, sweet, cold in nature, return liver, stomach warp, there is effect of heat-clearing and toxic substances removing, diuresis eliminating stagnation, cure mainly acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
Fructus Forsythiae, bitter in the mouth, cold nature, enters the heart, lung, small intestine meridian, has effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, cure mainly carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma send out speckle, pyretic stranguria urine retention.
Cortex Phellodendri, bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, effect except hectic fever due to YIN-deficiency clearind deficient heat, cure mainly hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Radix Angelicae Sinensis, sweet in the mouth, pungent, bitter, warm in nature, return liver, the heart, spleen channel, have enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation, cure mainly that all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot are poly-, weight, ulcer sores, injury from falling down after metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, bloody dysentery.
Rhizoma Chuanxiong, acrid in the mouth, warm in nature, return liver, gallbladder, heart channel, there is effect of blood-activating and qi-promoting, wind-expelling pain-stopping, cure mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia stomachache, lump, heart pain in chest and hypochondrium, traumatic injury swell and ache, have a headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores.
Radix Paeoniae Rubra, bitter in the mouth, cold nature, returns Liver Channel, has effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, cures mainly that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.
Cortex Moutan, have another name called Cortex Moutan, bitter in the mouth, cool, cold nature, GUIXIN, liver, kidney, lung meridian, there is effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, cure mainly the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, hot Fu Yin of calentura later stage divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the pain of injury, rheumatism pyretic arthralgia.
Flos Carthami, acrid in the mouth, warm in nature, return liver, kidney channel, there is effect of promoting blood circulation to restore menstrual flow, blood-activating analgetic, cure mainly enclosed mass in blood stasis amenorrhea, dysmenorrhea, abdomen.
Eupolyphaga, salty in the mouth, cold in nature, return Liver Channel, there is effect of removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones, cure mainly injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
Herba Artemisiae Scopariae, bitter in the mouth, pungent, cold nature, returns spleen, stomach, liver, gallbladder meridian, has effect of clearing away heat-damp and promoting diuresis, jaundice eliminating, cures mainly jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.
Semen Coicis, sweet in the mouth, warm in nature, return spleen, stomach warp, there is effect of invigorating spleen to remove dampness, clearing away heat and discharging pus, cure mainly cold syndrome of the stomach pain, deficient qi and blood.
Herba Eupatorii, acrid in the mouth, property is flat, returns spleen, stomach, lung meridian, has removing dampness by means of aromatics, the appetizing of being amusing, delivers effect of expelling summer-heat, cures mainly sweet greasy, halitosis in turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, mouth, sialism, heat-damp in summer table disease, feeling of fullness in the head uncomfortable in chest.
Radix Et Rhizoma Rhei, bitter in the mouth, cold in nature, return spleen, stomach, large intestine, liver, pericardium channel, there is the effect of attacking stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances, cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, haematemesis, spitting of blood, epistaxis, have blood in stool, hematuria, blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scald.
Herba Hedyotidis Diffusae, bitter in the mouth, light, cold in nature, there is effect of heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness, cure mainly tonsillitis, pharyngolaryngitis, urinary tract infection, pelvic inflammatory disease, appendicitis, hepatitis, bacillary dysentery, venom, tumor.
Spina Gleditsiae, acrid in the mouth, warm in nature, return liver, stomach warp, there is effect of the evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence, cure mainly that carbuncle, sore, pus become not burst, scabies.
Flos Chrysanthemi Indici, bitter in the mouth, pungent, cold nature, returns lung, Liver Channel, has effect of heat-clearing and toxic substances removing, detumescence, cures mainly furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension.
Herba Violae, bitter in the mouth, cold in nature, GUIXIN, Liver Channel, have effect of heat-clearing and toxic substances removing, cures mainly that carbuncle sore is swollen, jaundice interior-heat, children's's nose bleeding, appendicitis, venom.
The Flos Sophorae Immaturus, sweet in the mouth, flat, cold in nature, cool, return liver, large intestine channel, there is effect of cooling blood for hemostasis, liver heat removing pathogenic fire reducing, cure mainly discharging fresh blood stool, hemorrhoidal bleeding, hematuria, stranguria with blood, metrorrhagia,, dysentery with red and white feces, the diseases such as conjunctival congestion, sore, hypertension.
Rhizoma Alismatis, sweet in the mouth, light, cold in nature, return kidney, urinary bladder channel, there is promoting diuresis to eliminate damp pathogen, the treating stranguria effect that expels the heat-evil, cure mainly dysuria, the puckery pain of pyretic stranguria, edema distension, have loose bowels, dizziness due to fluid-retention, seminal emission.
Fructus Crataegi, sour in the mouth, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel, has effect of promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, cures mainly meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipemia.
The present invention also provides a kind of preparation method of medicine for the treatment of intractable acne, it is characterized in that: comprise the following steps:
1) get by weight crude drug;
2) soak;
3) decoct.
A kind of prioritization scheme, soaks crude drug 2 hours in described soaking step.
Another kind of prioritization scheme, described decoction step is carried out at twice.
Another prioritization scheme, described decoction for the first time comprises the following steps:
1) crude drug after soaking being placed in to marmite adds water to and exceedes 5 centimetres, crude drug surface;
2) heating;
3) slag liquid separates.
Further prioritization scheme, in described slag liquid separating step, isolated medicinal residues add water to and exceed 3 centimetres, medicinal residues surface, carry out the separation of slag liquid after heating.
Further prioritization scheme, adopts intense fire heating before not boiling in described heating steps, adopt slow fire heating 30 minutes after boiling again.
Further prioritization scheme, adopts intense fire heating before not boiling in described heating steps, adopt slow fire heating 40 minutes after boiling again.
The medicine that adopts above-mentioned preparation method to make, is characterized in that: described medicine is used for the treatment of the effective percentage of intractable acne more than 96%.
The present invention adopts after above technical scheme, compared with prior art, have the following advantages: the reason that the present invention adopts the theory of Chinese medicine to form acne has been carried out deep analysis, the acne one disease traditional Chinese medical science think belong to lung stomach and have heat, have wet, have pyretic toxicity, have congestion, the main cause of its formation is due to vital organs of the human body qi depression to blood stasis, damp and hot malicious heresy can not be dissolved eliminating in vivo in time, due to stasis.The present invention by the Chinese herbal medicine with heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, dredging the meridian, adjusting internal organs, Yin Yang balancing according to pharmacological property, according to the physiological characteristics of human body and rule, dosage, mediation compatibility in proportion,, treat targetedly intractable acne, fundamentally carry out blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, toxic removing heat clearing away, fundamentally Acne treatment, therapeutic effect is good, does not recur, do not stay scar, and have no side effect.
Below in conjunction with embodiment, the present invention is described in detail.
The specific embodiment
Embodiment 1, treat a medicine for intractable acne, its effective ingredient and weight part ratio are: 15 parts of 20 parts of Folium Eriobotryaes, 20 parts, Folium Mori, 20 parts of Cortex Mori, 20 parts of Flos Loniceraes, 20 parts of Herba Taraxaci, 10 parts of Fructus Forsythiaes, 10 parts of Cortex Phellodendris, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 10 parts of Radix Paeoniae Rubra, 10 parts of Cortex Moutans, 10 parts, Flos Carthami, 10 parts of eupolyphaga, 20 parts of Herba Artemisiae Scopariaes, 20 parts of Semen Coiciss, 10 parts of Herba Eupatoriis, 15 parts of Radix Et Rhizoma Rhei, 15 parts of Herba Hedyotidis Diffusaes, 15 parts of Spina Gleditsiae, 15 parts of Flos Chrysanthemi Indicis, 20 parts of Herba Violaes, 15 parts of the Flos Sophorae Immaturus, 15 parts of Rhizoma Alismatis and Fructus Crataegi.
Embodiment 2, treat a medicine for intractable acne, its effective ingredient and weight part ratio are: 12 parts of 18 parts of Folium Eriobotryaes, 17 parts, Folium Mori, 18 parts of Cortex Mori, 21 parts of Flos Loniceraes, 15 parts of Herba Taraxaci, 15 parts of Fructus Forsythiaes, 12 parts of Cortex Phellodendris, 25 parts of Radix Angelicae Sinensis, 11 parts of Rhizoma Chuanxiongs, 12 parts of Radix Paeoniae Rubra, 9 parts of Cortex Moutans, 8 parts, Flos Carthami, 12 parts of eupolyphaga, 18 parts of Herba Artemisiae Scopariaes, 19 parts of Semen Coiciss, 8 parts of Herba Eupatoriis, 16 parts of Radix Et Rhizoma Rhei, 16 parts of Herba Hedyotidis Diffusaes, 18 parts of Spina Gleditsiae, 16 parts of Flos Chrysanthemi Indicis, 23 parts of Herba Violaes, 12 parts of the Flos Sophorae Immaturus, 14 parts of Rhizoma Alismatis and Fructus Crataegi.
Embodiment 3, treat a medicine for intractable acne, its effective ingredient and weight part ratio are: 13 parts of 21 parts of Folium Eriobotryaes, 19 parts, Folium Mori, 22 parts of Cortex Mori, 24 parts of Flos Loniceraes, 18 parts of Herba Taraxaci, 13 parts of Fructus Forsythiaes, 8 parts of Cortex Phellodendris, 23 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 8 parts of Radix Paeoniae Rubra, 13 parts of Cortex Moutans, 11 parts, Flos Carthami, 9 parts of eupolyphaga, 17 parts of Herba Artemisiae Scopariaes, 18 parts of Semen Coiciss, 9 parts of Herba Eupatoriis, 14 parts of Radix Et Rhizoma Rhei, 17 parts of Herba Hedyotidis Diffusaes, 10 parts of Spina Gleditsiae, 10 parts of Flos Chrysanthemi Indicis, 25 parts of Herba Violaes, 15 parts of the Flos Sophorae Immaturus, 20 parts of Rhizoma Alismatis and Fructus Crataegi.
Described in above-mentioned three embodiment, the preparation method of medicine comprises the following steps:
1) get it filled: get crude drug according to above-mentioned weight part ratio;
2) soak: crude drug is soaked 2 hours, crude drug is fully expanded, can make crude drug deliquescing by soaking, after histiocyte expands, recover its native state, while boiling medicine, be easy to effective ingredient and leach;
3) decoct: the crude drug after soaking is placed in to marmite and decocts with water, described decoction is carried out at twice, while decoction for the first time, amount of water is as the criterion to exceed 5 centimetres, crude drug surface, before not boiling, adopt intense fire heating, after boiling, adopt again slow fire heating 30 minutes, leach medicinal liquid for subsequent use, medicinal residues add water and decoct for the second time again, while decoction for the second time, amount of water is as the criterion to exceed 3 centimetres, medicinal residues surface, before not boiling, adopt intense fire heating, after boiling, adopt again slow fire heating 40 minutes, leach medicinal liquid and merge with the medicinal liquid decocting for the first time.
Instructions of taking: each serving using 300mL, be a course for the treatment of at twice, ten day every day.
Efficacy assessment standard: adopt skin lesion counting method that face is divided into 5th district, i.e. volume, left cheek, right cheek, nose and lower jaw, records respectively the number of every district skin lesion, according to the percentage rate evaluation curative effect of skin lesion decreased number.
Skin lesion reduces the front skin lesion number of percentage rate=(skin lesion number-skin lesion number after each course for the treatment of before treatment)/treatment.
Recovery from illness: skin lesion reduces percentage rate >=90%; Effective: skin lesion reduces percentage rate 60%~89%; Take a turn for the better: skin lesion reduces percentage rate 20%~59%; Invalid: skin lesion reduces percentage rate≤19%.
Contrast test:
Choose 400 routine intractable seat skin ulcer patients, wherein female patient 267 examples, male patient's 133 examples, choose at random 300 examples as treatment group, other 100 examples as a control group, wherein 300 for the treatment of group routine patients are divided into treatment group 1, treatment group 2 and treatment group 3, each treatment group is chosen 100 routine patients at random, treatment group 1 is taken medicine prepared by the embodiment of the present invention 1, treatment group 2 is taken medicine prepared by the embodiment of the present invention 2, treatment group 3 is taken medicine prepared by the embodiment of the present invention 3, matched group adopts conventional Therapeutic Method, before sleeping, clean acne affected part, smear adapalene gel.
The adjustment that is careful in one's diet during treatment, greasy, the maror that consumes oil less, suitably polyphagia vegetable and fruit, diet is light, drinks more water; Keep being in a light hearted mood calmness, emotion is steady; Keep free movement of the bowels, keep sufficient sleep, forbid voluntarily with hands or other apparatuses extruding skin lesion, and stop using that all affect medicine or the Therapeutic Method of this clinical research.
Therapeutic outcome after three courses for the treatment of contrast situation is as following table:
Contrast group |
Recovery from illness/example |
Effective/example |
Improvement/example |
Invalid/example |
Effective percentage |
Treatment group 1 |
71 |
18 |
10 |
1 |
99% |
Treatment group 2 |
63 |
26 |
8 |
3 |
97% |
Treatment group 3 |
66 |
15 |
15 |
4 |
96% |
Matched group |
28 |
32 |
20 |
20 |
80% |
As can be seen from the above data, the Drug therapy intractable acne that uses three embodiment of the present invention to prepare, the effective percentage of medicine prepared by three embodiment of the present invention is all high than the effective percentage of matched group conventional therapy, average effectiveness level reaches 97.3%, wherein the effect of embodiment 1 is best, and effective percentage reaches 99%.
Medicine described in above-mentioned three embodiment also can adopt modern crafts to make oral liquid, the processing technique of described oral liquid adopts and well known to a person skilled in the art that processing mode carries out, therefore repeat no more, confirm through clinical trial, adopt described oral liquid treatment intractable acne, its effective percentage all reaches more than 95%, higher than the effective percentage of matched group conventional therapy.
The reason that the present invention adopts the theory of Chinese medicine to form acne has been carried out deep analysis, the acne one disease traditional Chinese medical science think belong to lung stomach and have heat, have wet, have pyretic toxicity, have congestion, the main cause of its formation is due to vital organs of the human body qi depression to blood stasis, damp and hot malicious heresy can not be dissolved eliminating in vivo in time, due to stasis.The present invention by the Chinese herbal medicine with heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating, dredging the meridian, adjusting internal organs, Yin Yang balancing according to pharmacological property, according to the physiological characteristics of human body and rule, in proportion, dosage, mediation compatibility, treat targetedly intractable acne, fundamentally carry out blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, toxic removing heat clearing away, fundamentally Acne treatment, therapeutic effect is good, do not recur, do not stay scar, and have no side effect.
The above is giving an example of best mode for carrying out the invention, and the part of wherein not addressing is in detail those of ordinary skills' common practise.Protection scope of the present invention is as the criterion with the content of claim, and any equivalent substitution carrying out based on technology enlightenment of the present invention, also within protection scope of the present invention.