CN103788011B - 一种非布索坦中间体及其制备方法 - Google Patents
一种非布索坦中间体及其制备方法 Download PDFInfo
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- CN103788011B CN103788011B CN201210431710.0A CN201210431710A CN103788011B CN 103788011 B CN103788011 B CN 103788011B CN 201210431710 A CN201210431710 A CN 201210431710A CN 103788011 B CN103788011 B CN 103788011B
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- 0 CC1N=C(*c2cc(C(N)=C)c(C)cc2)SC1C(OCc1ccccc1)=O Chemical compound CC1N=C(*c2cc(C(N)=C)c(C)cc2)SC1C(OCc1ccccc1)=O 0.000 description 3
- CWABZJKSQXUSBX-UHFFFAOYSA-N CC(C)COc(cc1)c(C)cc1-c1nc(C)c(C(O)=[U])[s]1 Chemical compound CC(C)COc(cc1)c(C)cc1-c1nc(C)c(C(O)=[U])[s]1 CWABZJKSQXUSBX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (31)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210431710.0A CN103788011B (zh) | 2012-11-01 | 2012-11-01 | 一种非布索坦中间体及其制备方法 |
Applications Claiming Priority (1)
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CN201210431710.0A CN103788011B (zh) | 2012-11-01 | 2012-11-01 | 一种非布索坦中间体及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN103788011A CN103788011A (zh) | 2014-05-14 |
CN103788011B true CN103788011B (zh) | 2016-03-30 |
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CN201210431710.0A Active CN103788011B (zh) | 2012-11-01 | 2012-11-01 | 一种非布索坦中间体及其制备方法 |
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CN (1) | CN103788011B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011073617A1 (en) * | 2009-12-14 | 2011-06-23 | Cipla Limited | Processes for the preparation of febuxostat and salts thereof |
CN102285937A (zh) * | 2011-09-14 | 2011-12-21 | 安润医药科技(苏州)有限公司 | 非布索坦的合成方法 |
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2012
- 2012-11-01 CN CN201210431710.0A patent/CN103788011B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011073617A1 (en) * | 2009-12-14 | 2011-06-23 | Cipla Limited | Processes for the preparation of febuxostat and salts thereof |
CN102285937A (zh) * | 2011-09-14 | 2011-12-21 | 安润医药科技(苏州)有限公司 | 非布索坦的合成方法 |
Non-Patent Citations (2)
Title |
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le in Febuxostat drug substance by LC–MS/MS technique.《Journal of Pharmaceutical and Biomedical Analysis》.2011,第56卷(第4期),第752页. * |
Mustakhusen H. Kadivar et al.Study of impurity carryover and impurity profi * |
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Publication number | Publication date |
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CN103788011A (zh) | 2014-05-14 |
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Address after: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: SOUTHWEST SYNTHETIC PHARMACEUTICAL Corp.,Ltd. Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
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Effective date of registration: 20221013 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: PKU HEALTHCARE Corp.,Ltd. Patentee before: PKU HEALTHCARE INDUSTRY Group |