CN103784540A - Composition for treating hypertensive renal complications - Google Patents
Composition for treating hypertensive renal complications Download PDFInfo
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- CN103784540A CN103784540A CN201410028212.0A CN201410028212A CN103784540A CN 103784540 A CN103784540 A CN 103784540A CN 201410028212 A CN201410028212 A CN 201410028212A CN 103784540 A CN103784540 A CN 103784540A
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- composition
- renal
- renal complications
- hypertensive renal
- treating hypertensive
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Abstract
The invention belongs to the technical field of medicine, and particularly relates to a composition for treating hypertensive renal complications, and the composition mainly comprises Carthamus tinctorius flower, Hypericum perforatum, Semen Armeniacae Amarum and Paeonia suffruticosa root bark. The composition provided by the invention can be used for preventing and treating hypertensive renal complications, and has no obvious toxic and adverse side effect.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of compositions for the treatment of hypertension kidney complication.
Background technology
Kidney is not only the main Excretory organ of human body, or important endocrine organ, to maintaining balance and stable the playing an important role of organismic internal environment.Hypertensive nephropathy is a hypertensive serious complication, poor prognosis, and increase the weight of gradually along with the prolongation of hypertensive disease.In China hyperpietic, approximately 10%～15% can be developed to chronic renal failure, and hypertensive nephropathy has accounted for the first place of old people's chronic renal insufficiency pathogenic factor.The arteriolosclerosis pathological changes that long-term hypertension causes can spread all over whole body, but the most obvious with kidney.Due to ischemic renal tubules pathological changes, urine concentrating power goes down, and patient's nocturia increases; Because albuminuria appears in ischemic Glomerular lesions; Relatively normal glomerule HT and high filtration have further been increased the weight of glomerular sclerosis.The renal arteriolosclerosis that hypertension causes, often than other complication as left ventricular hypertrophy, coronary heart disease, cerebrovascular occur more late.The early stage routine examination of hypertensive nephropathy can, without extremely, oneself have hypertension so many patients only know, does not but know the existing infringement of renal function, has lost early diagnosis, early treatment's chance.In the time that hyperpietic's urine protein, serum creatinine, blood urea nitrogen raise, illustrate that the state of an illness has developed into quite heavy degree, general being difficult to recovered.So early discovery, early diagnosis, early treatment's hypertensive nephropathy are particularly important.The drug of first choice of hypertensive nephropathy is angiotensin-convertion enzyme inhibitor, angiotensin receptor blocker, is conducive to prevent nephropathy progress.
The traditional Chinese medical science is to hypertensive renal damage without clear understanding, the category such as that clinical manifestation is attributed to more is dizzy, headache, cardiopalmus, edema, be mainly due to the main water mistake of kidney department, open entire not normal due to.Chinese medicine can improve from entirety patient's clinical symptoms, aspect the prevention of hypertensive nephropathy and treatment, is having certain effect.Chinese medicine or effective extract (Radix Salviae Miltiorrhizae, the Radix Astragali, breviscapine, Semen Ginkgo extrac), herbal mixture (kidney tonifying suppressing the hyperactive liver side, Long Lu Zishuiqinggan drink, TIANMAGOUTENG soup, BUYANG HUANWU TANG), Chinese patent medicine (Yanggan Yishui Granule, Heart pill of Musk, ginseng rhizome of chuanxiong glucose injection, DANHONG ZHUSHEYE) all has good preventive and therapeutic effect to hypertensive renal damage.Its mechanism of action may be to improve blood circulation of kidney, reduces blood viscosity, anti-platelet aggregation, reduce glomerule, renal tubules ischemia, improve renal blood vessels endothelial function, and then alleviate renal function injury and urine protein generation, delay even to reverse the development of renal damage.
Summary of the invention
The object of the invention is the deficiency in order to make up product on market, a kind of compositions for the treatment of hypertension kidney complication is provided.
To achieve these goals, the present composition is made up of the Chinese medicine of following weight portion: 5～10 parts, Flos Carthami, 15～20 parts of Herba Hyperici perforatis, 10～20 parts of Semen Armeniacae Amarums, 20～25 parts of Cortex Moutans.
The present invention also provides the preparation method of the compositions for the treatment of hypertension kidney complication: above-mentioned raw materials is decocted altogether, decocted 2 hours for the first time with 8～12 times of water gagings, add for the second time 8～10 times of water gagings and decoct 1 hour, collecting decoction, filters, concentrated, to obtain final product.
Find through zoopery, the present invention has good preventive and therapeutic effect to hypertension kidney complication, and the renal cortex that is embodied in medication group SHR rat is thick/and renal medulla thick (RCT/RMT) is apparently higher than solvent matched group.
The present invention can make with one or more pharmaceutic adjuvants the dosage forms such as tablet, capsule, granule.
The specific embodiment
Embodiment 1. prevents and treats the evaluation of hypertension kidney complication effect
One. laboratory animal
SHR rat.
Two. experimental technique
SHR rat is divided into administration group of the present invention and solvent matched group at random, every day 1 time, successive administration 4 weeks.Experiment finish after, put to death animal, calculate renal cortex thick/renal medulla thick (RCT/RMT).
Three. experimental result and conclusion
Table 1. the present invention on SHR renal cortex of rats thick/impact of renal medulla thick (RCT/RMT)
With the comparison of solvent matched group
△p<0.05
Conclusion: the renal cortex of solvent control animals is thick/and renal medulla is thick is starkly lower than administration group of the present invention, show that the present invention has good preventive and therapeutic effect to hypertension kidney complication, also illustrate that hypertension kidney complication is take renal cortex atrophy as main pathological characters simultaneously.
Claims (2)
1. the compositions for the treatment of hypertension kidney complication, is characterized in that, is made up of: 5～10 parts, Flos Carthami, 15～20 parts of Herba Hyperici perforatis, 10～20 parts of Semen Armeniacae Amarums, 20～25 parts of Cortex Moutans the Chinese medicine of following weight portion.
2. the compositions for the treatment of hypertension kidney complication according to claim 1, is characterized in that, can be made into the dosage forms such as tablet, capsule, granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410028212.0A CN103784540A (en) | 2014-01-17 | 2014-01-17 | Composition for treating hypertensive renal complications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410028212.0A CN103784540A (en) | 2014-01-17 | 2014-01-17 | Composition for treating hypertensive renal complications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103784540A true CN103784540A (en) | 2014-05-14 |
Family
ID=50660877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410028212.0A Pending CN103784540A (en) | 2014-01-17 | 2014-01-17 | Composition for treating hypertensive renal complications |
Country Status (1)
| Country | Link |
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| CN (1) | CN103784540A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671001A (en) * | 2012-05-21 | 2012-09-19 | 唐武 | Traditional Chinese medicine combination for treating hypertension |
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2014
- 2014-01-17 CN CN201410028212.0A patent/CN103784540A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671001A (en) * | 2012-05-21 | 2012-09-19 | 唐武 | Traditional Chinese medicine combination for treating hypertension |
Non-Patent Citations (3)
| Title |
|---|
| 傅奕；等: "试谈慢性肾衰竭从瘀论治", 《四川中医》, vol. 31, no. 3, 31 December 2013 (2013-12-31), pages 29 - 31 * |
| 徐皓: "贯叶连翘的化学成分及药理作用", 《安徽农业科学》, vol. 35, no. 14, 31 December 2007 (2007-12-31), pages 4219 - 4221 * |
| 林扬；等: "中医药在慢性肾衰治疗中的应用概况", 《中国中医基础医学杂志》, vol. 11, no. 10, 31 December 2005 (2005-12-31), pages 796 - 799 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140514 |