CN103782167B - 吉西他滨免疫测定 - Google Patents

吉西他滨免疫测定 Download PDF

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Publication number
CN103782167B
CN103782167B CN201280036559.9A CN201280036559A CN103782167B CN 103782167 B CN103782167 B CN 103782167B CN 201280036559 A CN201280036559 A CN 201280036559A CN 103782167 B CN103782167 B CN 103782167B
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CN
China
Prior art keywords
antibody
gemcitabine
compound
sulfydryl
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280036559.9A
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English (en)
Chinese (zh)
Other versions
CN103782167A (zh
Inventor
S·J·萨拉莫内
J·B·考特尼
H·萨尔德
C·斯佩达列雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saladax Biomedical Inc
Original Assignee
Saladax Biomedical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saladax Biomedical Inc filed Critical Saladax Biomedical Inc
Publication of CN103782167A publication Critical patent/CN103782167A/zh
Application granted granted Critical
Publication of CN103782167B publication Critical patent/CN103782167B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18Water
    • G01N33/1826Organic contamination in water
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2430/00Assays, e.g. immunoassays or enzyme assays, involving synthetic organic compounds as analytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18Water
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/13Tracers or tags

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
CN201280036559.9A 2011-05-24 2012-05-07 吉西他滨免疫测定 Expired - Fee Related CN103782167B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/114,218 US8426143B2 (en) 2011-05-24 2011-05-24 Gemcitabine immunoassay
US13/114,218 2011-05-24
US13/160,370 US8946392B2 (en) 2011-05-24 2011-06-14 Gemcitabine immunoassay
US13/160,370 2011-06-14
PCT/US2012/036723 WO2012161948A1 (en) 2011-05-24 2012-05-07 Gemcitabine immunoassay

Publications (2)

Publication Number Publication Date
CN103782167A CN103782167A (zh) 2014-05-07
CN103782167B true CN103782167B (zh) 2016-01-20

Family

ID=47217602

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280036559.9A Expired - Fee Related CN103782167B (zh) 2011-05-24 2012-05-07 吉西他滨免疫测定

Country Status (7)

Country Link
US (3) US8426143B2 (enExample)
EP (1) EP2715340A4 (enExample)
JP (1) JP2014519036A (enExample)
CN (1) CN103782167B (enExample)
BR (1) BR112013029974A2 (enExample)
CA (1) CA2836539A1 (enExample)
WO (1) WO2012161948A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426143B2 (en) * 2011-05-24 2013-04-23 Saladax Biomedical Inc. Gemcitabine immunoassay
CA3007357C (en) 2015-12-03 2023-12-05 Epidestiny, Inc. Compositions containing decitabine, 5azacytidine and tetrahydrouridine and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569358B2 (en) * 2005-03-30 2009-08-04 Saladax Biomedical Inc. Doxorubicin immunoassay

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2010200A (en) * 1932-11-17 1935-08-06 Internat Carbonic Engineering Sealing device for pressure containers
US3996344A (en) 1972-05-15 1976-12-07 Biological Developments, Inc. Phenethylamine antigenic conjugates, their preparation, antibodies and use
US4016146A (en) 1974-12-10 1977-04-05 Biological Developments, Inc. Phenethylamine antigenic conjugates, their preparation, antibodies, and use
US4269511A (en) 1979-02-15 1981-05-26 Abbott Laboratories Apparatus and method for measuring the magnitude of polarization of light
US4420568A (en) 1980-07-30 1983-12-13 Abbott Laboratories Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5101015A (en) 1989-04-10 1992-03-31 Abbott Laboratories Reagents for an amphetamine-class fluorescence polarization immunoassay
CA2096495C (en) 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
US7829064B2 (en) 1999-05-10 2010-11-09 Immunomedics, Inc. Anti-CD74 immunoconjugates and methods
FR2836995B1 (fr) * 2002-03-05 2006-09-22 Centre Nat Rech Scient Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US20060177883A1 (en) 2005-02-08 2006-08-10 Saladax Biomedical Inc. 5-Fluoro-uracil immunoassay
US8039220B2 (en) 2008-09-17 2011-10-18 Saladax Biomedical Inc. Stabilized standards for busulfan immunoassay
BR112012008772A2 (pt) 2009-10-13 2017-06-20 Rexahn Pharmaceuticals Inc sistemas poliméricos para a liberação de agentes anti-câncer
US8426143B2 (en) * 2011-05-24 2013-04-23 Saladax Biomedical Inc. Gemcitabine immunoassay

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569358B2 (en) * 2005-03-30 2009-08-04 Saladax Biomedical Inc. Doxorubicin immunoassay

Also Published As

Publication number Publication date
EP2715340A4 (en) 2014-12-31
BR112013029974A2 (pt) 2017-01-31
CN103782167A (zh) 2014-05-07
US8946392B2 (en) 2015-02-03
WO2012161948A1 (en) 2012-11-29
US8426143B2 (en) 2013-04-23
US20120301902A1 (en) 2012-11-29
US20120301901A1 (en) 2012-11-29
CA2836539A1 (en) 2012-11-29
US20150104818A1 (en) 2015-04-16
EP2715340A1 (en) 2014-04-09
JP2014519036A (ja) 2014-08-07

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Granted publication date: 20160120

CF01 Termination of patent right due to non-payment of annual fee