CN103748086B - 吡啶和吡嗪衍生物 - Google Patents

吡啶和吡嗪衍生物 Download PDF

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Publication number
CN103748086B
CN103748086B CN201280025133.3A CN201280025133A CN103748086B CN 103748086 B CN103748086 B CN 103748086B CN 201280025133 A CN201280025133 A CN 201280025133A CN 103748086 B CN103748086 B CN 103748086B
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Prior art keywords
amino
pyridin
nicotinamide
compound
hplc
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Chinese (zh)
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CN103748086A (zh
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G·霍茨曼
H-M·埃根维勒
S·R·卡拉
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CN201280025133.3A 2011-05-23 2012-04-11 吡啶和吡嗪衍生物 Expired - Fee Related CN103748086B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488997P 2011-05-23 2011-05-23
US61/488,997 2011-05-23
PCT/US2012/032983 WO2012161877A1 (en) 2011-05-23 2012-04-11 Pyridine-and pyrazine derivatives

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CN103748086B true CN103748086B (zh) 2016-05-25

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KR (1) KR101581522B1 (https=)
CN (1) CN103748086B (https=)
AU (1) AU2012259333B2 (https=)
BR (1) BR112013029640A2 (https=)
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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012161877A1 (en) * 2011-05-23 2012-11-29 Merck Patent Gmbh Pyridine-and pyrazine derivatives
GB201303109D0 (en) 2013-02-21 2013-04-10 Domainex Ltd Novel pyrimidine compounds
NZ717552A (en) * 2013-08-07 2021-07-30 Merck Patent Gmbh Piperidine urea derivatives
US9856223B2 (en) 2013-12-13 2018-01-02 Dana-Farber Cancer Institute, Inc. Methods to treat lymphoplasmacytic lymphoma
EP3079682A4 (en) 2013-12-13 2017-08-30 Dana-Farber Cancer Institute, Inc. Methods to treat lymphoplasmacytic lymphoma
CA2939164A1 (en) 2014-02-12 2015-08-20 Iteos Therapeutics Novel 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use
PE20170247A1 (es) 2014-05-15 2017-03-29 Iteos Therapeutics Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1
TW201613916A (en) 2014-06-03 2016-04-16 Gilead Sciences Inc TANK-binding kinase inhibitor compounds
NZ729618A (en) 2014-09-26 2018-07-27 Gilead Sciences Inc Aminotriazine derivatives useful as tank-binding kinase inhibitor compounds
US9994547B2 (en) 2014-10-06 2018-06-12 Takeda Pharmaceutical Company Limited Heteroarylamide inhibitors of TBK1
US10112957B2 (en) 2014-10-22 2018-10-30 Dana-Farber Cancer Institute, Inc. Thiazolyl-containing compounds for treating proliferative diseases
MA41598A (fr) * 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc Composés thérapeutiques de pyridazine et leurs utilisations
WO2016147144A1 (en) 2015-03-17 2016-09-22 Pfizer Inc. Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
EP3334733A1 (en) 2015-08-10 2018-06-20 Pfizer Inc 3-indol substituted derivatives, pharmaceutical compositions and methods for use
EP3394044A1 (en) 2015-12-17 2018-10-31 Gilead Sciences, Inc. Tank-binding kinase inhibitor compounds
WO2017102091A1 (en) 2015-12-18 2017-06-22 Bayer Pharma Aktiengesellschaft Heteroarylbenzimidazole compounds
WO2017207534A1 (en) 2016-06-03 2017-12-07 Bayer Pharma Aktiengesellschaft Substituted heteroarylbenzimidazole compounds
US10710980B2 (en) 2016-07-20 2020-07-14 Novartis Ag Aminopyridine derivatives and their use as selective ALK-2 inhibitors
DE102016113714A1 (de) 2016-07-26 2018-02-01 Rosa Karl Transfektionsverfahren mit nicht-viralen Genliefersystemen
GB201702947D0 (en) 2017-02-23 2017-04-12 Domainex Ltd Novel compounds
TWI771410B (zh) * 2017-04-27 2022-07-21 日商石原產業股份有限公司 N-(4-吡啶基)菸鹼醯胺化合物或其鹽
CN115038443A (zh) 2019-11-22 2022-09-09 因西特公司 包含alk2抑制剂和jak2抑制剂的组合疗法
JP2023530316A (ja) 2020-06-16 2023-07-14 インサイト・コーポレイション 貧血の治療のためのａｌｋ２阻害剤
CN116710090A (zh) * 2020-10-09 2023-09-05 Napa医疗有限公司 Cd38的杂芳基酰胺抑制剂
CN116099004B (zh) * 2022-12-30 2024-01-30 深圳开悦生命科技有限公司 Rna解旋酶dhx33抑制剂在制备用于治疗膀胱癌的药物中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186113A1 (en) * 2001-07-05 2004-09-23 Stefan Berg Heterocyclic amines for the treatment of conditions associated with gsk-3
CN1551869A (zh) * 2001-07-05 2004-12-01 新化合物
US20060173014A1 (en) * 2002-12-17 2006-08-03 Astrazeneca Ab Nobel compounds having selective inhibiting effect at gsk3
CN1933838A (zh) * 2004-02-12 2007-03-21 默克公司 作为代谢型谷氨酸受体－5调节剂的联吡啶酰胺
CN101394851A (zh) * 2006-03-08 2009-03-25 阿斯利康(瑞典)有限公司 用于治疗骨质疏松症的gsk-3抑制剂
WO2010071837A1 (en) * 2008-12-19 2010-06-24 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
CN102812017A (zh) * 2010-01-19 2012-12-05 阿斯利康(瑞典)有限公司 吡嗪衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
SE0203754D0 (sv) 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
EP2016075A1 (en) 2006-05-03 2009-01-21 AstraZeneca AB Thiazole derivatives and their use as anti-tumour agents
WO2009030890A1 (en) 2007-09-03 2009-03-12 University Court Of The University Of Dundee Pyrimidine compounds for the treatment of cancer, septic shock and/or primary open angle glaucoma
ATE523508T1 (de) 2007-10-25 2011-09-15 Astrazeneca Ab Für die behandlung von zellproliferativen erkrankungen geeignete pyridin- und pyrazinderivate
WO2009122180A1 (en) * 2008-04-02 2009-10-08 Medical Research Council Pyrimidine derivatives capable of inhibiting one or more kinases
GB0903759D0 (en) * 2009-03-04 2009-04-15 Medical Res Council Compound
WO2012161877A1 (en) * 2011-05-23 2012-11-29 Merck Patent Gmbh Pyridine-and pyrazine derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186113A1 (en) * 2001-07-05 2004-09-23 Stefan Berg Heterocyclic amines for the treatment of conditions associated with gsk-3
CN1551869A (zh) * 2001-07-05 2004-12-01 新化合物
US20060173014A1 (en) * 2002-12-17 2006-08-03 Astrazeneca Ab Nobel compounds having selective inhibiting effect at gsk3
CN1933838A (zh) * 2004-02-12 2007-03-21 默克公司 作为代谢型谷氨酸受体－5调节剂的联吡啶酰胺
CN101394851A (zh) * 2006-03-08 2009-03-25 阿斯利康(瑞典)有限公司 用于治疗骨质疏松症的gsk-3抑制剂
WO2010071837A1 (en) * 2008-12-19 2010-06-24 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
CN102812017A (zh) * 2010-01-19 2012-12-05 阿斯利康(瑞典)有限公司 吡嗪衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation;Dominik Paquet et al.;《The Journal of Clinical Investigation》;20090530;第119卷(第5期);1382-1395 *

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