Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of hyperosteogeny; Chinese medicine preparation of the present invention has effect of softening bony spur, relaxing muscles and tendons and activating QI and blood in the collateral, dehumidifying cold expelling, reducing swelling and alleviating pain, the pain caused for hyperosteogeny is heavy, aching pain in should and back, the symptoms such as numbness is unable have significant curative effect, the medicinal raw material chosen is easy to get, with low cost, good effect, instant effect, without any side effects, and non-relapse after healing, can wide popularization and application clinically.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for hyperosteogeny, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of hyperosteogeny, comprise following processing step:
(1) Fructus Lycii, Poria, Herba Arundinae Chinensis, Caulis Clematidis Armandii and Radix Serissae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density under 60 DEG C of environment is the thick paste of 1.10 ~ 1.16, for subsequent use;
(2) Radix Dendropanacis, Herba Asari Forbesii, Folium et Ramulus Callicarpae nudiflorae and Rhizoma Polygoni Cuspidati are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 50% of 4 times amount, heating extraction 3 hours, reclaim ethanol, filter, being condensed into relative density under 65 DEG C of environment is the thick paste of 1.15 ~ 1.20, for subsequent use;
(3) get Nidus Vespae decontamination, immersed in the yellow wine of 5 times amount and soak 3 ~ 4 hours, take out microwave drying, be placed in mortar and grind into powder, cross 180 order fine powders, for subsequent use;
(4) get Lignum et Radix Naucleae, Radix achyranthis asperae (Herba Achyranthis Asperae), Radix Sanguisorbae and Radix Angelicae Dahuricae decontamination, microwave drying, is placed in mortar and grinds into powder, crosses 180 order fine powders, for subsequent use;
(5) get Borneolum Syntheticum to be placed in mortar and to grind into powder, cross 160 order fine powders, dissolved by fine powder and stir with the distilled water of 3 times amount, filtration, obtains filtrate for subsequent use;
(6) cleaned by Herba hylotelephii erythrosticti decontamination, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(7) by the thick paste obtained by above-mentioned steps (1) ~ (6), fine powder, filtrate and juice mixing, make tablet, obtain the Chinese medicine preparation for the treatment of hyperosteogeny of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Fructus Lycii: sweet in the mouth, property is put down; Return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.Modern medicine study confirms, Fructus Lycii can strengthen immune function of human body, has blood pressure lowering, blood sugar lowering and lipotropic effect.
Radix Dendropanacis: sweet in the mouth, warm in nature.Expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.For migraine, brachial plexus neuritis, rheumatic arthritis, rheumatoid arthritis, lumbar muscle strain, chronic lambago and skelalgia, hemiplegia, traumatic injury, bruise; External is controlled on cutter hemorrhage." Zhejiang conventional medical herbs among the people " carries: " expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, pain relieving.”
Nidus Vespae: sweet in the mouth, property is put down; Return stomach warp.Removing the necrotic tissue and promoting granulation, anti-inflammatory analgetic, antiallergic.Be suitable for toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot, allergic constitution." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, method rheumatism, diuresis.Treating rheumatic arthritis, waist knee joint arthralgia chiefly caused by damp pathogen, oedema due to nephritis." modern medicine study confirmation, Nidus Vespae preparation has the effect promoting Immune Function.
Poria: sweet in the mouth, light, property is put down.Promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieves internal heat anticancer.Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.Modern medicine study confirms, pachymic acid contained by Poria has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc., and can relax gastrointestinal smooth muscle, and gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial.
Herba Arundinae Chinensis: bitter in the mouth, property is put down.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Cure mainly pyretic stranguria, jaundice, edema, beriberi edema, hernia is suffered from abdominal pain, rheumatic arthralgia, venom, sore and toxic, traumatic injury." choosing of Simao, Yunnan Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, wind-damp dispelling, antiinflammatory, diuresis.Treating rheumatic lumbago and skelalgia, stomachache, urinary tract infection, beriberi edema, alimentary toxicosis.”
Lignum et Radix Naucleae: bitter in the mouth, cold in nature; Return lung, large intestine, gallbladder, urinary bladder channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Cure mainly cold, fever, bronchitis, pneumonia, acute tonsillitis, pharyngolaryngitis, mastitis, enteritis, bacillary dysentery, urinary tract infection, cholecystitis, ulcer of the lower limb, tinea pedis infects, furuncle and phyma pus infections, dermatitis and eczema.
Radix achyranthis asperae (Herba Achyranthis Asperae): bitter in the mouth, pungent, cold in nature; Return liver, lung, urinary bladder channel.Blood circulation promoting and blood stasis dispelling, clearing away heat and expelling pathogen in the exterior.Cure mainly cold, fever, dysentery, malaria, laryngalgia, beriberi, gonorrhea, edema, traumatic injury." Guangxi Chinese medicinal herbal " carries: " diuresis, purifies the blood, sterilization.Control red-white dysentery, larynx disease, traumatic injury, strengthening bone and muscle, loose blood, pain relieving, reason beriberi.”
Radix Sanguisorbae: bitter in the mouth, acid, cold in nature, nontoxic; Enter liver, lung, kidney, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Cure mainly haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, sore, carbuncle and painful swelling, eczema, pudendal pruritus." not Lu " carries: " malignant boil, disappear wine, and except quenching one's thirst, mending and hindering absolutely, in puerperal, plug, can make incised wound cream, and main internal hemorrhage due to trauma is more than, insufficiency of blood for only pus and blood, all flaccidity." modern medicine study confirmation, Radix Sanguisorbae contains a large amount of tannin, has stronger convergence, and energy vasoconstrictive, reduces the permeability of blood vessel, reduces inflammatory exudation, also has obvious bactericidal action simultaneously, can resist charrin's disease.
Herba Asari Forbesii: acrid in the mouth, warm in nature, mild toxicity; Return lung, liver, kidney, urinary bladder channel.Expelling wind and cold, expectorant diuretic, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, phlegm retention is breathed with cough, edema, anemofrigid-damp arthralgia, traumatic injury, headache, toothache, stomachache, and eruptive disease is suffered from abdominal pain, scrofula, toxic swelling, venom." Jiangsu medical material will " carries: " diaphoresis is eliminated the phlegm.Cure cold headache, toothache, aphtha of the mouth and tongue.”
Caulis Clematidis Armandii: bitter in the mouth, light, cold in nature; GUIXIN, lung, small intestinal, urinary bladder channel.Clearing away heat and promoting diuresis, stimulating milk secretion of stimulating the menstrual flow.For edema, gonorrhea, urinary obstruction, arthralgia, amenorrhea breast less, pathogenic fire reducing." Japan hanako materia medica " carries: " relieving restlessness of feeling at ease, quenches the thirst and bring down a fever, and improve visual and auditory acuity controls nasal obstruction, and logical small intestinal, lower water, removing mass gathers clot, evacuation of pus, controls furuncle, pain relieving." research confirmation, this product has diuresis, has inhibitory action to multiple pathomycete.
Folium et Ramulus Callicarpae nudiflorae: mildly bitter flavor, property is put down.Hemostasis and anti-inflammation, blood stasis dispelling, pain relieving.Cure mainly pneumorrhagia type leptospirosis, pulmonary tuberculosis, lung abscess, hemorrhage, Peptic Ulcers that lobar pneumonia etc. cause etc." Nanning City's medicine will " carries: " hemostasis, pain relieving.Control traumatic injury, gunshot wound." modern medicine confirmation, Folium et Ramulus Callicarpae nudiflorae has hemostasis, antibacterial and wind dispelling detumescence effect.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.For soft tissue contusion, hyperosteogeny, muscular strain, rheumatic myositis, fracture, costal chondritis, scapulohumeral periarthritis, the treatment of the diseases such as intercostal neuralgia." detailed outline " carries: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, bleeding urine, married woman's blood dizziness due to wind pathogen is transported, and regurgitation of food from the stomach tells food; Solution arsenic poison, snakebite, cutter arrow incised wound." modern medicine study confirmation, the Radix Angelicae Dahuricae all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature; Return liver, gallbladder, lung meridian.Heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia , WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Modern medicine study confirms, Huzhang has obvious anastalsis to traumatic hemorrhage, and for oral administration also have anastalsis to upper gastrointestinal hemorrhage, and Rhizoma Polygoni Cuspidati extract has antipyretic effect, has convergence, protects from infection and antiinflammation to scald wound.
Radix Serissae: bitter in the mouth, pungent, cool in nature; Return liver, spleen channel.Expelling wind and removing dampness, heat-clearing and toxic substances removing.Cure mainly flu, icterohepatitis, oedema due to nephritis, cough, laryngalgia, keratitis, enteritis, dysentery, lumbago and skelalgia, hemoptysis, hematuria, women's amenorrhea, leucorrhea, infantile malnutrition, infantile convulsion, acute toothache, swollen ulcer drug, traumatic injury." Guizhou folk medicine " carries: " heat-clearing and toxic substances removing, soothing the channels and quicking the network vessels.Control knife injury, paralysis, the weak disease of men and women, flies furuncle.”
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature; Enter the heart, lung meridian.Logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain, refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Zhang Jingyue " book on Chinese herbal medicine just " carries: " the micro-sweet great Xin of taste, it is cool to ice to apply user, and the male power of gas is sharp.This is non-thermal, has the moon also in sun.Kind loose gas, loose blood, loose fire, loose stagnant, sensible, ward off evil, by trusted subordinate's pathogen.
Herba hylotelephii erythrosticti: sour in the mouth, hardship, property is put down.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis, hemostasis and pain-relieving.For laryngitis, urticaria, spits blood, infantile erysipelas; Furuncle carbuncle is controlled in external, traumatic injury, clavus, burn and scald, venom, herpes zoster, tinea pedis.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention has effect of softening bony spur, relaxing muscles and tendons and activating QI and blood in the collateral, dehumidifying cold expelling, reducing swelling and alleviating pain, the pain caused for hyperosteogeny is heavy, aching pain in should and back, the symptoms such as numbness is unable have significant curative effect, the medicinal raw material chosen is easy to get, with low cost, good effect, instant effect, without any side effects, and non-relapse after healing, can wide popularization and application clinically.
Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of hyperosteogeny, the hyperosteogeny Patients with 300 Cases made a definite diagnosis is selected to carry out clinical observation, patient is divided into treatment group and matched group two groups at random, treatment group 150 example, wherein male 75 example, women 75 example, 45 ~ 67 years old age, 53.1 years old mean age, the shortest person of the course of disease 3 months, most elder 10 years, average 4.6 years.Matched group 150 example, wherein male 74 example, women 76 example, 46 ~ 68 years old age, 52.5 years old mean age, the shortest person of the course of disease 4 months, most elder 11 years, average 5.1 years.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, 1 course for the treatment of of the lighter, severe one can be fully recovered 2 ~ 3 courses for the treatment of.
Matched group takes nimesulide granule, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 15 days, be 1 course for the treatment of, 1 course for the treatment of of the lighter, severe one can be fully recovered 2 ~ 4 courses for the treatment of, and the person of being in a bad way is usually invalid.
3, efficacy determination:
(1) cure: the transference cures such as the pain that hyperosteogeny causes is heavy, aching pain in should and back, numbness are unable, physical recovery is normal, thoroughly fully recovers.
(2) take a turn for the better: above-mentioned symptom is alleviated to some extent, and pain obviously alleviates.
(3) invalid: by treating rear hyperosteogeny symptom without improvement.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 110 examples, take a turn for the better 36 examples, invalid 4 examples, cure rate 44.7%, total effective rate 97.3%.
Cure 58 examples in matched group, take a turn for the better 31 examples, invalid 61 examples, cure rate 38.7%, total effective rate 59.3%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Zhao, female, 46 years old, individual operator, people from Xuzhou.Patient suffers from bone matrix hyperplasia 1 year, often feels aching pain in should and back, numb unable.After taking 1 course for the treatment of of Chinese medicine preparation of the present invention, the state of an illness takes a turn for the better to some extent, after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, cures, follows up a case by regular visits to and do not recur so far.
2, Lee, man, 51 years old, civil servant, Jinan, Shandong Province people.Patient gives prominence to and sciatic nerve crush because suffering from hyperosteogeny companion lumbar vertebra point dish, rear to certain people's hospitalize, has spent nearly 10,000 yuans all without positive effect.To our hospital afterwards, after taking 1 course for the treatment of of Chinese medicine preparation of the present invention, health slightly improves, and after taking 2 courses for the treatment of of Chinese medicine preparation of the present invention, cures, can be engaged in physical work, follow up a case by regular visits to and do not recur for 3 years.
3, certain is revived, female, 65 years old, retired worker, Heze City, Shandong Province people.Patient suffers from bone matrix hyperplasia 5 years, layer repeatedly carries out performing the operation and Drug therapy, has no positive effect, in recent years increases the weight of again, to our hospital afterwards, take Chinese medicine preparation of the present invention, after taking 1 course for the treatment of, symptom alleviates to some extent, after taking 2 courses for the treatment of, transference cure, hyperosteogeny is fully recovered, and follows up a case by regular visits to without recurrence after 1 year.