CN103735671B - 一种治疗痛风的药物 - Google Patents
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Abstract
本发明公开了一种治疗痛风的药物，由内服制剂及外用制剂组成，同时使用，具有协同增效功能,用于治疗痛风,疗效确切,经临床研究表明,本发明药物用于治疗痛风疗效较好,且未发现明显的副作用及不良反应。
Description
技术领域
本发明涉及医药技术领域,更确切地说涉及治疗痛风的药物组合物。
背景技术
痛风又称高尿酸血症,发病率高、治愈难、反复发作,属于嘌呤代谢障碍引起的代谢性疾病。痛风多发生于中老年人、肥胖者和脑力劳动者,其临床特点为高尿酸血症及由此引起的痛风性急性关节炎反复发作,痛风石沉积、痛风石性慢性关节炎和关节畸形等,以关节红肿、热痛、反复发作、关节活动不灵活为主要临床表现。常累及肾脏引起慢性间质性肾炎和尿酸肾结石形成。根据血中尿酸增高原因可分为原发性和继发性两大类。原发性痛风的病因是由于先天性嘌呤代谢紊乱所致,属遗传性。继发性痛风的病因,可由肾脏病、白血病、药物、食物等多种原因引起,好发于男性及绝经期女性。痛风属于中医学“痹证”范畴。《血证论》“:痛风、身体不仁、四肢疼痛、今名痛风、古曰痹证”。
目前用于治疗痛风的西药主要有:秋水仙碱、保泰松或羟基保泰松、消炎痛、布洛芬(ibvprofen,异丁苯丙酸)、炎痛喜康(piroxicanum)、萘普生(naproxen消痛灵)、ACTH及强的松等。但上述药物大多只能稳定病情,不能根治痛风;还会引起严重的副作用造成肝肾功能的损害;即使近期治疗有效也不能控制病情复发,而且可产生耐药性和抵抗性,甚至会出现白细胞减少、心脏功能受损、肝肾功能受损、刺激肠胃系统、再生障碍性贫血、导致糖尿病等合并症。越来越多的专家认为:从中医的整体观念出发,用中医药整体辨证施治,不失为治疗痛风疾病的又一条佳径;不但中药本身的毒副作用大大减少,而且可降低西药服用量,克服长期单纯服用西药所带来的巨大毒副作用。但目前市场上治疗痛风的中成药极少,疗效较好的更是缺乏,患者仍然只能靠大量服用毒副作用较大的西药来稳定病情。
发明内容
本发明的目的在于提供一种治疗痛风的、疗效确切的药物组合物。该药物组合物治疗痛风针对性强,疗效较好,副作用小,安全性好。
为了实现上述目的,本发明提供的技术方案为:
一种治疗痛风的药物，其特征在于由内服制剂及外用制剂组成，
所述内服制剂由重量配比穿山甲生片、红萝卜、威灵仙、鸡血藤、海风藤、延胡索、海金沙、徐长卿、车前子、金钱草、红花、三七、路路通、骨碎补、水蛭、鹅不食草、甘草各一份制成；
所述外用制剂三七、三棱、莪术、川芎、没药、马钱子、败酱草、皂角刺、黄柏、王不留行各一份,经水提取制成。
上述内服制剂可以按照常规方法将各原料药经处理后制成药剂学上适宜的任意一种剂型的药物,优选制成颗粒剂、片剂、硬胶囊、口服液、软胶囊、滴丸剂。
上述外用制剂可以按照常规方法将各原料药经处理后制成药剂学上适宜的任意一种剂型的药物,优选制成擦剂、喷雾剂。
本发明中药组合应用,具有协同增效功能,用于治疗痛风,疗效确切,经临床研究表明,本发明药物用于治疗痛风疗效较好,且未发现明显的副作用及不良反应。
具体实施方式
实施例1
取重量配比的穿山甲生片3份、红萝卜1份、威灵仙1份、鸡血藤1份、海风藤1份、延胡索1份、海金沙1份、徐长卿1份、车前子1份、金钱草1份、红花1份、三七1份、路路通1份、骨碎补1份、水蛭0.5份、鹅不食草0.5份、甘草0.5份制成内服制剂；
取三七2份、三棱2份、莪术1份、川芎1份、没药1份、马钱子1份、败酱草1份、皂角刺0.5份、黄柏1份、王不留行0.5份，加入10倍量(W:V)水煮30min，过滤，取滤液作为搽剂。
本发明具体用法为：内服制剂每次6g、每日3次；每次服药时，同时使用外用制剂。通过786例临床试验，本发明治愈率达95%以上。
实施例2
取穿山甲生片5份、红萝卜3份、威灵仙2份、鸡血藤2份、海风藤2份、延胡索3份、海金沙3份、徐长卿3份、车前子3份、金钱草3份、红花2份、三七2份、路路通2份、骨碎补3份、水蛭2份、鹅不食草1份、甘草1份制成内服制剂；
取三七5份、三棱4份、莪术2份、川芎3份、没药2份、马钱子2份、败酱草2份、皂角刺2份、黄柏2份、王不留行1份，加入10倍量(W:V)水煮30min，过滤，取滤液作为搽剂。
实施例3
穿山甲生片4份、红萝卜2份、威灵仙1份、鸡血藤2份、海风藤2份、延胡索1份、海金沙2份、徐长卿2份、车前子2份、金钱草2份、红花1份、三七2份、路路通1份、骨碎补2份、水蛭1份、鹅不食草0.5份、甘草0.5份制成；
取三七3份、三棱3份、莪术2份、川芎2份、没药1份、马钱子1份、败酱草1份、皂角刺1份、黄柏1份、王不留行0.5份，加入10倍量(W:V)水煮30min，过滤，取滤液作为搽剂。
为了证实本发明药物的疗效和安全性,还对内服制剂进行了药效学试验考察。所采用的研究方法及试验结果如下：
取昆明种小鼠60只，雌雄各半，体重18-22g，随机分为生理盐水组、本发明内服药物低剂量组(4g生药材/kg)、本发明药物中剂量组(8g生药材/kg)、本发明药物高剂量组(16g生药材/kg)、阳性对照组,分别灌服生理盐水、本发明药物和秋水仙碱,每日1次,连续4d。末次给药1h后,除生理盐水组外,其余各组动物腹腔注射次黄嘌呤1mg/kg造成小鼠高血尿酸,生理盐水组注射等容量空白对照液。注射后0.5h,各组动物摘眼球取血,3000r/min离心15min,取血清测血尿酸值。
从表可知，本发明高中低剂量组均能够降低小鼠血尿酸水平，与模型组比较有显著性差异。
Claims (3)
1.一种治疗痛风的药物，其特征在于由内服制剂及外用制剂组成，所述内服制剂由重量配比穿山甲生片3-5份、红萝卜1-3份、威灵仙1-2份、鸡血藤1-2份、海风藤1-2份、延胡索1-3份、海金沙1-3份、徐长卿1-3份、车前子1-3份、金钱草1-3份、红花1-2份、三七1-2份、路路通1-2份、骨碎补1-3份、水蛭0.5-2份、鹅不食草0.5-1份、甘草0.5-1份制成；所述外用制剂由三七2-5份、三棱2-4份、莪术1-2份、川芎1-3份、没药1-2份、马钱子1-2份、败酱草1-2份、皂角刺0.5-2份、黄柏1-2份、王不留行0.5-1份，经水提取制成。
2.根据权利要求1所述的一种治疗痛风的药物，其特征在于由内服制剂及外用制剂组成，所述内服制剂由重量配比穿山甲生片4份、红萝卜2份、威灵仙1份、鸡血藤2份、海风藤2份、延胡索1份、海金沙2份、徐长卿2份、车前子2份、金钱草2份、红花1份、三七2份、路路通1份、骨碎补2份、水蛭1份、鹅不食草0.5份、甘草0.5份制成；所述外用制剂由三七3份、三棱3份、莪术2份、川芎2份、没药1份、马钱子1份、败酱草1份、皂角刺1份、黄柏1份、王不留行0.5份，经水提取制成。
3.根据权利要求1或2所述的一种治疗痛风的药物，其特征在于所述外用制剂制法为：取各组分，加入10倍量水煮30min，过滤，取滤液，即得。
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