CN103721241A - Antimicrobial compound zinc bacitracin particle for pigs and preparation method thereof - Google Patents
Antimicrobial compound zinc bacitracin particle for pigs and preparation method thereof Download PDFInfo
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- CN103721241A CN103721241A CN201210389885.XA CN201210389885A CN103721241A CN 103721241 A CN103721241 A CN 103721241A CN 201210389885 A CN201210389885 A CN 201210389885A CN 103721241 A CN103721241 A CN 103721241A
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Abstract
The invention relates to an antimicrobial compound zinc bacitracin particle for pigs and a preparation method thereof. The particle comprises the following components by mass: 5-15 parts of zinc bacitracin; 5-10 parts of enrofloxacin; 1-3 parts of Tiandi flavoring; 1-2 parts of aspartame; 20-40 parts of beta-cyclodextrin; 10-20 parts of cane sugar; 5-10 parts of HPMCP; and 20-50 parts of starch. Each bag contains 100 g particles including 5-10 g of zinc bacitracin and 5-10 g of enrofloxacin, and spray drying technology is adopted for coating the raw materials to prepare the finished product. The particle of the invention is uniform, good in fluidity, and consistent in color, has a particle size meeting the specification, and is bright and clean in appearance; zinc bacitracin has good antimicrobial activity to most Gram-positive bacteria; enrofloxacin is a bactericidal wide-spectrum antibacterial drug specially used for animals; the combination of the two drugs enhances the antimicrobial spectrum, and has synergistic effect; the treatment effect is better than that of single-component preparations; the particle is simple in process, good in taste, and suitable for industrial production. The product realizes reasonable combination of the components to enhance the drug effects, which reduces tedious administration of single doses, covers inherent bitter taste of the drugs, and enhances animal compliance to drug administration. The product has the characteristic of simple, convenient, and rapid usage, and is more suitable for pig bacterial disease treatment, growth promotion, and feed utilization rate improvement than other dosage forms.
Description
Technical field
The invention belongs to field of medicine preparing technology, especially antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for a boar.
Background technology
Bacitracin zinc is in polypeptide class antimicrobial drug, to be exclusively used in the medicine of gram positive bacteria, and it can react by nonspecific blocking-up phosphorylase, anti-bacteria mucopeptide synthetic and produce antibacterial action.Bacitracin zinc has good antibacterial activity to staphylococcus aureus, streptococcus, enterococcus, clostridium and corynebacterium etc., also effective to actinomycetes and spirillum.Sensitive organism seldom produces drug resistance phenomenon to it, in addition owing to having added zinc element to make bacitracin zinc have certain astriction can reduce inflammatory reaction.
Enrofloxacin is the bactericidal properties spectrum antibacterials of animal specific, escherichia coli, Salmonella, klebsiella, brucella, pasteurellosis bacillus, Actinobacillus pleuropneumoniae, erysipelas bacillus, Bacillus proteus, clayey Serratieae, suppurative corynebacterium, deteriorated blood baud Salmonella, staphylococcus aureus, mycoplasma and chlamydia etc. are all had to good action, a little less than Pseudomonas aeruginosa and streptococcus effect, faint to anaerobe effect.This product to the MIC of most of bacterial strains all lower than 1 μ g/ml.Sensitive organism is had to obvious antibacterial after effect (PAE).The antibacterial mechanisms of this product is the DNA gyrase that acts on bacterial cell, and that disturbs DNA of bacteria copies, transcribes and repair restructuring, and antibacterial can not normal growth breeding and dead.Animal energy for oral administration good absorption, pig bioavailability for oral administration is 80%-100%.
Bacitracin zinc and enrofloxacin share, and not only can expand antimicrobial spectrum, Synergistic, and antibacterial effect is far away higher than single prescription in proportion, and can promote the growth of pig, improve efficiency of feed utilization.
Coating technique and the world are fragrant, the use of aspartame can be eliminated bitter taste of drug, improve mouthfeel and grains of sand sense, increase the compliance of domestic animal animal to medicine, reduce loaded down with trivial details step and the administration time of raiser's administration.Granule is drying agent, produce and use procedure in be difficult for generation dust, there is steady quality, transportation, store, carry, apply all more convenient; Mechanization production, output is large, and cost is low, and sanitary standard also easily reaches.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, propose a kind of safe and efficient, compatibility rationally, antimicrobial spectrum scope is wide, mouthfeel good, convenient drug administration, antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for the simple boar of technique.
The technical scheme that the present invention realizes object is:
Antimicrobial compound recipe bacitracin zinc granule for one boar, forms component and mass fraction thereof and is respectively:
Bacitracin zinc 5-15 part; Enrofloxacin 5-10 part;
The fragrant 1-3 part in the world; Aspartame 1-2 part;
Beta-schardinger dextrin-20-40 part; Sucrose 10-20 part;
HPMCP 5-10 part; Starch 20-50 part.
Antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for one boar, step is:
(1) take bacitracin zinc, enrofloxacin, HPMCP, the beta-schardinger dextrin-of recipe quantity, add the water for injection that the 5-10 of principal agent total amount doubly measures fully to mix, make mixed solution and be coated with, spraying airpillow-dry.
(2) world perfume, aspartame, sucrose, 9/10 starch of recipe quantity are added successively in (1) and fully mix 30 minutes.
(3) 1/10 starch are made gelatinized corn starch, and wet method is made soft material, require to hold agglomerating finger pressure loose, and 17 mesh sieves are granulated;
(4) by the granule 68-72 obtaining ℃ dry 2-3 hour, 17 mesh sieve granulate;
(5) subpackage, obtains compound recipe bacitracin zinc granule.
And, described in to add HPMCP be enteric solubility enclose material Hydroxypropyl Methylcellulose Phathalate, the described world fragrant for poultry fragrant with the world.
Advantage of the present invention and beneficial effect are:
1, the present invention has innovated the compatibility of drugs use of antimicrobial drug, bacitracin zinc, enrofloxacin coupling in its formula, has a broad antifungal spectrum, fully demonstrated the advantage of compound preparation in antimicrobial application, the important breakthrough of domestic antimicrobial process technology, for domestic domestic animal antimicrobial therapy has been opened up new product novel composing prescription.
2, adding of the coating technique relating in the present invention's formula and world perfume, aspartame, can cover bitter taste of drug, improve mouthfeel and grains of sand sense, increase the compliance of domestic animal animal to medicine, reduce loaded down with trivial details step and the administration time of raiser's administration.And melting is good, and bioavailability is high.Have use simply, feature easily and efficiently, compared with other products and dosage form, be more suitable for the treatment of domestic animal microbial diseases.
3, the drying process with atomizing the present invention relates to has that production equipment is simple, processing ease, advantage easy to use, to be applicable to expanding production, made up the blank of domestic veterinary drug market aspect antimicrobial agents, innovated the compound medicine of reasonable compatibility, the bacterial disease mycoplasma infection and the growth promotion that are widely used in treatment pig improve efficiency of feed utilization.
The specific embodiment
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Bacitracin zinc 5-15 part; Enrofloxacin 5-10 part;
The fragrant 1-3 part in the world; Aspartame 1-2 part;
Beta-schardinger dextrin-20-40 part; Sucrose 10-20 part;
HPMCP 5-10 part; Starch 20-50 part.
In embodiment, every bag of 100g is containing three bacitracin zinc 5-15g, containing enrofloxacin 5-10g below.
Embodiment 1:
Antimicrobial compound recipe bacitracin zinc granule for one boar, it forms component and parts by weight are respectively (by every bag of 100g supplementary material proportioning, following examples are same):
Antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for one boar, comprises the steps:
(1) take bacitracin zinc, enrofloxacin, HPMCP, the beta-schardinger dextrin-of recipe quantity, add the water for injection that the 5-10 of principal agent total amount doubly measures fully to mix, make mixed solution and be coated with, spraying airpillow-dry.
(2) world perfume, aspartame, sucrose, 9/10 starch of recipe quantity are added successively in (1) and fully mix 30 minutes.
(3) 1/10 starch are made gelatinized corn starch, and wet method is made soft material, require to hold agglomerating finger pressure loose, and 17 mesh sieves are granulated;
(4) by the granule 68-72 obtaining ℃ dry 2-3 hour, 17 mesh sieve granulate;
(5) subpackage, obtains compound recipe bacitracin zinc granule.
Embodiment 2:
Antimicrobial compound recipe bacitracin zinc granule for one boar, it forms component and parts by weight are respectively:
The step of the present embodiment preparation method is same as embodiment 1.
Embodiment 3:
Antimicrobial compound recipe bacitracin zinc granule for one boar, it forms component and parts by weight are respectively:
The step of the preparation method of the present embodiment is same as embodiment 1.
Claims (3)
1. antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for a boar, is characterized in that: form component and mass fraction thereof and be respectively:
Bacitracin zinc 5-15 part; Enrofloxacin 5-10 part;
The fragrant 1-3 part in the world; Aspartame 1-2 part;
Beta-schardinger dextrin-20-40 part; Sucrose 10-20 part;
HPMCP 5-10 part; Starch 20-50 part.
2. antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for pig as claimed in claim 1, is characterized in that: the step of preparation is:
(1) take bacitracin zinc, enrofloxacin, HPMCP, the beta-schardinger dextrin-of recipe quantity, add the water for injection that the 5-10 of principal agent total amount doubly measures fully to mix, make mixed solution and be coated with, spraying airpillow-dry.
(2) world perfume, aspartame, sucrose, 9/10 starch of recipe quantity are added successively in (1) and fully mix 30 minutes.
(3) 1/10 starch are made gelatinized corn starch, and wet method is made soft material, require to hold agglomerating finger pressure loose, and 17 mesh sieves are granulated;
(4) by the granule 68-72 obtaining ℃ dry 2-3 hour, 17 mesh sieve granulate;
(5) subpackage, obtains compound recipe bacitracin zinc granule.
3. antimicrobial compound recipe bacitracin zinc granule and preparation method thereof for a boar according to claim 2, it is characterized in that: described in to add HPMCP be enteric solubility enclose material Hydroxypropyl Methylcellulose Phathalate, the described world fragrant for poultry fragrant with the world.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210389885.XA CN103721241A (en) | 2012-10-15 | 2012-10-15 | Antimicrobial compound zinc bacitracin particle for pigs and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210389885.XA CN103721241A (en) | 2012-10-15 | 2012-10-15 | Antimicrobial compound zinc bacitracin particle for pigs and preparation method thereof |
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| CN103721241A true CN103721241A (en) | 2014-04-16 |
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| CN201210389885.XA Pending CN103721241A (en) | 2012-10-15 | 2012-10-15 | Antimicrobial compound zinc bacitracin particle for pigs and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
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- 2012-10-15 CN CN201210389885.XA patent/CN103721241A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857501A (en) * | 2015-06-08 | 2015-08-26 | 信阳农林学院 | Chinese and western medicine composition for treating piglet diarrhea and preparation method thereof |
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Application publication date: 20140416 |