CN103721000A - Medicinal preparation for treating epidemic keratoconjunctivitis - Google Patents
Medicinal preparation for treating epidemic keratoconjunctivitis Download PDFInfo
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Abstract
The invention provides a medicinal preparation for treating epidemic keratoconjunctivitis. The preparation comprises crude medicines such as saposhnikovia divaricata, senecio scandens ham, mint, centipeda minima, concha haliotidis, stigma croci, white mulberry root bark, isatis roots, semen cuscutae, ash bark, eclipta, liriope spicata, honeysuckle, buddleja officinalis, plantain herbs, schizonepeta, glossy privet fruits, coptis chinensis, flatstem milkvetch seeds, Chinese yams, polygonum aviculare, selfheal spike, fructus broussonetiae, feather cockscomb seeds, raspberries, pipewort, caryopteris incana and bidens bipinnata. The medicinal preparation is low in side effect occurrence rate, stable in treatment effect, reliable, high in safety and higher in clinical application value.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of pharmaceutical preparation that is used for the treatment of epidemic keratoconjunctivitis.
Background technology
Epidemic keratoconjunctivitis is that a kind of infectiousness is strong, and the ophthalmic diseases rapidly of falling ill, how by due to adenovirus infection.If treatment is incured loss through delay, can leave sequela.Corneal is damaged sustainable several months or several years, and very person leaves over corneal nebula and affects one's power of vision.Epidemic keratoconjunctivitis, can have upper sense history before disease, be 5～7 incubation period, a lore onset, another eye is got involved subsequently, have foreign body sensation, itch, bitterly, water sample mucus secretions, photophobia, shed tears.Conjunctiva palpebrae congestion and edema, a large amount of folliculus of palpebral conjunctiva fornix portion, can have subconjunctival hemorrhage and pseudomembrane to form, and after falling ill 1～2 week, conjunctiva inflammation disappears gradually, occurs that lower bunch of shape of corneal epithelium infiltrates and inflammation.Within 2～3 days, to climax, if there is cornea inflammatory infiltration, cornea fluorescent staining is positive in epidemic keratoconjunctivitis morbidity.Primary disease is contagion, and all face-washing appliances and contact article, all can be Vector of infection.Conventionally in outbreak, very easily infect in 1～12 day, patient should avoid rubbing one's eyes as far as possible, should isolate, in order to avoid spread and epidemic in period of disease.Epidemic keratoconjunctivitis is a kind of strong communicable contagious disease that has, if mistake is controlled, wrong treatment, can cause permanent inpairment of vision.
Medically treating this sick method is generally to use anti-inflammatory agent or hormone medicine, anti-inflammatory drug effect is not significantly and have features such as drug resistance, the side effect of life-time service hormone medicine causes greatly and easily the ocular complications such as hormonal cataract and glaucoma, to patient, has serious consequences.
The epidemic keratoconjunctivitis traditional Chinese medical science belongs to the category of " acute and chronic conjunctivitis ", " epidemic keratoconjunctivitis ", and the traditional Chinese medical science thinks that primary disease belongs to diseases caused by exogenous pathogenic factor pestilential pathogen and falls ill.If patient's element body lung stomach accumulated heat or Liver Channel latent heat, feel pestilential pathogen again, evil in exopathogen priming, inside and outside combined pathogens, hands over and attacks in order, and the state of an illness is heavier, has more the malicious deteriorated cases such as network or the raw nebula of epidemic disease poison that burn of existing epidemic disease.
With respect to western medical treatment, adopt Chinese traditional treatment epidemic keratoconjunctivitis side effect incidence rate low, therapeutic effect is stable, and reliable, safe, clinical value is higher.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical preparation that is used for the treatment of epidemic keratoconjunctivitis, and its side effect incidence rate is low, and therapeutic effect is stable, and reliable, safe, clinical value is higher.
For solving the problems of the technologies described above, the invention provides a kind of pharmaceutical preparation that is used for the treatment of epidemic keratoconjunctivitis, its crude drug comprise Radix Saposhnikoviae, Herba Senecionis Scandentis, Herba Menthae, Herba Centipedae, Concha Haliotidis, Stigma Croci, Cortex Mori, Radix Isatidis, Semen Cuscutae, Cortex Fraxini, Herba Ecliptae, Radix Liriopes, Flos Lonicerae, Flos Buddlejae, Herba Plantaginis, Herba Schizonepetae, Fructus Ligustri Lucidi, Rhizoma Coptidis, Semen Astragali Complanati, Rhizoma Dioscoreae,
hold, Spica Prunellae, Fructus Broussonetiae, Semen Celosiae, Fructus Rubi, Flos Eriocauli, Herba Caryopteridis Incanae and Herba Bidentis Bipinnatae.
Wherein, in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 25 weight portion～35 weight portions, Herba Senecionis Scandentis 35 weight portion～45 weight portions, Herba Menthae 20 weight portion～30 weight portions, Herba Centipedae 15 weight portion～25 weight portions, Concha Haliotidis 35 weight portion～45 weight portions, Stigma Croci 20 weight portion～30 weight portions, Cortex Mori 20 weight portion～30 weight portions, Radix Isatidis 45 weight portion～55 weight portions, Semen Cuscutae 35 weight portion～45 weight portions, Cortex Fraxini 25 weight portion～35 weight portions, Herba Ecliptae 20 weight portion～30 weight portions, Radix Liriopes 25 weight portion～35 weight portions, Flos Lonicerae 35 weight portion～45 weight portions, Flos Buddlejae 25 weight portion～35 weight portions, Herba Plantaginis 15 weight portion～25 weight portions, Herba Schizonepetae 20 weight portion～30 weight portions, Fructus Ligustri Lucidi 35 weight portion～45 weight portions, Rhizoma Coptidis 65 weight portion～75 weight portions, Semen Astragali Complanati 25 weight portion～35 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions,
hold 20 weight portion～30 weight portions, Spica Prunellae 20 weight portion～30 weight portions, Fructus Broussonetiae 25 weight portion～35 weight portions, Semen Celosiae 35 weight portion～45 weight portions, Fructus Rubi 25 weight portion～35 weight portions, Flos Eriocauli 25 weight portion～35 weight portions, Herba Caryopteridis Incanae 30 weight portion～40 weight portions and Herba Bidentis Bipinnatae 25 weight portion～35 weight portions.
Wherein, in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 28 weight portion～32 weight portions, Herba Senecionis Scandentis 38 weight portion～42 weight portions, Herba Menthae 23 weight portion～27 weight portions, Herba Centipedae 18 weight portion～22 weight portions, Concha Haliotidis 38 weight portion～42 weight portions, Stigma Croci 23 weight portion～27 weight portions, Cortex Mori 23 weight portion～27 weight portions, Radix Isatidis 48 weight portion～52 weight portions, Semen Cuscutae 38 weight portion～42 weight portions, Cortex Fraxini 28 weight portion～32 weight portions, Herba Ecliptae 23 weight portion～27 weight portions, Radix Liriopes 28 weight portion～32 weight portions, Flos Lonicerae 38 weight portion～42 weight portions, Flos Buddlejae 28 weight portion～32 weight portions, Herba Plantaginis 18 weight portion～22 weight portions, Herba Schizonepetae 23 weight portion～27 weight portions, Fructus Ligustri Lucidi 38 weight portion～42 weight portions, Rhizoma Coptidis 68 weight portion～72 weight portions, Semen Astragali Complanati 28 weight portion～32 weight portions, Rhizoma Dioscoreae 38 weight portion～42 weight portions,
hold 23 weight portion～27 weight portions, Spica Prunellae 23 weight portion～27 weight portions, Fructus Broussonetiae 28 weight portion～32 weight portions, Semen Celosiae 38 weight portion～42 weight portions, Fructus Rubi 28 weight portion～32 weight portions, Flos Eriocauli 28 weight portion～32 weight portions, Herba Caryopteridis Incanae 33 weight portion～37 weight portions and Herba Bidentis Bipinnatae 28 weight portion～33 weight portions.
Wherein, in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 30 weight portions, Herba Senecionis Scandentis 40 weight portions, Herba Menthae 25 weight portions, Herba Centipedae 20 weight portions, Concha Haliotidis 40 weight portions, Stigma Croci 25 weight portions, Cortex Mori 25 weight portions, Radix Isatidis 50 weight portions, Semen Cuscutae 40 weight portions, Cortex Fraxini 30 weight portions, Herba Ecliptae 25 weight portions, Radix Liriopes 30 weight portions, Flos Lonicerae 40 weight portions, Flos Buddlejae 30 weight portions, Herba Plantaginis 20 weight portions, Herba Schizonepetae 25 weight portions, Fructus Ligustri Lucidi 40 weight portions, Rhizoma Coptidis 70 weight portions, Semen Astragali Complanati 30 weight portions, Rhizoma Dioscoreae 40 weight portions,
hold 25 weight portions, Spica Prunellae 25 weight portions, Fructus Broussonetiae 30 weight portions, Semen Celosiae 40 weight portions, Fructus Rubi 30 weight portions, Flos Eriocauli 30 weight portions, Herba Caryopteridis Incanae 35 weight portions and Herba Bidentis Bipinnatae 30 weight portions.
Wherein, described pharmaceutical preparation is exterior-applied formulation.
Wherein, described pharmaceutical preparation is prepared into eye drop.
The present invention also provides the preparation method of said medicine preparation, is specially:
The first step, each crude drug component is mixed by weight, obtain mixture, the alcohol reflux that is 80%～90% with determining alcohol 3 times～5 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20～1.23 (60 ℃), the amount of the ethanol adding is 2～4 times of mixture quality, be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to 3～5 times of amounts of its quality, under stirring, add with respect to powder quality 5%～10% sodium hydroxide hydrotropy, regulating pH value is 7～8, filter, filtrate decompression is condensed into the mastic that relative density is 1.29～1.32 (60 ℃) and is dried, be ground into powder,
Second step, the powder obtaining is above mixed, add the distilled water with respect to 15～25 times of amounts of mixture quality, the boric acid of 0.01～0.03 times, the Borax of 0.02～0.04 times, the sodium chloride of 0.2～0.4 times, stirs, and is heated to 100 ℃ and be incubated 30～40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop.
The present invention also provides a kind of pharmaceutical preparation eye drop, and its crude drug comprises: Radix Saposhnikoviae, Herba Senecionis Scandentis, Herba Menthae, Herba Centipedae, Concha Haliotidis, Stigma Croci, Cortex Mori, Radix Isatidis, Semen Cuscutae, Cortex Fraxini, Herba Ecliptae, Radix Liriopes, Flos Lonicerae, Flos Buddlejae, Herba Plantaginis, Herba Schizonepetae, Fructus Ligustri Lucidi, Rhizoma Coptidis, Semen Astragali Complanati, Rhizoma Dioscoreae,
hold, Spica Prunellae, Fructus Broussonetiae, Semen Celosiae, Fructus Rubi, Flos Eriocauli, Herba Caryopteridis Incanae and Herba Bidentis Bipinnatae;
The preparation method of described eye drop is specially,
The first step, each crude drug component is mixed by weight, obtain mixture, the alcohol reflux that is 80%～90% with determining alcohol 3 times～5 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20～1.23 (60 ℃), the amount of each ethanol adding is 2～4 times of mixture quality, be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to 3～5 times of amounts of its quality, under stirring, add with respect to powder quality 5%～10% sodium hydroxide hydrotropy, regulating pH value is 7～8, filter, filtrate decompression is condensed into the mastic that relative density is 1.29～1.32 (60 ℃) and is dried, be ground into powder,
Second step, the powder obtaining is above mixed, add the distilled water with respect to 15～25 times of amounts of mixture quality, the boric acid of 0.01～0.03 times, the Borax of 0.02～0.04 times, the sodium chloride of 0.2～0.4 times, stirs, and is heated to 100 ℃ and be incubated 30～40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop.
Wherein, in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 25 weight portion～35 weight portions, Herba Senecionis Scandentis 35 weight portion～45 weight portions, Herba Menthae 20 weight portion～30 weight portions, Herba Centipedae 15 weight portion～25 weight portions, Concha Haliotidis 35 weight portion～45 weight portions, Stigma Croci 20 weight portion～30 weight portions, Cortex Mori 20 weight portion～30 weight portions, Radix Isatidis 45 weight portion～55 weight portions, Semen Cuscutae 35 weight portion～45 weight portions, Cortex Fraxini 25 weight portion～35 weight portions, Herba Ecliptae 20 weight portion～30 weight portions, Radix Liriopes 25 weight portion～35 weight portions, Flos Lonicerae 35 weight portion～45 weight portions, Flos Buddlejae 25 weight portion～35 weight portions, Herba Plantaginis 15 weight portion～25 weight portions, Herba Schizonepetae 20 weight portion～30 weight portions, Fructus Ligustri Lucidi 35 weight portion～45 weight portions, Rhizoma Coptidis 65 weight portion～75 weight portions, Semen Astragali Complanati 25 weight portion～35 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions,
hold 20 weight portion～30 weight portions, Spica Prunellae 20 weight portion～30 weight portions, Fructus Broussonetiae 25 weight portion～35 weight portions, Semen Celosiae 35 weight portion～45 weight portions, Fructus Rubi 25 weight portion～35 weight portions, Flos Eriocauli 25 weight portion～35 weight portions, Herba Caryopteridis Incanae 30 weight portion～40 weight portions and Herba Bidentis Bipinnatae 25 weight portion～35 weight portions.
Beneficial effect of the present invention:
The pharmaceutical preparation that is used for the treatment of epidemic keratoconjunctivitis provided by the invention, its side effect incidence rate is low, and therapeutic effect is stable, and reliable, safe, clinical value is higher.
The specific embodiment
Epidemic keratoconjunctivitis, the traditional Chinese medical science is referred to as " epidemic keratoconjunctivitis ", its name of disease head sees < < Gujin Yitong Daquan, Medical Complete Book > >, this secretary is carried " this adds because of fortune; wind-fire is excessive strongly fragrant ... must have blood stasis, should go it ".Its etiology and pathogenesis can be summarized as: diseases caused by exogenous pathogenic factor epidemic miasma, and the high Sheng of interior double lung-fire, inside and outside combined pathogens, lung gold Ling Mu, invades Liver Channel, above attacks in order and falls ill.According to the traditional Chinese medical science five, take turns theory, white of the eye belongs to lung, and lung meridian has hyperemia of the bulbar conjunctiva edema of heat.Cornea and iris associating with kidney, flaming up of liver-fire is black eyeball punctate keratitis, order gritty photophobia, the present invention is with wind and heat dispersing, removing nebula to improve visual acuity is Therapeutic Principle, a kind of pharmaceutical preparation that is used for the treatment of epidemic keratoconjunctivitis is provided, its crude drug comprise Radix Saposhnikoviae, Herba Senecionis Scandentis, Herba Menthae, Herba Centipedae, Concha Haliotidis, Stigma Croci, Cortex Mori, Radix Isatidis, Semen Cuscutae, Cortex Fraxini, Herba Ecliptae, Radix Liriopes, Flos Lonicerae, Flos Buddlejae, Herba Plantaginis, Herba Schizonepetae, Fructus Ligustri Lucidi, Rhizoma Coptidis, Semen Astragali Complanati, Rhizoma Dioscoreae,
hold, Spica Prunellae, Fructus Broussonetiae, Semen Celosiae, Fructus Rubi, Flos Eriocauli, Herba Caryopteridis Incanae and Herba Bidentis Bipinnatae.
Further preferably, described pharmaceutical preparation only consists of above-mentioned raw materials medicine.
In described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 25 weight portion～35 weight portions, Herba Senecionis Scandentis 35 weight portion～45 weight portions, Herba Menthae 20 weight portion～30 weight portions, Herba Centipedae 15 weight portion～25 weight portions, Concha Haliotidis 35 weight portion～45 weight portions, Stigma Croci 20 weight portion～30 weight portions, Cortex Mori 20 weight portion～30 weight portions, Radix Isatidis 45 weight portion～55 weight portions, Semen Cuscutae 35 weight portion～45 weight portions, Cortex Fraxini 25 weight portion～35 weight portions, Herba Ecliptae 20 weight portion～30 weight portions, Radix Liriopes 25 weight portion～35 weight portions, Flos Lonicerae 35 weight portion～45 weight portions, Flos Buddlejae 25 weight portion～35 weight portions, Herba Plantaginis 15 weight portion～25 weight portions, Herba Schizonepetae 20 weight portion～30 weight portions, Fructus Ligustri Lucidi 35 weight portion～45 weight portions, Rhizoma Coptidis 65 weight portion～75 weight portions, Semen Astragali Complanati 25 weight portion～35 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions,
hold 20 weight portion～30 weight portions, Spica Prunellae 20 weight portion～30 weight portions, Fructus Broussonetiae 25 weight portion～35 weight portions, Semen Celosiae 35 weight portion～45 weight portions, Fructus Rubi 25 weight portion～35 weight portions, Flos Eriocauli 25 weight portion～35 weight portions, Herba Caryopteridis Incanae 30 weight portion～40 weight portions and Herba Bidentis Bipinnatae 25 weight portion～35 weight portions.
In described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 28 weight portion～32 weight portions, Herba Senecionis Scandentis 38 weight portion～42 weight portions, Herba Menthae 23 weight portion～27 weight portions, Herba Centipedae 18 weight portion～22 weight portions, Concha Haliotidis 38 weight portion～42 weight portions, Stigma Croci 23 weight portion～27 weight portions, Cortex Mori 23 weight portion～27 weight portions, Radix Isatidis 48 weight portion～52 weight portions, Semen Cuscutae 38 weight portion～42 weight portions, Cortex Fraxini 28 weight portion～32 weight portions, Herba Ecliptae 23 weight portion～27 weight portions, Radix Liriopes 28 weight portion～32 weight portions, Flos Lonicerae 38 weight portion～42 weight portions, Flos Buddlejae 28 weight portion～32 weight portions, Herba Plantaginis 18 weight portion～22 weight portions, Herba Schizonepetae 23 weight portion～27 weight portions, Fructus Ligustri Lucidi 38 weight portion～42 weight portions, Rhizoma Coptidis 68 weight portion～72 weight portions, Semen Astragali Complanati 28 weight portion～32 weight portions, Rhizoma Dioscoreae 38 weight portion～42 weight portions,
hold 23 weight portion～27 weight portions, Spica Prunellae 23 weight portion～27 weight portions, Fructus Broussonetiae 28 weight portion～32 weight portions, Semen Celosiae 38 weight portion～42 weight portions, Fructus Rubi 28 weight portion～32 weight portions, Flos Eriocauli 28 weight portion～32 weight portions, Herba Caryopteridis Incanae 33 weight portion～37 weight portions and Herba Bidentis Bipinnatae 28 weight portion～33 weight portions.
Most preferably, in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 30 weight portions, Herba Senecionis Scandentis 40 weight portions, Herba Menthae 25 weight portions, Herba Centipedae 20 weight portions, Concha Haliotidis 40 weight portions, Stigma Croci 25 weight portions, Cortex Mori 25 weight portions, Radix Isatidis 50 weight portions, Semen Cuscutae 40 weight portions, Cortex Fraxini 30 weight portions, Herba Ecliptae 25 weight portions, Radix Liriopes 30 weight portions, Flos Lonicerae 40 weight portions, Flos Buddlejae 30 weight portions, Herba Plantaginis 20 weight portions, Herba Schizonepetae 25 weight portions, Fructus Ligustri Lucidi 40 weight portions, Rhizoma Coptidis 70 weight portions, Semen Astragali Complanati 30 weight portions, Rhizoma Dioscoreae 40 weight portions,
hold 25 weight portions, Spica Prunellae 25 weight portions, Fructus Broussonetiae 30 weight portions, Semen Celosiae 40 weight portions, Fructus Rubi 30 weight portions, Flos Eriocauli 30 weight portions, Herba Caryopteridis Incanae 35 weight portions and Herba Bidentis Bipinnatae 30 weight portions.
Each crude drug pharmacology is as follows:
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature, enters lung, liver, spleen, urinary bladder channel, has expelling cold and relieving exterior syndrome, and removing dampness to relieve pain, expellings wind and relieving convulsion, and antipruritic effect is mainly used in affection of exogenous wind-cold card and cold-evil's closing, the syndrome of superficies cold and interior heat of interior-heat pent-up etc.
Herba Senecionis Scandentis: latin name Senecionis Scandentis Hebra, cold in nature, bitter in the mouth, returns lung, Liver Channel, has the effect of heat-clearing and toxic substances removing, improving eyesight dampness removing, has the cards such as carbuncle sore tumefacting virus, cold, fever, conjunctival congestion and swelling pain, dysentery, skin eczema.
Herba Menthae: acrid in the mouth, cool in nature, enter lung, Liver Channel, has the effect of dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, dispersing the stagnated live-QI to relieve the stagnation of QI, for affection due to external wind and heat or epidemic febrile disease from the beginning of, headache due to pathogenic wind-heat, the many tear of Ramulus et Folium Bischofiae Javanicae, laryngopharynx swelling and pain, measles is sent out not smooth thoroughly, and rubella is scratched where it itches, irritability stasis, and uncomfortable in chest not relaxing waited card.
Herba Centipedae: latin name Centipedae Hebra, acrid in the mouth, warm in nature, enter lung, Liver Channel, there is cold-dispelling, clearing the nasal passage, eliminating phlegm and stopping cough, the effect of dissipating blood stasis for subsidence of swelling, for exterior syndrome due to wind-cold, nasal obstruction watery nasal discharge and nasal sinusitis, cough with copious phlegm, pertussis, the cards such as sore, carbuncle and painful swelling.
Concha Haliotidis: taste becomes, property is flat, has the effect of suppressing the hyperactive liver to relieve the wind syndrome, YANG hyperactivity suppressing, heat extraction improving eyesight, cures mainly the cards such as excessive rising of liver-YANG, the vertigo, asthenia hectic fever due to YIN-deficiency, haematemesis, optic atrophy.
Stigma Croci: sweet in the mouth, property is flat, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens, pain relieving.Be used for the treatment of troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, frightened fear in a trance, women's amenorrhea, and stasis menoxenia, prolonged lochia, blood stasis is had a pain, measles, the cards such as traumatic injury.
Cortex Mori: sweet in the mouth, cold in nature, enter lung meridian, there is eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema, for lung-heat cough with asthma, the edema of the face, the cards such as dysuria.
Radix Isatidis: latin name Isatidis Radix, bitter in the mouth, cold in nature, enters the heart, liver, gallbladder, stomach warp, has the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving, is used for the treatment of maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat the cards such as epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis, Radix Isatidis has inhibitory action to various bacteria. and infusion has inhibitory action in various degree to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will he, Fu Shi) bacillus, bacillus enteritidis etc.
Semen Cuscutae: sweet in the mouth, pungent, property is flat, returns liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, and the effect of nourishing the liver to improve visual acuity is mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; The pain in the lumbar region of suffering from a deficiency of the kidney, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the cards such as aqueous-grainy diarrhea.
Cortex Fraxini: bitter in the mouth, puckery, cold in nature, enter liver, gallbladder, large intestine channel, have that dampness-eliminating and dysentery-stopping, liver heat removing purge heat, the effect of relieving cough and asthma, be mainly used in treating the red white dysentery that damp and hot pent-up, gastrointestinal conduction are obstructed, tenesmus; The leucorrhea with red and white discharge of damp invasion of lower energizer; The conjunctival congestion and swelling pain of flaming up of liver-fire, the raw nebula film of order and lung-heat cough with asthma excessive phlegm, the symptoms such as asthma, Cortex Fraxini has stronger inhibitory action to dysentery bacterium, alpha streptococcus etc., has the effect that suppresses enterokinesia, link enterospasm.
Herba Ecliptae: sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, is used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Radix Liriopes: sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, the effect that lung moistening clears away heart-fire, for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.
Flos Lonicerae: sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, there is the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, can promote leukocytic phagocytic function, multiple pyococcus and pathogenic entero becteria are had to stronger bacteriostasis, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, bacillus pyocyaneus, tubercule bacillus etc., the pyretic toxicity that Flos Lonicerae is divided QI and blood battalion is all effective, and has broad-spectrum antibacterial action.
Flos Buddlejae: latin name Buddlejae Flos, sweet in the mouth, cold nature, returns liver, and gallbladder meridian has heat clearing away nourishing the liver, and the effect of improving acuity of vision and removing nebula, cures mainly conjunctival congestion and swelling pain, many tear photophobia, the nebula of looking unfamiliar film, hepatasthenia dim eyesight, the cards such as blurring of vision.
Herba Plantaginis: sweet in the mouth, light, cold nature, returns lung meridian, Liver Channel, kidney channel, urinary bladder channel, and the effect of have clearing away heat and promoting diuresis, eliminating dampness by diuresis antidiarrheal, improving eyesight, eliminating the phlegm, cures mainly main dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily, and Herba Plantaginis has diuresis, calculus removing effect.
Herba Schizonepetae: latin name Schizonepetae Herba, acrid in the mouth, slightly warm in nature, enters lung, Liver Channel, has relieving the exterior syndrome by diaphoresis, declares malicious rash, and the effect of blood hemostasis, cures mainly the fever and headache due to affection of exogenous wind-cold wind heat, no matter has antiperspirant lossless, all can apply; The headache of attacking in wind heat is dizzy, and rash goes out not saturating; Puerperal blood faints apoplexy, the cards such as discharging fresh blood stool.
Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enter liver, kidney channel, there is strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.Fructus Ligustri Lucidi can promote leukocyte, strengthens the effect of immunologic function.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for improving eyesight, is usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, the card such as vexed, thirsty.
Semen Astragali Complanati: warm in nature, sweet in the mouth, has temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect of improving eyesight, for impotence due to deficiency of the kidney, seminal emission premature ejaculation, frequent micturition, or leukorrhagia, soreness of the waist and knees, lumbago; Deficiency of the liver and kindey, blurred vision order is dark, the cards such as visual deterioration.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help that the five internal organs, bone and muscle strengthening, long will are calmed the nerves, the effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red card such as swollen, fat of the frequent micturition of quenching one's thirst, the premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.
Spica Prunellae: bitter in the mouth, pungent, cold in nature, enter liver, gallbladder meridian, have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, the effect of detumescence, cures mainly conjunctival congestion and swelling pain, and order pearl nyctalgia, has a headache dizzy, scrofula, goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.
Fructus Broussonetiae: sweet in the mouth, cold in nature, return liver, kidney channel, there is the kidney invigorating liver heat removing, the effect of improving eyesight diuresis, cures mainly deficiency of the liver and kindey, soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, has a dizzy spell, the card such as edema distension.
Semen Celosiae: bitter in the mouth, cold nature, returns Liver Channel, has purging liver-fire, and the effect of improving acuity of vision and removing nebula cures mainly liver-heat conjunctival congestion, the raw nebula film of order, blurring of vision, the cards such as dizziness due to liver-fire.
Fructus Rubi: sweet in the mouth, flat, enter liver, kidney channel, there is the effect of the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight, be used for the treatment of impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, the card such as blurred vision is dark, early whitening of beard and hair.
Flos Eriocauli: acrid in the mouth, sweet, property is put down, return liver, stomach warp, there is the effect of wind-dispelling heat-dissipating, improving acuity of vision and removing nebula, for cards such as conjunctival congestion and swelling pain, the many tear of photophobia, headache due to pathogenic wind-heat, toothache, staphylococcus aureus, bacterium flexneri, Bacillus typhi, escherichia coli, bacillus pyocyaneus etc. are had to stronger inhibitory action.
Herba Caryopteridis Incanae: acrid in the mouth, warm in nature, there is the cold relieving of inducing sweat, the effect of dehumidifying dissipating blood stasis, cures mainly anemofrigid cold headache, cough, pertussis, coldness and pain in the epigastrium, dyspeptic vomiting and diarrhea, cold stasis of blood dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, anemofrigid-damp arthralgia, traumatic injury, the cards such as eczema.
Herba Bidentis Bipinnatae: have heat-clearing and toxic substances removing, the effect of expelling wind and activating blood circulation, cures mainly laryngopharynx swelling and pain, has loose bowels, dysentery, jaundice, acute appendicitis, furuncle swelling toxin, snake bite and insect sting, rheumatic arthralgia, the cards such as traumatic injury.
The present invention also provides the preparation method of said medicine preparation, is specially:
The first step, each crude drug component is mixed by weight, obtain mixture, the alcohol reflux that is 80%～90% with determining alcohol 3 times～5 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20～1.23 (60 ℃), the amount of each ethanol adding is 2～4 times of mixture quality, be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to 3～5 times of amounts of its quality, under stirring, add with respect to powder quality 5%～10% sodium hydroxide hydrotropy, regulating pH value is 7～8, filter, adding concentration and be 10% sulfur acid for adjusting pH value is 3～4, static 2～4 hours, filter, filtrate decompression is condensed into the mastic that relative density is 1.29～1.32 (70 ℃) and is dried, be ground into powder,
Second step, the powder obtaining is above mixed, add the distilled water with respect to 15～25 times of amounts of mixture quality, the boric acid of 0.01～0.03 times, the Borax of 0.02～0.04 times, the sodium chloride of 0.2～0.4 times, stirs, and is heated to 100 ℃ and be incubated 30～40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop.
Modern pharmacological research, the pharmaceutical preparation that is used for the treatment of epidemic keratoconjunctivitis provided by the invention is anti-bacteria, fungus and viral growth directly, have antibacterial, antiviral effect, this medicine can also be adjusted body, reach the effect of elimination and amelioration of inflammation, and the reaction that can reduce inflammation, the permeability of blood vessel while reducing inflammation, reduces the edema that inflammatory exudation causes, reduce the formation of granulation, promote the absorption of inflammation.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 eye drop 1
By Radix Saposhnikoviae 30g, Herba Senecionis Scandentis 40g, Herba Menthae 25g, Herba Centipedae 20g, Concha Haliotidis 40g, Stigma Croci 25g, Cortex Mori 25g, Radix Isatidis 50g, Semen Cuscutae 40g, Cortex Fraxini 30g, Herba Ecliptae 25g, Radix Liriopes 30g, Flos Lonicerae 40g, Flos Buddlejae 30g, Herba Plantaginis 20g, Herba Schizonepetae 25g, Fructus Ligustri Lucidi 40g, Rhizoma Coptidis 70g, Semen Astragali Complanati 30g, Rhizoma Dioscoreae 40g,
hold 25g, Spica Prunellae 25g, Fructus Broussonetiae 30g, Semen Celosiae 40g, Fructus Rubi 30g, Flos Eriocauli 30g, Herba Caryopteridis Incanae 35g and Herba Bidentis Bipinnatae 30g mix, obtain mixture, the ethanol 3kg reflux, extract, that is at every turn 90% with determining alcohol 4 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20 (60 ℃), be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to its quality 4 amounts, under stirring, add with respect to powder quality 5% sodium hydroxide hydrotropy, regulating pH value is 7, filter, filtrate decompression is condensed into the mastic that relative density is 1.30 (60 ℃) and is dried, be ground into powder, get the powder mixing that 100g obtains above, the distilled water that adds 1.5kg, the boric acid of 2g, 3g Borax doubly, the sodium chloride of 25g, stir, be heated to 100 ℃ and be incubated 40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop 1.
Embodiment 2 eye drops 2
By Radix Saposhnikoviae 28g, Herba Senecionis Scandentis 38g, Herba Menthae 23g, Herba Centipedae 18g, Concha Haliotidis 38g, Stigma Croci 23g, Cortex Mori 23g, Radix Isatidis 48g, Semen Cuscutae 38g, Cortex Fraxini 28g, Herba Ecliptae 23g, Radix Liriopes 28g, Flos Lonicerae 38g, Flos Buddlejae 28g, Herba Plantaginis 18g, Herba Schizonepetae 23g, Fructus Ligustri Lucidi 38g, Rhizoma Coptidis 68g, Semen Astragali Complanati 28g, Rhizoma Dioscoreae 38g,
hold 23g, Spica Prunellae 23g, Fructus Broussonetiae 28g, Semen Celosiae 38g, Fructus Rubi 28g, Flos Eriocauli 28g, Herba Caryopteridis Incanae 33g and Herba Bidentis Bipinnatae 28g mix, obtain mixture, the ethanol 3kg reflux, extract, that is at every turn 90% with determining alcohol 4 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20 (60 ℃), be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to its quality 4 amounts, under stirring, add with respect to powder quality 5% sodium hydroxide hydrotropy, regulating pH value is 7, filter, filtrate decompression is condensed into the mastic that relative density is 1.30 (60 ℃) and is dried, be ground into powder, get the powder mixing that 100g obtains above, the distilled water that adds 1.5kg, the boric acid of 2g, 3g Borax doubly, the sodium chloride of 25g, stir, be heated to 100 ℃ and be incubated 40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop 2.
Embodiment 3 eye drops 3
By Radix Saposhnikoviae 32g, Herba Senecionis Scandentis 42g, Herba Menthae 27g, Herba Centipedae 22g, Concha Haliotidis 42g, Stigma Croci 27g, Cortex Mori 27g, Radix Isatidis 52g, Semen Cuscutae 42g, Cortex Fraxini 32g, Herba Ecliptae 27g, Radix Liriopes 32g, Flos Lonicerae 42g, Flos Buddlejae 32g, Herba Plantaginis 22g, Herba Schizonepetae 27g, Fructus Ligustri Lucidi 42g, Rhizoma Coptidis 72g, Semen Astragali Complanati 32g, Rhizoma Dioscoreae 42g,
hold 27g, Spica Prunellae 27g, Fructus Broussonetiae 32g, Semen Celosiae 42g, Fructus Rubi 32g, Flos Eriocauli 32g, Herba Caryopteridis Incanae 37g and Herba Bidentis Bipinnatae 32g mix, obtain mixture, the ethanol 3kg reflux, extract, that is at every turn 90% with determining alcohol 4 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20 (60 ℃), be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to its quality 4 amounts, under stirring, add with respect to powder quality 5% sodium hydroxide hydrotropy, regulating pH value is 7, filter, filtrate decompression is condensed into the mastic that relative density is 1.30 (60 ℃) and is dried, be ground into powder, get the powder mixing that 100g obtains above, the distilled water that adds 1.5kg, the boric acid of 2g, 3g Borax doubly, the sodium chloride of 25g, stir, be heated to 100 ℃ and be incubated 40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop 3.
Embodiment 4 irritant experiments and toxicity test
Toxicity test
60 of Cavia porcelluss (being provided by Qingdao City's laboratory animal and zoopery center) are provided, male and female half and half, body weight is 250g～300g, be divided into 3 groups, every group 20, 24h lose hair or feathers by rat spine with depilatory (about 4cm * 5cm) before administration, the eye drop of embodiment 1 preparation is evenly spread upon to the depilation district of the 1st group for more than 1 time, the eye drop of embodiment 2 preparations is evenly spread upon to the depilation district of the 2nd group for more than 2 time, the eye drop of embodiment 3 preparations is evenly spread upon to the depilation district of the 3rd group for more than 3 time, every animal is smeared administration (through repetition test according to 7.5mL/kg dosage, 7.5mL/kg is the maximum dosage-feeding of this extractum), after coating 24h, by the residual tested material of warm water wiping.
After administration, each organizes rat Continuous Observation 14d, observe every day 1～2 time, and 7d before administration and after administration, 14d claims weight, the main general reaction of observing animal after administration, comprises fur, eyes, oral mucosa, breathing, autonomic activities, muscular tension etc., have or not tremble, tremble, the toxic reaction symptom such as tic, sialorrhea, diarrhoea, few moving, lethargy is depressed, stupor.Record without dead, if there is death to perform an autopsy on sb． immediately, if macroscopy has when obviously abnormal, further carry out histopathologic examination.
Administration same day, rat is clear-headed, Continuous Observation 14d, it is all glossy that each organizes rat fur, eyes occur without secretions, and oral mucosa is without the irritation such as festering, congested and red and swollen, can autonomic activities, behavior is without change, all, without the abnormal mental status and whole body poisoning symptoms such as agitations, after 14d, put to death animal, dissect, each main organs of perusal, skin and internal organs are all without obvious pathological change.
Fixing by putting into immediately formalin after administration place skin and not administration place skin sampling, routine sampling, wax buries, section, film-making, dewaxing, HE dyeing, mounting, in test under microscope photography.Visible under mirror, administration place is complete with not administration place skin epidermis and skin corium organizational structure, and interstitial is without hyperemia, edema and inflammatory cell infiltration.
Skin irritation test
Get 60 of Cavia porcelluss, male and female half and half, are divided into intact skin group and damaged skin group at random, 20 every group.By substrate (75% ethanol) as negative control, consubstantiality left and right sides self-contrast method.Before test, 24h shaves hair by guinea pig back, unhairing scope left and right Ge Yue 3cm * 3cm.The damaged skin group position of losing hair or feathers is drawn " well " word with injection needle and be take and occurs that oozing of blood is as degree.The eye drop of embodiment 1 preparation is evenly spread upon to the depilation district of the 1st group for more than 1 time, the eye drop of embodiment 2 preparations is evenly spread upon to the depilation district of the 2nd group for more than 2 time, the eye drop of embodiment 3 preparations is evenly spread upon to the depilation district of the 3rd group for more than 3 time, every animal is applied on the skin of unhairing of left side according to 1.5g, and opposite side is smeared the substrate contrast of same volume.By upper method administration every day 1 time, be total to 7d, each coating positions are conformed to each other.
Observation index and evaluation criterion:
Before each coating, under available light, observe and record coating position and have or not erythema, edema, pigmentation, petechia, pachylosis or epidermatic atrophy situation and time of origin and regression time, and mark by table 1 pair erythema and edema.After last coating, 48h and 72h perusal record are smeared position and are had or not the situations such as erythema and edema.After each coating and after last coating, all by table 1, calculate and put the mean scores of respectively organizing tested material and negative control thing skin irritation reaction integration each observing time, and carry out stimulus intensity evaluation by table 2.
Table 1 skin irritation reaction standards of grading
| Irritant reaction | Score value |
| Erythema | ? |
| Without erythema | 0 |
| Slight erythema (visible reluctantly) | 1 |
| Moderate erythema (obviously visible) | 2 |
| Severe erythema | 3 |
| Aubergine erythema forms to slight eschar | 4 |
| Edema | ? |
| Without edema | 0 |
| Mild edema (visible reluctantly) | 1 |
| Intermediate edema (obviously protuberance) | 2 |
| Severe edema (cutaneous protuberance 1mm, profile is clear) | 3 |
| Serious edema (cutaneous protuberance 1mm above and have expansion) | 4 |
Table 2 skin irritation intensity evaluation standard
| Score value | Evaluate |
| 0～0.49 | Nonirritant |
| 0.5～2.99 | Slight zest |
| 3.0～5.99 | Moderate zest |
| 6.0～8.00 | Severe zest |
The no abnormality seen such as each treated animal general state, behavior, sign during administration.Each treated animal medicine-feeding part is showed no the abnormal symptoms such as erythema and edema.Each treated animal administration and viewing duration zest score value and zest intensity evaluation the results are shown in Table 3 and table 4.
Table 3 is respectively organized medicine to Cavia porcellus normal skin irritative response situation
Table 4 is respectively organized medicine to Cavia porcellus damaged skin irritative response situation
From table 3 and table 4, can find out, pharmaceutical preparation of the present invention does not all have zest to normal skin and damaged skin.
Embodiment 5 zooperies
Medicine: test group adopts the eye drop 1 of embodiment 1 preparation, negative control group adopts normal saline.
The preparation of rabbit conjunctivitis model
30 of rabbit, rabbit age is 4 months, male and female half and half, weight 2.0～2.2kg.Before experiment, double ocellus ofloxacin eye drops (Beijing Tongren Hospital) is with prevention infection, Oxybuprocaine hydrochloride eye drops (Santen Pharmaceutical Co. Ltd.) table fiber crops, bulbar conjunctiva is apart from limbus of corneae 2mm place up, use looper that No. 7 lines (Chinese medical equipment company limited of Johnson & Johnson) are sewed up under conjunctiva, scope is 10 point～2 points, and two ends are naked wire head not.
Grouping and treatment
Within after modeling the 2nd day, according to the scoring of pathological changes, laboratory animal is divided into basically identical 2 groups of lesion degree, every group of 15 rabbit (30 eyes), every group of every day, every eye dripped 50 μ l, every day 5～7 times, begin treatment after grouping.
Pathological changes is observed
Observe before treatment, the pathological changes situation of conjunctiva and cornea when 7d, 14d after treatment, and to the lesion degree record of marking.
Lesion degree scoring
Conjunctive disorder scoring
Comprise hyperemia, edema, 3 subitems of secretions, conjunctive disorder scoring is this 3 item rating sum.(1) hyperemia: 0 minute, blood vessel was normal; 1 minute, the congestion of blood vessel was cerise; 2 minutes, the congestion of blood vessel was peony, and blood vessel is difficult for differentiating; 3 minutes, diffusivity hyperemia was aubergine.(2) edema: 0 minute, without edema; 1 minute, slight edema (comprising instant embrane); 2 minutes, obvious edema, with part ectropion of lid; 3 minutes, edema caused the nearly semi-closed of eyelid; 4 minutes, edema caused eyelid to surpass semi-closed.(3) secretions: 0 minute, without secretions; 1 minute, a small amount of secretions; 2 minutes, secretions makes eyelid and eyelashes are moist or adhesion; 3 minutes, secretions made whole eye district's humidity or adhesion.
Keratopathy scoring: with 2% fluorescent staining cornea, add blue color filter and observe, tiny stain appears in cornea, for polishing, as ulcer appears in limbus of corneae, for infiltrating; Adding green color filter and observe limbus of corneae, if any the conjunctiva blood vessel cornea of growing into, is pannus.Mark as follows: 0 minute, normal; 1 minute, polish; 2 minutes, infiltrate; 3 minutes, pannus.
Therapeutic evaluation
Relatively treatment is latter the 7th day and the 14th day, conjunctiva and keratopathy scoring, and do statistical analysis, determine the standard of curing and do not heal.
Cure: treating pathological changes scoring after 14 days is 0 minute; Do not heal: treat pathological changes scoring after 14 days and be more than or equal to 1 minute.Cure rate=healing eye number/(curing the eye number+eye number of not healing) * 100%.
Statistical method
Each is organized data and all uses mean soil standard deviation
represent, each is organized mean and does test of normality and repeated measure homogeneity test of variance, younger check between organizing with one factor analysis of variance), P < 0.05 is for differing significantly, and P < 0.01 is for differing highly significant.Statistical computation all adopts SPSS12.0 software to complete.
Conjunctive disorder scoring relatively
Before treatment, two groups of pathological changes scorings approach, the difference of not statistically significant (P > 0.05), latter the 7th day and the 14th day for the treatment of, test group scoring is significantly lower than matched group, and difference has statistical significance (P < 0.01), the results are shown in Table 5.
Each the conjunctive disorder scoring in period of table 5 conjunctivitis rabbit
| Group | Before treatment | Treatment 7d | Treatment 14d |
| Negative group | 2.33±0.37 | 2.17±0.35 | 2.02±0.32 |
| Test group | 2.31±0.29 | 1.17±0.26 | 0.73±0.16 |
Keratopathy
Before treatment, to the rear 14d for the treatment of, test group lagophthalmos finds no keratopathy.
Cure rate comparison
Relatively within 14 days, respectively organize afterwards pathological changes scoring and be 0,1 and 2 eye number, calculate cure rate of each group, as can be seen from Table 6, adopts pharmaceutical preparation of the present invention thering is significant effect treating aspect epidemic keratoconjunctivitis.
Table 6 is respectively organized pathological changes scoring and the cure rate after conjunctivitis rabbit treatment 14d
Embodiment 6 clinical datas
Patient's data
Choose year June in January, 2010 to 2012 in epidemic keratoconjunctivitis patient 160 examples of outpatient service diagnosis and treatment, diagnostic criteria: eyes morbidity; Suffer from bloodshot eyes, pain, photophobia, with watery secretion; Blepharoedema, conjunctival congestion edema, companion's folliculus and subconjunctival hemorrhage, can have pseudomembrane (being true film sometimes) to form; The visible mottled epithelium infringement of cornea central authorities or epithelium infiltrate; Often have preauricular lymph nodes to swell and ache, be divided into two groups, every group of 80 examples, 18～54 years old treatment group age, average (32.21 ± 2.55) year; The course of disease 2～6d, average (2.50 ± 1.50) d.19～52 years old matched group age, average (30.54 ± 2.50) year; The course of disease 2～5d, average (2.52 ± 1.54) d.Two groups of equal eyes morbidities, two groups of data difference not statistically significants (P > 0.05).
Therapeutic Method
Matched group gives recombinant human interferon-alpha
1b eye drop (Changsheng Gene Medicine Co., Ltd.,Changchun's production) drips suffers from eye, every 2 hours 1 time, each 2; 0.15% ganciclovir ophthalmic gel (Hubei KeYi Pharmacentic Co., Ltd.'s production) drips suffers from eye, every day 4 times, each 2.
Treatment group gives the eye drop 1 of the embodiment of the present invention 1 preparation and treats, and every 2 hours 1 time, each 2.
All treat 1 week for two groups.
Criterion of therapeutical effect: cure: hyperemia of the bulbar conjunctiva disappeared, transference cure, black eyeball fluorescent staining is negative.Take a turn for the better: hyperemia of the bulbar conjunctiva alleviates, symptom takes a turn for the better, and black eyeball fluorescent staining reduces.Do not heal: symptom does not subtract, all diseases are the same.
Statistical procedures
Each is organized data and all uses mean soil standard deviation
represent, each is organized mean and does test of normality and repeated measure homogeneity test of variance, younger check between organizing with one factor analysis of variance), P < 0.05 is for differing significantly, and P < 0.01 is for differing highly significant.Statistical computation all adopts SPSS12.0 software to complete.
As a result, in Table 7.
As can be seen from Table 7, adopt patient's curative effect of pharmaceutical preparation eye drops in treatment of the present invention significantly better than matched group, there is comparability, P < 0.05.
Table 7 liang group Clinical efficacy comparison example (%)
| Group | n | Cure | Take a turn for the better | Invalid | Effectively total |
| Treatment group | 80 | 53(66.3) | 23(28.8) | 4(5) | 76(95) |
| Matched group | 80 | 39(48.8) | 29(36.3) | 12(15) | 68(85) |
Model case
Wu, man, 29 years old, medical on May 17th, 2011.The scratchy pain of eyes, photophobia over 3 days, shed tears, eyelid is red and swollen, and mucous secretions is more, defecate dry, and yellow urine, red tongue with yellow fur, wiry and frequent pulse.Examination of eyes is shown in: Vou0.8, Dual-eyelid bulbar conjunctiva acute congestion (+++), chemosis (+), there are a large amount of folliculus in palpebral conjunctiva and bulbar conjunctiva fornix portion, a small amount of white pseudomembrane covers, and cornea central authorities are dispersed in 5～6 some columnar epitheliums and infiltrate, fluorescent staining (+).Preauricular lymph nodes silght enlargement also has tenderness.Diagnosis: epidemic keratoconjunctivitis, the eye drop that adopts the embodiment of the present invention 1 to prepare, every 2 hours 1 time, each 2, further consultation after 5 days, outside slight photophobia, She's disease disappears, inspection is shown in: Vou1.2, Dual-eyelid bulbar conjunctiva (-), chemosis disappears, and cornea central authorities are dispersed in 2～3 columnar epitheliums and infiltrate, fluorescent staining (±), preauricular lymph nodes enlargement and tenderness disappear.Treat 3 days, symptom and sign all disappears and fully recovers again.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. be used for the treatment of a pharmaceutical preparation for epidemic keratoconjunctivitis, it is characterized in that: crude drug comprise Radix Saposhnikoviae, Herba Senecionis Scandentis, Herba Menthae, Herba Centipedae, Concha Haliotidis, Stigma Croci, Cortex Mori, Radix Isatidis, Semen Cuscutae, Cortex Fraxini, Herba Ecliptae, Radix Liriopes, Flos Lonicerae, Flos Buddlejae, Herba Plantaginis, Herba Schizonepetae, Fructus Ligustri Lucidi, Rhizoma Coptidis, Semen Astragali Complanati, Rhizoma Dioscoreae,
hold, Spica Prunellae, Fructus Broussonetiae, Semen Celosiae, Fructus Rubi, Flos Eriocauli, Herba Caryopteridis Incanae and Herba Bidentis Bipinnatae.
2. pharmaceutical preparation as claimed in claim 1, it is characterized in that: in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 25 weight portion～35 weight portions, Herba Senecionis Scandentis 35 weight portion～45 weight portions, Herba Menthae 20 weight portion～30 weight portions, Herba Centipedae 15 weight portion～25 weight portions, Concha Haliotidis 35 weight portion～45 weight portions, Stigma Croci 20 weight portion～30 weight portions, Cortex Mori 20 weight portion～30 weight portions, Radix Isatidis 45 weight portion～55 weight portions, Semen Cuscutae 35 weight portion～45 weight portions, Cortex Fraxini 25 weight portion～35 weight portions, Herba Ecliptae 20 weight portion～30 weight portions, Radix Liriopes 25 weight portion～35 weight portions, Flos Lonicerae 35 weight portion～45 weight portions, Flos Buddlejae 25 weight portion～35 weight portions, Herba Plantaginis 15 weight portion～25 weight portions, Herba Schizonepetae 20 weight portion～30 weight portions, Fructus Ligustri Lucidi 35 weight portion～45 weight portions, Rhizoma Coptidis 65 weight portion～75 weight portions, Semen Astragali Complanati 25 weight portion～35 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions,
hold 20 weight portion～30 weight portions, Spica Prunellae 20 weight portion～30 weight portions, Fructus Broussonetiae 25 weight portion～35 weight portions, Semen Celosiae 35 weight portion～45 weight portions, Fructus Rubi 25 weight portion～35 weight portions, Flos Eriocauli 25 weight portion～35 weight portions, Herba Caryopteridis Incanae 30 weight portion～40 weight portions and Herba Bidentis Bipinnatae 25 weight portion～35 weight portions.
3. pharmaceutical preparation as claimed in claim 1 or 2, it is characterized in that: in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 28 weight portion～32 weight portions, Herba Senecionis Scandentis 38 weight portion～42 weight portions, Herba Menthae 23 weight portion～27 weight portions, Herba Centipedae 18 weight portion～22 weight portions, Concha Haliotidis 38 weight portion～42 weight portions, Stigma Croci 23 weight portion～27 weight portions, Cortex Mori 23 weight portion～27 weight portions, Radix Isatidis 48 weight portion～52 weight portions, Semen Cuscutae 38 weight portion～42 weight portions, Cortex Fraxini 28 weight portion～32 weight portions, Herba Ecliptae 23 weight portion～27 weight portions, Radix Liriopes 28 weight portion～32 weight portions, Flos Lonicerae 38 weight portion～42 weight portions, Flos Buddlejae 28 weight portion～32 weight portions, Herba Plantaginis 18 weight portion～22 weight portions, Herba Schizonepetae 23 weight portion～27 weight portions, Fructus Ligustri Lucidi 38 weight portion～42 weight portions, Rhizoma Coptidis 68 weight portion～72 weight portions, Semen Astragali Complanati 28 weight portion～32 weight portions, Rhizoma Dioscoreae 38 weight portion～42 weight portions,
hold 23 weight portion～27 weight portions, Spica Prunellae 23 weight portion～27 weight portions, Fructus Broussonetiae 28 weight portion～32 weight portions, Semen Celosiae 38 weight portion～42 weight portions, Fructus Rubi 28 weight portion～32 weight portions, Flos Eriocauli 28 weight portion～32 weight portions, Herba Caryopteridis Incanae 33 weight portion～37 weight portions and Herba Bidentis Bipinnatae 28 weight portion～33 weight portions.
4. the pharmaceutical preparation as described in claims 1 to 3, it is characterized in that: in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 30 weight portions, Herba Senecionis Scandentis 40 weight portions, Herba Menthae 25 weight portions, Herba Centipedae 20 weight portions, Concha Haliotidis 40 weight portions, Stigma Croci 25 weight portions, Cortex Mori 25 weight portions, Radix Isatidis 50 weight portions, Semen Cuscutae 40 weight portions, Cortex Fraxini 30 weight portions, Herba Ecliptae 25 weight portions, Radix Liriopes 30 weight portions, Flos Lonicerae 40 weight portions, Flos Buddlejae 30 weight portions, Herba Plantaginis 20 weight portions, Herba Schizonepetae 25 weight portions, Fructus Ligustri Lucidi 40 weight portions, Rhizoma Coptidis 70 weight portions, Semen Astragali Complanati 30 weight portions, Rhizoma Dioscoreae 40 weight portions,
hold 25 weight portions, Spica Prunellae 25 weight portions, Fructus Broussonetiae 30 weight portions, Semen Celosiae 40 weight portions, Fructus Rubi 30 weight portions, Flos Eriocauli 30 weight portions, Herba Caryopteridis Incanae 35 weight portions and Herba Bidentis Bipinnatae 30 weight portions.
5. the pharmaceutical preparation as described in claim 1 to 4, is characterized in that: described pharmaceutical preparation is exterior-applied formulation.
6. the pharmaceutical preparation as described in claim 1 to 5, is characterized in that: described pharmaceutical preparation is prepared into eye drop.
7. the preparation method of pharmaceutical preparation described in claim 1 to 6, is characterized in that:
The first step, each crude drug component is mixed by weight, obtain mixture, the alcohol reflux that is 80%～90% with determining alcohol 3 times～5 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20～1.23 (60 ℃), the amount of each ethanol adding is 2～4 times of mixture quality, be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to 3～5 times of amounts of its quality, under stirring, add with respect to powder quality 5%～10% sodium hydroxide hydrotropy, regulating pH value is 7～8, filter, filtrate decompression is condensed into the mastic that relative density is 1.29～1.32 (60 ℃) and is dried, be ground into powder,
Second step, the powder obtaining is above mixed, add the distilled water with respect to 15～25 times of amounts of mixture quality, the boric acid of 0.01～0.03 times, the Borax of 0.02～0.04 times, the sodium chloride of 0.2～0.4 times, stirs, and is heated to 100 ℃ and be incubated 30～40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop.
8. a pharmaceutical preparation eye drop, is characterized in that: crude drug comprise Radix Saposhnikoviae, Herba Senecionis Scandentis, Herba Menthae, Herba Centipedae, Concha Haliotidis, Stigma Croci, Cortex Mori, Radix Isatidis, Semen Cuscutae, Cortex Fraxini, Herba Ecliptae, Radix Liriopes, Flos Lonicerae, Flos Buddlejae, Herba Plantaginis, Herba Schizonepetae, Fructus Ligustri Lucidi, Rhizoma Coptidis, Semen Astragali Complanati, Rhizoma Dioscoreae,
hold, Spica Prunellae, Fructus Broussonetiae, Semen Celosiae, Fructus Rubi, Flos Eriocauli, Herba Caryopteridis Incanae and Herba Bidentis Bipinnatae;
The preparation method of described eye drop is specially,
The first step, each crude drug component is mixed by weight, obtain mixture, the alcohol reflux that is 80%～90% with determining alcohol 3 times～5 times, filter, merging filtrate, being evaporated to relative density is the mastic of 1.20～1.23 (60 ℃), the amount of the ethanol adding is 2～4 times of mixture quality, be dried subsequently, and be ground into powder, powder after pulverizing is added to the water dissolution with respect to 3～5 times of amounts of its quality, under stirring, add with respect to powder quality 5%～10% sodium hydroxide hydrotropy, regulating pH value is 7～8, filter, adding concentration and be 10% sulfur acid for adjusting pH value is 3～4, static 2～4 hours, filter, filtrate decompression is condensed into the mastic that relative density is 1.29～1.32 (70 ℃) and is dried, be ground into powder,
Second step, the powder obtaining is above mixed, add the distilled water with respect to 15～25 times of amounts of mixture quality, the boric acid of 0.01～0.03 times, the Borax of 0.02～0.04 times, the sodium chloride of 0.2～0.4 times, stirs, and is heated to 100 ℃ and be incubated 30～40 minutes, cooling, filter, subpackage, sterilizing obtains eye drop.
9. pharmaceutical preparation eye drop as claimed in claim 8, it is characterized in that: in described pharmaceutical preparation, the weight portion of each crude drug is respectively Radix Saposhnikoviae 25 weight portion～35 weight portions, Herba Senecionis Scandentis 35 weight portion～45 weight portions, Herba Menthae 20 weight portion～30 weight portions, Herba Centipedae 15 weight portion～25 weight portions, Concha Haliotidis 35 weight portion～45 weight portions, Stigma Croci 20 weight portion～30 weight portions, Cortex Mori 20 weight portion～30 weight portions, Radix Isatidis 45 weight portion～55 weight portions, Semen Cuscutae 35 weight portion～45 weight portions, Cortex Fraxini 25 weight portion～35 weight portions, Herba Ecliptae 20 weight portion～30 weight portions, Radix Liriopes 25 weight portion～35 weight portions, Flos Lonicerae 35 weight portion～45 weight portions, Flos Buddlejae 25 weight portion～35 weight portions, Herba Plantaginis 15 weight portion～25 weight portions, Herba Schizonepetae 20 weight portion～30 weight portions, Fructus Ligustri Lucidi 35 weight portion～45 weight portions, Rhizoma Coptidis 65 weight portion～75 weight portions, Semen Astragali Complanati 25 weight portion～35 weight portions, Rhizoma Dioscoreae 35 weight portion～45 weight portions,
hold 20 weight portion～30 weight portions, Spica Prunellae 20 weight portion～30 weight portions, Fructus Broussonetiae 25 weight portion～35 weight portions, Semen Celosiae 35 weight portion～45 weight portions, Fructus Rubi 25 weight portion～35 weight portions, Flos Eriocauli 25 weight portion～35 weight portions, Herba Caryopteridis Incanae 30 weight portion～40 weight portions and Herba Bidentis Bipinnatae 25 weight portion～35 weight portions.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310508140.5A CN103721000A (en) | 2013-10-24 | 2013-10-24 | Medicinal preparation for treating epidemic keratoconjunctivitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310508140.5A CN103721000A (en) | 2013-10-24 | 2013-10-24 | Medicinal preparation for treating epidemic keratoconjunctivitis |
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| CN104027621A (en) * | 2014-05-15 | 2014-09-10 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine composition for treating acute conjunctivitis |
| CN104840791A (en) * | 2015-05-19 | 2015-08-19 | 王猛 | Traditional Chinese medicine for treating epidemic keratoconjunctivitis, preparation method and using method |
| CN104888015A (en) * | 2015-06-18 | 2015-09-09 | 王峰 | Oral traditional Chinese medicine for treating conjunctivitis |
| CN104922518A (en) * | 2015-06-18 | 2015-09-23 | 王峰 | Traditional Chinese medicine composition for treating conjunctivitis |
| CN104940686A (en) * | 2015-06-18 | 2015-09-30 | 王峰 | Chinese medicinal formula for treating conjunctivitis |
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- 2013-10-24 CN CN201310508140.5A patent/CN103721000A/en active Pending
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| 鄢小维 等: "石决明散结合西药治疗流行性角结膜炎36例", 《陕西中医》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027621A (en) * | 2014-05-15 | 2014-09-10 | 当涂县科辉商贸有限公司 | Traditional Chinese medicine composition for treating acute conjunctivitis |
| CN104840791A (en) * | 2015-05-19 | 2015-08-19 | 王猛 | Traditional Chinese medicine for treating epidemic keratoconjunctivitis, preparation method and using method |
| CN104888015A (en) * | 2015-06-18 | 2015-09-09 | 王峰 | Oral traditional Chinese medicine for treating conjunctivitis |
| CN104922518A (en) * | 2015-06-18 | 2015-09-23 | 王峰 | Traditional Chinese medicine composition for treating conjunctivitis |
| CN104940686A (en) * | 2015-06-18 | 2015-09-30 | 王峰 | Chinese medicinal formula for treating conjunctivitis |
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Application publication date: 20140416 |