A kind of medical shoe pad with anti-treating chilblain effect and preparation method thereof
Technical field
The present invention relates to a kind of medicated health-care shoe-pad, be specifically related to a kind of medical shoe pad with anti-treating chilblain effect and preparation method thereof.
Background technology
As pernio, its pin is also multiple position, is mainly in toes, sufficient edge, heel etc. and locates.Pernio is common in winter, due to the local skin erythema repeatedly that very cold causes, and swelling infringement, can there is blister, ulcer in severe patient, and the course of disease is slow, and general weather turns warm self-healing, easily recurrence.Cold is the main cause of pernio morbidity, the skin that its morbidity cause is pernio patient is when running into cold (0-10 ℃), humidity or the changes in temperature sudden turn of events, and local parteriole shrinks, and arteries of a specified duration is benumbed and expanded, venous congestion, local blood circulates bad and falls ill.In addition, also have and may participate in morbidity because of factors such as patient's self humidity of skin, tip capilary deformity, autonomic nerve dysfunction, malnutrition, dysendocrinisms.Pernio betides well early winter, early spring, especially common with the bad person of children, women and peripheral blood circulation, these patients often with acral skin send out cool, acrocyanosis, hidrosis.The generation of pernio is often with gargalesthesia, pain, and blister can occur severe patient, breaking forms erosion or ulcer, to patient, causes very large misery.The existing generation that prevents frostbite of foot is padding the insulations such as heavy weave or animal skin in footwear, but with regard to its effect only as momentary insulation, once there is pernio, cannot fundamentally impel pernio healing.Existing commercially available medical shoe pad, mainly with deodorization, perspiration removing, it is main preventing and treating the pedopathys such as beriberi, medical shoe pad existing market for anti-treating chilblain yet there are no sale, existing patent CN2077651U is disclosed to be treated and the medicine footwear of anti-frostbite, its shoe-pad is by waterproof nylon, medicine and fat-soluble medium, comprises Chinese cassia tree, cassia twig and lanolin, and the effect of its anti-treating chilblain is also not satisfactory.
Summary of the invention
The object of this invention is to provide a kind of medical shoe pad with anti-treating chilblain effect.
The present invention also aims to provide a kind of preparation method of the medical shoe pad with anti-treating chilblain effect.
In order to realize the present invention, specifically adopted following technical scheme:
A kind of medical shoe pad with anti-treating chilblain effect, it is characterized in that this shoe-pad comprises superficial layer, intermediate layer and bottom composition, the one or both sides of its intermediate layer and superficial layer scribble pharmaceutical intermixture, described pharmaceutical intermixture is by the camphor 3-5% of mass ratio, boric acid 5-7%, menthol 6-8%, tannic acid 1-2%, thymol 0.25-0.75%, vitamin E 0.5-1.5%, nicotinic acid 0.25-0.5%, Salvia root P.E 4-6%, Tween 80 6-12%, pure water 68-74% is mixed and made into liquid, get aforesaid liquid 70-90%, add adhesive 10-30% Hybrid Heating to become thick.
Adhesive described above is comprised of by weight 7:3 starch and sodium carboxymethylcellulose.
Superficial layer and bottom described above consist of pure cotton cloth, and intermediate layer consists of wool felt.
A preparation method with the medical shoe pad of anti-treating chilblain effect, is characterized in that:
(1) get camphor 3-5%, menthol 6-8%, thymol 0.25-0.75% puts in mortar and grinds and make congruent melting, then adds vitamin E 0.5-1.5% to grind well, and makes into liquid material;
(2) separately get boric acid 5-7%, tannic acid 1-2%, nicotinic acid 0.25-0.5%, Salvia root P.E 4-6% respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder;
(3) get mixed powder that liquid material that above-mentioned (1) make makes with (2) and mix and add Tween 80 6-12%, grind all, then add pure water 68-74% to be mixed into liquid;
(4) get the liquid 70-90% that above-mentioned (3) make, add adhesive 10-30% Hybrid Heating to become the thick pharmaceutical intermixture of making;
(5) pharmaceutical intermixture is brushed equably to any one or both sides between intermediate layer and superficial layer, then, by superficial layer, intermediate layer, bottom is bonding, dry after through making and get final product.
Described adhesive is comprised of by weight 7:3 starch and sodium carboxymethylcellulose.
Superficial layer and bottom described above consist of pure cotton cloth, and intermediate layer consists of wool felt.
Described is dry, is to adopt 26-32 ℃ of low temperature drying 6-8 hour.
According to shoe-pad, vary in size, every pair of shoe-pad is brushed pharmaceutical intermixture at 4-4.5g.
Boric acid, this product can be combined and bring into play bacteriostasis, nonirritant by the amino in bacterioprotein.
Menthol, the cold receptor of the alternative chafe of this product, topical application, has the blood circulation of promotion and anti-inflammatory, antipruritic, analgesic effect.
Tannic acid, energy precipitating proteins, has astringing to arrest bleeding effect, is usually used in skin ulcer, eczema, pernio, bedsore etc.
Thymol, this product has bactericidal action, and strong compared with phenol, and especially stronger to fungi, actinomycetic effect, toxicity is little, is usually used in treating skin fungus or infection, eczema, pernio and dermatozoon and infects.
Vitamin E, this product has the peripheral blood circulation of improvement, increases capillary of skin CBF, and maintains the effect such as normal permeability of capillary.
Nicotinic acid, this product has the little blood vessel of expansion, improves microcirculatory effect, to pernio, can improve local blood supply, has certain therapeutic action.
Salvia root P.E, through being ground into meal by the red sage root, add alcohol heating reflux and extract three times, filter merging filtrate, decompression recycling ethanol and be condensed into relative density and be 1.30-1.35 thick paste after, in 80 ℃, dry, pulverize into fine powder and make, there is hemangiectasis, improve microcirculation, increase the effects such as CBF, thrombus dissolving and alleviation limbs pain due to blood stasis.
Beneficial effect of the present invention
Product of the present invention has well antibacterial, sterilization, block, analgesic effect, to improving RBF, maintain capillary penetrating, improving local blood supply function all has good effect, be conducive to improvement and the healing of foot pernio, to not forming pernio, have good preventive and therapeutic effect.
A kind of medical shoe pad with anti-treating chilblain effect of the present invention, its preparation method is simple, be beneficial to and apply, concerning pernio is not sent out well person, after early winter, early spring wear, can effectively bring into play shoe-pad medicine hemangiectasis, improve microcirculation, increase the effect such as CBF, can effectively prevent the generation of pernio, to sending out patient frostbitten, there is good therapeutic action, medical shoe pad of the present invention to foot chap, pernio effect is fairly obvious, suitable applying.
A kind of medical shoe pad with anti-treating chilblain effect of the present invention, shows to have good remarkable result by following clinical trial.
Select personnel 60 people that suffer from pernio former years, the person between twenty and fifty in age 25-40 year, in then, (2012) just adopt shoe-pad of the present invention to 30 people, wear try to the coming year (2013) by the end of March, there is pernio in result no one, efficiently accounts for 100%; And control group 30 people wear arbitrarily footwear and do not add shoe-pad of the present invention, there is foot pernio in 16 people as a result, efficiently accounts for 46.66%; To above-mentioned send out 16 people frostbitten and give shoe-pad of the present invention try on, within 1 month, cure 5 examples, account for and cure 9 examples in 31.25%, 2 month, account for 56.25%, 2 examples that take a turn for the better, account for 12.5%, total effective rate 100%, cure rate 87.5%.
The specific embodiment
Embodiment 1
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 30g, menthol 60g, thymol 2.5g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 5g to grind evenly, makes into liquid material 97.5g; (2) get boric acid 50g, tannic acid 10g, nicotinic acid 2.5g, Salvia root P.E 40g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 102.5g; (3) after the mixed powder 102.5g that the liquid material 97.5g (1) being obtained obtains with (2) mixes, add Tween 80 60g, fully grind all, then add pure water 740g to be mixed into liquid; (4) get aforesaid liquid 900g, add starch 70g, sodium carboxymethylcellulose 30g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably on intermediate layer and superficial layer below, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 32 ℃ of low temperature dryings after 6 hours, through making and obtain approximately 200 pairs of shoe-pads.
Embodiment 2
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 45g, menthol 65g, thymol 3.5g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 6g to grind evenly, makes into liquid material 119.5g; (2) get boric acid 60g, tannic acid 15g, nicotinic acid 3g, Salvia root P.E 45g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 123g; (3) after the mixed powder 123g that the liquid material 119.5g (1) being obtained obtains with (2) mixes, add Tween 80 70g, fully grind all, then add pure water 687.5g to be mixed into liquid; (4) get aforesaid liquid 700g, add starch 210g, sodium carboxymethylcellulose 90g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably on intermediate layer, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 26 ℃ of low temperature dryings after 8 hours, through making and obtain approximately 225 pairs of shoe-pads.
Embodiment 3
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 40g, menthol 60g, thymol 5g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 10g to grind evenly, makes into liquid material 115g; (2) get boric acid 55g, tannic acid 10g, nicotinic acid 3.75g, Salvia root P.E 45g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 113.75g; (3) after the mixed powder 113.75g that the liquid material 115g (1) being obtained obtains with (2) mixes, add Tween 80 90g, fully grind all, then add pure water 681.25g to be mixed into liquid; (4) get aforesaid liquid 800g, add starch 140g, sodium carboxymethylcellulose 60g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably below superficial layer, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 26 ℃ of low temperature dryings after 8 hours, through making and obtain approximately 225 pairs of shoe-pads.
Embodiment 4
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 50g, menthol 60g, thymol 3g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 5g to grind evenly, makes into liquid material 118g; (2) get boric acid 70g, tannic acid 10g, nicotinic acid 2.5g, Salvia root P.E 55g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 137.5g; (3) after the mixed powder 137.5g that the liquid material 118g (1) being obtained obtains with (2) mixes, add Tween 80 60g, fully grind all, then add pure water 684.5g to be mixed into liquid; (4) get aforesaid liquid 850g and add starch 105g, sodium carboxymethylcellulose 45g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably on intermediate layer and superficial layer below, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 30 ℃ of low temperature dryings after 7 hours, through making and obtain approximately 210 pairs of shoe-pads.
Embodiment 5
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 30g, menthol 80g, thymol 2.5g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 5g to grind evenly, makes into liquid material 117.5g; (2) get boric acid 50g, tannic acid 10g, nicotinic acid 2.5g, Salvia root P.E 60g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 122.5g; (3) after the mixed powder 122.5g that the liquid material 117.5g (1) being obtained obtains with (2) mixes, add Tween 80 60g, fully grind all, then add pure water 700g to be mixed into liquid; (4) get aforesaid liquid 750g and add starch 175g, sodium carboxymethylcellulose 75g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably on intermediate layer, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 28 ℃ of low temperature dryings after 7.5 hours, through making and obtain approximately 218 pairs of shoe-pads.
Embodiment 6
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 50g, menthol 80g, thymol 7.5g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 14.5g to grind evenly, makes into liquid material 152g; (2) get boric acid 50g, tannic acid 10g, nicotinic acid 2.5g, Salvia root P.E 40g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 102.5g; (3) after the mixed powder 102.5g that the liquid material 152g (1) being obtained obtains with (2) mixes, add Tween 80 65g, fully grind all, then add pure water 680.5g to be mixed into liquid; (4) get aforesaid liquid 800g and add starch 140g, sodium carboxymethylcellulose 60g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably on intermediate layer and superficial layer below, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 32 ℃ of low temperature dryings after 6 hours, through making and obtain approximately 215 pairs of shoe-pads.
Embodiment 7
Shoe-pad of the present invention is comprised of superficial layer, intermediate layer and bottom, and wherein superficial layer and bottom consist of pure cotton cloth, and intermediate layer consists of wool felt, and any one or both sides between intermediate layer and superficial layer are brushed pharmaceutical intermixture; While making shoe-pad, first prepare pharmaceutical intermixture: (1) gets camphor 30g, menthol 80g, thymol 2.5g, puts in mortar and grinds and make congruent melting liquefaction, then adds vitamin E 5g to grind evenly, makes into liquid material 117.5g; (2) get boric acid 50g, tannic acid 10g, nicotinic acid 2.5g, Salvia root P.E 40g respectively porphyrize mixes, and crosses 100 mesh sieves, obtains mixed powder 102.5g; (3) after the mixed powder 102.5g that the liquid material 117.5g (1) being obtained obtains with (2) mixes, add Tween 80 100g, fully grind all, then add pure water 680g to be mixed into liquid; (4) get aforesaid liquid 700g and add starch 210g, sodium carboxymethylcellulose 90g Hybrid Heating becomes thick pharmaceutical intermixture 900g; (5) pharmaceutical intermixture making is brushed in right amount equably on intermediate layer and superficial layer below, then by bonding to superficial layer, intermediate layer and bottom, be placed in baking oven in 30 ℃ of low temperature dryings after 7 hours, through making and obtain approximately 220 pairs of shoe-pads.