CN103705964A - Self-crosslinked gel as well as preparation method and application thereof - Google Patents
Self-crosslinked gel as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN103705964A CN103705964A CN201310695850.3A CN201310695850A CN103705964A CN 103705964 A CN103705964 A CN 103705964A CN 201310695850 A CN201310695850 A CN 201310695850A CN 103705964 A CN103705964 A CN 103705964A
- Authority
- CN
- China
- Prior art keywords
- self
- wound
- gel
- crosslinked gel
- polyvinyl alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses self-crosslinked gel as well as a preparation method and an application thereof. The self-crosslinked gel consists of the following raw materials in percentage by weight: 10-18% of polyethylene oxide, 4-8% of polyvinyl alcohol, 1-2% of alum, 0.5-1% of natural calcium alginate, 3-4% of chelating agent and 67-81.5% of water. The self-crosslinked gel disclosed by the invention has the beneficial effects that (1) the polyoxyethylene-polyvinyl alcohol copolymer is self-crosslinked to form a network structure by use of initiators such as chelating agent and aluminum salt, and the production technology for preparing gel patches through a coating process can realize the effects of low energy consumption and low cost; (2) the self-crosslinked gel is safe and environment-friendly, meets the requirements of energy conservation and emission reduction, promotes the development of related industries and has good social benefits; (3) the patch is flat and smooth with good touch; and the hydrocolloid absorbs the wound exudate and can maintain the wet environment of the wound and accelerate wound healing; and (4) after the seepage of the patch and wound ends, the functions of releasing calcium ions into the wound, inducing platelet activation and accelerating wound healing are realized through calcium ion-body fluid sodium ion exchange.
Description
Technical field
The present invention relates to a kind of gel products, be specially a kind of self-crosslinking gel, and the preparation method and application of this gel.
Background technology
2000, U.S. FDA is lay special stress in new < < wound surface medical supplies (medicine for external use and dressing) the industry guide > > promulgating, keeping the moist environment of wound surface is the processing method of standard.The U.S. is wound wet treatment as industry processing specification, and this absolutely proves that moist dressing can be all the main flow in Wound dressing market now with future very over a long time.
The dressing of bandage generally adopts cotton or non-weaving cloth on the market now, also not obvious for the healing role of wound face.Emerging has cooling and promotes the medical accessory hydrogel of wound healing effect to arise at the historic moment.
Summary of the invention
The object of the invention is for a kind of self-crosslinking gel is provided, to make up the blank on market.
Another object of the present invention is to provide the preparation method and application of this self-crosslinking gel.
The object of the invention is to be achieved through the following technical solutions:
A self-crosslinking gel, is comprised of the raw material of following weight percent meter:
Described chelating agen is medical ethylenediaminetetraacetic acid.
The preparation method of above-mentioned self-crosslinking gel, concrete steps are as follows:
Step 1: a certain amount of Alumen and natural calcium alginate are joined in aqueous solvent, stir, form mixed solution.
Step 2: chelating agen is joined in mixed solution, stir.
Step 3: a certain amount of poly(ethylene oxide) and polyvinyl alcohol are added in above-mentioned solution, be uniformly mixed under 90 ℃ of conditions until spontaneous formation gel is placed in dissolving completely.
After tested, to skin without any stimulation; Can be directly in wound cold compress, without any sensitization; At room temperature environment, keep below 20 ℃ >=1h.Therefore can be applicable to cold patch.
Self-crosslinking gel paster prepared by the present invention is a kind of novel wound wound paster, has certain cold compress effect, can alleviate soft tissue injury and the distending pain sense that produces.The raw material preparation that main employing is natural, nontoxic, utilizes the auxiliary agents such as medicinal aluminum salt and chelating agen, forms network-like structure in raw material, finally by coating processes processing procedure gel paster.After the medical chelating agen that this product is selected impels natural polymer self-crosslinking, product presents gel automatically,
The present invention has following beneficial effect:
1, utilize the initiators such as chelating agen, aluminum salt to make polyethylene glycol oxide-polyvinyl alcohol copolymer self-crosslinking form network-like structure, by coating processes, make the production technology of gel paster, can reach low energy consumption, effect cheaply.
2, safety and environmental protection, meets the requirement of energy-saving and emission-reduction, and promotes related industry development, and social benefit is good.
3, paster is smooth smooth, and sense of touch is good, and hydrocolloid absorbs Wound exudate, can maintain wound moist environment, accelerating wound healing.
4, when paster and wound exudate finish, by calcium ion-body fluid sodium ion, exchange, reach and discharge calcium ion in wound, induced platelet activation, acceleration of wound face healing effect.
The specific embodiment
Below in conjunction with specific embodiment, further set forth technical characterstic of the present invention.
Embodiment of the present invention 1-5 adopts following preparation technology:
The formula of embodiment 1-5 is as follows:
Embodiment 1
Poly(ethylene oxide) (PEO) 10%; Polyvinyl alcohol (PVA) 4%; Alumen (aluminum salt) 1%; Natural calcium alginate (calcium alginate) 0.5%; Chelating agen 3%; Water 81.5%.
Embodiment 2
Poly(ethylene oxide) (PEO) 18%; Polyvinyl alcohol (PVA) 8%; Alumen (aluminum salt) 2%; Natural calcium alginate (calcium alginate) 1%; Chelating agen 4%; Water 67%.
Embodiment 3
Poly(ethylene oxide) (PEO) 17%; Polyvinyl alcohol (PVA) 6%; Alumen (aluminum salt) 2%; Natural calcium alginate (calcium alginate) 1%; Chelating agen 4%; Water 70%.
Embodiment 4
Poly(ethylene oxide) (PEO) 15%; Polyvinyl alcohol (PVA) 5%; Alumen (aluminum salt) 1%; Natural calcium alginate (calcium alginate) 1%; Chelating agen 3%; Water 75%.
Embodiment 5
Poly(ethylene oxide) (PEO) 16%; Polyvinyl alcohol (PVA) 7%; Alumen (aluminum salt) 1.5%; Natural calcium alginate (calcium alginate) 0.5%; Chelating agen 3.5%; Water 71.5%.
Table 1 is the data of the test of embodiment 1-5
By upper table test data, can be found out, product of the present invention to skin without any stimulation, can be directly in wound cold compress, without any sensitization; There is good cold performance, can be used as the cold patch that wound is deleted.
Claims (4)
1. a self-crosslinking gel, is characterized in that: the raw material by following weight percent meter forms:
2. a kind of self-crosslinking gel according to claim 1, is characterized in that: described chelating agen is ethylenediaminetetraacetic acid.
3. a method of preparing self-crosslinking gel described in claim 1, is characterized in that: concrete steps are as follows:
Step 1: a certain amount of Alumen and natural calcium alginate are joined in aqueous solvent, stir, form mixed solution.
Step 2: chelating agen is joined in mixed solution, stir.
Step 3: a certain amount of poly(ethylene oxide) and polyvinyl alcohol are added in above-mentioned solution, be uniformly mixed under 90 ℃ of conditions until spontaneous formation gel is placed in dissolving completely.
4. a kind of self-crosslinking gel according to claim 1, is characterized in that: be applied to prepare cold patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310695850.3A CN103705964B (en) | 2013-12-15 | 2013-12-15 | Self-crosslinked gel as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310695850.3A CN103705964B (en) | 2013-12-15 | 2013-12-15 | Self-crosslinked gel as well as preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103705964A true CN103705964A (en) | 2014-04-09 |
| CN103705964B CN103705964B (en) | 2015-07-08 |
Family
ID=50399543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310695850.3A Active CN103705964B (en) | 2013-12-15 | 2013-12-15 | Self-crosslinked gel as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103705964B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159215A (en) * | 2021-11-24 | 2022-03-11 | 武汉纺织大学 | Production method of intelligent fabric beneficial to wound healing |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1263472A (en) * | 1997-05-16 | 2000-08-16 | 安姆根有限公司 | Sustained-release delayed gels |
| CN1960736A (en) * | 2004-02-27 | 2007-05-09 | 海德罗默公司 | Anti-infectious hydrogel compositions |
| WO2009005814A2 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
| CN101810874A (en) * | 2009-12-15 | 2010-08-25 | 北京欧凯纳斯科技有限公司 | Sustained-release chlorine dioxide gel, preparation method and application thereof |
| CN102580134A (en) * | 2011-12-20 | 2012-07-18 | 山东省医疗器械研究所 | Biological and haemostatic wound dressing and preparation method thereof |
-
2013
- 2013-12-15 CN CN201310695850.3A patent/CN103705964B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1263472A (en) * | 1997-05-16 | 2000-08-16 | 安姆根有限公司 | Sustained-release delayed gels |
| CN1960736A (en) * | 2004-02-27 | 2007-05-09 | 海德罗默公司 | Anti-infectious hydrogel compositions |
| WO2009005814A2 (en) * | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
| CN101810874A (en) * | 2009-12-15 | 2010-08-25 | 北京欧凯纳斯科技有限公司 | Sustained-release chlorine dioxide gel, preparation method and application thereof |
| CN102580134A (en) * | 2011-12-20 | 2012-07-18 | 山东省医疗器械研究所 | Biological and haemostatic wound dressing and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杨占山等: "PEO/PVA水凝胶伤口敷料的毒性和疗效评价", 《辐射研究与辐射工艺学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159215A (en) * | 2021-11-24 | 2022-03-11 | 武汉纺织大学 | Production method of intelligent fabric beneficial to wound healing |
| CN114159215B (en) * | 2021-11-24 | 2023-09-29 | 武汉纺织大学 | Production method of intelligent fabric beneficial to wound healing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103705964B (en) | 2015-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107050048B (en) | Cold compress patch and preparation method thereof | |
| CN101982202B (en) | Medical hydrogel dressings and preparation method thereof | |
| CN102600493B (en) | Natural pullulan polysaccharide hydrogel wound dressing and preparation method thereof | |
| CN103736134B (en) | Medical sponge dressing and preparation method thereof | |
| CN101502667A (en) | Medical chitosan transparent hydrogel wound dressing as well as preparation and application thereof | |
| CN102850598B (en) | Alginate-gelatin-carboxymethylcellulose sodium blend membrane, and preparation and application thereof | |
| CN106563156A (en) | Gel wound dressing having film-forming property | |
| CN103656731A (en) | Medical chitosan dressing | |
| CN108837179A (en) | A kind of antibacterial imbibition type sodium alginate composite nano fiber medical dressing | |
| CN103768650A (en) | Wound regenerating and repairing bandage and manufacture method thereof | |
| CN101293110A (en) | Medical hydrogel wound dressing and preparation method thereof | |
| CN103920180A (en) | Chitosan hydrogel for antibacterial dressing and preparation method thereof | |
| CN103690989A (en) | Medical chitosan haemostatic wound dressing | |
| CN105327382B (en) | The method that double cross connection method prepares medical transparent polyethylene alcohol hydrogel | |
| CN102294047B (en) | Antibacterial dressing based on cellulose fibre fabric modification and preparation method thereof | |
| CN106943445A (en) | A kind of hemostatic medicine composition and its application | |
| CN103705964B (en) | Self-crosslinked gel as well as preparation method and application thereof | |
| CN103480032B (en) | A kind of argentiferous plural gel dressing and preparation method thereof | |
| CN104056301A (en) | Traditional Chinese medicine-type hemostatic anti-inflammation liquid bandage and preparation method thereof | |
| CN113209354A (en) | Preparation method of antibacterial dressing | |
| CN107177980B (en) | Contact wound dressing and preparation method thereof | |
| CN104324413A (en) | Preparation method of hydrogel dressing | |
| CN104174062A (en) | Sodium alginate kinesio tape and preparation method thereof | |
| CN103705985A (en) | Nasal polymer gel filling material and preparation method thereof | |
| CN108404201A (en) | A kind of anti-bacterial, anti-itching dressing and preparation method thereof containing tea oil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 314107 129 Ting Yao East Road, dry kiln town, Jiashan County, Jiaxing, Zhejiang Patentee after: Zhejiang 3win New Material Co. Ltd. Address before: 201714 129 Ting Yao East Road, dry kiln town, Jiashan County, Jiaxing, Zhejiang Patentee before: Zhejiang Triple Win Medical Appliance Co., Ltd. |
|
| CP03 | Change of name, title or address | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220128 Address after: No. 129, Tingyao East Road, ganyao Town, Jiashan County, Jiaxing City, Zhejiang Province, 314100 Patentee after: ZHEJIANG TRIPLE WIN NEW MATERIAL Co.,Ltd. Patentee after: Inner Mongolia Sanying polymer material R & D Center Co., Ltd Address before: 314107 129 Ting Yao East Road, dry kiln town, Jiashan County, Jiaxing, Zhejiang Patentee before: ZHEJIANG TRIPLE WIN NEW MATERIAL Co.,Ltd. |
|
| TR01 | Transfer of patent right |