CN103705549A - Method for preparing granules for scald - Google Patents
Method for preparing granules for scald Download PDFInfo
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- CN103705549A CN103705549A CN201310726132.8A CN201310726132A CN103705549A CN 103705549 A CN103705549 A CN 103705549A CN 201310726132 A CN201310726132 A CN 201310726132A CN 103705549 A CN103705549 A CN 103705549A
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- granule
- preparation
- scald
- scalding
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Abstract
The invention belongs to the field of preparation of traditional Chinese medicines and particularly discloses a method for preparing granules for scald. The method comprises the following steps: taking fresh pine barks, cleaning, sterilizing, crushing and screening the fresh pine barks so as to obtain pine bark powder; freeze-drying on the pine bark powder for later use; uniformly mixing the pine bark powder and borneol to prepare the granules for scald. The preparation method has the characteristics of simplicity and easiness in operation, and the prepared product reaches the standard and is high in stability. Moreover, according to the process, the microbial population of the product is reduced, and various heat-sensitive active ingredients of the traditional Chinese medicinal materials are preserved to the greatest degree.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of preparation method of scalding with granule.
Background technology
Cortex Pini, another name: Pinus densiflora skin, tongue squama, Cortex Pini Massonianae, Cortex Pini, tongue skin.Latin plant animal mineral name: 1.Pinus kesiya Royel ex Gord var.langbianensis (A.Chev.) Gaussen; 2.Pinus massoniana Lamb, originates as the trunk endothelium of the Pinus massoniana Lamb in Pinaceae pine genus plant, Pinus tabuliformis, Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen etc.Burn and scald is controlled in external, infantile eczema.External method dresses or decocts washing for grinding into powder.
Existing clinical practice is generally dried fine grinding by Cortex Pini exactly, after mixing with appropriate Borneolum Syntheticum, directly be sprinkling upon on wound surface and use, require the Cortex Pini period of storage in source to be no more than 1 year for well (referring to Hu Fuqing, II ° of above burn and scald 50 examples [J] of Cortex Pini treated powder, Hunan Journal of Traditional Chinese Medicine, the 01st phase in 1993).Cortex Pini powdery medicament for treating scald is constantly explored and is got through ancestors generations, in life, to broad masses, brought convenience, curative effect has also obtained approval and the checking of extensive patients in therapeutic process, and the burn from the burn of small size to extra-large area has very many use experience and the embodiment of curative effect.Along with constantly curative effect accumulation and experience accumulation in therapeutic process, fathers and mothers also, constantly improving and fill a prescription, makes its more convenient making and effect rapider, clinical show without any side effects.Cortex Pini powdery medicament for treating scald has obvious difference with respect to other common medicament for treating scalds, this medicine is all generally to make by traditional handicraft, processing method be all generally by raw material Cortex Pini by naturally drying, cut off, then the working procedure processing powdered product such as pulverizing manually.But, the problem that the processing method of traditional handicraft exists is that pulverizing operation causes the meticulous inequality of medicament for treating scald powder particle, can cause in use powder-product not well to be fitted on skin, thereby it is complete well to be healed in skin scald place, and curative effect is not ideal.Therefore, exploitation is easy to fit and makes that its healing is complete and curative effect is desirable on skin, and the product that patient suffering is alleviated is significant.
Summary of the invention
The shortcoming and defect existing for above-mentioned prior art, object of the present invention aims to provide a kind of preparation method of scalding with granule, and the product that this preparation method is processed is easy to be fitted on skin and curative effect ideal, can alleviate patient suffering.
Particularly, inventor provides following technical scheme:
Scald the preparation method with granule, comprise the steps:
(1) pretreatment
Get fresh Cortex Pini, after cleaning remove impurity, naturally dry, pulverize and sieve,
(2) lyophilization
The Cortex Pini powder that step (1) is obtained is at 0 ℃ in temperature, and cold preservation is more than 24 hours,
(3) prepare granule product
In the semi-finished product granule obtaining in step (2), add the 5-8% Chinese patent medicine Borneolum Syntheticum in semi-finished product granular mass, mix, obtain scalding and use granule finished product, this finished product carries out fill at the relative humidity that controls environment in the situation that between 25-32%, obtains scalding and uses granule product.
As preferably, in the present invention, the Cortex Pini in described step (1) is Cortex Pini more than thickness 1cm.The finished product that the bark that thickness is higher obtains is higher than regular meeting, and residue still less result of use is better.
As preferably, in the present invention, sieving in described step (1) refers to that the Cortex Pini after pulverizing filters through 20 eye mesh screens.Cross and filter thick granule, make evengranular covering wound, wound is stimulated less.
As preferably, in the present invention, naturally drying in described step (1) requires under natural air, and the temperature of drying is not less than 27 ℃.Ultraviolet solar ray energy better prevents that bacteria breed from better protecting wound.
As preferably, in the present invention, the Borneolum Syntheticum crystal in described step (3) need to roll and use after 40 eye mesh screens sieve.Borneolum Syntheticum can better mix and mix with semi-finished product granule, makes granule finished product cover more uniformly wound, wound is stimulated less.
Scald prepared by the present invention by the using method of granule is: get disinfectant (1/5000 potassinm permanganate solution or salt water etc.) and clean wound; cut off blister or slough; coat domestic vegetable oil; granule has been sprinkling upon on vegetable oil wound surface; site of injury has misery to alleviate sensation at once; every day 2～3 times; until recovery from illness; as there being transudate on wound surface, then after cleaning with disinfectant, sprinkle medicated powder; after general one hour; transudate on wound surface is absorbed by medicated powder, forms the dry protective layer flap coverage of one deck, until can naturally come off by whole layer after recovery from illness.
Compared with prior art, the present invention has the following advantages:
The scald that preparation method of the present invention obtains has been guaranteed stability and the homogeneity of powdery medicament for treating scald quality with granule product, greatly improved stickiness and the healing property of product.Meanwhile, in the preparation process of granule, avoid the destruction of processing method to medicament for treating scald active component, retained to the full extent various effective ingredient.Preparation method of the present invention does not produce dust pollution to atmosphere, and the powder obtaining has the advantages that opaque is loose, bright in colour, simultaneously because the raw material adopting is dry under field conditions (factors), be unfavorable for microbial growth and breeding, the microbial limit of finished product is controlled to certain effect of having played.The product obtaining according to preparation method of the present invention has better curative effect, more can reduce patient's misery.
The specific embodiment
Below in conjunction with embodiment, be described more specifically content of the present invention.
In the present invention, if not refer in particular to, all part, percentage ratios are unit of weight, and all equipment and raw material etc. all can be buied from market or the industry is conventional.Method in following embodiment, if no special instructions, is the conventional method of this area.
Embodiment 1
Scald the preparation method with granule, comprise the steps:
(1) pretreatment
Get fresh Cortex Pini more than thickness 1cm, clean, remove impurity, be then placed under natural air, dry being not less than high temperature at 27 ℃, then pulverize and filter through 20 eye mesh screens through pulverizer,
(2) lyophilization
The Cortex Pini powder that step (1) is obtained carries out lyophilization in freezer dryer, and specific operation process is as follows: after material sabot, open refrigeration machine material is lowered the temperature, temperature is down to 0 ℃, and cold preservation is more than 24 hours,
(3) prepare granule product
In the semi-finished product granule obtaining in step (2), add 5% Borneolum Syntheticum (Borneolum Syntheticum has rolled and sieved through 40 eye mesh screens) in semi-finished product granular mass, mix, obtain scalding and use granule finished product, finished product pick test, this finished product is to carry out fill 25% time at the relative humidity that controls environment, and obtains scalding using granule product.In pouring process, regularly loading amount detected and keep a record.To after fill finished product lamp inspection, pack.To package granule and deliver to outsourcing post from pass-through box, pack, mounted box, coding, cover heat shrink films, vanning, in packaging process, the censorship of QA randomization, meets relevant criterion.After having packed, final finished is deposited to Holding Area, warehouse, and keeps a record, with the qualified warehouse-in of finished product.
Embodiment 2
Scald the preparation method with granule, comprise the steps:
(1) pretreatment
Get fresh Cortex Pini more than thickness 1cm, clean, remove impurity, be then placed under natural air, dry being not less than high temperature at 25 ℃, then pulverize and filter through 20 eye mesh screens through pulverizer,
(2) lyophilization
The Cortex Pini powder that step (1) is obtained carries out lyophilization in freezer dryer, and specific operation process is as follows: after material sabot, open refrigeration machine material is lowered the temperature, temperature is down to 0 ℃, and cold preservation is more than 24 hours,
(3) prepare granule product
In the semi-finished product granule obtaining in step (2), add 8% Borneolum Syntheticum (Borneolum Syntheticum has rolled and sieved through 40 eye mesh screens) in semi-finished product granular mass, mix, obtain scalding and use granule finished product, finished product pick test, this finished product is to carry out fill 32% time at the relative humidity that controls environment, and obtains scalding using granule product.In pouring process, regularly loading amount detected and keep a record.To after fill finished product lamp inspection, pack.To package granule and deliver to outsourcing post from pass-through box, pack, mounted box, coding, cover heat shrink films, vanning, in packaging process, the censorship of QA randomization, meets relevant criterion.After having packed, final finished is deposited to Holding Area, warehouse, and keeps a record, with the qualified warehouse-in of finished product.
Application examples
Clinical use be product prepared by above-mentioned arbitrary embodiment, therapeutic effect there is no significant difference.
Getting typical case makes an explanation to medicine of the present invention:
1, in the clinical example for the treatment of burn and scald, male 30 examples, female's 50 examples; The oldest person 58 years old, reckling 3 years old; Burn surface area the maximum 20%, reckling 0.5%, most between 1～3%; Depth of burn: 2 degree; Burn cause: scald 63 examples, remaining 17 examples for fire, electricity, molten iron burn.Burned part: in the majority with instep, shank, thigh, palm, the back of the hand, forearm person; Minority is the scalds such as chest, cervical region, face, buttocks.
2 Therapeutic Method
Get disinfectant (1/5000 potassinm permanganate solution) and clean wound, cut off blister or slough, coat domestic vegetable oil; granule has been sprinkling upon on vegetable oil wound surface, and site of injury has misery to alleviate sensation at once, every day 2～3 times; until recovery from illness; as there being transudate on wound surface, then after cleaning with disinfectant, sprinkle granule; after general one hour; transudate on wound surface is absorbed by medicated powder, forms the dry protective layer flap coverage of one deck, until can naturally come off by whole layer after recovery from illness.
3, therapeutic effect
What wound was little can preventing from scar, reduces significantly the wounded's misery, and general can entirely heal in 3-4 days; Wound area large depending on practical situation, generally need one week above time.
Application comparative example
1, clinical example explanation
In the clinical data example for the treatment of burn and scald, male 10 examples, female's 15 examples; The oldest person 55 years old, reckling 3 years old; Burn surface area the maximum 20%, reckling 0.5%, most between 1～3%; Depth of burn: 2 degree; Burn cause: scald 20 examples, remaining 5 examples for fire, electricity, molten iron burn.Burned part: in the majority with instep, shank, thigh, palm, the back of the hand, forearm person; Minority is the scalds such as chest, cervical region, face, buttocks.
2, Therapeutic Method
2.1 medicines preparations: get pinaster and remove its outer rough bark, appropriate with internal layer bark, dry fine ground end standby.Get Borneolum Syntheticum grind into powder in right amount (pinaster corium farinosum: Borneolum Syntheticum=200: 10), mix with pinaster corium farinosum, standby.Attention: pinaster corium farinosum is more fresh better, storage must not surpass 1 year, otherwise affects the treatment.
2.2 usages: get disinfectant (1/5000 potassinm permanganate solution) and clean wound; cut off blister or slough; the powder making is sprinkling upon on wound surface, and every day 2～3 times, until recovery from illness; as there being transudate on wound surface; after cleaning with disinfectant again, sprinkle medicated powder, after general half day; transudate on wound surface is absorbed by medicated powder, forms the dry protecting film flap coverage of one deck.
3, therapeutic effect
General can entirely heal within a week; Wound area large depending on practical situation, generally need two weeks above time.
What clinical comparative example adopted is existing conventional medicament for treating scald, the powder plucked of this medicine, and Borneolum Syntheticum size inequality causes mixing inhomogeneous; in therapeutic process, stickiness is bad; protective layer easily breaks and can cause healing time to extend, and can not reduce efficiently the wounded's misery, stays cicatrix probability high.Medicine provided by the invention can fully solve above weak point, to patient, brings better curative effect.
Finally, it should be pointed out that above embodiment is only the more representational example of the present invention.Obviously, technical scheme of the present invention is not limited to above-described embodiment, can also have many distortion.Every all distortion of directly deriving or associate from content disclosed by the invention, all should think protection scope of the present invention.
Claims (5)
1. scald the preparation method with granule, it is characterized in that comprising the steps:
(1) pretreatment
Get fresh Cortex Pini, after cleaning remove impurity, naturally dry, pulverize and sieve,
(2) freeze-drying lyophilization
The Cortex Pini powder that step (1) is obtained is cold preservation more than 24 hours at 0 ℃ in temperature,
(3) prepare granule product
In the semi-finished product granule obtaining in step (2), add the Borneolum Syntheticum crystal in the 5-8% of semi-finished product granular mass, mix, obtain scalding and use granule finished product, this finished product is to carry out fill between 25-32% in the situation that at the relative humidity that controls environment, and obtains scald granule product.
2. a kind of preparation method of scalding with granule as claimed in claim 1, is characterized in that, the Cortex Pini in described step (1) is Cortex Pini more than thickness 1cm.
3. a kind of preparation method of scalding with granule as claimed in claim 1, is characterized in that, sieving in described step (1) refers to that the Cortex Pini after pulverizing filters through 20 eye mesh screens.
4. a kind of preparation method of scalding with granule as claimed in claim 1, is characterized in that, naturally drying in described step (1) requires under natural air, and the temperature of drying is not less than 27 ℃.
5. a kind of preparation method of scalding with granule as claimed in claim 1, is characterized in that, the Borneolum Syntheticum crystal in described step (3) need to roll and use after 40 eye mesh screens sieve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310726132.8A CN103705549A (en) | 2013-12-15 | 2013-12-15 | Method for preparing granules for scald |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310726132.8A CN103705549A (en) | 2013-12-15 | 2013-12-15 | Method for preparing granules for scald |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103705549A true CN103705549A (en) | 2014-04-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310726132.8A Pending CN103705549A (en) | 2013-12-15 | 2013-12-15 | Method for preparing granules for scald |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519319A (en) * | 2017-08-29 | 2017-12-29 | 宁波保税区攀峒信息科技有限公司 | A kind of loose skin tea oil ointment for treating burn and scald and usage food ointment chemical product physiotherapy ointment |
| CN114796288A (en) * | 2022-04-25 | 2022-07-29 | 吴彩芳 | External medicine for burns and scalds and preparation method thereof |
-
2013
- 2013-12-15 CN CN201310726132.8A patent/CN103705549A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 胡辅庆: "松树皮粉治疗II°以上烧烫伤50例", 《湖南中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519319A (en) * | 2017-08-29 | 2017-12-29 | 宁波保税区攀峒信息科技有限公司 | A kind of loose skin tea oil ointment for treating burn and scald and usage food ointment chemical product physiotherapy ointment |
| CN114796288A (en) * | 2022-04-25 | 2022-07-29 | 吴彩芳 | External medicine for burns and scalds and preparation method thereof |
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Effective date of abandoning: 20170531 |