CN103687584B - 表现出低眼刺激潜能的个人清洁体系 - Google Patents
表现出低眼刺激潜能的个人清洁体系 Download PDFInfo
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Abstract
本发明公开了一种对眼部无刺激性的不含乙氧基化组分的个人护理浓缩物组合物，所述组合物不含环氧乙烷、不含二氧六环、不含甲醛，所述组合物包含水、烷基硫酸钠、丙二醇以及选自由椰油酰胺丙基羟基磺基甜菜碱和椰油酰胺丙基甜菜碱组成的组中的合成两性表面活性剂。所述组合物特别适用于无刺激性的婴儿香波。在一些实施方案中，所述组合物不含甲醛。
Description
相关申请的交叉引用
本申请要求于2011年1月28日提交的美国临时申请序列No.61/437,110的优先权，其内容以引用方式并入本文。
技术领域
本发明涉及个人清洁组合物，更具体而言涉及眼部刺激潜能（eyeirritationpotential）低（有时称为“无泪”或“无眼泪”）的个人清洁体系。
背景技术
目前，用于婴儿护理应用的眼刺激低的体系通常包含一种或多种非离子乙氧基化组分，例如十三烷醇聚醚硫酸钠（sodiumtridecethsulfate）、PEG150双硬脂酸酯、或PEG80失水山梨醇月桂酸酯，这样的组分会导致最终的配制物存在潜在的有害杂质，例如1,4-二噁烷和残留的环氧乙烷（ethyleneoxide）。所述组合物通常包含主要成分椰油酰胺基丙基甜菜碱作为两性表面活性剂组分，还包含C13烷基醚硫酸盐作为非离子表面活性剂和PEG150双硬脂酸酯作为非离子增稠剂。可以使用非乙氧基化组分，但这通常会导致最终的产品在物理性质上基本上不同于目前市售的配制物，并且通常会比现有的包含乙氧基化表面活性剂的市售体系更加昂贵而较少被消费者选用。
本发明的目的是提供一种个人护理清洁体系，其具有低的眼部刺激潜能、具有与本领域市售的个人清洁配制物相似的物理性质，并且是节省成本的。
发明内容
该目的以及其他方面是通过本发明来实现的，通过以下公开内容该目的以及其他方面将变得明显，本发明一方面包括一种个人清洁体系，其不含乙氧基化组分。在有些实施方案中，所述组合物还不含非离子表面活性剂和聚合材料，因此不包含残留的环氧乙烷或二氧六环，然而所述体系在诸如婴儿护理配制物等要求具有低眼刺激的消费品应用中是有效的，从而获得了清洁、粘稠、有效的配制物，该配制物在标准眼刺激测试中表现出低刺激潜能。在一些实施方案中，所述组合物还不含甲醛。虽然通常优选不含会引起刺激的聚合组分，但在一些实施方案中，可以使用常规量的荷电性高、水溶性高的阳离子共聚物（例如CondicarePQ-7），其能够赋予阴离子体系澄清度（clarity）和兼容性，这样的阳离子共聚物被用于很多头发和皮肤护理应用中。本发明的组合物为刺激性低的个人护理配制物，其包含低水平的烷基硫酸盐和高水平的磺基甜菜碱（sultaine）和/或甜菜碱作为基础物质，并且由低水平的第三表面活性剂改性，从而调整产品的属性。我们已经发现，虽然在所述配制物中单独使用磺基甜菜碱和甜菜碱可引起刺激性，以及单独使用烷基硫酸盐会引起刺激性，但一起使用时，它们会以协同的方式提供降低的刺激性。
在一些实施方案中，所述第三表面活性剂为选自由癸基葡萄糖苷、PCA钠、椰油酰基牛磺酸钠（sodiumcocoyltaurate）、椰油酰基甘氨酸钠(sodiumcocoylglycinate)、油酰酰胺基MIPA磺基琥珀酸二钠（disodiumoleamidoMIPAsulfosuccinate）、椰油两性基二乙酸二钠(disodiumcocoamphodiacetate)、月桂基两性基二乙酸二钠（disodiumlauroamphodiacetate）、椰油酰胺基丙基羟基磺基甜菜碱（cocamidopropylhydroxysultaine）组成的组中的一者或多者。
所述组合物可以通过包含香精、染料、或其它性能添加剂（例如抗缠结聚合物和防腐剂）而被制成即可使用的状态，或者被制成：处于更浓的形式，随后根据需要被水稀释并转化成特定的最终消费品。
本发明的组合物是这样的清洁体系：其不含潜在的有害组分，具有与基于乙氧基化成分的体系（其含有不希望的副产物和杂质）相似的物理性质和刺激行为，是经济、节省成本的。本发明的组合物在被稀释后在视觉上是澄清的。
具体实施方式
本发明的配制物适用于各种个人护理产品，例如香波（如婴儿香波）、宠物产品（例如宠物香波）、和其它用于敏感性皮肤的个人护理产品。
所述组合物包含水和至少三种其它组分，它们为丙二醇、椰油基硫酸钠、和磺基甜菜碱或甜菜碱。磺基甜菜碱或甜菜碱的量必须相对较大，而椰油基硫酸钠的量必须相对较小。
其它组分为选自由月桂基两性二乙酸二钠、椰油两性二乙酸二钠、月桂基两性羟丙基磺酸盐和癸基葡萄糖苷组成的组中的一种或多种表面活性剂，以及选自由油基酰胺基MIPA磺基琥珀酸酯二钠和油基酰胺基MEA磺基琥珀酸二钠组成的组中的一种或多种表面活性剂。
本发明的个人护理产品是通过用水稀释浓缩物使其具有合适的粘度而制备的。所述浓缩物具有与常规的个人护理组合物浓缩物相似的固体%和pH，通常为至少40%固体，在一些实施方案中为大于45%固体。在一些情况中，固体水平为约45-50%。在一些实施方案中，pH水平为约6.5至9.5，在某些实施方案中，pH为约6.5至7.5。
在一些实施方案中，稀释粘度为约3000至4000，固体为约10-12%。在一些实施方案中，稀释粘度为1100至4100（这是急剧的响应(steepresponse)），在其它实施方案中，稀释粘度为约2600-4600（这是平缓的响应(linearresponse)）。
实施例
以下例子示出了本发明的一些非限制性实施方案。除非特别说明，所有份和百分比均以重量计。
实施例1-不含环氧乙烷的婴儿香波
由浓缩物制备了稀释的组合物，所加入的组分和百分比如表1所示。
表1
表1示出的浓缩物组合物具有46-49%的固体。向浓缩物中加入水以将固体降低至11-12%，从而制备稀释物。稀释物的pH为6.5-7，粘度为约3000cps，具有婴儿香波可接受的外观。根据工业公认的刺激性标准测试方法（称为HETCAM），该组合物的结果为0.11，这表明对眼睛无刺激。按照由Spielmann和Liebsch改编的草案no.47（INVITTOX1992）进行HET-CAM测试。
实施例2-不含环氧乙烷的婴儿香波
根据表2示出的百分比，加入表2示出的组分，由此制备部分浓缩物。
表2
表2示出的部分浓缩物的pH（10%）为9.5-11.0，粘度为约7500cpsmax.，固体（M）为40-44%，并且具有澄清的液体外观。通过以下方式制备稀释物：加入3.2份油酰亚胺MIPA磺基琥珀酸二钠（disodiumsulfosuccinateolimidoMIPA）（商标：MackanateOPV-N）和足够的水，从而形成固体水平为11-12%的最终的产品。
根据工业公认的刺激性标准测试方法（称为HETCAM），该组合物的结果为0.11，这表明对眼睛无刺激。根据由Spielmann和Liebsch改编的草案no.47流程（INVITTOX1992）进行HET-CAM测试。
实施例3-婴儿香波
通过以下方式制备本发明的婴儿香波稀释配制物：向浓缩物中加入水，得到具有表3示出的组分和浓度的组合物。所述组合物的性质也在表3中示出。
表3
性质
因此，本发明很适合实现所述的目的和获得提及的结果和优点以及本发明所固有的其它方面。虽然已经参照本发明的特别优选的实施方案描述、说明并定义了本发明，但这些参照并不表示是对本发明的限制，并且也不能推断出这样的限制。如相关领域的普通技术人员能够理解的那样，本发明可以在形式和功能上具有多种改变、替换和等价形式。本发明所描述和说明的优选实施方案仅是示例性的，而不是为了穷举本发明的范围。因此，本发明旨在仅通过所附的权利要求书的精神和范围进行限定，该权利要求书给出了所有方面的等价形式的全面理解。
Claims (8)
1.一种个人护理组合物，其包含水、烷基硫酸钠、选自由油基酰胺基MIPA磺基琥珀酸二钠和油基酰胺基MEA磺基琥珀酸二钠组成的组中的表面活性剂、以及合成两性表面活性剂，其中所述合成两性表面活性剂为椰油酰胺丙基羟基磺基甜菜碱，并且所述烷基硫酸钠为椰油基硫酸钠，所述组合物对眼部无刺激性并且不含乙氧基化组分。
2.根据权利要求1所述的组合物，其还包含选自由月桂基两性二乙酸二钠、椰油两性二乙酸二钠、月桂基两性羟丙基磺酸盐和癸基葡萄糖苷组成的组中的表面活性剂。
3.根据权利要求1所述的组合物，其形式是对皮肤和眼部无刺激性的婴儿香波。
4.根据权利要求1所述的组合物，其中所述组合物不含甲醛。
5.根据权利要求1所述的组合物，其中所述组合物不含二氧六环。
6.根据权利要求1所述的组合物，其中所述组合物不含环氧乙烷。
7.根据权利要求1所述的组合物，其中所述组合物不含非离子表面活性剂和聚合材料。
8.根据权利要求1所述的组合物，其形式是对皮肤和眼部无刺激性并且不含甲醛、环氧乙烷、非离子表面活性剂和聚合材料的婴儿香波。
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| US201161437110P | 2011-01-28 | 2011-01-28 | |
| US61/437,110 | 2011-01-28 | ||
| PCT/US2012/022317 WO2012103061A2 (en) | 2011-01-28 | 2012-01-24 | Personal cleansing systems exhibiting low eye irritation potential |
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| CN103687584B true CN103687584B (zh) | 2016-03-30 |
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| EP (1) | EP2667846B1 (zh) |
| JP (1) | JP2014522374A (zh) |
| KR (1) | KR20140003545A (zh) |
| CN (1) | CN103687584B (zh) |
| BR (1) | BR112013019249A2 (zh) |
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| KR102096761B1 (ko) * | 2012-08-24 | 2020-04-03 | 사우디 아람코 테크놀로지스 컴퍼니 | 금속 착물 |
| US9480629B2 (en) | 2013-08-06 | 2016-11-01 | Rhodia Operations | Sulfate-free structured liquid surfactants |
| RU2529811C1 (ru) * | 2013-10-21 | 2014-09-27 | Открытое акционерное общество "Новосибхимфарм" | Детский шампунь для купания |
| US9084733B2 (en) | 2013-12-09 | 2015-07-21 | L'oreal | Cleansing composition with cationic silanes and silicones |
| US9006162B1 (en) | 2013-12-09 | 2015-04-14 | L'oreal | Cleansing composition with increased conditioning effect |
| US9066859B1 (en) | 2013-12-09 | 2015-06-30 | L'oreal | Viscoelastic cleansing gel |
| US9018150B1 (en) | 2013-12-09 | 2015-04-28 | L'oreal | Cleansing composition with cationic surfactants |
| DE102014203267A1 (de) * | 2014-02-24 | 2015-08-27 | Beiersdorf Ag | Reinigungszubereitungen aus natürlichen Komponenten für Haut und Haar |
| US10767137B2 (en) * | 2014-04-23 | 2020-09-08 | Sageway Solutions, Llc | Cleaning formulations for chemically sensitive individuals: compositions and methods |
| WO2016168241A1 (en) * | 2015-04-13 | 2016-10-20 | Rhodia Operations | Sulfate-free formulations for skin cleansing |
| JP6761274B2 (ja) * | 2016-04-14 | 2020-09-23 | 株式会社ニイタカ | 身体洗浄剤組成物及び身体の洗浄方法 |
| CN106309241B (zh) * | 2016-09-28 | 2019-05-17 | 珠海姗拉娜化妆品有限公司 | 一种无泪配方香波组合物 |
| KR102682809B1 (ko) * | 2023-11-23 | 2024-07-09 | 한국콜마주식회사 | 자연유래 세정 네트워크 기술로 생분해와 안정성이 우수한 친환경 화장료 조성물 |
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2012
- 2012-01-24 CA CA2825879A patent/CA2825879A1/en not_active Abandoned
- 2012-01-24 KR KR1020137021583A patent/KR20140003545A/ko not_active Application Discontinuation
- 2012-01-24 US US13/356,723 patent/US8470753B2/en active Active
- 2012-01-24 EP EP12739878.2A patent/EP2667846B1/en active Active
- 2012-01-24 BR BR112013019249A patent/BR112013019249A2/pt not_active IP Right Cessation
- 2012-01-24 JP JP2013551283A patent/JP2014522374A/ja active Pending
- 2012-01-24 WO PCT/US2012/022317 patent/WO2012103061A2/en active Application Filing
- 2012-01-24 CN CN201280006439.4A patent/CN103687584B/zh active Active
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| Publication number | Publication date |
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| CA2825879A1 (en) | 2012-08-02 |
| JP2014522374A (ja) | 2014-09-04 |
| EP2667846A4 (en) | 2015-08-05 |
| WO2012103061A3 (en) | 2014-02-27 |
| US20120196783A1 (en) | 2012-08-02 |
| EP2667846B1 (en) | 2016-10-19 |
| WO2012103061A2 (en) | 2012-08-02 |
| CN103687584A (zh) | 2014-03-26 |
| KR20140003545A (ko) | 2014-01-09 |
| BR112013019249A2 (pt) | 2016-08-09 |
| EP2667846A2 (en) | 2013-12-04 |
| US8470753B2 (en) | 2013-06-25 |
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