CN1036634C - Preparation method of sodium alginate couplant for ultrasonic diagnostic apparatus - Google Patents
Preparation method of sodium alginate couplant for ultrasonic diagnostic apparatus Download PDFInfo
- Publication number
- CN1036634C CN1036634C CN91111771A CN91111771A CN1036634C CN 1036634 C CN1036634 C CN 1036634C CN 91111771 A CN91111771 A CN 91111771A CN 91111771 A CN91111771 A CN 91111771A CN 1036634 C CN1036634 C CN 1036634C
- Authority
- CN
- China
- Prior art keywords
- sodium alginate
- couplant
- ultrasonic diagnostic
- diagnostic apparatus
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 18
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 18
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000012153 distilled water Substances 0.000 claims abstract description 6
- 239000000049 pigment Substances 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 3
- 241000199919 Phaeophyceae Species 0.000 abstract description 2
- 239000007822 coupling agent Substances 0.000 abstract description 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 241000512259 Ascophyllum nodosum Species 0.000 abstract 1
- 239000000686 essence Substances 0.000 abstract 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 229960004494 calcium gluconate Drugs 0.000 description 3
- 239000004227 calcium gluconate Substances 0.000 description 3
- 235000013927 calcium gluconate Nutrition 0.000 description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 235000018958 Gardenia augusta Nutrition 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- -1 as PrA Polymers 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000003845 household chemical Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
A method for preparing sodium alginate couplant for ultrasonic diagnostic apparatus is used for producing couplant for ultrasonic diagnostic apparatus. Sodium alginate is a hydrophilic polymer belonging to aldehydic sugars extracted from kelp or other brown algae. The oil-free ultrasonic coupling agent is prepared by dissolving nipagin E in small amount of ethanol, adding glycerol and appropriate amount of distilled water, stirring, dissolving sodium alginate, adjusting pH, adding pigment, essence and distilled water, and stirring. The main technical indexes of the product reach or exceed the domestic and foreign levels. The product has the advantages of easily available raw materials, simple preparation method, low raw material cost and good product stability.
Description
The present invention relates to a kind of preparation method of sodium alginate couplant for ultrasonic diagnostic instrument, be used to produce the couplant that diasonograph uses.
The couplant basic demand that diasonograph is used is, the acoustic impedance of acoustic impedance and human body is close, and ultrasonic attenuation is little, in the hope of obtaining visual clearly and higher resolution; To human body avirulence, nonirritant, stability is preferably arranged; Ultrasonic probe there are not corrosion and damage.Domestic each hospital adopts petrolatum Emulsion etc. to contain the couplant of oils and surfactant more, and this class couplant ultrasonic attenuation is bigger, and probe is had certain damaging action.The couplant reported of pharmaceutical journal at home, its main component mostly is carboxymethyl cellulose sodium or synthetic macromolecular compound such as polyvinyl alcohol, acrylate copolymer etc., and is preferable with the performance of latter's preparation, but the cost of material height, still there is not medicinal specification, refining comparatively trouble.
Task of the present invention is to study the preparation method of the couplant of using with sodium alginate preparation diasonograph.
Sodium alginate is a kind of hydrophilic polymer that belongs to the alditol class that extracts from Thallus Laminariae (Thallus Eckloniae) or other Brown algae, has the characteristic of general polymeric sol, and its aqueous solution is translucent uniform thick liquid, and viscosity increases with concentration.Owing to have the safety and the compatibility of height, in medicine and household chemicals, be widely used as additive, stabilizing agent, thickening agent, skin protectant etc.
With the no oily ultrasonic coupling agent of sodium alginate preparation, through screening, experiment and detection and through clinical practice, its prescription and preparation process are as follows:
Prescription: the couplant of preparation 1000ml should add:
Sodium alginate 10.0-35.0g
Glycerol 50.0-250.0g
Nipalgin E 1.0g
Medicinal pigment is an amount of
Medicinal essence is an amount of
Calcium gluconate 0.5-3.0g
Distilled water adds to 1000ml
Preparation process:
Get nipalgin E with a little dissolve with ethanol, add glycerol and an amount of distilled water and stir evenly, sodium alginate is disperseed wherein, slowly after the dissolving, regulate PH6.5-7.0, add pigment, essence, adding distil water stirs promptly to full dose again.
Sodium alginate is the most stable between PH5.0-10.0, PH7.0 viscosity maximum, during preparation, can be according to the viscosity of raw material and season different, the suitable adjustment sodium alginate and the inventory of wetting agent glycerol.Calcium salt can increase the denseness of sodium alginate, and in case of necessity, every preparation 1000ml couplant can add the 0.5-3.0g calcium gluconate to improve viscosity.
The main quality index of sodium alginate couplant can with use CMC-Na or synthetic macromolecular compound, as PrA, acrylate copolymer, the couplant that Carbopol etc. prepared compares favourably.Its acoustic impedance and tissue are close, and ultrasonic attenuation only is 1/60 of a paraffin oil Emulsion, and image definition, resolution are not second to couplant Japanese, the U.S..Non-stimulated to skin, to probe not damaged and corrosiveness.1/12 of the Carbopol easy, that method for making is easy, cost of material only is import draws materials.Its good stability.
Embodiment:
Get nipalgin E 1g and add the 20ml dissolve with ethanol, add glycerol 100ml and distilled water 800ml and stir evenly, the 30g sodium alginate is disperseed wherein, slowly dissolving.Regulate PH7.0, under agitation, slowly Dropwise 5 % calcium gluconate 20ml adds 5 of 1% serge blues again, and 5 of 5% Fructus Citri Limoniae yellow liquor 10ml and jasmin essence stir promptly.
Claims (1)
- A kind of preparation method of sodium alginate couplant for ultrasonic diagnostic instrument, it is characterized in that getting nipalgin E1.0g with a little dissolve with ethanol, adding glycerol 50.0-250.0g and an amount of distilled water stirs evenly, the sodium alginate of 10.0～35.0g is disperseed wherein, slowly after the dissolving, regulate PH6.5～7.0, add an amount of pigment, essence, adding distil water stirs promptly to 1000ml again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN91111771A CN1036634C (en) | 1991-12-17 | 1991-12-17 | Preparation method of sodium alginate couplant for ultrasonic diagnostic apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN91111771A CN1036634C (en) | 1991-12-17 | 1991-12-17 | Preparation method of sodium alginate couplant for ultrasonic diagnostic apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1065400A CN1065400A (en) | 1992-10-21 |
| CN1036634C true CN1036634C (en) | 1997-12-10 |
Family
ID=4910837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN91111771A Expired - Fee Related CN1036634C (en) | 1991-12-17 | 1991-12-17 | Preparation method of sodium alginate couplant for ultrasonic diagnostic apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1036634C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100318049B1 (en) * | 1999-04-12 | 2001-12-22 | 김정식 | Biosonic ultrasound transmission gel |
| CN1301126C (en) * | 2004-07-30 | 2007-02-21 | 梅喜 | Coupling agent for external stone crushing and its preparing method |
| CN102451475B (en) * | 2010-10-25 | 2014-09-17 | 重庆融海超声医学工程研究中心有限公司 | Ultrasonic couplant, supporting astringent and preparation methods thereof |
| CN105199631A (en) * | 2015-10-26 | 2015-12-30 | 青岛高新区尚达医药研究所 | Natural biodegradable medical conducting resin and preparation method thereof |
| CN106620733A (en) * | 2016-11-10 | 2017-05-10 | 董晓 | Preparation method for biodegradable medical ultrasonic coupling agent |
| CN107802846A (en) * | 2017-12-13 | 2018-03-16 | 中南大学湘雅三医院 | A kind of couplant for ultrasonic diagnostic probe |
-
1991
- 1991-12-17 CN CN91111771A patent/CN1036634C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 《中国海洋药物》91/10(1) 1991.12.1 林必杰；褐藻酸钠超声耦合剂的研究 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1065400A (en) | 1992-10-21 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |