CN1096459A

CN1096459A - Novel ultrasonic coupling agent

Info

Publication number: CN1096459A
Application number: CN93106531A
Authority: CN
Inventors: 林必杰
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-06-15
Filing date: 1993-06-15
Publication date: 1994-12-21

Abstract

A kind of novel ultrasonic coupling agent, as ultrasonic diagnosis and the acoustic conductive media detected, what both be applicable to medical ultrasound diagnosis instrument and industrial reflectoscope leads sound scanning glue, also is applicable to the conducting resinl of electrocardiogram, electroencephalograph etc., also is applicable to the lubricating jelly of various optical fiber endoscope.The present invention is with 0.3～6% alginate, 0.01 the water-soluable gel with double base viscosity that～0.5% soluble calcium salt and 94～99% solvents are formulated, has excellent conducting performance and a lubrication again at existing good acoustic characteristic and tight security, stability.

Description

Novel ultrasonic coupling agent

The present invention relates to a kind of novel ultrasonic coupling agent.As ultrasonic diagnosis and the acoustic conductive media detected, what both be applicable to medical ultrasound diagnosis instrument and industrial reflectoscope leads sound scanning glue, also is applicable to the conducting resinl of electrocardiogram, electroencephalograph etc., is applicable to the lubricating jelly of optics, fibrescope again.

Ultrasonic diagnosis and be that the hyperacoustic probe of emission is touched the surface of being detected the position when detecting is from vertical or angle of inclination emission ultrasound wave is diagnosed.Because running into definition and the resolving power that its energy of air will decay to ultrasonic image significantly, ultrasound wave descends significantly.For making ultrasonic energy be conducted into the position that is detected to greatest extent, need to lead the good medium of acoustic performance at probe between the position with being detected, this medium sanction must possess:

1, the velocity of sound, acoustic impedance and tissue are close, and acoustic attenuation coefficient is little;

2, to human body avirulence, nonirritant, no sensitization;

3, do not damage ultrasonic probe;

4, stability is high, modest viscosity, and greasy property is good, not pollution clothes.

The couplant of many in the past employing oil-containings and surfactant such as petrolatum Emulsion etc. are as acoustic conductive media, this type of medium is because of the acoustic attenuation coefficient height, probe there is certain damaging action, and pollution clothes substitutes by high molecular polymer PVA, CMC-Na and with compounded couplants such as gelatin, agar, alginate.But countries in the world are most widely used at present is to be the acoustic conductive media of raw material manufacturing with acrylate copolymer-Carbomer, its acoustic characteristic, image definition, resolving power and clinical application effect are all good, only eye is had big zest and meets the easy oxidation of light, its gel meet light easily degraded cause and lose viscosity rapidly and liquefy.

At present also all there is the shortcoming of poor stability in the lubricating jelly of also most conducting resinl made from electrolyte and macromolecular material such as the conducting medium that leads that contact with human body as electrocardiogram, electroencephalograph etc. and various optical fiber endoscope-uses.

Task of the present invention is by screening, UR to various raw materials, is primary raw material with the alginate, makes a kind of novel ultrasound waveguide acoustic medium, and existing tight security, stability have excellent conducting performance and lubrication again.

Novel ultrasonic coupling agent contains:

1,0.3～6% alginate;

2,0.01～0.5% soluble calcium salt;

3,94～99% solvents.

Be a kind of water-soluable gel with double base viscosity (thixotropy).

Preparation process: get alginate and be scattered in the solvent, slowly under agitation add the solubility calcium saline solution after the dissolving, regulate PH6.5～7.5, solubilizer fully stirs to full dose again, handles promptly through homogenizing and vacuum outgas.

Composition (1)

Alginate is a kind of hydrophilic high molecular polymer that belongs to the alditol class, has the characteristic of polymeric sol.Its aqueous solution is translucent uniform thick liquid, and viscosity increases with concentration.Owing to have tight security and matching property, in medicine and household chemicals, be widely used.Alginate can be sodium salt, potassium salt, ammonium salt, magnesium salt, calcium salt, mantoquita, aluminum salt.Comparatively desirable with multivalent metal salt in final products.The consumption of alginate should be according to the viscosity and production different suitably adjustment the in season of raw material.

Composition (2)

Calcium salt can increase denseness, and soluble calcium salt can be used Calcium d-tartrate, Citric acid calcium, calcium gluconate or calcium chloride etc.

Composition (3)

Solvent can or contain the mixed solvent of heat preserving agent with distilled water.

For guaranteeing the stability and the sense organ of product, can add antibacterial and an amount of medicinal pigment and essence in case of necessity.

Embodiment one:

Getting potassium alginate 50g is scattered in the distilled water mixed solution that contains glycerol 10%, slowly be dissolved into the colloidal sol shape, under agitation add 5% Calcium d-tartrate solution 70ml, regulate PH6.5～7.5, add an amount of medicinal pigment, essence and antibacterial stir evenly, and add distilled water again and stir evenly to full dose 1000ml, handle through vacuum outgas, promptly get this product.

Embodiment two:

Sodium Alginate 10g adds glycerol 50g, under agitation adds aquae destillata and 0.5g Citric acid calcium after the dispersion, fully stirs, and regulates PH6.5～7.5, adds distilled water again to full dose 1000ml, handles through the degassing, promptly.

Embodiment three:

Sodium Alginate 8g adds a little ethanol, 80g glycerol and 450ml distilled water and stirs evenly, and adding under agitation contains 0.2% calcium chloride solution 400ml and fully stirs evenly, and regulates PH7.0, handles through the degassing, promptly.

Formulation cost of the present invention is low, and process for preparation is simple, and the product acoustic characteristic is good, and ultrasonic image is clear, and resolving power is strong, and performance can compare favourably with the advanced product in the world.To the human body nonirritant, do not damage ultrasonic probe.Existing tight security, stability have excellent conducting performance and lubrication again.

Claims

1, a kind of novel ultrasonic coupling agent is characterized in that to contain 0.3～6% alginate, 0.01～0.5% soluble calcium salt, the water-soluable gel with double base viscosity that the cooperation of 94～99% solvents forms.

2, novel ultrasonic coupling agent according to claim 1, it is characterized in that its process for preparation is: get alginate and be scattered in the solvent, under agitation add the solubility calcium saline solution after the dissolving evenly, regulate PH6.5～7.5, solubilizer is to full dose again, stir, handle promptly through homogenizing and vacuum outgas.

3, novel ultrasonic coupling agent according to claim 1 is characterized in that in case of necessity, can add antibacterial and an amount of medicinal pigment and essence.