CN103656298A - Traditional Chinese medicine preparation for curing hemicrania as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine preparation for curing hemicrania as well as preparation method and application thereof Download PDFInfo
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- CN103656298A CN103656298A CN201310685524.4A CN201310685524A CN103656298A CN 103656298 A CN103656298 A CN 103656298A CN 201310685524 A CN201310685524 A CN 201310685524A CN 103656298 A CN103656298 A CN 103656298A
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Abstract
The invention discloses a traditional Chinese medicine preparation for curing hemicrania, which comprises the following raw materials in parts by weight: 10 to 25 parts of antelope's horn, 5 to 15 parts of uncaria, 5 to 20 parts of flos chrysanthemi from Hangzhou of China, 8 to 18 parts of roots of Raeonia lactiflora pall., 5 to 20 parts of dried rehamnnia roots, 6 to 25 parts of mulberry leaves, 6 to 25 parts of bulbus fritillariae cirrhosae, 6 to 25 parts of ligusticum wallichii, 6 to 25 parts of radix angelicae, 6 to 25 parts of poria cocos, 1 to 6 parts of liquorice, 5 to 20 parts of caulis bambusae in taeniam, 6 to 15 parts of gastrodia elata, 4 to 8 parts of lumbricus, 4 to 12 parts of gentiana scabra bge, 1 to 3 parts of scorpio, 1 to 3 parts of centipede and 1 to 4 parts of stiff silkworm. The raw materials of the invention are wide in sources and low in cost; the traditional Chinese medicine preparation provided by the invention has an accurate clinical effect in curing hemicrania and has a high cure rate; the preparation method of the traditional Chinese medicine preparation provided by the invention is simple and easy, and the prepared preparation is convenient to use.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, preparation method and application, be specifically a kind ofly used for the treatment of migrainous Chinese medicine preparation, preparation method and application.
Background technology
Migrainous sickness rate accounts for 3.7%～13.5% of total population, account for the more than 1/4 of headache, this disease is often asks that one-sided or bilatenal headache occurs having a rest property, and with feeling sick, the symptom such as vomiting, women is more than male, have obvious family history person, the headache of small part female patient is relevant with menstrual cycle more.Clinical three kinds of the common migraines, classic form migraine, special type migraine that are divided into of headache type, wherein the most common with common migraine, its pathogeny is comparatively complicated, still can not illustrate completely at present, but a series of biochemical changes relevant with it have been found, especially with the variation of 5 one hydroxytryptamines, therefore think that primary disease may be the vasomotor disturbance disease due to a kind of human endocrine is lacked of proper care, be that cerebral vasospasm shrinks and expansion causes hemodynamic change and obstacle, near causing, tissue blood becomes silted up and hinders.At present, western medicine migraine can only respite symptom, is difficult to remove old complaint.Chinese medicine thinks, migrainous pathomechanism key is obstructed, and general rule is not bitterly, pain is obstructed, and the obstructed qi depression to blood stasis that has its source in causes the QI and blood of cerebral tissue can not normal unimpeded operation.Thereby the spasm that causes blood vessel is shunk and is had a headache.The spasm of blood vessel is shunk, and certainly will cause hemodynamic change and obstacle and forms blood stasis, so that form vicious cycle.
Summary of the invention
Goal of the invention: the object of the present invention is to provide a kind of migraine, toxic and side effects Chinese medicine preparation little, evident in efficacy for the treatment of, the present invention also provides the preparation method of this Chinese medicine preparation, and the application in treatment migraine.
Technical scheme: in order to realize foregoing invention object, the technical solution adopted in the present invention is:
Be used for the treatment of a migrainous Chinese medicine preparation, by the raw material of following parts by weight, formed: 10 ~ 25 parts of Cornu Saigae Tataricae, 5 ~ 15 parts of Ramulus Uncariae Cum Uncis, 5 ~ 20 parts of Flos Chrysanthemi, 8 ~ 18 parts of Radix Paeoniae Alba, 5 ~ 20 parts of Radix Rehmanniae, 6 ~ 25 parts, Folium Mori, 6 ~ 25 parts of Bulbus Fritillariae Cirrhosaes, 6 ~ 25 parts of Rhizoma Chuanxiongs, 6 ~ 25 parts of the Radixs Angelicae Dahuricae, 6 ~ 25 parts, Poria, 1 ~ 6 part of Radix Glycyrrhizae, 5 ~ 20 parts of Caulis Bambusae In Taenia, 6 ~ 15 parts, Rhizoma Gastrodiae, 4 ~ 8 parts of Pheretimas, 4 ~ 12 parts of Radix Gentianaes, 1 ~ 3 part of Scorpio, 1 ~ 3 part of Scolopendra, 1 ~ 4 part of Bombyx Batryticatus.
Preferably, the raw material by following parts by weight forms: 10 ~ 18 parts of Cornu Saigae Tataricae, 8 ~ 15 parts of Ramulus Uncariae Cum Uncis, 10 ~ 20 parts of Flos Chrysanthemi, 12 ~ 18 parts of Radix Paeoniae Alba, 10 ~ 20 parts of Radix Rehmanniae, 10 ~ 25 parts, Folium Mori, 10 ~ 25 parts of Bulbus Fritillariae Cirrhosaes, 10 ~ 25 parts of Rhizoma Chuanxiongs, 10 ~ 25 parts of the Radixs Angelicae Dahuricae, 10 ~ 20 parts, Poria, 2 ~ 5 parts of Radix Glycyrrhizae, 5 ~ 15 parts of Caulis Bambusae In Taenia, 8 ~ 15 parts, Rhizoma Gastrodiae, 6 ~ 8 parts of Pheretimas, 4 ~ 8 parts of Radix Gentianaes, 1 ~ 2 part of Scorpio, 1 ~ 2 part of Scolopendra, 1 ~ 3 part of Bombyx Batryticatus.
Preferably, the raw material by following parts by weight forms: 12 parts of Cornu Saigae Tataricae, 10 parts of Ramulus Uncariae Cum Uncis, 15 parts of Flos Chrysanthemi, 15 parts of Radix Paeoniae Alba, 16 parts of Radix Rehmanniae, 18 parts, Folium Mori, 18 parts of Bulbus Fritillariae Cirrhosaes, 18 parts of Rhizoma Chuanxiongs, 18 parts of the Radixs Angelicae Dahuricae, 18 parts, Poria, 4 parts of Radix Glycyrrhizae, 10 parts of Caulis Bambusae In Taenia, 12 parts, Rhizoma Gastrodiae, 6 parts of Pheretimas, 5 parts of Radix Gentianaes, 1.5 parts of Scorpios, 1.5 parts of Scolopendras, 2 parts of Bombyx Batryticatus.
Method for the preparation of the migrainous Chinese medicine preparation for the treatment of, the step of described method is: Cornu Saigae Tataricae is decocted first, the Flos Chrysanthemi preparing by portion rate, Radix Paeoniae Alba, Radix Rehmanniae, Folium Mori, Bulbus Fritillariae Cirrhosae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Poria, Radix Glycyrrhizae, Caulis Bambusae In Taenia, Rhizoma Gastrodiae, Radix Gentianae are added to hydrology fire fried, under after Ramulus Uncariae Cum Uncis, Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus add fried good medicinal liquid after grinding to form powdery, stir.
Described slow fire heating 20 ~ 40min.
After grinding, described Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus cross 60 ~ 80 mesh sieves.
Made medicinal liquid warm water is taken, and 1 dose of every day, serveing on 7 is a course for the treatment of, and pain gesture sharply person doubles the course for the treatment of.
We are purged heat with Cornu Saigae Tataricae, Ramulus Uncariae Cum Uncis, Folium Mori, the cool liver of Flos Chrysanthemi, relieving spasm by subduing liver-wind, and Radix Rehmanniae, the Radix Paeoniae Alba, Radix Glycyrrhizae easing the affected liver emergency, Caulis Bambusae In Taenia, Bulbus Fritillariae Cirrhosae, Poria reduce phlegm and calm the nerves, and full side has share removing heat in the liver to subdue the wind syndrome, has moistened the merit of reducing phlegm.Rhizoma Chuanxiong, the Radix Angelicae Dahuricae both can expelling wind and activating blood circulation, removing obstruction in the collateral to relieve pain, can help again that sun is with multiple its position clearly, and the justice of getting mutual causality of ascending and descending, increases its effect to oppose each other and yet also complement each other, and Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus are that insects are searched the product that pick, more increase its effect.
Beneficial effect: compared with prior art, remarkable advantage of the present invention is: raw material sources of the present invention are extensive, cheap; ; Chinese medicine preparation of the present invention clinical efficacy in treatment migraine is definite, and cure rate is high; Preparation method of the present invention is simple, the preparation taking convenience of making.
The specific embodiment
Below by specific embodiment, the present invention is further described; it should be pointed out that for the person of ordinary skill of the art, under the premise without departing from the principles of the invention; can also make some modification and improvement, these also should be considered as belonging to protection scope of the present invention.
Embodiment 1
10g Cornu Saigae Tataricae is decocted first, Ramulus Uncariae Cum Uncis 5g, Flos Chrysanthemi 5g, Radix Paeoniae Alba 8g, Radix Rehmanniae 5g, Folium Mori 6g, Bulbus Fritillariae Cirrhosae 6g, Rhizoma Chuanxiong 6g, Radix Angelicae Dahuricae 6g, Poria 6g, Radix Glycyrrhizae 1g, Caulis Bambusae In Taenia 5g, Rhizoma Gastrodiae 6g, Radix Gentianae 4g, adds the fried 20min of hydrology fire, Pheretima 4g, Scorpio 1g, Scolopendra 1g, after Bombyx Batryticatus 1g grinds, cross 60 mesh sieves, add fried good medicinal liquid, stir.Made medicinal liquid warm water is taken, and 1 dose of every day, serveing on 7 is a course for the treatment of, and pain gesture is 2 ~ 3 courses for the treatment of of person sharply.
Embodiment 2
25g Cornu Saigae Tataricae is decocted first, Ramulus Uncariae Cum Uncis 15g, Flos Chrysanthemi 20g, Radix Paeoniae Alba 18g, Radix Rehmanniae 20g, Folium Mori 25g, Bulbus Fritillariae Cirrhosae 25g, Rhizoma Chuanxiong 25g, Radix Angelicae Dahuricae 25g, Poria 25g, Radix Glycyrrhizae 6g, Caulis Bambusae In Taenia 20g, Rhizoma Gastrodiae 15g, Radix Gentianae 12g, adds the fried 40min of hydrology fire, Pheretima 8g, Scorpio 3g, Scolopendra 3g, after Bombyx Batryticatus 4g grinds, cross 80 mesh sieves, add fried good medicinal liquid, stir.Made medicinal liquid warm water is taken, and 1 dose of every day, serveing on 7 is a course for the treatment of, and pain gesture is 2 ~ 3 courses for the treatment of of person sharply.
Embodiment 3
15g Cornu Saigae Tataricae is decocted first, Ramulus Uncariae Cum Uncis 10g, Flos Chrysanthemi 15g, Radix Paeoniae Alba 12g, Radix Rehmanniae 15g, Folium Mori 17g, Bulbus Fritillariae Cirrhosae 18g, Rhizoma Chuanxiong 18g, Radix Angelicae Dahuricae 18g, Poria 18g, Radix Glycyrrhizae 3g, Caulis Bambusae In Taenia 12g, Rhizoma Gastrodiae 10g, Radix Gentianae 8g, adds hydrology fire fried, 30min, Pheretima 6g, Scorpio 2g, Scolopendra 2g, after Bombyx Batryticatus 3g grinds, cross 60 mesh sieves, add fried good medicinal liquid, stir.Made medicinal liquid warm water is taken, and 1 dose of every day, serveing on 7 is a course for the treatment of, and pain gesture is 2 ~ 3 courses for the treatment of of person sharply.
Embodiment 4
12g Cornu Saigae Tataricae is decocted first, Ramulus Uncariae Cum Uncis 10g, Flos Chrysanthemi 15g, Radix Paeoniae Alba 15g, Radix Rehmanniae 16g, Folium Mori 18g, Bulbus Fritillariae Cirrhosae 18g, Rhizoma Chuanxiong 18g, Radix Angelicae Dahuricae 18g, Poria 18g, Radix Glycyrrhizae 4g, Caulis Bambusae In Taenia 10g, Rhizoma Gastrodiae 12g,, Radix Gentianae 5g, adds the fried 30min of hydrology fire, Pheretima 6g, Scorpio 1.5g, Scolopendra 1.5g, after Bombyx Batryticatus 2g grinds, cross 80 mesh sieves, add fried good medicinal liquid, stir.Made medicinal liquid warm water is taken, and 1 dose of every day, serveing on 7 is a course for the treatment of, and pain gesture is 2 ~ 3 courses for the treatment of of person sharply.
Embodiment 5
Clinical effectiveness for checking preparation of the present invention, has carried out clinical experiment.
1, data and method
1.1 physical data
86 routine patients are out-patient.Be divided at random treatment group and matched group.Treatment group 43 examples, wherein, male's 13 examples, women's 30 examples, 18～42 years old age, average 31 years old; Matched group 43 examples, routine women's 30 examples of male 13,18～41 years old age, average 31 years old.In two groups, the course of disease is the longest 19 years, the shortest 3 years, average out to 12 years, all without serious liver, kidney, heart and lung diseases, equal row TCD(neck cranium doppler ultrasound before and after all cases treatment) check, all get rid of due to the headache due to upper respiratory tract infection, sinusitis, intracranial infection, the cerebral tumor, cervical spondylosis.Epidemiological Analysis by statistics, two groups of case-data there was no significant differences (P<0.05).
1.2 diagnosis basis
Meet the international association's local pain classification diagnosis standard of having a headache in 1988, and brain CT is normal, and TED checks all promptings: " cerebral vasospasm " and " cerebral arterial insufficiency ".Tcm diagnosis is with reference to < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > (the wind syndrome of head diagnostic criteria: headache position is many on head one side volume temporo, forehead, the crown of State Administration of Traditional Chinese Medicine's promulgation in 1994, or left or right tosses about in bed outbreak, sustainable several minutes of each duration of seizure, a few hours, a couple of days, also there is lasting several weeks of person.The character of headache mostly is jumping pain, twinge, distending pain, dull pain etc.
1.3 Therapeutic Method
Treatment group adopts treatment by Chinese herbs, adopts 1 dose of 1 every day of embodiment, and serveing on 7 is a course for the treatment of.Matched group is used merely flunarizine hydrochloride sheet 10mg, 3 times/d, oral.All take 1 month for two groups.After 1 month finishes, observe the variation of headache and simultaneous phenomenon, and be analyzed.
2 results
2.1 curative effect determinate standard
Cure: transference cure is without recurrence, and laboratory inspection is normal; Effective: transference cure, TCD checks normal, half a year is with interior nothing recurrence; Effective: symptom alleviates, lab testing makes moderate progress; Invalid: symptom and lab testing are all without improving.
2.2 therapeutic outcome
Treatment group is cured 26 examples, effective 10 examples, and effective 3 examples, invalid 4 examples, total effective rate is 90.7%; Matched group is cured 12 examples, effective 7 examples, and effective 13 examples, invalid 11 examples, total effective rate is 74.4%, treatment group total effective rate is apparently higher than matched group, specifically in Table 1.
Table 1 liang group therapeutic effect comparison
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 43 | 26 | 10 | 3 | 4 | 90.7 |
| Matched group | 43 | 12 | 7 | 13 | 11 | 74.4 |
Claims (7)
1. be used for the treatment of a migrainous Chinese medicine preparation, it is characterized in that being formed by the raw material of following parts by weight: 10 ~ 25 parts of Cornu Saigae Tataricae, 5 ~ 15 parts of Ramulus Uncariae Cum Uncis, 5 ~ 20 parts of Flos Chrysanthemi, 8 ~ 18 parts of Radix Paeoniae Alba, 5 ~ 20 parts of Radix Rehmanniae, 6 ~ 25 parts, Folium Mori, 6 ~ 25 parts of Bulbus Fritillariae Cirrhosaes, 6 ~ 25 parts of Rhizoma Chuanxiongs, 6 ~ 25 parts of the Radixs Angelicae Dahuricae, 6 ~ 25 parts, Poria, 1 ~ 6 part of Radix Glycyrrhizae, 5 ~ 20 parts of Caulis Bambusae In Taenia, 6 ~ 15 parts, Rhizoma Gastrodiae, 4 ~ 8 parts of Pheretimas, 4 ~ 12 parts of Radix Gentianaes, 1 ~ 3 part of Scorpio, 1 ~ 3 part of Scolopendra, 1 ~ 4 part of Bombyx Batryticatus.
2. be as claimed in claim 1ly used for the treatment of migrainous Chinese medicine preparation, it is characterized in that being formed by the raw material of following parts by weight: 10 ~ 18 parts of Cornu Saigae Tataricae, 8 ~ 15 parts of Ramulus Uncariae Cum Uncis, 10 ~ 20 parts of Flos Chrysanthemi, 12 ~ 18 parts of Radix Paeoniae Alba, 10 ~ 20 parts of Radix Rehmanniae, 10 ~ 25 parts, Folium Mori, 10 ~ 25 parts of Bulbus Fritillariae Cirrhosaes, 10 ~ 25 parts of Rhizoma Chuanxiongs, 10 ~ 25 parts of the Radixs Angelicae Dahuricae, 10 ~ 20 parts, Poria, 2 ~ 5 parts of Radix Glycyrrhizae, 5 ~ 15 parts of Caulis Bambusae In Taenia, 8 ~ 15 parts, Rhizoma Gastrodiae, 6 ~ 8 parts of Pheretimas, 4 ~ 8 parts of Radix Gentianaes, 1 ~ 2 part of Scorpio, 1 ~ 2 part of Scolopendra, 1 ~ 3 part of Bombyx Batryticatus.
3. be as claimed in claim 1ly used for the treatment of migrainous Chinese medicine preparation, it is characterized in that being formed by the raw material of following parts by weight: 12 parts of Cornu Saigae Tataricae, 10 parts of Ramulus Uncariae Cum Uncis, 15 parts of Flos Chrysanthemi, 15 parts of Radix Paeoniae Alba, 16 parts of Radix Rehmanniae, 18 parts, Folium Mori, 18 parts of Bulbus Fritillariae Cirrhosaes, 18 parts of Rhizoma Chuanxiongs, 18 parts of the Radixs Angelicae Dahuricae, 18 parts, Poria, 4 parts of Radix Glycyrrhizae, 10 parts of Caulis Bambusae In Taenia, 12 parts, Rhizoma Gastrodiae, 6 parts of Pheretimas, 5 parts of Radix Gentianaes, 1.5 parts of Scorpios, 1.5 parts of Scolopendras, 2 parts of Bombyx Batryticatus.
4. prepare the method that is used for the treatment of migrainous Chinese medicine preparation as claimed in claim 1, it is characterized in that: the step of described method is: Cornu Saigae Tataricae is decocted first, the Flos Chrysanthemi preparing by portion rate, Radix Paeoniae Alba, Radix Rehmanniae, Folium Mori, Bulbus Fritillariae Cirrhosae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Poria, Radix Glycyrrhizae, Caulis Bambusae In Taenia, Rhizoma Gastrodiae, Radix Gentianae are added to hydrology fire fried, under after Ramulus Uncariae Cum Uncis, Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus add fried good medicinal liquid after grinding to form powdery, stir.
5. the method for the preparation of the migrainous Chinese medicine preparation for the treatment of as claimed in claim 4, is characterized in that: described slow fire heating 20 ~ 40min.
6. the method for the preparation of the migrainous Chinese medicine preparation for the treatment of as claimed in claim 4, is characterized in that: after described Pheretima, Scorpio, Scolopendra, Bombyx Batryticatus grind, cross 60 ~ 80 mesh sieves.
7. the application of Chinese medicine preparation claimed in claim 1 in preparing migraine remedy.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310685524.4A CN103656298A (en) | 2013-12-16 | 2013-12-16 | Traditional Chinese medicine preparation for curing hemicrania as well as preparation method and application thereof |
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| CN201310685524.4A CN103656298A (en) | 2013-12-16 | 2013-12-16 | Traditional Chinese medicine preparation for curing hemicrania as well as preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398861A (en) * | 2014-12-18 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation for treating migraine as well as preparation method and application thereof |
| CN105663784A (en) * | 2016-01-30 | 2016-06-15 | 宋秀磊 | Traditional Chinese medicine for treating migraine |
-
2013
- 2013-12-16 CN CN201310685524.4A patent/CN103656298A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 王克俭: "羚角钩藤汤治疗偏头痛30例", 《山东中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398861A (en) * | 2014-12-18 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation for treating migraine as well as preparation method and application thereof |
| CN105663784A (en) * | 2016-01-30 | 2016-06-15 | 宋秀磊 | Traditional Chinese medicine for treating migraine |
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Application publication date: 20140326 |