CN103655619A - Process technology of biologically extracting lyophilic active calcium ionic crystals - Google Patents
Process technology of biologically extracting lyophilic active calcium ionic crystals Download PDFInfo
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- CN103655619A CN103655619A CN201210321470.9A CN201210321470A CN103655619A CN 103655619 A CN103655619 A CN 103655619A CN 201210321470 A CN201210321470 A CN 201210321470A CN 103655619 A CN103655619 A CN 103655619A
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Abstract
The invention relates to a process technology of biologically extracting lyophilic active calcium ions. The active calcium ions are obtained from pure calcium carbonate on a conchiolin fibrous membrane through extraction and dissociation under the conditions of the temperature range (25 to 40 DEG C) of vital movement, wet-process extraction of 70% moisture content required by physiological and biochemical requirements of life and a slightly acidic environment (about pH 4) which is suitable for exciting and catalyzing the activities of hormones and enzymes. The active calcium ions are chelated with water into a structurally stable, colorless, transparent and nontoxic calcium-ion true solution (Ca.H2O), and then the calcium-ion true solution is crystallized into colorless and transparent hexagonal lyophilic active calcium ionic crystals. The biological extraction process technology provided by the invention is a quick, efficient and safe intelligent micro-production process capable of enrichment and purification. The biological extraction process technology is a saving type production process technology implemented under a low-energy consumption, pollution-free, non-toxic and safe extraction environment.
Description
Background of invention
Calcium is one of the abundantest, most important element of content in human body, is also the element the most generally lacking; China per capita every day effective calcium intake, do not reach the standard of required 800-1500 milligram every day far away.
Activated calcium cation could be charged to life! Increase vitality, calcium is that origin is remote as the understanding of the nutrient and healthcare products of building body, by common people are known.
Long-term calcium constituent overdraw is one of reason causing a lot of difficult miscellaneous diseases.The harm causing will be irreversible, from life, be born and will have to calcium ion the whole life process of life apoptosis the effect of not replacing.
So how correctly, effectively replenish the calcium, be medical circle, the generally acknowledged difficult problem of nutrition educational circles always.
Calcium is a kind of active metal, mainly with the form of calcium salt, is present in nature.Calcium salt need, through resolving into ionic state, just can be absorbed and used." calcium salt " goods on market, difficult by human body decomposition, digestion, absorption and utilization again.
Therefore, how effectively to replenish the calcium, be international medical community, the generally acknowledged difficult problem of nutrition educational circles always.
For strengthening vitality, improve survival ability, strong health-physical fitness, being devoted to the research and development ion level calcium constituent utilizing that can be absorbed by the body is completely object of the present invention.
Ionic nature
Single ionic diameter is more much smaller than 10-9m (nanometer), and naked eyes are to cannot see also can not touch.In water, be also the uniform crystalline liquid of water white transparency;
Ionic osmotic pressure is little, can absorb loose by Concentraton gradient rapid diffusion 100% equally with water;
Solion stable performance, in dispersion liquid, the ion of variable concentrations is all independent existence, and keeps dynamic equilibrium; And Presence of an interface not between dispersate particle, without other materials, getting involved while disturbing is can Precipitation;
Ionic medium reaches capacity after water evaporates, and ion is just condensed into arranges the neat ionic crystals of geometric shape rule.
Ion is with electric charge, and the ion that is crystal is movement can not conduct electricity, and ionic liquid phase just can move freely and can conduct electricity.
The Biological Principles of acive calcium ion usefulness
1. acive calcium ion is the electronics transduction activity based on mobilizing function cell:
Calcium cation and potassium cationic phase antagonism, convection current, in cell membrane both sides, forms the potential difference not waiting, the electron stream transduction activity of active cell device:
Open, calcium ion pumps into potassium ion and pumps, and is peak value action potential, the secretion of mobilizing function cell and excitation-contraction;
Close, calcium ion pumps potassium ion and pumps into, and is valley resting potential, and deexcitation action reset tranquillization suppresses diastole.
This one open-one close, stretched and relaxed, activation and tranquillization, excited and inhibition, contraction and diastole: constantly rhythm and pace of moving things ground replaces, participate in regulating several functions cell from steady self-discipline, to carry out again and again physiological activity by biological clock cycle, the activity of sustaining life is played to special important function.
As cardiac muscle self-discipline shrink and diastole completes blood circulation, lung and one exhales one to suck into oxygen uptake and exhalation carbonic acid gas equably;
The activation of hormone, enzyme system and deactivation complete the metabolism of material, for body provides the kinetic energy of organizing base brick and vital movement ..., maintain basic vital movement.
2. active cell physiological and biochemical activity, calcium ion plays trigger role
Calcium ion activated protein kinase, calcium pump on active cell film (Ca++ATP enzyme), activated adenyl cyclase (cAMP enzyme), the electronics transduction activity of active cell device, under cyclophorase effect, the materials such as sugar, fat, protein are carried out to dehydrogenation, oxidation, generate adenosine triphosphate (ATP), after ATP releases energy, change a series of physiological activities such as cyclisation AMP into.
When obstacle appears in calcium ion activated intracellular adenosine cyclase, a series of physiological regulation are just lacked of proper care and are caused a disease, and ATP generates while stopping, and are also in life stops.
3. acive calcium ion is pressed the Nature cycle day and night, makes the physiological activity that multiple biological clock cycle length is different coordinate to carry out:
As aroused in interest second cycle, metabolism diurnal periodicity; From life, breed to be born and play the life cycle of life termination.Calcium ion regulatory people's overall process in all one's life, has the effect of not replacing.
4. calcium cation can build rapidly brain and neuro humor functional activity LAN:
Calcium cation can be pressed the will signal of brain burst, builds rapidly functional activity LAN between brain and neuro humor, and two-way flash transmission bioelectrical signals between net, realizes brain will voluntary activity neatly.After burst functional activity completes, this LAN just disappears.As repeated over and over same bulesis signal, the reconstruction of correlation function LAN, brain memory strengthening thinking prosperity is wise.
Calcium ion plays trigger role at the physiological and biochemical activity of living cells;
Calcium ion has the special role to life charging to life sciences.
Biological extraction acive calcium ion technique is described
1, the present invention relates to select a kind of through shell biological gene password program, the pure calcium carbonate (RCaCO of naturally synthetic organic facies
3), this is extremely complicated first biologically pure engineering.By shell, be raw material, omit Liao Zhe road purification engineering.
2, the present invention relates to carry out the biological extraction of second, pure calcium carbonate segregation is reduced into water white calcium ion; Extraction process extracts calcium ion from shell, more omnidistance of crystallization needs 15 hours.Improved the speed of extraction acive calcium ion.
3, the present invention relates to the process characteristic of biological extraction acive calcium ion
● the biology extraction the present invention relates to is non-corrosiveness.
Hard shell after extractive reaction, only stay one deck as thin as a wafer, complete, floating, softening shell fibrin film and dynein, be not corroded; In reaction boiling, bark graft touches skin without burning, without twinge, without sensations such as heatings.
● the biology extraction the present invention relates to is to carry out under mild acid conditions.
PH value 4 left and right are best suited for activation and the catalysis of multiple hormone and enzyme, improve extraction calcium ion speed and concentration.
● the biology extraction the present invention relates to is to take water as dispersant (H3O)
The hydrogen bond of H+ is the energy-poor bond of easy fracture, and hydrogen bond not only participates in nucleic acid function, also affects the configuration of protein molecule;
In vital movement, play an important role.Therefore participate in cell physiological activity, take hydrophilic active calcium ion as best character.
● the temperature that the present invention relates to biological extraction is the temperature range that is controlled at vital movement
Extraction temperature must be controlled at 25-40 ℃.In extraction " acive calcium ion liquid ", also can obtain the functional matrix that is rich in biological value: enzyme albumen, nucleic acid small peptide ossein isoreactivity material.
Table 1 2.2% calcium ion liquid protein content (ultraviolet spectrometry) and nucleic acid amount (nucleic acid instrument)
| Detection method | Protein content μ g/ml | Nucleic acid content μ g/ml |
| Uv-spectrophotometric instrument | 37.42 | |
| Foranalysis of nucleic acids instrument | 71 |
Experiment: by the acive calcium ion liquid of variable concentrations, make cell culture fluid, cell can be survived.
Use high-temperature calcination shell, by the equal deactivation of all active substances, determined that high-temperature calcination and biological low-temperature extraction have essential difference.
● the biology extraction the present invention relates to is concentration method
Be that to take gram be percentage value concentration unit, recovery rate is high; Extraction acive calcium ion concentration can be up to 19 ± 2% (W/W).
● the biology extraction calcium ion technique the present invention relates to is the intellectualized operation of quick, efficient, enrichment, purification; Radiationless, pollution-free to environment, floor space is little, the miniature economizing type operating environment of low energy consumption, the ability to ward off risks is strong.
The enforcement of " biologic activated calcium ion liquid " wet method preparation process
1. biology extracts " acive calcium ion " production technology program
● take shell biomaterial as extracting the raw material of acive calcium ion;
Accurately weigh biological shell and extract → 4 hours → coarse strainer of (25-40 ℃) reaction at vital movement temperature (filter shellfish shrinking away from theshell azelon film) → finly filtration → calcium ion concentration liquid → dehydration → crystallization → filling mould, sealer, pack → put in storage.
2. production process requisite quality is controlled:
● the control up to standard of raw materials quality: the proportioning of critical point, extractive reaction liquid calcium ion concentration (1.9 ± 0.2%) reaches company standard scope.
● the control up to standard of reaction filtrate quality: the clean amount of residue reaches the transparent liquid of company standard scope (0.5%) appearance colorless.
● the control up to standard of thickening quality: calcium ion concentration initial and end point process is linear (from 0-19 ± 2%) and reaches company standard scope.
● the control up to standard of crystalline quality: the transparent hexagonal crystal of appearance colorless, 1 gram of calcium ion crystal concentration (0.19 ± 0.02%), reaches company standard scope.
● the control up to standard of crystals solubility quality: 100% dissolves.Under sealing state, place for many years and never precipitate, outward appearance is: water white transparency liquid.The calcium ion concentration content of calcium ion dissolving crystallized can regulate arbitrarily by different user requirement.
● crystal is filled with the control up to standard of mould airtight quality: pack air tight, not air-blowing; In temperature, be less than and under 15 ℃ of conditions, preserve crystal and do not melt.
● liquid is filled with the control up to standard of mould airtight quality: it is non-leakage to pack liquid; Can under normal temperature condition, preserve.
● the control up to standard of outer package metering: by the packing material requirement of food grade.(not using mental package)
Claims (7)
1. the biology extraction the present invention relates to is to select shell to refine synthetic pure calcium carbonate (R CaCO through gene-code program
3).For the raw material of extraction acive calcium ion, omit the extremely complicated biologically pure enrichment engineering in Liao Zhe road.
2. the biology extraction the present invention relates to, is by the pure calcium carbonate of shell enrichment, segregation acive calcium ion: only stay one deck as thin as a wafer, complete, floating, softening shell fibrin film and dynein, extraction process non-corrosiveness.
3. the biology extraction calcium ion the present invention relates to is to activate multiple hormone and enzymatic optimum acidity (pH value 4 left and right).
4. the biology extraction the present invention relates to is to take water as dispersant (H
3o), its H
+hydrogen bond be the energy-poor bond of easy fracture, not only participate in nucleic acid function, also affect the cell adaptation physiological activity of the spatial configuration of protein molecule.
5. the present invention relates to biological extraction, temperature is the temperature range (25-40 ℃) that is controlled at vital movement, also can obtain the functional matrix that is rich in biological value: enzyme albumen, nucleic acid small peptide ossein isoreactivity material in extraction.
6. the biology extraction the present invention relates to, calcium ion concentration Shi Yikewei percentage value unit, concentration can be up to 19 ± 2% (W/W), the concentration method that recovery rate is high.
7. the biology extraction calcium ion technique the present invention relates to is the intellectualized operation of quick, efficient, enrichment, purification.
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| CN201210321470.9A CN103655619A (en) | 2012-09-03 | 2012-09-03 | Process technology of biologically extracting lyophilic active calcium ionic crystals |
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| CN201210321470.9A CN103655619A (en) | 2012-09-03 | 2012-09-03 | Process technology of biologically extracting lyophilic active calcium ionic crystals |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072661A (en) * | 2016-06-21 | 2016-11-09 | 陆兴弟 | A kind of shellfish solution calcium ion extraction process |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648725A (en) * | 2009-05-19 | 2010-02-17 | 大连獐子岛渔业集团股份有限公司 | Method for preparing industrial calcium chloride |
| CN102028709A (en) * | 2009-09-24 | 2011-04-27 | 赵青华 | Process for extracting biologically active calcium ions by biotechnological wet method |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648725A (en) * | 2009-05-19 | 2010-02-17 | 大连獐子岛渔业集团股份有限公司 | Method for preparing industrial calcium chloride |
| CN102028709A (en) * | 2009-09-24 | 2011-04-27 | 赵青华 | Process for extracting biologically active calcium ions by biotechnological wet method |
Non-Patent Citations (1)
| Title |
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| 孙学军: "用贝壳制备食用钙强化剂——乙酸钙", 《食品工业科技》, no. 4, 31 December 1998 (1998-12-31), pages 63 - 64 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072661A (en) * | 2016-06-21 | 2016-11-09 | 陆兴弟 | A kind of shellfish solution calcium ion extraction process |
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Application publication date: 20140326 |