CN103638441B

CN103638441B - A kind of Chinese medicine composition treating liver-depression spleen-insufficiency type fatty liver

Info

Publication number: CN103638441B
Application number: CN201310722886.6A
Authority: CN
Inventors: 张吉敏; 林治辉
Original assignee: Individual
Current assignee: Lin Zhihui; Zhang Jimin
Priority date: 2013-12-15
Filing date: 2013-12-15
Publication date: 2016-08-03
Anticipated expiration: 2033-12-15
Also published as: CN103638441A

Abstract

The invention discloses the Chinese medicine composition of a kind of liver-depression spleen-insufficiency type fatty liver.Fatty liver belong to the traditional Chinese medical science " gather ", " hypochondriac pain ", " phlegm-damp ", " liver addiction " category.The traditional Chinese medical science thinks liver-depression spleen-insufficiency type fatty liver system liver deficiency of spleen-QI, caused by hypofunction.The present invention selects to be had depressed liver-energy dispersing and QI regulating spleen invigorating, is aided with the Chinese medicine Flos Amomi villosi of blood stasis dispersing and phlegm expelling, Fructus Akebiae, Vascular aurantii, Fructus Platycaryae strobilaceac, Radix Aristolochiae, Radix Et Rhizoma Nardostachyos, Radix Inulae, Radix Bauhiniae Lecomtei, mouse, Radix Et Rhizoma Tylophorae Ovatae, Radix Lactucae elatae, Folium Citri Limoniae, traditionally make decoction, through clinical trial, total effective rate reaches 97.6%, and have no side effect, without recurrence, therapeutic effect is stable.

Description

A kind of Chinese medicine composition treating liver-depression spleen-insufficiency type fatty liver

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition treating liver-depression spleen-insufficiency type fatty liver.

Background technology

Fatty liver refers to the common clinical phenomenon of athero in the hepatocyte that a variety of causes causes.Most of fatty liver is caused by the accumulation of triglyceride (TG).It is more common in obesity, heavy drinking and other Disease.Light-duty Patients with Fatty Liver can be asymptomatic, but most patient has the hepatalgia that degree is different.A few patients can be with having spider angioma, breast development, menorrhagia, amenorrhea, atrophy of testis, sexual impotence etc. under slight jaundice, serious conditions.Owing to Western medicine exists certain side effect, and there is no method and the medicine of specially good effect up to now, many scholars inside and outside native land, Ji Xi is in seeking treatment the new method of fatty liver and novel drugs from Chinese medicine, the combination of Chinese and Western medicine or natural drug angle, Chinese medicine takes a turn for the better the Clinical symptom and sign of fatty liver or disappearances, blood fat reducing, liver retraction and liver function again often, reduce the aspects such as body weight and all have preferable curative effect, have that effect is extensive, effect stability, use safety, untoward reaction are little, the feature of suitable long-term taking.

Summary of the invention

It is an object of the invention to provide the Chinese medicine composition of a kind of liver-depression spleen-insufficiency type fatty liver.Fatty liver belong to the traditional Chinese medical science " gather ", " hypochondriac pain ", " phlegm-damp ", " liver addiction " category.On the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the therapeutic rules of fatty liver should follow " Plain Questions. the most pure virginity to be discussed greatly " so-called: " heavily fortified point person disappears it, disease caused by accumulations of pathogen should be treated with therapy of dispersion, disease with retention of pathogen in the body should be treated by elimination therapy, sluggishness of QI and blood should be treated by activation, patients with debility should be treated by tonifying, and appearance person is except it ".Under this principle instructs, primary disease is distinguished specimen deficiency and excess, deficiency syndrome should be treated by tonifying method, sthenia syndrome requiring purgation.Therefore this disease of Chinese traditional treatment should distinguish the cause of disease, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Liver-depression spleen-insufficiency type fatty liver system liver deficiency of spleen-QI, caused by hypofunction, Therapeutic Principle is depressed liver-energy dispersing and QI regulating spleen invigorating, is aided with blood stasis dispersing and phlegm expelling.

It is an object of the invention to be achieved through the following technical solutions, the Chinese medicine composition of this treatment liver-depression spleen-insufficiency type fatty liver is made up of the Chinese medicine of following weight portion: Flos Amomi villosi 2-3 part, Fructus Akebiae 15-30 part, Vascular aurantii 3-5 part, Fructus Platycaryae strobilaceac 9-18 part, Radix Aristolochiae 6-9 part, Radix Et Rhizoma Nardostachyos 2-4 part, Radix Inulae 3-6 part, Radix Bauhiniae Lecomtei 6-9 part, mouse 30-60 part, Radix Et Rhizoma Tylophorae Ovatae 3-9 part, Radix Lactucae elatae 6-9 part, Folium Citri Limoniae 9-15 part.

Preferred: Flos Amomi villosi 2.5 parts, Fructus Akebiae 20 parts, Vascular aurantii 4 parts, Fructus Platycaryae strobilaceac 14 parts, Radix Aristolochiae 7 parts, Radix Et Rhizoma Nardostachyos 3 parts, Radix Inulae 5 parts, Radix Bauhiniae Lecomtei 7 parts, mouse 45 parts, Radix Et Rhizoma Tylophorae Ovatae 6 parts, Radix Lactucae elatae 7 parts, Folium Citri Limoniae 12 parts.

Above-mentioned Chinese medicine decocting is made decoction by preparation method.

Fang Zhong: Flos Amomi villosi the chest stuffiness relieving is regulated the flow of vital energy, eliminating phlegm and relieving asthma；Fructus Akebiae depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis；Vascular aurantii activating QI to eliminate phlegm dredging collateral；The pleasant pain relieving of Fructus Platycaryae strobilaceac, reducing phlegm, expelling pathologic wind detumescence；Radix Aristolochiae promoting the circulation of QI to relieve pain, spleen invigorating；Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, activating spleen and strengthening stomach；Radix Inulae promoting the circulation of QI to relieve pain, invigorating the spleen and regulating the stomach；Radix Bauhiniae Lecomtei regulating QI to relieve pain, reduce phlegm diuretic；Mouse expectorant detumescence, eliminating stasis to stop pain；Radix Et Rhizoma Tylophorae Ovatae dispelling pathogenic wind and eliminating phlegm, removing toxic substances dissipating blood stasis；Radix Lactucae elatae relieving cough and resolving phlegm dispels the wind；Folium Citri Limoniae reduces phlegm, appetizing of regulating the flow of vital energy.

Clinical data

1. physical data is chosen 42 example Patients with Fatty Liver and is consulting patients in out-patient department in January, 2012 in January, 2011 to, diagnosis meets the diagnostic criteria that " Chinese Medical Association's hepatology branch fatty liver and alcoholic liver disease group " is formulated 2006, and gets rid of the diseases such as viral hepatitis, autoimmune hepatitis and drug intoxication hepatitis.Man 28 examples, female 14 example, age 19-68 year, 46.2 years old mean age, average course of disease 4.5 years.

2. diagnostic criteria (1) is without history of drinking history or the equivalent amount of alcohol male 140 grams weekly that drinks, women 70 grams；(2) get rid of viral hepatitis, drug-induced liver disease, total parenteral nutrition, hepatolenticular degeneration etc. and may result in the specified disease of fatty liver.(3) in addition to primary disease clinical manifestation, there are nonspecific symptom and the signs such as weak, dyspepsia, dull pain in liver, hepatosplenomegaly.(4) overweight/Abdominal obesity, fasting glucose can be had to increase, the metabolism syndrome such as blood fat disorder, hypertension.(5) serum transaminase and glutamyl transpeptidase level can be increased (less than 5 times of Upper Limit of Normal Values) by mild to moderate, generally rise a height of master with alanine aminotransferase (" GPT " that be commonly called as the most in the past).(6) tcm diagnosis standard: right flank distending pain, the lower mass in the abdomen of the side of body, abdominal distention uncomfortable in chest, loss of appetite, loose stool or half congealed, lassitude, thin white fur of tongue.

3. during Therapeutic Method patient treatment, formulate individuation dietary program and suitable exercise scheme, control body weight, do not apply other to protect the liver, the medicine such as blood fat reducing.Take Chinese medicine preparation of the present invention on this basis, weigh Flos Amomi villosi 2.5g, Fructus Akebiae 20g, Vascular aurantii 4g, Fructus Platycaryae strobilaceac 14g, Radix Aristolochiae 7g, Radix Et Rhizoma Nardostachyos 3g, Radix Inulae 5g, Radix Bauhiniae Lecomtei 7g, mouse 45g, Radix Et Rhizoma Tylophorae Ovatae 6g, Radix Lactucae elatae 7g, Folium Citri Limoniae 12g.Decocting becomes decoction, and potion, divided and sooner or later took for 2 times, serve on 3 months every day.

4. criterion of therapeutical effect is cured: symptom and sign disappears, and ultrasound diagnosis liver size is normal, and echo is uniform, and liver blood vessel is clear；Blood fat three is the most normal.Effective: symptom and sign disappears, ultrasound diagnosis liver size is normal, and echo slightly strengthens, and liver blood vessel is clear；Blood fat three is normal.Effective: symptom and sign alleviates, ultrasound diagnosis and blood fat laboratory examination slightly take a turn for the better.Invalid: symptom and sign is constant, ultrasound diagnosis and laboratory checking index do not improve.

5. therapeutic effect carries out effect assessment after treating 3 months, cures 21 examples (50%), effective 8 examples (19%), effective 12 examples (28.6%), invalid 1 example (2.4%), total effective rate 97.6%.Period all cases of taking medicine have no adverse reaction, and follow up a case by regular visits to without recurrence after 1 year.

6. model case Lee, man, 38 years old, mesh first visit February 1 in 2012.Patient haves a medical check-up discovery fatty liver, previously has hepatitis B medical history, treats, be on ordinary days addicted to drink.Immediate cause body weight is continuously increased, and weak goes to a doctor, and sees that patient is fat, height 168cm, body weight 93kg, and right flank dull pain is weak, loose stool, and stomach is received typically, and urine is normal, and pale tongue fertilizer has tooth print, tongue in vain, stringy and rolling pulse.Biochemical investigation is shown: HbsAg+, TC10.8mmol/L (3.6～6.1mmol/L), TG4.1mmol/L (0.56～1.70mm/L), and HDL0.36mmol/L (0.40～2.00mmol/L), liver function is normal.B ultrasonic shows: severe fatty liver.Tcm diagnosis: hypochondriac pain stagnation of liver-QI with deficiency of the spleen.Western medicine diagnose: fatty liver, hepatitis B virus carriers.Treatment by Chinese herbs is main and auxiliary with blood stasis dispersing and phlegm expelling with depressed liver-energy dispersing and QI regulating spleen invigorating.Side's medicine: weigh Flos Amomi villosi 2.5g, Fructus Akebiae 20g, Vascular aurantii 4g, Fructus Platycaryae strobilaceac 14g, Radix Aristolochiae 7g, Radix Et Rhizoma Nardostachyos 3g, Radix Inulae 5g, Radix Bauhiniae Lecomtei 7g, mouse 45g, Radix Et Rhizoma Tylophorae Ovatae 6g, Radix Lactucae elatae 7g, Folium Citri Limoniae 12g.Decocting becomes decoction, and potion, divided and sooner or later took for 2 times every day.Patient is advised to strengthen physical training, light diet, avoid and drink.Patient's transference cure after treating 3 months, weight loss is obvious.Blood fat inspection is normal, and B ultrasonic shows: mild fatty liver.

Detailed description of the invention

Embodiment one: weigh Flos Amomi villosi 2.5g, Fructus Akebiae 20g, Vascular aurantii 4g, Fructus Platycaryae strobilaceac 14g, Radix Aristolochiae 7g, Radix Et Rhizoma Nardostachyos 3g, Radix Inulae 5g, Radix Bauhiniae Lecomtei 7g, mouse 45g, Radix Et Rhizoma Tylophorae Ovatae 6g, Radix Lactucae elatae 7g, Folium Citri Limoniae 12g, becomes decoction by above-mentioned Chinese medicine decocting.

Embodiment two: weigh Flos Amomi villosi 3g, Fructus Akebiae 15g, Vascular aurantii 5g, Fructus Platycaryae strobilaceac 9g, Radix Aristolochiae 9g, Radix Et Rhizoma Nardostachyos 2g, Radix Inulae 6g, Radix Bauhiniae Lecomtei 6g, mouse 60g, Radix Et Rhizoma Tylophorae Ovatae 3g, Radix Lactucae elatae 9g, Folium Citri Limoniae 9g, becomes decoction by above-mentioned Chinese medicine decocting.

Embodiment three: weigh Flos Amomi villosi 2g, Fructus Akebiae 30g, Vascular aurantii 3g, Fructus Platycaryae strobilaceac 18g, Radix Aristolochiae 6g, Radix Et Rhizoma Nardostachyos 4g, Radix Inulae 3g, Radix Bauhiniae Lecomtei 9g, mouse 30g, Radix Et Rhizoma Tylophorae Ovatae 9g, Radix Lactucae elatae 6g, Folium Citri Limoniae 15g, becomes decoction by above-mentioned Chinese medicine decocting.

Claims

1. the Chinese medicine composition treating liver-depression spleen-insufficiency type fatty liver, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight: weigh Flos Amomi villosi 3g, Fructus Akebiae 15g, Vascular aurantii 5g, Fructus Platycaryae strobilaceac 9g, Radix Aristolochiae 9g, Radix Et Rhizoma Nardostachyos 2g, Radix Inulae 6g, Radix Bauhiniae Lecomtei 6g, mouse 60g, Radix Et Rhizoma Tylophorae Ovatae 3g, Radix Lactucae elatae 9g, Folium Citri Limoniae 9g, above-mentioned Chinese medicine decocting is become decoction.