CN103638366A - Traditional Chinese medicine used for women vaginal discharge diseases and preparation method thereof - Google Patents
Traditional Chinese medicine used for women vaginal discharge diseases and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and relates to a traditional Chinese medicine used for women vaginal discharge diseases and a preparation method thereof. The traditional Chinese medicine is prepared from the following traditional Chinese medicinal material medicines in parts by weight: 18-32 parts of beautiful sweetgum fruits, 3-9 parts of tetrapanax papyriferus, 6-12 parts of golden cypress, 6-12 parts of felwort, 6-12 parts of Chinese rhubarb, 9-15 parts of fructus forsythia, 6-12 parts of jasmine, 12-18 parts of mints, 9-15 parts of platycodon grandiflorum, 12-18 parts of lophatherum gracile, 9-15 parts of radix angelicae, 12-18 parts of semen plantaginis, 9-15 parts of gordon Euryale, 3-9 parts of ginkgoes, 9-15 parts of radix sophorae flavescentis, 9-15 parts of salviae miltiorrhizae, 9-15 parts of fructus cnidii, 9-15 parts of dried rehmannia roots, 9-15 parts of Chinese angelica, 9-15 parts of ligusticum wallichii, 9-15 parts of red peony roots, 9-15 parts of dittany barks, 9-15 parts of herba schizonepetae, 9-15 parts of divaricate saposhnikovia roots, 9-15 parts of radix bupleuri, 9-15 parts of radix angelicae pubescentis and 9-15 parts of periostracum cicada. The traditional Chinese medicine has the effects of clearing away heat and toxic materials, dispelling wind, arresting itching, resolving dampness and checking vaginal discharge.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of Chinese medicine for vaginal discharge diseases of women and preparation method thereof.
Background technology
Leukorrheal diseases refer to leukorrhagia amount showed increased, and color, matter, abnormal smells from the patient are abnormal, or with whole body or local symptom, are commonly encountered disease, frequently-occurring disease; Cause the reason of leukorrheal diseases a lot, as trichomonal vaginitis, colpitis mycotica, senile vaginitis, cervical erosion, cervical polyp, endometritis, cervical cancer etc.; The common leucorrhoea grow in quantity of leukorrheal diseases clinical manifestation, continuous constantly, lumbago, Mental fatigue etc., or see and redly hold concurrently mutually in vain, or the five colors assorted under, or the turbid sample of pus, has foul smell; If rancid unpleasant, when watching out for, whether there is canceration.The western medicine cause of disease is thought, when Abwehrkraft des Koepers declines or ignores vulvovaginal health, pathogenic microorganism is driven in the wrong direction and is invaded vagina by vagina collar extension, destroy the natural defensive enginery of vagina, cause various vaginitiss, mainly comprise " nonspecific vaginitis ", " colpitis mycotica ", " trichomonal vaginitis " etc., its clinical symptoms is equivalent to the leukorrheal diseases of Chinese medicine.
In view of this, the inventor has developed a kind of easy to use, determined curative effect and without the pure Chinese medicinal preparation of obvious toxic-side effects, to meet the demand of extensive patients.
Summary of the invention
The object of this invention is to provide a kind of easy to use, determined curative effect and without a kind of Chinese medicine for vaginal discharge diseases of women of obvious toxic-side effects and preparation method thereof.
The present invention is achieved through the following technical solutions:
A kind of Chinese medicine for vaginal discharge diseases of women, raw material of Chinese medicine medicine by following weight portion proportioning is made: Fructus Liquidambaris 18-32 part, Medulla Tetrapanacis 3-9 part, Cortex Phellodendri 6-12 part, Radix Gentianae 6-12 part, Radix Et Rhizoma Rhei 6-12 part, Fructus Forsythiae 9-15 part, Fructus Gardeniae 6-12 part, Herba Menthae 12-18 part, Radix Platycodonis 9-15 part, Herba Lophatheri 12-18 part, Radix Angelicae Dahuricae 9-15 part, Semen Plantaginis 12-18 part, Semen Euryales 9-15 part, Semen Ginkgo 3-9 part, Radix Sophorae Flavescentis 9-15 part, Radix Salviae Miltiorrhizae 9-15 part, Fructus Cnidii 9-15 part, Radix Rehmanniae 9-15 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Paeoniae Rubra 9-15 part, Cortex Dictamni 9-15 part, Herba Schizonepetae 9-15 part, Radix Saposhnikoviae 9-15 part, Radix Bupleuri 9-15 part, Radix Angelicae Pubescentis 9-15 part, Periostracum Cicadae 9-15 part.
Preferably, the above-mentioned Chinese medicine for vaginal discharge diseases of women, raw material of Chinese medicine medicine by following weight portion proportioning is made: Fructus Liquidambaris 21-27 part, Medulla Tetrapanacis 5-7 part, Cortex Phellodendri 8-10 part, Radix Gentianae 8-10 part, Radix Et Rhizoma Rhei 8-10 part, Fructus Forsythiae 10-14 part, Fructus Gardeniae 8-10 part, Herba Menthae 13-17 part, Radix Platycodonis 10-14 part, Herba Lophatheri 13-17 part, Radix Angelicae Dahuricae 10-14 part, Semen Plantaginis 13-17 part, Semen Euryales 10-14 part, Semen Ginkgo 5-7 part, Radix Sophorae Flavescentis 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Fructus Cnidii 10-14 part, Radix Rehmanniae 10-14 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Chuanxiong 10-14 part, Radix Paeoniae Rubra 10-14 part, Cortex Dictamni 10-14 part, Herba Schizonepetae 10-14 part, Radix Saposhnikoviae 10-14 part, Radix Bupleuri 10-14 part, Radix Angelicae Pubescentis 10-14 part, Periostracum Cicadae 10-14 part.
Preferred, the above-mentioned Chinese medicine for vaginal discharge diseases of women, is made by the raw material of Chinese medicine medicine of following weight portion proportioning: 24 parts of Fructus Liquidambaris, 6 parts of Medulla Tetrapanaciss, 9 parts of Cortex Phellodendris, 9 parts of Radix Gentianaes, 9 parts of Radix Et Rhizoma Rhei, 12 parts of Fructus Forsythiaes, 9 parts of Fructus Gardeniaes, 15 parts of Herba Menthaes, 12 parts of Radix Platycodoniss, 15 parts of Herba Lophatheris, 12 parts of the Radixs Angelicae Dahuricae, 15 parts of Semen Plantaginiss, 12 parts of Semen Euryaless, 6 parts of Semen Ginkgoes, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Fructus Cnidiis, 12 parts, the Radix Rehmanniae, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Paeoniae Rubra, 12 parts of Cortex Dictamnis, 12 parts of Herba Schizonepetae, 12 parts of Radix Saposhnikoviaes, 12 parts of Radix Bupleuri, 12 parts of Radix Angelicae Pubescentiss, 12 parts of Periostracum Cicadaes.
The crude drug of the Chinese medicine for vaginal discharge diseases of women of the present invention, is 2010 editions medical materials that record of Chinese Pharmacopoeia.
The above-mentioned Chinese medicine for vaginal discharge diseases of women, the dosage form of this Chinese medicine is external preparation.
The above-mentioned Chinese medicine for vaginal discharge diseases of women, the dosage form of this Chinese medicine is external wash liquid.
The preparation method of the above-mentioned Chinese medicine for vaginal discharge diseases of women, comprises the steps:
A) according to required weight portion, take various raw materials;
B), by Fructus Forsythiae, Herba Menthae, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Chuanxiong water vapour distillation volatile oil, the another device of aqueous solution after distillation is collected;
C) medicinal residues after all the other 20 taste components and above-mentioned distillating extracting oil, decoct with water extraction secondary, add for the first time 8 times of water gagings of injection volume and decoct 2 hours, add for the second time 5 times of water gagings of injection volume and decoct 1 hour, collecting decoction, filter, it is 1.10～1.15 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, add ethanol to reaching 70% containing alcohol amount, stir evenly, 2～5 ℃ of standing cold preservation 24 hours, filters; It is 1.14～1.20 that filtrate recycling ethanol 60 ℃ are concentrated into relative density, adds the water dilution of equivalent, stirs evenly, and 2～5 ℃ of standing cold preservations 24 hours again, filter;
D) aqueous solution that step a makes after distillation mixes with the concentrated solution of step b, stirs; And regulate pH value to 5.0～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, obtains.
Chinese medicine for vaginal discharge diseases of women of the present invention, has the effect of heat-clearing and toxic substances removing, dispelling wind for relieving itching, removing dampness leukorrhagia stopping, for vaginal discharge diseases of women, disease see leucorrhoea grow in quantity, continuous constantly, lumbago, Mental fatigue, or see and redly hold concurrently mutually in vain, or the five colors assorted under, or the turbid sample of pus, there is foul smell etc.
The usage and dosage of lotion of medication of the present invention is: with the lotion of medication of the present invention (get this product 20ml and add warm water to 200ml, mix) of 10% concentration, clean pudendum; Or with irrigator, the lotion of medication of the present invention of 10% concentration is delivered to vagina deep washing vagina.2 times on the one 7 days is a course for the treatment of.
Band purgation name is for < < Plain Questions bone empty talk > > " conception vessel is disease, ties seven kinds of hernia in man, and woman's leukorrhagia abdominal mass is poly-".Chinese medicine is thought: traditional Chinese medical science disease leukorrheal diseases refer to woman vagina secretions showed increased, color, matter, the abnormal symptom of abnormal smells from the patient; Leukorrhagia is commonly encountered disease extremely, by multiple gynecological illness, is caused.In < < Fu Qingzhu works on obstetrics and gynecology > >, discuss that are detailed, blue or green, red, yellow, white, the black coloured vaginal discharge of its opinion is to control later age to be with to point the direction.Leukorrheal diseases are many because of damp and hot, noxious dampness, or insufficiency of the spleen, suffer from a deficiency of the kidney etc. due to, cold-damp or damp invasion of lower energizer, or pyretic toxicity contamination, or the Chang Kejian leukorrhagia such as spleen kidney yang gas virtual loss is abnormal; Leukorrhagia generally sees the evil poison of cysthus local infection, or the pathological changes of uterus etc., and women has physiological defect, if daily life accidentally or live and be uncleanly often subject to exopathogen invasion and attack and cause a disease.
Chinese medicine for vaginal discharge diseases of women of the present invention, Medulla Tetrapanacis, Cortex Phellodendri, Radix Gentianae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Radix Platycodonis, Herba Lophatheri, Semen Plantaginis, Fructus Cnidii, Cortex Dictamni heat-clearing and toxic substances removing, dampness leukorrhagia stopping; Fructus Liquidambaris, Fructus Forsythiae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Bupleuri, Radix Angelicae Pubescentis, Periostracum Cicadae, Herba Menthae dispelling wind for relieving itching; Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra promoting blood circulation by removing wind are antipruritic; Semen Euryales, Semen Ginkgo invigorating spleen and kidney, kidney tonifying leukorrhagia stopping; The Radix Angelicae Dahuricae, Radix Sophorae Flavescentis removing dampness and killing parasites are antipruritic.All medicines share, and play altogether the effect of heat-clearing and toxic substances removing, dispelling wind for relieving itching, removing dampness leukorrhagia stopping.
The invention has the advantages that:
(1) the invention provides a kind of new Chinese medicine for leukorrheal diseases, met clinical needs.
(2) the present invention becomes washing liquid by treatment for the Chinese drug preparation of vaginal discharge diseases of women, easy to use, and patient's no pain has been avoided the oral medicine shortcoming such as taste bad bitter to the taste.
(3) clinical test results shows, Chinese medicine of the present invention, 1 the course for the treatment of obvious effective rate up to 75.53%, and JIEERYIN matched group cure rate only has 42.57%, both have significant difference (p < 0.05); 1 the course for the treatment of total effective rate up to 98.04%, and JIEERYIN matched group effective percentage only have 74.26% both there is significant difference (p < 0.05).
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but with this, does not limit the present invention.
Embodiment 1
Prescription: Fructus Liquidambaris 24g, Medulla Tetrapanacis 6g, Cortex Phellodendri 9g, Radix Gentianae 9g, Radix Et Rhizoma Rhei 9g, Fructus Forsythiae 12g, Fructus Gardeniae 9g, Herba Menthae 15g, Radix Platycodonis 12g, Herba Lophatheri 15g, Radix Angelicae Dahuricae 12g, Semen Plantaginis 15g, Semen Euryales 12g, Semen Ginkgo 6g, Radix Sophorae Flavescentis 12g, Radix Salviae Miltiorrhizae 12g, Fructus Cnidii 12g, Radix Rehmanniae 12g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Radix Paeoniae Rubra 12g, Cortex Dictamni 12g, Herba Schizonepetae 12g, Radix Saposhnikoviae 12g, Radix Bupleuri 12g, Radix Angelicae Pubescentis 12g, Periostracum Cicadae 12g.
Preparation method:
A) take Fructus Liquidambaris 24g, Medulla Tetrapanacis 6g, Cortex Phellodendri 9g, Radix Gentianae 9g, Radix Et Rhizoma Rhei 9g, Fructus Forsythiae 12g, Fructus Gardeniae 9g, Herba Menthae 15g, Radix Platycodonis 12g, Herba Lophatheri 15g, Radix Angelicae Dahuricae 12g, Semen Plantaginis 15g, Semen Euryales 12g, Semen Ginkgo 6g, Radix Sophorae Flavescentis 12g, Radix Salviae Miltiorrhizae 12g, Fructus Cnidii 12g, Radix Rehmanniae 12g, Radix Angelicae Sinensis 12g, Rhizoma Chuanxiong 12g, Radix Paeoniae Rubra 12g, Cortex Dictamni 12g, Herba Schizonepetae 12g, Radix Saposhnikoviae 12g, Radix Bupleuri 12g, Radix Angelicae Pubescentis 12g, Periostracum Cicadae 12g;
B), by Fructus Forsythiae, Herba Menthae, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Chuanxiong water vapour distillation volatile oil, the another device of aqueous solution after distillation is collected;
C) medicinal residues after all the other 20 taste components and above-mentioned distillating extracting oil, decoct with water extraction secondary, add for the first time 8 times of water gagings of injection volume and decoct 2 hours, add for the second time 5 times of water gagings of injection volume and decoct 1 hour, collecting decoction, filter, it is 1.10～1.15 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, add ethanol to reaching 70% containing alcohol amount, stir evenly, 2～5 ℃ of standing cold preservation 24 hours, filters; It is 1.14～1.20 that filtrate recycling ethanol 60 ℃ are concentrated into relative density, adds the water dilution of equivalent, stirs evenly, and 2～5 ℃ of standing cold preservations 24 hours again, filter;
D) aqueous solution that step a makes after distillation mixes with the concentrated solution of step b, stirs; And regulate pH value to 5.0～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, obtains.
Embodiment 2
Prescription: Fructus Liquidambaris 21g, Medulla Tetrapanacis 7g, Cortex Phellodendri 8g, Radix Gentianae 10g, Radix Et Rhizoma Rhei 8g, Fructus Forsythiae 14g, Fructus Gardeniae 8g, Herba Menthae 17g, Radix Platycodonis 10g, Herba Lophatheri 17g, Radix Angelicae Dahuricae 10g, Semen Plantaginis 17g, Semen Euryales 10g, Semen Ginkgo 7g, Radix Sophorae Flavescentis 10g, Radix Salviae Miltiorrhizae 14g, Fructus Cnidii 10g, Radix Rehmanniae 14g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 14g, Radix Paeoniae Rubra 10g, Cortex Dictamni 14g, Herba Schizonepetae 10g, Radix Saposhnikoviae 14g, Radix Bupleuri 10g, Radix Angelicae Pubescentis 14g, Periostracum Cicadae 10g.
Preparation method:
A) take Fructus Liquidambaris 21g, Medulla Tetrapanacis 7g, Cortex Phellodendri 8g, Radix Gentianae 10g, Radix Et Rhizoma Rhei 8g, Fructus Forsythiae 14g, Fructus Gardeniae 8g, Herba Menthae 17g, Radix Platycodonis 10g, Herba Lophatheri 17g, Radix Angelicae Dahuricae 10g, Semen Plantaginis 17g, Semen Euryales 10g, Semen Ginkgo 7g, Radix Sophorae Flavescentis 10g, Radix Salviae Miltiorrhizae 14g, Fructus Cnidii 10g, Radix Rehmanniae 14g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 14g, Radix Paeoniae Rubra 10g, Cortex Dictamni 14g, Herba Schizonepetae 10g, Radix Saposhnikoviae 14g, Radix Bupleuri 10g, Radix Angelicae Pubescentis 14g, Periostracum Cicadae 10g;
B), by Fructus Forsythiae, Herba Menthae, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Chuanxiong water vapour distillation volatile oil, the another device of aqueous solution after distillation is collected;
C) medicinal residues after all the other 20 taste components and above-mentioned distillating extracting oil, decoct with water extraction secondary, add for the first time 8 times of water gagings of injection volume and decoct 2 hours, add for the second time 5 times of water gagings of injection volume and decoct 1 hour, collecting decoction, filter, it is 1.10～1.15 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, add ethanol to reaching 70% containing alcohol amount, stir evenly, 2～5 ℃ of standing cold preservation 24 hours, filters; It is 1.14～1.20 that filtrate recycling ethanol 60 ℃ are concentrated into relative density, adds the water dilution of equivalent, stirs evenly, and 2～5 ℃ of standing cold preservations 24 hours again, filter;
D) aqueous solution that step a makes after distillation mixes with the concentrated solution of step b, stirs; And regulate pH value to 5.0～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, obtains.
Embodiment 3
Prescription: Fructus Liquidambaris 27g, Medulla Tetrapanacis 5g, Cortex Phellodendri 10g, Radix Gentianae 8g, Radix Et Rhizoma Rhei 10g, Fructus Forsythiae 10g, Fructus Gardeniae 10g, Herba Menthae 13g, Radix Platycodonis 14g, Herba Lophatheri 13g, Radix Angelicae Dahuricae 14g, Semen Plantaginis 13g, Semen Euryales 14g, Semen Ginkgo 5g, Radix Sophorae Flavescentis 14g, Radix Salviae Miltiorrhizae 10g, Fructus Cnidii 14g, Radix Rehmanniae 10g, Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 14g, Cortex Dictamni 10g, Herba Schizonepetae 14g, Radix Saposhnikoviae 10g, Radix Bupleuri 14g, Radix Angelicae Pubescentis 10g, Periostracum Cicadae 14g.
Preparation method:
A) take Fructus Liquidambaris 27g, Medulla Tetrapanacis 5g, Cortex Phellodendri 10g, Radix Gentianae 8g, Radix Et Rhizoma Rhei 10g, Fructus Forsythiae 10g, Fructus Gardeniae 10g, Herba Menthae 13g, Radix Platycodonis 14g, Herba Lophatheri 13g, Radix Angelicae Dahuricae 14g, Semen Plantaginis 13g, Semen Euryales 14g, Semen Ginkgo 5g, Radix Sophorae Flavescentis 14g, Radix Salviae Miltiorrhizae 10g, Fructus Cnidii 14g, Radix Rehmanniae 10g, Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 14g, Cortex Dictamni 10g, Herba Schizonepetae 14g, Radix Saposhnikoviae 10g, Radix Bupleuri 14g, Radix Angelicae Pubescentis 10g, Periostracum Cicadae 14g;
B), by Fructus Forsythiae, Herba Menthae, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Chuanxiong water vapour distillation volatile oil, the another device of aqueous solution after distillation is collected;
C) medicinal residues after all the other 20 taste components and above-mentioned distillating extracting oil, decoct with water extraction secondary, add for the first time 8 times of water gagings of injection volume and decoct 2 hours, add for the second time 5 times of water gagings of injection volume and decoct 1 hour, collecting decoction, filter, it is 1.10～1.15 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, add ethanol to reaching 70% containing alcohol amount, stir evenly, 2～5 ℃ of standing cold preservation 24 hours, filters; It is 1.14～1.20 that filtrate recycling ethanol 60 ℃ are concentrated into relative density, adds the water dilution of equivalent, stirs evenly, and 2～5 ℃ of standing cold preservations 24 hours again, filter;
D) aqueous solution that step a makes after distillation mixes with the concentrated solution of step b, stirs; And regulate pH value to 5.0～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, obtains.
Embodiment 4
Prescription: Fructus Liquidambaris 18g, Medulla Tetrapanacis 9g, Cortex Phellodendri 6g, Radix Gentianae 12g, Radix Et Rhizoma Rhei 6g, Fructus Forsythiae 15g, Fructus Gardeniae 6g, Herba Menthae 18g, Radix Platycodonis 9g, Herba Lophatheri 18g, Radix Angelicae Dahuricae 9g, Semen Plantaginis 18g, Semen Euryales 9g, Semen Ginkgo 9g, Radix Sophorae Flavescentis 9g, Radix Salviae Miltiorrhizae 15g, Fructus Cnidii 9g, Radix Rehmanniae 15g, Radix Angelicae Sinensis 9g, Rhizoma Chuanxiong 15g, Radix Paeoniae Rubra 9g, Cortex Dictamni 15g, Herba Schizonepetae 9g, Radix Saposhnikoviae 15g, Radix Bupleuri 9g, Radix Angelicae Pubescentis 15g, Periostracum Cicadae 9g.
Preparation method is with embodiment 1.
Embodiment 5
Prescription: Fructus Liquidambaris 32g, Medulla Tetrapanacis 3g, Cortex Phellodendri 12g, Radix Gentianae 6g, Radix Et Rhizoma Rhei 12g, Fructus Forsythiae 9g, Fructus Gardeniae 12g, Herba Menthae 12g, Radix Platycodonis 15g, Herba Lophatheri 12g, Radix Angelicae Dahuricae 15g, Semen Plantaginis 12g, Semen Euryales 15g, Semen Ginkgo 3g, Radix Sophorae Flavescentis 15g, Radix Salviae Miltiorrhizae 9g, Fructus Cnidii 15g, Radix Rehmanniae 9g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 9g, Radix Paeoniae Rubra 15g, Cortex Dictamni 9g, Herba Schizonepetae 15g, Radix Saposhnikoviae 9g, Radix Bupleuri 15g, Radix Angelicae Pubescentis 9g, Periostracum Cicadae 15g.
Preparation method is with embodiment 1.
The preparation of embodiments of the invention l has been carried out to clinical pharmacodynamics test, and Details as Follows:
1. clinical data
Treatment group 102, JIEERYIN matched group 101 examples, at minimum 24 years old of age, maximum 72 years old is all married woman.24 years old ~ 50 years old 90 examples for the treatment of group, 51 years old ~ 60 years old 8 examples, 61 years old ~ 74 years old 4 examples, wherein clear and thin leucorrhea is if tears are as saliva, body void person 19 examples; Yellow with vagina discomfort person 25 examples; Yellow band blood person 22 examples; Purulence is with colpodynia or uterus adnexa pain person 2 examples; Bean curd slag specimen is with pruritus of vagina person 21 examples; Cystose is with pruritus of vagina person 12 examples; Like the non-pus of pus, like the non-water of water, foul unclear person's 2 examples.24 years old ~ 50 years old 88 examples of matched group, 51 years old ~ 60 years old 8 examples, 61 years old ~ 74 years old 5 examples, wherein clear and thin leucorrhea is if tears are as saliva, body void person 18 examples; Yellow with vagina discomfort person 26 examples; Yellow band blood person 20 examples; Purulence is with colpodynia or uterus adnexa pain person 3 examples; Bean curd slag specimen is with pruritus of vagina person 19 examples; Cystose is with pruritus of vagina person 14 examples; Like the non-pus of pus, like the non-water of water, foul unclear person's 2 examples.All cases all get rid of through the super inspection of B and/or pathologic finding the possibility that cancerates.Overwhelming majority case concentrates on endometritis, cervicitis, colpitis mycotica, trichomonal vaginitis, senile vaginitis, gonococcus property or nongonococcal vaginitis etc.Two groups of there are no significant at aspects such as sex, age, course of disease distributions differences, have comparability (P>0.05).
2 Therapeutic Method
Treatment group: clean pudendum with the lotion of medication of the present invention (get this product 20ml and add warm water to 200ml, mix) of 10% concentration; Or with irrigator, the lotion of medication of the present invention of 10% concentration is delivered to vagina deep washing vagina.2 times on the one 7 days is a course for the treatment of.
Matched group: by JIEERYIN XIYE, the same treatment group of usage.All take 7 days as 1 course for the treatment of, finish rear observe the curative effect 1 course for the treatment of for two groups.
3. efficacy analysis
3. 1 criterion of therapeutical effect
With clinical symptoms and sign, disappear, following up a case by regular visits to 3 months is healing without recurrence; Clinical symptoms and sign alleviate as effectively; Sings and symptoms is invalid without changing into.
3. 2 therapeutic outcomes
Table 1 liang group Comparison of therapeutic
| Group | Number of cases | Effective | Effectively | Invalid | Obvious effective rate (%) | Total effective rate (%) |
| Treatment group | 102 | 75 | 25 | 2 | 73.53* | 98.04* |
| Matched group | 101 | 43 | 32 | 26 | 42.57 | 74.26 |
Note: two groups of comparisons, P<0.05, difference has statistical significance
Compare with matched group, the Chinese medicine for leukorrheal diseases of the present invention, 1 the course for the treatment of obvious effective rate up to 75.53%, and JIEERYIN matched group cure rate only has 42.57%, both have significant difference (p < 0.05; 1 the course for the treatment of total effective rate up to 98.04%, and JIEERYIN matched group effective percentage only have 74.26% both there is significant difference (p < 0.05).
Two groups of patients are showed no untoward reaction.
Claims (6)
1. for a Chinese medicine for vaginal discharge diseases of women, by the raw material of Chinese medicine medicine of following weight portion proportioning, made:
Fructus Liquidambaris 18-32 part, Medulla Tetrapanacis 3-9 part, Cortex Phellodendri 6-12 part, Radix Gentianae 6-12 part, Radix Et Rhizoma Rhei 6-12 part, Fructus Forsythiae 9-15 part, Fructus Gardeniae 6-12 part, Herba Menthae 12-18 part, Radix Platycodonis 9-15 part, Herba Lophatheri 12-18 part, Radix Angelicae Dahuricae 9-15 part, Semen Plantaginis 12-18 part, Semen Euryales 9-15 part, Semen Ginkgo 3-9 part, Radix Sophorae Flavescentis 9-15 part, Radix Salviae Miltiorrhizae 9-15 part, Fructus Cnidii 9-15 part, Radix Rehmanniae 9-15 part, Radix Angelicae Sinensis 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Paeoniae Rubra 9-15 part, Cortex Dictamni 9-15 part, Herba Schizonepetae 9-15 part, Radix Saposhnikoviae 9-15 part, Radix Bupleuri 9-15 part, Radix Angelicae Pubescentis 9-15 part, Periostracum Cicadae 9-15 part.
2. the Chinese medicine for vaginal discharge diseases of women according to claim 1, is characterized in that, by the raw material of Chinese medicine medicine of following weight portion proportioning, is made:
Fructus Liquidambaris 21-27 part, Medulla Tetrapanacis 5-7 part, Cortex Phellodendri 8-10 part, Radix Gentianae 8-10 part, Radix Et Rhizoma Rhei 8-10 part, Fructus Forsythiae 10-14 part, Fructus Gardeniae 8-10 part, Herba Menthae 13-17 part, Radix Platycodonis 10-14 part, Herba Lophatheri 13-17 part, Radix Angelicae Dahuricae 10-14 part, Semen Plantaginis 13-17 part, Semen Euryales 10-14 part, Semen Ginkgo 5-7 part, Radix Sophorae Flavescentis 10-14 part, Radix Salviae Miltiorrhizae 10-14 part, Fructus Cnidii 10-14 part, Radix Rehmanniae 10-14 part, Radix Angelicae Sinensis 10-14 part, Rhizoma Chuanxiong 10-14 part, Radix Paeoniae Rubra 10-14 part, Cortex Dictamni 10-14 part, Herba Schizonepetae 10-14 part, Radix Saposhnikoviae 10-14 part, Radix Bupleuri 10-14 part, Radix Angelicae Pubescentis 10-14 part, Periostracum Cicadae 10-14 part.
3. the Chinese medicine for vaginal discharge diseases of women according to claim 3, is characterized in that, by the raw material of Chinese medicine medicine of following weight portion proportioning, is made:
24 parts of Fructus Liquidambaris, 6 parts of Medulla Tetrapanaciss, 9 parts of Cortex Phellodendris, 9 parts of Radix Gentianaes, 9 parts of Radix Et Rhizoma Rhei, 12 parts of Fructus Forsythiaes, 9 parts of Fructus Gardeniaes, 15 parts of Herba Menthaes, 12 parts of Radix Platycodoniss, 15 parts of Herba Lophatheris, 12 parts of the Radixs Angelicae Dahuricae, 15 parts of Semen Plantaginiss, 12 parts of Semen Euryaless, 6 parts of Semen Ginkgoes, 12 parts of Radix Sophorae Flavescentiss, 12 parts of Radix Salviae Miltiorrhizaes, 12 parts of Fructus Cnidiis, 12 parts, the Radix Rehmanniae, 12 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 12 parts of Radix Paeoniae Rubra, 12 parts of Cortex Dictamnis, 12 parts of Herba Schizonepetae, 12 parts of Radix Saposhnikoviaes, 12 parts of Radix Bupleuri, 12 parts of Radix Angelicae Pubescentiss, 12 parts of Periostracum Cicadaes.
4. according to the Chinese medicine for vaginal discharge diseases of women described in claim 1 or 2 or 3, it is characterized in that, the dosage form of this Chinese medicine is external preparation.
5. the Chinese medicine for vaginal discharge diseases of women according to claim 4, is characterized in that, the dosage form of this Chinese medicine is external wash liquid.
6. the preparation method of the Chinese medicine for vaginal discharge diseases of women claimed in claim 1, comprises the steps:
A) according to required weight portion, take various raw materials;
B), by Fructus Forsythiae, Herba Menthae, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Angelicae Sinensis, Rhizoma Chuanxiong water vapour distillation volatile oil, the another device of aqueous solution after distillation is collected;
C) medicinal residues after all the other 20 taste components and above-mentioned distillating extracting oil, decoct with water extraction secondary, add for the first time 8 times of water gagings of injection volume and decoct 2 hours, add for the second time 5 times of water gagings of injection volume and decoct 1 hour, collecting decoction, filter, it is 1.10～1.15 concentrated solution that 60 ℃ of filtrates are concentrated into relative density, lets cool, add ethanol to reaching 70% containing alcohol amount, stir evenly, 2～5 ℃ of standing cold preservation 24 hours, filters; It is 1.14～1.20 that filtrate recycling ethanol 60 ℃ are concentrated into relative density, adds the water dilution of equivalent, stirs evenly, and 2～5 ℃ of standing cold preservations 24 hours again, filter;
D) aqueous solution that step a makes after distillation mixes with the concentrated solution of step b, stirs; And regulate pH value to 5.0～6.0, and add water and be adjusted to 1000ml, filter, sterilizing, obtains.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104096046A (en) * | 2014-07-15 | 2014-10-15 | 亓荣华 | Traditional Chinese medicine preparation for treating woman leucorrhea disease |
| CN105055831A (en) * | 2015-09-24 | 2015-11-18 | 邢治华 | Traditional Chinese medicine for treating leukorrhagia of women and preparation method thereof |
| CN105381034A (en) * | 2015-12-24 | 2016-03-09 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation used for conditioning leucorrhea disease |
| CN107198752A (en) * | 2017-06-15 | 2017-09-26 | 合肥川迪医药技术有限公司 | A kind of natural labor woman private parts anti-inflammation washing lotion |
| CN107661419A (en) * | 2017-10-17 | 2018-02-06 | 雷海利 | A kind of rosemary gynecological gel and preparation method thereof |
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| CN1413607A (en) * | 2001-10-24 | 2003-04-30 | 邓大勇 | Medicine for treatment of gynecopathy |
| CN101926919A (en) * | 2009-06-25 | 2010-12-29 | 梁婧卉 | Pure traditional Chinese medicinal lotion for treating skin disease |
| CN102886006A (en) * | 2012-09-24 | 2013-01-23 | 孙凤霞 | Medicinal lotion for treating female vaginal discharge diseases and preparation method thereof |
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| CN1413607A (en) * | 2001-10-24 | 2003-04-30 | 邓大勇 | Medicine for treatment of gynecopathy |
| CN101926919A (en) * | 2009-06-25 | 2010-12-29 | 梁婧卉 | Pure traditional Chinese medicinal lotion for treating skin disease |
| CN102886006A (en) * | 2012-09-24 | 2013-01-23 | 孙凤霞 | Medicinal lotion for treating female vaginal discharge diseases and preparation method thereof |
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| CN104096046A (en) * | 2014-07-15 | 2014-10-15 | 亓荣华 | Traditional Chinese medicine preparation for treating woman leucorrhea disease |
| CN105055831A (en) * | 2015-09-24 | 2015-11-18 | 邢治华 | Traditional Chinese medicine for treating leukorrhagia of women and preparation method thereof |
| CN105381034A (en) * | 2015-12-24 | 2016-03-09 | 兰州古驰生物科技有限公司 | Traditional Chinese medicine health-care preparation used for conditioning leucorrhea disease |
| CN107198752A (en) * | 2017-06-15 | 2017-09-26 | 合肥川迪医药技术有限公司 | A kind of natural labor woman private parts anti-inflammation washing lotion |
| CN107661419A (en) * | 2017-10-17 | 2018-02-06 | 雷海利 | A kind of rosemary gynecological gel and preparation method thereof |
| CN107661419B (en) * | 2017-10-17 | 2020-11-03 | 雷海利 | Rosemary gynecological gel and preparation method thereof |
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