A kind ofly treat rheumatismal Chinese medicine composition
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of medicament for the treatment of rheumatismal Chinese medicine composition.
Background technology
Rheumatism is that one group of infringement joint, skeleton, muscle, blood vessel and relevant soft tissue or connective tissue are main disease, and wherein majority is autoimmune disease.Morbidity is many compared with hidden and slow, and the course of disease is longer, and mostly has genetic predisposition.Diagnosis and treatment all acquire a certain degree of difficulty; In blood, how can check out different autoantibodys, may be relevant from different HLA hypotypes; To nonsteroidal anti-inflammatory agent (NSAID), glucocorticoid and immunosuppressant have good short-term or long-term palliative reaction.
Rheumatismal Therapeutic Method, is many at present, medicine, the traditional Chinese medical science, operation, naturopathy, the treatment of little folk prescription etc.Rheumatism, because be different from internal medicine or the surgical diseases of general universality, has specific drug just can cure by a period of time.Rheumatism belongs to a kind of chronic disease of domestic trouble and foreign invasion type, in treatment, need to adopt distinct methods therapeutic scheme by the different body constitution of different time, apply in recent years modern scientific method, verified many classical prescriptions of Chinese medicine, found the multiple plant amedica that rheumatism is had to obvious curative effects, yet, in these Chinese patent medicines, the overwhelming majority be take pain relieving, activating blood circulation to dissipate blood stasis as its main effect, and rheumatism is played a part to mitigate the disease, still be difficult to reach the object that changes the course of disease, and have certain toxic and side effects.One of object of the present invention is to change reagent combination, thus provide a kind of nontoxic, have no side effect, medication economy, therapeutic effect better treats rheumatismal Chinese medicine preparation.
Summary of the invention
Object of the present invention aims to provide and a kind ofly can to rheumatic arthritis, play the Chinese medicine preparation of good curative effect, have effective, do not recur, the advantage such as the cycle is short, price is low, have no side effect.The inventor thinks by clinical practice for many years, rheumatism genus " arthromyodynia ", < < Plain Questions. numbness opinion > >: " wind, cold, wet three gas are mixed extremely, combined into numbness." through a large amount of clinical confirmations, it is inadequate that list is controlled arthromyodynia from the wet opinion of wind and cold, many patients' thermal image instead resembles more than rheumatism is wet.Your wing > > of < < gold: " internal organs meridians, first have accumulation of heat, and multiple in the wet visitor of wind and cold, heat stagnated by cold, and gas must not lead to, the of a specified duration also heat-transformation of trembling with fear, numbness Xi and also vexed.So " need strengthening vital QI to eliminate pathogenic factors; Specimen emergency (symptomatic treatment in acute condition, radical treatment in chronic case); Treatment in accordance with three factors(season,locality and individual) (giving treatment in accordance with seasonal conditions, treatment in accordance with local conditions, giving treatment in accordance with the patient’s individuality); Treating the same disease with different methods, treating different diseases with the same therapeutic principle.
Chinese medicine composition of the present invention is mainly comprised of Radix Aconiti, Rhizoma Chuanxiong, Rhizoma Curculiginis, Cortex erythrinae, Herba Aristolochiae Mollissimae, Rhizoma Homalomenae, Herba speranskiae tuberculatae, Semen Cuscutae, Herba Lycopi.In side, Radix Aconiti is hot in nature, acrid in the mouth, hardship, energy expelling wind and removing dampness, antalgic; Rhizoma Chuanxiong is warm in nature, and sweet in the mouth has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping; Rhizoma Curculiginis is warm in nature, and acrid in the mouth has kidney-replenishing, bone and muscle strengthening, the effect that cold expelling is wet.Above three medicine energy wind-expelling pain-stoppings, warming and recuperating the kidney-YANG, the effect of promoting blood circulation to remove obstruction in the collateral, in side as monarch drug.Cortex erythrinae is flat, bitter in the mouth, energy wind-damp dispelling, the meridian dredging; Herba Aristolochiae Mollissimae is flat, and acrid in the mouth, hardship, have expelling wind and removing dampness, the effect of promoting blood circulation to remove obstruction in the collateral; Rhizoma Homalomenae is warm in nature, acrid in the mouth, energy wind-damp dispelling; Relaxing muscles and tendons and activating QI and blood in the collateral; Herba speranskiae tuberculatae is warm in nature, acrid in the mouth, energy expelling wind and removing dampness, promoting blood circulation and detumescence pain relieving.Above four medicines can be strengthened expelling wind and removing dampness, the effect of promoting blood circulation to remove obstruction in the collateral, in side as ministerial drug.Semen Cuscutae slightly warm in nature, acrid in the mouth, sweet, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity; Herba Lycopi's slightly warm in nature, bitter in the mouth, pungent, has blood circulation promoting and blood stasis dispelling, the effect of line water detumescence.Two medicines as adjuvant, draw above-listed all medicines and enter through marrow skeleton in formula.In sum, the full side rheumatismal etiology and pathogenesis that links closely, scientific and reasonable compatibility, treating both the principal and secondary aspects of a disease, receives the merit of expelling wind and removing dampness, warming and recuperating the kidney-YANG, reducing swelling and alleviating pain, promoting blood circulation to remove obstruction in the collateral altogether.
The consumption of drug component of the present invention is groped in a large number to sum up through inventor and is drawn, each amounts of components has good curative effect in following ranges, and medicine of the present invention contains:
Radix Aconiti 10-30 part Rhizoma Chuanxiong 30-60 part Rhizoma Curculiginis 20-50 part Cortex erythrinae 30-60 part Caulis Piperis Kadsurae 40-70 part Herba Aristolochiae Mollissimae 30-60 part Rhizoma Homalomenae 20-50 part Herba speranskiae tuberculatae 20-50 part Semen Cuscutae 40-70 part Herba Lycopi 20-50 part
Optimum weight part is:
40 parts of 50 parts of Herba Lycopi of 40 parts of Semen Cuscutae of 40 parts of Herba speranskiae tuberculataes of 40 parts of Rhizoma Homalomenaes of 60 parts of Herba Aristolochiae Mollissimaes of 40 portions of Caulis Piperis Kadsuraes of 30 parts of Cortex erythrinaes of 50 portions of Rhizoma Curculiginises of 20 parts of Rhizoma Chuanxiongs of Radix Aconiti.
Medicine of the present invention can adopt Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful conventional formulation.For example, after these crude drug can being crushed into powder, mix homogeneously is made powder and is taken after mixing it with water; Also can be by these medicines together decocting, then condensed water decocting liquid, makes oral liquid.
Described dosage form is said dosage form on any pharmaceutics, as syrup, granule, capsule, tablet etc.; Described capsule is common capsule, effervescent capsule or other various suitable capsules; Described tablet is common tablet, effervescent tablet, dispersible tablet or other various suitable tablets.
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The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
Embodiment 1:
40 grams of 20 grams of Radix Aconitis, 50 grams of Rhizoma Chuanxiongs, 30 grams of Rhizoma Curculiginises, 40 grams of Cortex erythrinaes, 60 grams of Caulis Piperis Kadsuraes, 40 grams of Herba Aristolochiae Mollissimaes, 40 grams of Rhizoma Homalomenaes, 40 grams of Herba speranskiae tuberculataes, 50 grams of Semen Cuscutae, Herba Lycopi are cleaned, dried in the shade, then section or broken, and be immersed at 1: 5 in proportion and be equivalent in the above Chinese liquor of 45 ° of spirituosity degree, its brew cycle is 20~35 days, to after date, take out, add white sugar appropriate, filter bottling.
Embodiment 2:
20 grams of 10 grams of Radix Aconitis, 30 grams of Rhizoma Chuanxiongs, 20 grams of Rhizoma Curculiginises, 30 grams of Cortex erythrinaes, 40 grams of Caulis Piperis Kadsuraes, 30 grams of Herba Aristolochiae Mollissimaes, 20 grams of Rhizoma Homalomenaes, 20 grams of Herba speranskiae tuberculataes, 40 grams of Semen Cuscutae, Herba Lycopi are cleaned, dried in the shade, then section or broken, and be immersed at 1: 5 in proportion and be equivalent in the above Chinese liquor of 45 ° of spirituosity degree, its brew cycle is 20~35 days, to after date, take out, add white sugar appropriate, filter bottling.
Embodiment 3:
50 grams of 30 grams of Radix Aconitis, 60 grams of Rhizoma Chuanxiongs, 50 grams of Rhizoma Curculiginises, 60 grams of Cortex erythrinaes, 70 grams of Caulis Piperis Kadsuraes, 60 grams of Herba Aristolochiae Mollissimaes, 50 grams of Rhizoma Homalomenaes, 50 grams of Herba speranskiae tuberculataes, 70 grams of Semen Cuscutae, Herba Lycopi are cleaned, dried in the shade, then section or broken, and be immersed at 1: 5 in proportion and be equivalent in more than 45 Chinese liquor of spirituosity degree, its brew cycle is 20~35 days, to after date, take out, add white sugar appropriate, filter bottling.
The evaluation test that is used for the treatment of rheumatismal Chinese medicine composition result of use of the present invention:
Object of study: select and suffer from rheumatismal trier totally 120 people, male 60 people wherein, female 60 people, the mean age was 46 one full year of life.Diagnostic criteria: the standard of formulating with reference to " American Rheumatism Association ", that is: according to medical history, physical diagnosis and radiological examination result: knee-joint pain, determine clinical diagnosis for 3 that possess in following 6 conditions, 1. radiology shows hyperosteogeny formation simultaneously; 2. rise morning and be stiffly less than 30 minutes; 3. there is bone sound during joint motion; 4. knee joint bone increases; 5. there is bone tenderness; 6. without significantly synovial membrane intensification.Divide 3 groups, every 40 people of group, group 1 is used the Chinese medicine composition of embodiment mono-, and group 2 is used the Chinese medicine composition of embodiment bis-, and group 3 is used the Chinese medicine composition of embodiment tri-.Using method is: experimenter directly uses and is subject to trial product, and the Chinese medicine preparation that every day, early, middle and late 3 oral meal dosage were 100ml, adheres to using one month, at least check once and have no adverse reaction to understand weekly, and itemized record result.
Use the effect of embodiment mono-compositions:
Experimenter is totally 40 people, male 20 people wherein, female 20 people.Use one month, rear experimenter is all without occurring untoward reaction.After wherein 39 experimenters represent to use the Chinese medicine preparation of embodiment mono-, affected part pain reduces, and plays stiff obvious improvement morning; 1 subject perception effect is general, without too large, obviously improves.Effective percentage reaches 97.5%.
Use the effect of embodiment bis-compositionss:
Experimenter is totally 40 people, male 20 people wherein, female 20 people.Use one month, rear experimenter is all without occurring untoward reaction.After wherein 35 experimenters represent to use the Chinese medicine preparation of embodiment bis-, affected part pain reduces, and plays stiff obvious improvement morning; 5 subject perception effects are general, without too large, obviously improve.Effective percentage reaches 87.5%.
Use the effect of embodiment tri-compositionss:
Experimenter is totally 40 people, male 20 people wherein, female 20 people.Use one month, rear experimenter is all without occurring untoward reaction.After wherein 33 experimenters represent to use embodiment tri-Chinese medicine preparation, affected part pain reduces, and plays stiff obvious improvement morning; 7 subject perception effects are general, without too large, obviously improve.Effective percentage reaches 82.5%.
As can be seen from the above embodiments, embodiment mono-is optimum weight proportioning of the present invention.