CN103623012B - A kind of liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion - Google Patents
A kind of liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion Download PDFInfo
- Publication number
- CN103623012B CN103623012B CN201210305895.0A CN201210305895A CN103623012B CN 103623012 B CN103623012 B CN 103623012B CN 201210305895 A CN201210305895 A CN 201210305895A CN 103623012 B CN103623012 B CN 103623012B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- traditional chinese
- herb
- crude drug
- granule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The invention discloses a kind of liquid phase to shear dispersion and prepare the technology of nano traditional Chinese medicine material, this technology is raw material with Chinese crude drug, disperses crushing technology, prepare the nano traditional Chinese medicine granule of particle diameter at 50-300nm fast in liquid phase environment by high shear.Chinese medicine solid nanoparticles can be made, also nano traditional Chinese medicine suspension can be made.
Description
Technical field
The invention belongs to the fabricating technology field of nano traditional Chinese medicine, this technology with single medicinal material material and herbal mixture for raw material, crushing technology (Highsheardispersingemulsifier is disperseed by high shear in liquid phase environment, hereinafter referred to as HSDE), prepare the nano traditional Chinese medicine granule of particle diameter at 50-300nm fast.
Background technology
Although modern life science makes great progress, but the health problem of facing mankind is still severe, and modern medicine obviously can not solve all diseases and health problem.Along with the development of society and the transformation of people life style, the radiance of traditional medicine are more magnificent in new period.The predicament that current chemical drugs faces, form distinct contrast with the Green Peace ideological trend of common people's back to nature, the developmental research of Chinese medicine forms focus in the world.
The material base that traditional Chinese medicine disease prevention is cured the disease is from bioactive fraction or active chemical components.Therefore, the attention of medical scholar mainly concentrates on searching and has on various bioactive compound.But living organism is an extremely complicated process to the absorption of medicine, metabolism, excretion, and the pharmacodynamics effect that Chinese medicine produces can not give the credit to the distinctive chemical composition of this medicine uniquely, also closely related with the physical state of medicine etc.This just gives people one enlightenment: the physical state changing medicine may be a kind of effective ways of new medicine development.
Nanotechnology is one and handles atom and molecule in nano-space yardstick, processes, produces the new and high technology with specific function product to material.When particle size enters nanometer scale, due to quantum size effect and skin effect, nano material presents physics, the chemistry and biology characteristic of many novelties.Under the prerequisite meeting Traditional Chinese medical theory, utilizing HSDE to be broken into by Chinese crude drug and both keep the intrinsic natural property of medicine, have again the herb in granule form of nano-grade size, is the key technology of the modernization of Chinese medicine.
A series of nanometer formulations of the invention such as patent CN200510050739.4, CN01101991.3 adopt microwave extracting, concentrated, after spraying dry, prepares nano traditional Chinese medicine by supersonic jet technology.
Patent CN1586528A, at normal temperatures, utilizes totally enclosed type ultrafine crusher to prepare nano traditional Chinese medicine powder body.
Summary of the invention
A kind of liquid phase shearing dispersion is the object of the present invention is to provide to prepare the technology of nano traditional Chinese medicine material.
The present invention utilizes HSDE by traditional Chinese medicinal material raw materials nanorize under the condition of liquid phase, room temperature, farthest preserves the active factors of Chinese medicine, improves the bioavailability of Chinese medicine, ensures that the full powder of Chinese medicine is used as medicine, overcomes the deficiencies in the prior art.
The powerful kinetic energy that high shear dispersion disintegrating machine utilizes high tangential velocity and high frequency machinery effect belt, make Chinese crude drug granule in the narrow gap of stator and rotor, be subject to strong machinery and aquashear, centrifugal extruding, liquid layer friction, clash into and tear and the comprehensive function such as turbulent flow, thus make Chinese crude drug granule nanorize, and immiscible solid phase, liquid phase can be made in moment uniform dispersion due to this process, moving in circles through high frequency, reduce the agglomeration between nano-particle, finally make Chinese medicine nano-particle be dispersed in uniformly in solvent medium.Chinese medicine suspension after nanorize can be directly used in the production of preparation, or obtains nano-particle after dry dispersion.
All single medicinal material materials that the present invention records with " Chinese Pharmacopoeia " or compound recipe medical material, for raw material, by HSDE in liquid phase environment, prepare the nano traditional Chinese medicine granule of particle diameter at 50-300nm fast.The powerful kinetic energy that the high tangential velocity utilizing HSDE to produce in shattering process and high frequency machinery effect belt come, make Chinese crude drug granule in the narrow gap of stator and rotor, be subject to strong machinery and aquashear, centrifugal extruding, liquid layer friction, clash into and tear and the comprehensive function such as turbulent flow, thus make Chinese crude drug granule nanorize.
Liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion, it is characterized in that the method comprises the following steps:
A, by Chinese crude drug being less than at the temperature of 50 DEG C after drying, utilize pulverizer to pulverize, sieve, obtain being greater than 100 object herb in granule form;
B, herb in granule form is placed in the shearing tank of any one liquid filling deionized water, normal saline, aqueous buffer solution, vegetable oil or animals and plants compound oil, the mass ratio of herb in granule form and liquid is 1:3 ~ 30, after being uniformly dispersed, soaks 0.5 ~ 10h;
C, by shear tank chuck in pass into cooling water, make operating temperature control in room temperature; Then carry out shearing-crushing, shearing rotating speed is 13000 ~ 25000rmin
-1, shear time is 10 ~ 60min;
D, be less than at the temperature of 50 DEG C, utilize vacuum drying, vacuum microwave drying or constant pressure and dry that Chinese medicine nanosuspension is dry, nano traditional Chinese medicine particle aggregation becomes thin film, then is disperseed, and obtains nanoscale Chinese medicinal granule.
In D step, nanosuspension also directly can be used for the production of Chinese medicine preparation or health food by the present invention.
Theoretically, Chinese crude drug of the present invention is applicable to all single medicinal material materials of recording with " Chinese Pharmacopoeia " or any Chinese crude drug of compound recipe medical material; Preferred Chinese crude drug is selected from the Radix Astragali, Bulbus Lilii, Cornu Cervi Pantotrichum or Fructus Lycii.
The present invention with it difference be in, HSDE is an open breaker, working environment, under liquid phase state, can become multiformity by the stream of the complexity of the dispersion of HSDE and emulsification function and shear history and material like this, reduce the agglomeration between nano-particle.In addition, effectively hot-spot in airtight cavity is alleviated and the factors such as the functional factor degeneration that causes.
It is liquid phase, ambient operating conditions that the present invention does not exist together with it, and grinding time is short, and full powder is used as medicine, and destroys and run off without effective ingredient.
The present invention is simple to operate, and the time is short, and equipment and technology is less demanding, with low cost, and generalization is good, is conducive to the industrialization of nano traditional Chinese medicine.
Accompanying drawing explanation
Fig. 1 is the grain size analysis of nano astragalus granule.
Fig. 2 is the grain size analysis of nanometer Bulbus Lilii granule.
Fig. 3 is the grain size analysis of nano-antler granule.
Fig. 4 is the grain size analysis of nanometer Walfberry fruit particle.
Fig. 5 is the grain size analysis of nanometer Shiquandabu Granule.
As can be seen from Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, the Radix Astragali that high shear dispersion is broken under liquid phase environment, Bulbus Lilii, Cornu Cervi Pantotrichum, Fructus Lycii, Shiquandabu Granule are all in nano-scale.
Detailed description of the invention
Embodiment 1:
Take Milkvetch Root 200g, after 45 DEG C of dryings, utilize pulverizer to pulverize, cross 100 mesh sieves, obtain being greater than 100 object herb in granule form 150g.Herb in granule form is placed in the shearing tank filling deionized water, the mass ratio of herb in granule form and deionized water is 1:10, after being uniformly dispersed, soaks 1h.Pass into cooling water by the chuck of shearing tank, operating temperature is controlled in room temperature.Then carry out continuous shear stress fragmentation, shearing rotating speed is 16000rmin
-1, shear time is 40min.Under the condition of temperature 45 C, by vacuum drying, Radix Astragali suspension is dry, nano astragalus particle aggregation becomes thin film, then is disperseed, and obtains nanoscale HUANGQI KELI.
Embodiment 2:
Take Bulbus Lilii medical material 500g, after 30 DEG C of dryings, utilize pulverizer to pulverize, cross 100 mesh sieves, obtain being greater than 100 object herb in granule form 470g.Herb in granule form is placed in the shearing tank filling normal saline, the mass ratio of herb in granule form and normal saline is 1:20, after being uniformly dispersed, soaks 0.5h.Pass into cooling water by the chuck of shearing tank, operating temperature is controlled in room temperature.Then carry out continuous shear stress fragmentation, shearing rotating speed is 18000rmin
-1, shear time is 30min.Under the condition of temperature 30 DEG C, by vacuum microwave drying, Bulbus Lilii suspension is dry, nanometer Bulbus Lilii particle aggregation becomes thin film, then is disperseed, and obtains nanoscale Bulbus Lilii granule.
Embodiment 3:
Take Cornu Cervi Pantotrichum medical material 100g, after 25 DEG C of dryings, utilize pulverizer to pulverize, cross 100 mesh sieves, obtain being greater than 100 object herb in granule form 80g.Herb in granule form is placed in the shearing tank filling olive oil, the mass ratio of herb in granule form and olive oil is 1:5, after being uniformly dispersed, soaks 2h.Pass into cooling water by the chuck of shearing tank, operating temperature is controlled in room temperature.Then carry out continuous shear stress fragmentation, shearing rotating speed is 20000rmin
-1, shear time is 20min.Obtain the suspension of nano-antler, then directly use it for the preparation of nano-antler soft capsule.
Embodiment 4:
Take Fructus Lycii medical material 300g, after 35 DEG C of dryings, utilize pulverizer to pulverize, cross 100 mesh sieves, obtain being greater than 100 object herb in granule form 270g.Herb in granule form is placed in the shearing tank filling aqueous phosphate buffer, the mass ratio of herb in granule form and aqueous phosphate buffer is 1:15, after being uniformly dispersed, soaks 5h.Pass into cooling water by the chuck of shearing tank, operating temperature is controlled in room temperature.Then carry out continuous shear stress fragmentation, shearing rotating speed is 23000rmin
-1, shear time is 35min.Obtain the suspension of nanometer Fructus Lycii, then directly use it for the preparation of nanometer health wolfberry food.
Embodiment 5:
According to Chinese Pharmacopoeia regulation proportioning medicinal piece of shiquan dabu crude drug: Radix Codonopsis 80g, the Rhizoma Atractylodis Macrocephalae (stir-fry) 80g, Poria 80g, Radix Glycyrrhizae Preparata 40g, Radix Angelicae Sinensis 120g, Rhizoma Chuanxiong 40g, the Radix Paeoniae Alba (wine stir-fry) 80g, Radix Rehmanniae Preparata 120g, Radix Astragali Preparata 80g, Cortex Cinnamomi 20g, after 45 DEG C of dryings, pulverizer is utilized to pulverize, cross 100 mesh sieves, obtain being greater than 100 object herb in granule form 700g.Herb in granule form is placed in the shearing tank filling deionized water, the mass ratio of herb in granule form and deionized water is 1:8, after being uniformly dispersed, soaks 1.5h.Pass into cooling water by the chuck of shearing tank, operating temperature is controlled in room temperature.Then carry out continuous shear stress fragmentation, shearing rotating speed is 25000rmin
-1, shear time is 50min.Under the condition of temperature 45 C, by constant pressure and dry, medicinal piece of shiquan dabu suspension is dry, nanometer Shiquandabu Granule is gathered into thin film, then is disperseed, and obtains nanoscale Shiquandabu Granule.
Claims (4)
1. liquid phase shears the method that nano traditional Chinese medicine material is prepared in dispersion, it is characterized in that the method comprises the following steps:
A, by Chinese crude drug being less than at the temperature of 50 DEG C after drying, utilize pulverizer to pulverize, sieve, obtain being greater than 100 object herb in granule form;
B, herb in granule form is placed in the shearing tank of any one liquid filling deionized water, normal saline, aqueous buffer solution, vegetable oil or animals and plants compound oil, the mass ratio of herb in granule form and liquid is 1:3 ~ 30, after being uniformly dispersed, soaks 0.5 ~ 10h;
C, by shear tank chuck in pass into cooling water, make operating temperature control in room temperature; Then carry out shearing-crushing with open high shear dispersion disintegrating machine, shearing rotating speed is 13000 ~ 25000rmin
-1, shear time is 10 ~ 60min;
D, be less than at the temperature of 50 DEG C, utilize vacuum drying, vacuum microwave drying or constant pressure and dry that Chinese medicine nanosuspension is dry, nano traditional Chinese medicine particle aggregation becomes thin film, then is disperseed, and obtains nanoscale Chinese medicinal granule.
2. the method for claim 1, is characterized in that in D step, also directly nanosuspension can be used for the production of Chinese medicine preparation or health food.
3. the method for claim 1, is characterized in that all single medicinal material materials that described Chinese crude drug is applicable to record with " Chinese Pharmacopoeia " or any Chinese crude drug of compound recipe medical material.
4. method as claimed in claim 3, is characterized in that Chinese crude drug is selected from the Radix Astragali, Bulbus Lilii, Cornu Cervi Pantotrichum or Fructus Lycii.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210305895.0A CN103623012B (en) | 2012-08-27 | 2012-08-27 | A kind of liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210305895.0A CN103623012B (en) | 2012-08-27 | 2012-08-27 | A kind of liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103623012A CN103623012A (en) | 2014-03-12 |
| CN103623012B true CN103623012B (en) | 2016-01-13 |
Family
ID=50204697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210305895.0A Active CN103623012B (en) | 2012-08-27 | 2012-08-27 | A kind of liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103623012B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106137976A (en) * | 2015-04-21 | 2016-11-23 | 吴琦 | Chinese medicinal granule microwave preparation |
| CN106733065A (en) * | 2015-11-23 | 2017-05-31 | 威海康博尔生物药业有限公司 | A kind of Chinese medicine nanometer pulverization method |
-
2012
- 2012-08-27 CN CN201210305895.0A patent/CN103623012B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103623012A (en) | 2014-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100577134C (en) | Super micronization method for botanical medicinal, product obtained thereby and use thereof | |
| CN103393599B (en) | Preparation method of traditional Chinese medicine fine powder | |
| CN104739777B (en) | A kind of preparation method of single medicinal material powder | |
| CN104470504A (en) | Method for preparing granule or pill containing extract in high concentration | |
| CN101143154A (en) | Method for preparing surface cladding super-micro traditional Chinese medicine material crude slice | |
| CN104434743A (en) | Pure plant component cosmetic and manufacturing method thereof | |
| CN101491546A (en) | Traditional Chinese medicine formulation granules containing volatile oil and preparation method thereof | |
| CN103142760A (en) | Ginseng Yangyuanbao tablet and preparation method thereof | |
| CN103623012B (en) | A kind of liquid phase shears the technology that nano traditional Chinese medicine material is prepared in dispersion | |
| CN108078875A (en) | The preparation method and its production system of a kind of small molecule Chinese medicine antibacterial toothpaste and skin care item | |
| CN105232584A (en) | Decoction-free extraction process for precious Chinese herbal medicines | |
| CN101744964A (en) | Immunity adjusting raw material extracted from plant by supercritical CO2 extraction method and preparation method thereof | |
| CN109172789A (en) | A kind of preparation process of xiaoxuming decoction solid pharmaceutical preparation | |
| CN103202865B (en) | Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof | |
| CN101708192A (en) | Method for preparing Chinese medicament pills | |
| CN1969904A (en) | Ultramicro active ginseng powder | |
| CN105623844A (en) | Balsam pear seed oil, extraction method therefor and application thereof | |
| CN109893608A (en) | A kind of preparation method of Chinese patent drug gastrodia capsule content | |
| CN103566016B (en) | A kind of Radix Rehmanniae Preparata superfine powder decoction pieces and its production and use | |
| CN201586220U (en) | Punch of Chinese medicinal pill forming component | |
| CN104666629A (en) | Preparation method of Zhongganling capsules and quality detection method of Zhongganling capsules | |
| CN1106291A (en) | Tibetan drug and its prepn. | |
| CN110237182A (en) | A kind of composition for relieving physical fatigue, preparation method and purposes | |
| CN102630789A (en) | Green processing method of Gynostemma pentaphylla | |
| CN110772492A (en) | Preparation method of cold capsule |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |