CN103622998A - Production method for concentrated buffalo horn powder - Google Patents
Production method for concentrated buffalo horn powder Download PDFInfo
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- CN103622998A CN103622998A CN201210298253.2A CN201210298253A CN103622998A CN 103622998 A CN103622998 A CN 103622998A CN 201210298253 A CN201210298253 A CN 201210298253A CN 103622998 A CN103622998 A CN 103622998A
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Abstract
The invention relates to a production method for concentrated buffalo horn powder. The production method comprises the following steps: cleaning and sawing a buffalo horn, removing a horn stuff, carrying out milling, adding obtained powder into a barium hydroxide solution with a concentration of 2 mol/L, carrying out heating for hydrolysis for 72 h, adding sulfuric acid into a hydrolysate so as to adjust a pH value to 2 and standing the hydrolysate for deposition for 24 h; removing a sediment, adjusting the pH value of a supernatant to 3.5 with sodium hydroxide and continuing standing for deposition for 24 h; removing a sediment, filtering a supernatant, adjusting the pH value of a filtrate to 7 with sodium hydroxide, concentrating the filtrate to a proper amount, adding ethanol into a concentrate to allow alcohol content to be 75% and carrying out standing for 24 h; and removing a sediment, recovering ethanol in a supernatant, concentrating the supernatant until the supernatant becomes thick paste, drying the thick paste to obtain an extract and crushing the extract to prepare the product--the fully concentrated buffalo horn powder. According to the invention, hydrolysis and alcohol precipitation are employed for extraction of all the medicinal materials, so effective components in the buffalo horn are fully extracted, the utilization rate of the medicinal materials is substantially increased, the prepared powder has no impurity, and the advantages of simple and reasonable process, improvement of product yield by 2 to 3 times and good product quality are obtained.
Description
Technical field
The invention belongs to Chinese medicine manufacture technology field, relate to a kind of production method that whole medical materials is adopted to the Pulvis Cornus Bubali Concentratus that hydrolysis processs and alcohol precipitation process extract.
Background technology
Pulvis Cornus Bubali Concentratus has the effect of heat clearing away, removing heat from blood, removing toxic substances, cures mainly: control calentura headache, and high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.
In the processing technology of existing Cornu Bubali half concentrated powder, 81% of raw material decocts with water 2 times and extracts, and all the other of raw material 19% are directly used as medicine after adopting and pulverizing, and prepared product is the concentrated powder of Cornu Bubali half.Its shortcoming is that impurity is more because part material adopts the method for being directly used as medicine after pulverizing, and in leaching process, Cornu Bubali dissolubility is little, and medical material waste is large; Simultaneously, again owing to mostly being keratin not soluble in water etc. in Cornu Bubali main component, decocting method effective component extraction rate is very low, and medical material utilization rate is also low, prepared preparation drug effect a little less than, effect is slow.The method of being directly used as medicine after adopt pulverizing because of part again, impurity is more, is unfavorable for that people's is healthy.
According to < < Chinese Pharmacopoeia > > introduction: the manufacture method of existing Cornu Bubali half concentrated powder is, water intaking Cornu Bovis seu Bubali is clean, sawed-off, remove chamfer plug, be split into fritter, choose the real core segment in tip (practise and claim the top of the horn), with after 75% soak with ethanol or vapor sterilization, be ground into fine powder.Remainder (practise and claim angle stake) breaks into coarse granule or pound or thin slice, gets angle stake coarse granule or pound sheet, adds the decocting of 10 times of amounts to boil 2 times; each 7～10 hours, in decoction process, supplement at any time the moisture boiling off, then collecting decoction; filter; filtrate is concentrated, then add above-mentioned the top of the horn fine powder, mix; after 80 ℃ of following being dried; be ground into fine powder, filter, obtain Pulvis Cornus Bubali Concentratus product.The product yield of producing Pulvis Cornus Bubali Concentratus by the method for this decocting in water is very low, and every double centner Cornu Bubali can only make the concentrated powder product of Cornu Bubali half of 6～8 kilograms, simultaneously unstable product quality.
Summary of the invention
In order to overcome the above-mentioned shortcoming of prior art
,the invention provides and a kind ofly can fully extract the effective ingredient in Cornu Bubali, greatly improve the utilization rate of medical material, prepared preparation free from admixture, has technique advantages of simple, product yield and can improve 2～3 times, the production method of the Pulvis Cornus Bubali Concentratus of good product quality advantage.
The technical solution adopted for the present invention to solve the technical problems is: a kind of production method of Pulvis Cornus Bubali Concentratus, and its processing step is:
Water intaking Cornu Bovis seu Bubali is clean, sawed-off, remove and to chamfer plug, and pulverizing, is added in the barium hydroxide solution of 2mol/L, heating hydrolysis 72 hours, and hydrolyzed solution adds sulfur acid for adjusting pH value to 2, staticly settles 24 hours;
Remove precipitation, get sodium hydroxide adjust pH to 3.5 for supernatant, continue to staticly settle 24 hours;
Remove precipitation, get supernatant, filter, filtrate is with sodium hydroxide adjust pH to 7 and be concentrated in right amount, and concentrated solution adds ethanol, makes to contain alcohol amount and reaches 75%, standing 24 hours;
Remove precipitation, get supernatant and reclaim ethanol and be concentrated into thick paste shape, be dried to extractum, pulverize, make Cornu Bubali concentrated powder product entirely.
Good effect of the present invention is: to whole medical materials, adopt hydrolysis process and alcohol precipitation process to extract, can fully extract the effective ingredient in Cornu Bubali, greatly improve the utilization rate of medical material, prepared preparation free from admixture, having advantages of that technique advantages of simple, product yield can improve 2～3 times, good product quality, is a kind of Cornu Bubali economical and practical production method of concentrated powder entirely of preparing.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
A kind of production method of Pulvis Cornus Bubali Concentratus, its processing step is: water intaking Cornu Bovis seu Bubali is cleaned, sawed-off, except chamfering plug, pulverizing, be added in the barium hydroxide solution of 2mol/L, heating hydrolysis 72 hours, hydrolyzed solution adds sulfur acid for adjusting pH value to 2, staticly settle 24 hours, remove precipitation, get sodium hydroxide adjust pH to 3.5 for supernatant, continue to staticly settle 24 hours, remove precipitation, get supernatant, filter, filtrate is with sodium hydroxide adjust pH to 7 and be concentrated into appropriate, concentrated solution adds ethanol, make to reach 75% containing alcohol amount, standing 24 hours, remove precipitation, getting supernatant reclaims ethanol and is concentrated into thick paste shape, be dried to extractum, pulverize, make Cornu Bubali concentrated powder product entirely.Adopt the present invention, every double centner Cornu Bubali raw material can make the Cornu Bubali concentrated powder product entirely of 15～24 kilograms, product purity is high simultaneously, quality good.
The present invention adopts hydrolysis process and alcohol precipitation process to extract to whole medical materials, can fully extract the effective ingredient in Cornu Bubali, greatly improve the utilization rate of medical material, prepared preparation free from admixture, having advantages of that technique advantages of simple, product yield can improve 2～3 times, good product quality, is a kind of Cornu Bubali economical and practical production method of concentrated powder entirely of preparing.
Claims (1)
1. a production method for Pulvis Cornus Bubali Concentratus, is characterized in that processing step is:
Water intaking Cornu Bovis seu Bubali is clean, sawed-off, remove and to chamfer plug, and pulverizing, is added in the barium hydroxide solution of 2mol/L, heating hydrolysis 72 hours, and hydrolyzed solution adds sulfur acid for adjusting pH value to 2, staticly settles 24 hours;
Remove precipitation, get sodium hydroxide adjust pH to 3.5 for supernatant, continue to staticly settle 24 hours;
Remove precipitation, get supernatant, filter, filtrate is with sodium hydroxide adjust pH to 7 and be concentrated in right amount, and concentrated solution adds ethanol, makes to contain alcohol amount and reaches 75%, standing 24 hours;
Remove precipitation, get supernatant and reclaim ethanol and be concentrated into thick paste shape, be dried to extractum, pulverize, make Cornu Bubali concentrated powder product entirely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210298253.2A CN103622998A (en) | 2012-08-21 | 2012-08-21 | Production method for concentrated buffalo horn powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210298253.2A CN103622998A (en) | 2012-08-21 | 2012-08-21 | Production method for concentrated buffalo horn powder |
Publications (1)
| Publication Number | Publication Date |
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| CN103622998A true CN103622998A (en) | 2014-03-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210298253.2A Pending CN103622998A (en) | 2012-08-21 | 2012-08-21 | Production method for concentrated buffalo horn powder |
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| CN (1) | CN103622998A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523752A (en) * | 2014-12-03 | 2015-04-22 | 安徽海神寿春药业有限公司 | Process for producing cornu bubali concentration powder |
| CN106727349A (en) * | 2016-12-22 | 2017-05-31 | 江西济民可信药业有限公司 | A kind of preparation method for concentrating cornu bubali particle |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380376A (en) * | 2007-09-05 | 2009-03-11 | 哈药集团三精千鹤制药有限公司 | Wean Qingkailing dispersible tablets |
-
2012
- 2012-08-21 CN CN201210298253.2A patent/CN103622998A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380376A (en) * | 2007-09-05 | 2009-03-11 | 哈药集团三精千鹤制药有限公司 | Wean Qingkailing dispersible tablets |
Non-Patent Citations (2)
| Title |
|---|
| 刘天舒: "水牛角提取工艺的研究", 《湖南中医杂志》, vol. 21, no. 2, 31 March 2005 (2005-03-31), pages 77 - 78 * |
| 尚强，刘岩，等: "正交试验法优选水牛角水解工艺", 《中国中药杂志》, vol. 35, no. 20, 31 October 2010 (2010-10-31), pages 2693 - 2695 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523752A (en) * | 2014-12-03 | 2015-04-22 | 安徽海神寿春药业有限公司 | Process for producing cornu bubali concentration powder |
| CN106727349A (en) * | 2016-12-22 | 2017-05-31 | 江西济民可信药业有限公司 | A kind of preparation method for concentrating cornu bubali particle |
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Application publication date: 20140312 |