CN103621552B - Compound pesticide compositions of a kind of clothianidin-containing and Profenofos and uses thereof - Google Patents
Compound pesticide compositions of a kind of clothianidin-containing and Profenofos and uses thereof Download PDFInfo
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- CN103621552B CN103621552B CN201210312293.8A CN201210312293A CN103621552B CN 103621552 B CN103621552 B CN 103621552B CN 201210312293 A CN201210312293 A CN 201210312293A CN 103621552 B CN103621552 B CN 103621552B
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Abstract
The invention discloses compound pesticide compositions of a kind of clothianidin-containing and Profenofos and uses thereof, this Pesticidal combination is with clothianidin and Profenofos for principle active component, and wherein, the weight ratio of clothianidin and Profenofos is 0.1 ~ 80:0.5 ~ 80.This Pesticidal combination can produce higher synergistic function, overcomes and has delayed pest resistance to insecticide, and desinsection speed is fast, and the lasting period is long, reduces drug cost, and control efficiency uses apparently higher than its single dose.The present invention can prevent and treat crops occur Lepidoptera, Semiptera, coleoptera, Hymenoptera, diptera, Thysanoptera, especially have special efficacy to insects such as control Lepidoptera diamond-back moth, cotton bollworm, beet armyworm, thrips thrips and mite classes, its successful uses higher than its single dose.
Description
Technical field
The invention belongs to pesticide field, be specifically related to compound pesticide compositions of a kind of clothianidin-containing and Profenofos and uses thereof.
Background technology
Clothianidin (Clothianidin), chemical name: E)-1-(the chloro-1,3-thiazoles of 2--5-ylmethyl)-3-methyl-2-nitroguanidine; Chemical molecular formula: C
6h
8clN
5o
2s; Sterling outward appearance is white crystals, fusing point 176.8 DEG C, vapour pressure (20 DEG C) 3.8 × 10-11Pa, solvability (g/L, 25 DEG C): 0.327 (20 DEG C) in water, in ethyl acetate 2.03, <0.00104 in normal heptane, in dimethylbenzene 0.0128, in carrene 1.32, in octanol 0.938, in acetone 15.2, in methyl alcohol 6.26.Structural formula:
Clothianidin acute oral toxicity, rat male and female: LD50 > 5000mg/kg, acute dermal toxicity: rat male and female: LD50 > 2000mg/kg, inhales people's toxicity: rat male and female, 6.1mg/L.
Clothianidin belongs to anabasine insecticide, be a kind of activity high, there is interior absorption, tag and the broad spectrum pesticide of stomach poison function.Shi Wu field company is after Nitenpyram (nitenpyram), and another nicotinic insecticide of discovery, belongs to the second generation.The mechanism of action combines the nAChR being positioned at neural post-synapse.Be applicable to foliar spray, soil treatment effect, show good quick-acting, the lasting period was at about 7 days.Be mainly used in paddy rice, vegetables, fruit tree and other crop, control Semiptera, coleoptera, diptera and some lepidoptera pest.
Profenofos (profenofos) has another name called bromine chlorine phosphorus, many worms phosphorus, and chemical name is: O-(the bromo-2-chlorphenyl of 4-)-O-ethyl-S-propyl group-thiophosphate, is broad-spectrum organophosphorous pesticide, has quick-acting.Plant leaf blade has good permeability.Its mechanism of action suppresses cholinesterase in insect bodies.Structural formula is:
Former medicine is light yellow liquid, and tool is garlicky, boiling point 100 DEG C/1.80Pa, density 1.455 (20 DEG C), solvability in water: 28mg/L (25 DEG C), with most immiscible organic solvent, more stable under neutral and micro-sour condition, unstable in alkaline environment.This kind have tag, stomach toxicity and stifling three kinds of modes of action, its insecticidal spectrum is wide, toxicity is lower, efficient equally to above and below ground insect, it is the desirable insecticide of control grain, fruit tree, vegetables and other economic crops insect pests, particularly outstanding to the control efficiency of soil insect, be particularly suitable for the production of pollution-free vegetable.
But diamond-back moth, cotton bollworm and thrips are under the condition of current long-term prescription, resistance increases gradually, and the effect of agricultural chemicals single dose to control of insect declines gradually.Inventor finds after deliberation, and the synergistic complex of agricultural chemicals is expanding prevention spectrum and the effective measures improving preventive effect, not yet finds the Pesticidal combination about clothianidin and Profenofos up to now.
Summary of the invention
The object of this invention is to provide the compound pesticide compositions of a kind of clothianidin-containing and Profenofos, this Pesticidal combination is the multifunctional insecticide composition of control Hemipteran pest.
Another object of the present invention is to provide this compound pesticide compositions and is preparing the application that prevents and treats on the insecticidal materials of resistance Hemipteran pest, the application particularly on the insecticidal materials of preparation control diamond-back moth, cotton bollworm, thrips and mite pest.
The object of the invention is to be achieved through the following technical solutions:
A compound pesticide compositions for clothianidin-containing and Profenofos, this Pesticidal combination is with clothianidin and Profenofos for principle active component, and wherein, the weight ratio of clothianidin and Profenofos is 0.1 ~ 80:0.5 ~ 80.Be preferably 0.5 ~ 50:2 ~ 50, more preferably 0.5 ~ 10:4 ~ 30, most preferably the weight ratio of clothianidin and Profenofos is 1 ~ 10:1 ~ 10.This compound pesticide compositions can only containing active ingredient clothianidin and Profenofos, and also can add other components when using or prepare in active component, in this Pesticidal combination, effective ingredient is present in composition with enhancing effective amount.
In compound pesticide compositions of the present invention, both clothianidin and the Profenofos weight percentage in this compound pesticide compositions is 3% ~ 80%.Be preferably 5% ~ 55%, most preferably 10% ~ 40%.
Compound pesticide compositions of the present invention with clothianidin with Profenofos for principle active component becomes any one formulation that agricultural chemicals allows with insecticides adjuvant and excipient, the preferred emulsion of described formulation, suspending agent, wetting powder, aqueous emulsion, microemulsion or water dispersion granule.
Aforementionedly can be applicable to the not special restriction of insecticides adjuvant of the present invention, include, but are not limited to calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33
#), polyoxyethylene nonylphenol ether etc., aforementionedly can be applicable to excipient of the present invention and be also not particularly limited, include, but are not limited to cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent and excipient all can use one or more.
Compound pesticide compositions of the present invention has good preventive effect to the multiple Hemipteran pest that rice fulgorid and aphid etc. easily produce resistance; And suppress insect to produce the pesticide resistance of unitary agent (clothianidin or Profenofos arbitrary).
The compound pesticide compositions of clothianidin-containing and Profenofos prevents and treats a upper application for the insecticidal materials of resistance Hemipteran pest in preparation, especially remarkable at the effect of preparation control diamond-back moth, rice leaf roller and mite pest.
Compared with prior art beneficial effect of the present invention: (1) is compared with single dose, said composition antagonism lepidoptera pest such as diamond-back moth and Thysanoptera thrips etc. have obvious synergistic function, overcome and delayed pest resistance to insecticide, expanding prevention is composed, desinsection speed is fast, significantly improves control efficiency; (2) control recruitment, drug cost is reduced; (3) alternative high-toxic pesticide; (4) have concurrently quick-acting and long-acting; (5) with clothianidin compared with Profenofos single dose, produce and use cost reduction; (6) suppress lepidoptera pest, Semiptera, thrips and mite pest to strengthen the resistance of agricultural chemicals, its successful uses higher than its single dose.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but do not limit the present invention in any way.
Embodiment 1:
Take 30g clothianidin and Profenofos, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, vegetable oil to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 30%.The concrete ratio of clothianidin and Profenofos in table 1,2.
Adopt rice-stem dipping method to carry out indoor synergy biologicall test, selection rice leaf roller is target pest, and often process repetition 3 times, every concentration process 60, calculates each medicament to the toxicity regression equation of rice leaf roller and lethal concentration of 50 LC by probability value method
50, use LC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient, the results are shown in Table 1:
Table 1 clothianidin and Profenofos is composite and single dose to the toxicity test of rice leaf roller
As shown in Table 1, clothianidin and Profenofos composite, co-toxicity coefficient is all greater than 120, shows good synergistic function.Kill rice leaf roller synergistic effect when the weight ratio of clothianidin and Profenofos is 1 ~ 2:1 ~ 10 remarkable, when clothianidin and Profenofos 1:5, synergistic effect is the most obvious.
Adopt leaching leaf dip method to carry out indoor synergy biologicall test, selection resistant bollworm is target pest, often processes repetition 3 times, calculates toxicity regression equation and the lethal concentration of 50 LC of each medicament antagonism cotton bollworm by probability value method
50, use LC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient, the results are shown in Table 2:
Table 2 clothianidin and Profenofos is composite and the toxicity test of single dose antagonism cotton bollworm
As shown in Table 2, clothianidin and Profenofos composite, all 120 are greater than to the co-toxicity coefficient of cotton bollworm, show good synergistic function.Kill resistant bollworm synergistic effect when the weight ratio of clothianidin and Profenofos is 1 ~ 10:1 remarkable, when clothianidin and Profenofos 2.5:1, synergistic effect is the most obvious.
Embodiment 2:
Take 5g clothianidin, 50g Profenofos, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33
#2g, alkylphenol polyoxyethylene 1g, dimethylbenzene 13g, adds water to 100g.The method above raw material being prepared routinely aqueous emulsion drops into the mixing of mixing kettle high speed, forms the clothianidin profenofos emulsion in water that principle active component weight percentage is 55%.
Embodiment 3:
Take 2g clothianidin, 18g Profenofos, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33
#2g, alkylphenol polyoxyethylene 1g, cyclohexanone 10g, adds water to 100g.The method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and forms the clothianidin Profenofos microemulsion that principle active component weight percentage is 20%.
Carry out the control rice leaf roller test of pesticide effectiveness to embodiment 3, contrast medicament is 40% Profenofos EC(missible oil) and 15% clothianidin EC, dilute according to the extension rate of form 3 li, look into the result of 3 days, 7 days, 14 days and 28 days after medicine, result is in table 3:
Table 3: the composite field test results to rice leaf roller of clothianidin Profenofos
Field efficacy result shows, clothianidin Profenofos composition has excellent control efficiency to rice leaf roller, and control efficiency is all better than the effect that single dose kind is better than directly each single product simultaneously.
Control cotton cotton bollworm field medicine effect test is carried out to embodiment 3, contrast medicament is 40% Profenofos EC(missible oil) and 15% clothianidin EC, dilute according to the extension rate of form 3 li, after medicine, look into 3 days, the result of 7 days, 14 days and 28 days, result is in table 4:
Table 4: the composite field test results to cotton bollworm of clothianidin Profenofos
Field efficacy result shows, clothianidin Profenofos composition antagonism cotton bollworm has excellent control efficiency, and control efficiency is all better than the effect that single dose kind is better than directly each single product simultaneously.
Embodiment 4:
Take 1g clothianidin, 5g Profenofos, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 6%.
Embodiment 5:
Take 50g clothianidin, 20g Profenofos, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 70%.
Embodiment 6:
Take 2g clothianidin, 40g Profenofos, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 42%.
Embodiment 7:
Take 0.2g clothianidin, 50g Profenofos, calcium dodecyl benzene sulfonate 9g, phenethyl phenol polyethenoxy ether 8g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 50.2%.
Embodiment 8:
Take 5g clothianidin, 0.5g Profenofos, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 5.5%.
Embodiment 9:
Take 5g clothianidin, 30g Profenofos, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 35%.
Embodiment 10:
Take 20g clothianidin, 5g Profenofos, calcium dodecyl benzene sulfonate 7g, phenethyl phenol polyethenoxy ether 9g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 25%.
Embodiment 11:
Take 30g clothianidin, 12g Profenofos, sodium lignin sulfonate 2g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, under the effect of sand mill, make the clothianidin Profenofos suspending agent that principle active component weight percentage is 42%.
Embodiment 12:
Take 2g clothianidin, 5g Profenofos, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, diatomite 21g, makes by water dispersible granular agent method the clothianidin Profenofos water dispersion granule that principle active component weight percentage is 7% by above raw material.
Embodiment 13:
Take 50g clothianidin, 3g Profenofos, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 53%.
Embodiment 14:
Take 2g clothianidin, 18g Profenofos, sodium lignin sulfonate 10g, Negel 2g, add to 100g with diatomite, above raw material is mixed in micronizer, makes the clothianidin Profenofos wetting powder that principle active component weight percentage is 20%.
Embodiment 15:
Take 7g clothianidin, 70g Profenofos, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene are to 100g.The method above raw material being prepared routinely missible oil drops in mixing kettle and mixes, and makes the clothianidin Profenofos missible oil that principle active component weight percentage is 77%.
Embodiment 16:
Take 60g clothianidin, 5g Profenofos, wooden sodium sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 13g, makes by water dispersible granular agent method the clothianidin Profenofos water dispersible granules that principle active component weight percentage is 65% by above raw material.
Claims (2)
1. the compound pesticide compositions for the clothianidin-containing and Profenofos of preventing and treating cotton bollworm, it is characterized in that this Pesticidal combination with clothianidin and Profenofos for principle active component, take 2g clothianidin, 18g Profenofos, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33
#2g, alkylphenol polyoxyethylene 1g, cyclohexanone 10g, adds water to 100g, and the method above raw material being prepared routinely microemulsion drops in mixing kettle and mixes, and forms the clothianidin Profenofos microemulsion that principle active component weight percentage is 20%.
2. the application of the compound pesticide compositions of clothianidin-containing according to claim 1 and Profenofos on the insecticidal materials of preparation control cotton bollworm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210312293.8A CN103621552B (en) | 2012-08-29 | 2012-08-29 | Compound pesticide compositions of a kind of clothianidin-containing and Profenofos and uses thereof |
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| CN201210312293.8A CN103621552B (en) | 2012-08-29 | 2012-08-29 | Compound pesticide compositions of a kind of clothianidin-containing and Profenofos and uses thereof |
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| CN103621552B true CN103621552B (en) | 2016-01-20 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045261A (en) * | 1988-12-27 | 1990-09-12 | 武田药品工业株式会社 | Guanidine derivative, its production and sterilant |
| CN1077843A (en) * | 1988-12-27 | 1993-11-03 | 武田药品工业株式会社 | Guanidine derivatives, their production and insecticides |
| US20040259736A1 (en) * | 2001-09-28 | 2004-12-23 | Reinhold Dieing | Biodegradable solid preparation of a phytopathologicalagent with delayed active substance release |
| CN101796962A (en) * | 2010-04-16 | 2010-08-11 | 陕西美邦农药有限公司 | Insecticidal composition containing clothianidin and malathion |
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2012
- 2012-08-29 CN CN201210312293.8A patent/CN103621552B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045261A (en) * | 1988-12-27 | 1990-09-12 | 武田药品工业株式会社 | Guanidine derivative, its production and sterilant |
| CN1077843A (en) * | 1988-12-27 | 1993-11-03 | 武田药品工业株式会社 | Guanidine derivatives, their production and insecticides |
| US20040259736A1 (en) * | 2001-09-28 | 2004-12-23 | Reinhold Dieing | Biodegradable solid preparation of a phytopathologicalagent with delayed active substance release |
| CN101796962A (en) * | 2010-04-16 | 2010-08-11 | 陕西美邦农药有限公司 | Insecticidal composition containing clothianidin and malathion |
Non-Patent Citations (1)
| Title |
|---|
| 防治稻纵卷叶螟高毒农药替代药剂的室内筛选;高忠文 等;《中国水稻科学》;20081110;第22卷(第6期);第631-636页 * |
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