CN103621547A - Synergistic insecticidal composition containing clothianidin and nitenpyram and applications thereof - Google Patents
Synergistic insecticidal composition containing clothianidin and nitenpyram and applications thereof Download PDFInfo
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- CN103621547A CN103621547A CN201210312874.1A CN201210312874A CN103621547A CN 103621547 A CN103621547 A CN 103621547A CN 201210312874 A CN201210312874 A CN 201210312874A CN 103621547 A CN103621547 A CN 103621547A
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- nitenpyram
- clothianidin
- synergistic insecticidal
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Abstract
The invention discloses a synergistic insecticidal composition containing clothianidin and nitenpyram and applications thereof. The synergistic insecticidal composition employs clothianidin and nitenpyram as main effective components, wherein, the weight ratio of clothianidin to nitenpyram is 0.1-70:0.5-70. The composition has high synergistic effects, delays drug resistance of insects, and can lower drug cost. The composition can be prepared into missible oil, wettable powder, microemulsion, emulsion in water, suspending agents and water dispersion granules, and is used for control of various insects of hemiptera, coleopteran, lepidoptera, hymenoptera and the like with resistance.
Description
Technical field
The invention belongs to the pesticide field that contains heterocyclic compound, be specifically related to a kind of Pesticidal combination and application thereof that clothianidin and Nitenpyram be main active ingredient of take.
Background technology
Clothianidin (Clothianidin), chemical name: E)-1-(the chloro-1,3-thiazoles-5-of 2-ylmethyl)-3-methyl-2-nitroguanidine; Chemical molecular formula: C
6h
8clN
5o
2s; Sterling outward appearance is white crystals, 176.8 ℃ of fusing points, vapour pressure (20 ℃) 3.8 * 10-11Pa, solvability (g/L, 25 ℃): 0.327 (20 ℃) in water, in ethyl acetate 2.03, <0.00104 in normal heptane, in dimethylbenzene 0.0128, in carrene 1.32, in octanol 0.938, in acetone 15.2, in methyl alcohol 6.26.Structural formula:
Clothianidin acute oral toxicity, rat male and female: LD50 > 5000mg/kg, acute dermal toxicity: rat male and female: LD50 > 2000mg/kg, inhales people's toxicity: rat male and female, 6.1mg/L.Clothianidin belongs to anabasine insecticide, be a kind of activity high, there is interior absorption, tag and the broad spectrum pesticide of stomach poison function.Shi Wu field company is after Nitenpyram (nitenpyram), and another nicotinic insecticide of discovery, belongs to the second generation.The mechanism of action is in conjunction with the nAChR that is positioned at neural post-synapse.Be applicable to foliar spray, soil treatment effect, show good quick-acting, the lasting period is about 7 days.Be mainly used in paddy rice, vegetables, fruit tree and other crop, control Semiptera, coleoptera, diptera and some lepidoptera pest.
Nitenpyram (nitenpyram), is a kind of novel nicotinamide insecticide, chemical name: (E)-N-(6-chloro-3-pyridylmethyl)-N '-methyl-2-nitro ethenylidene diamines, molecular formula: C
11h
15clN
4o
2.Sterling is light yellow crystalline solid, fusing point 83-84 ℃, density 1.40 (26 ℃).Vapour pressure 1.1 * 10-9Pa (25 ℃).Solvability (g/L, 20 ℃): water (pH=7) 840, chloroform 700, acetone 290, dimethylbenzene 4.5.Rat acute LD50 of passing through mouth: male 1680mg/Kg, female 1575mg/Kg; Chmice acute LD50 of passing through mouth: male 867mg/Kg, female 1281mg/Kg; Rat acute is through skin LD50: male, female >2000mg/Kg; Rat sucks LC50 (4 hours): 5.8g/L; This product has minimal irritation to lagophthalmos, non-stimulated to rabbit skin.Without teratogenesis, mutagenesis, carcinogenesis.
Often there is defect in clothianidin and Nitenpyram containing single component: use is easily developed immunity to drugs continuously, and insecticidal spectrum is narrow, can not provide comprehensive protection for crop, and peasant's drug cost is high in agricultural chemicals control of insect.By two kinds or being combined in to a certain extent of two or more active components, can overcome to a certain extent above-mentioned shortcoming.
Summary of the invention
The Synergistic insecticidal compositions that the object of this invention is to provide a kind of clothianidin-containing and Nitenpyram, said composition can be used for preventing and treating various agricultural insect, such as preventing and treating rice hoppers or vegetable aphid and thrips etc., can reach the effect of very high Synergistic.
The Synergistic insecticidal compositions that another object of the present invention is to provide clothianidin-containing and Nitenpyram is prevented and treated the application in the insecticidal materials of one or more insects in resistance Semiptera, Lepidoptera, Hymenoptera or coleoptera in preparation.
The present invention adopts following technical scheme:
The Synergistic insecticidal compositions of a kind of clothianidin-containing and Nitenpyram, it take clothianidin and Nitenpyram is main active ingredient, wherein, the weight ratio of clothianidin and Nitenpyram is 0.1 ~ 70:0.5 ~ 70, be preferably 1 ~ 60:1 ~ 70, more preferably 1 ~ 30:1 ~ 30, further preferred weight ratio are 1 ~ 10:1 ~ 10, and most preferably the weight ratio of clothianidin and Nitenpyram is 1:1 ~ 10.This Synergistic insecticidal compositions can only contain active ingredient clothianidin and Nitenpyram, also can when using or prepare, in active component, add other components, and the effective ingredient of above-mentioned Insecticidal combinations is present in composition with synergy effective dose.
At the Synergistic insecticidal compositions of clothianidin-containing of the present invention and Nitenpyram, the two weight percentage in this Synergistic insecticidal compositions of clothianidin and Nitenpyram is 2% ~ 80%, is preferably 8% ~ 60%, and optimum is 20% ~ 40%.
The Synergistic insecticidal compositions of above-mentioned clothianidin-containing and Nitenpyram be take clothianidin and Nitenpyram and is mixed with any one formulation allowing on agricultural chemicals as main active ingredient (active component) and insecticides adjuvant, excipients.The preferred pulvis of formulation, wetting powder, suspending agent, missible oil and water dispersion granule.
Aforementionedly can be applicable to the not special restriction of insecticides adjuvant of the present invention, include, but are not limited to calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33#), polyoxyethylene nonylphenol ether etc., aforementionedly can be applicable to excipient of the present invention and be also not particularly limited, include, but are not limited to cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient and the upper known auxiliary material of other agricultural can alone or and use.
Application in the insecticidal materials of above-mentioned clothianidin-containing and the Synergistic insecticidal compositions of Nitenpyram one or more insects in preparation control Semiptera, Lepidoptera, Hymenoptera or coleoptera.Especially the effect of preventing and treating in the insecticidal materials of rice hoppers or vegetable aphid and thrips in preparation is remarkable.
Synergistic insecticidal compositions antagonism Semiptera insect of the present invention has significant preventive effect, especially for the easy various pests that produces resistance such as vegetable aphid and plant hopper, has good preventive effect; And suppress insect the pesticide resistance of unitary agent (clothianidin or Nitenpyram) is produced.
The insecticidal materials of being prepared by the Synergistic insecticidal compositions of described clothianidin-containing and Nitenpyram is when preventing and treating resistance Lepidoptera, Hymenoptera or coleopteran pest, can prevent and treat Semiptera insect again, especially rice hoppers or vegetable aphid and thrips are had to good preventive effect, improve drug effect, reached the effect that a medicine is controlled more." % " of the present invention is mass percent.
Pesticidal combination of the present invention compared with prior art, produces following beneficial effect: (1) is compared with single dose, and said composition insect has notable synergistic, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests simultaneously, reduce control recruitment cost; (3) alternative high-toxic pesticide, and significantly reduce field dosage, effectively reduce environmental pollution and residue of pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with Nitenpyram single dose, produce and use cost reduction; (6) suppressing insect strengthens the resistance of agricultural chemicals;
Embodiment
Below in conjunction with embodiment, the invention will be further described, but do not limit the present invention in any way.
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.First by indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage; On this basis, then carry out field trial.
Embodiment 1:
Take 30g clothianidin and Nitenpyram, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, vegetable oil to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 30%.The concrete ratio of clothianidin and Nitenpyram is in Table 1.
Adopt rice infusion process to measure clothianidin and Nitenpyram and the virulence of composite sample to rice hoppers thereof, every processing repeats 3 times, and every concentration is processed 30, uses LC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
Table 1 clothianidin, Nitenpyram and composite sample thereof are to the toxicity test of rice hoppers and co-toxicity coefficient
In table, data show, after clothianidin and Nitenpyram are mixed, rice hoppers are had to synergistic effect, and four proportioning co-toxicity coefficients listed in table are all much larger than 120, so clothianidin and Nitenpyram are mixed and have significant synergies.Wherein when the ratio of Nitenpyram and clothianidin is 2.5:1, be mixed and kill the synergistic effect maximum of rice hoppers, co-toxicity coefficient is 217.24.
Embodiment 2:
Taking clothianidin, Nitenpyram adopts conventional formulation method to be mixed with by different proportion the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 30%.Concrete ratio is in Table 2.
Adopt feed to add malicious method and measure clothianidin and Nitenpyram and the virulence of composite sample to vegetable aphid thereof, every processing repeats 3 times, uses LC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
Table 2 clothianidin, Nitenpyram and composite sample thereof are to the toxicity test of vegetable aphid and co-toxicity coefficient
In table, data show, after clothianidin and Nitenpyram are mixed, vegetable aphid are had to synergistic effect, and four proportioning co-toxicity coefficients listed in table are all much larger than 120, so clothianidin and Nitenpyram are mixed and have significant synergies.Wherein when the ratio of clothianidin and Nitenpyram is 1:2.5, be mixed and kill the synergistic effect maximum of vegetable aphid, co-toxicity coefficient is 209.15.
Embodiment 3:
Take 4g clothianidin, 20g Nitenpyram, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 24%.
Adopt 3 sample product of embodiment to carry out the field trial of control in field rice hoppers, contrast medicament is 15% clothianidin EC and 10% Nitenpyram WDG, and concrete consumption is in Table 3, every mu of water consumption is 30kg, looks into 7 days after medicine 3 days, 14 days, 28 days results, result of the test is in Table 3:
The field test results of table 3 embodiment 3 samples to rice hoppers
3 pairs of rice hoppers of example have fabulous quick-acting as can be seen from Table 3, and the lasting period is more intense, in field performance well, are the outstanding medicaments of preventing and treating rice hoppers.
Embodiment 4:
Adopt 3 sample product of embodiment to carry out the field trial of control in field vegetable aphid, contrast medicament is 15% clothianidin EC and 10% Nitenpyram WDG, and concrete consumption is in Table 4, every mu of water consumption is 30kg, looks into 7 days after medicine 3 days, 14 days, 28 days results, result of the test is in Table 4:
The field test results of table 4 embodiment 3 samples to vegetable aphid
Example 3 samples have fabulous effect to vegetable aphid as can be seen from Table 4, and the lasting period is long, in field performance well, are the outstanding medicaments that prevents vegetable aphid.
Through indoor synergism test, measure and show: by clothianidin and Nitenpyram built agent, rice hoppers and vegetable aphid are all had to significant synergistic insecticidal action; Field control effectiveness test equally also shows that all built agents of the present invention are all significantly higher than the effect of corresponding single dose agricultural chemicals to the insecticidal effect of rice hoppers and vegetable aphid.
Embodiment 5:
Take 0.2g clothianidin, 20g Nitenpyram, lignin 10g, Negel 2g, with kaolin, add to 100g, above raw material is mixed in micronizer, make the clothianidin Nitenpyram wetting powder that main active ingredient weight percentage is 20.2%.
Embodiment 6:
Take 78g clothianidin, 0.5g Nitenpyram, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 6g, dimethylbenzene and add to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 78.5%.
Embodiment 7:
Take 2g clothianidin, 10g Nitenpyram, nonyl phenol phosphate 5g, alkylphenol polyoxyethylene 4g, n-butanol 3g, the dimethylbenzene of 30g and the pyrrolidones of 20g, the xanthans of 0.1g, all the other waters are supplied 100g, n-butanol and water-soluble solution form water, and all the other component mix and blends form oil phases, go in slowly water being added to oil phase under clipper effect, and continue to shear 10 ~ 30 minutes, make the clothianidin Nitenpyram aqueous emulsion that main active ingredient weight percentage is 12%.
Embodiment 8:
Take 10g clothianidin, 30g Nitenpyram, calcium dodecyl benzene sulfonate 5g, alkylphenol polyoxyethylene 4g, the solvent xylene of 30g and the pyrrolidones of 15g, all the other waters complement to 100g, former medicine, solvent, emulsifier, cosolvent mix and blend form homogeneous phase transparent solution, then slowly add water and stir to form clear solution, be the clothianidin Nitenpyram microemulsion that main active ingredient weight percentage is 40%.
Embodiment 9:
Take 4g clothianidin, 4g Nitenpyram, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 3g, dimethylbenzene to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 8%.
Embodiment 10:
Take 3g clothianidin, 30g Nitenpyram, sodium lignin sulfonate 3g, polyoxyethylene poly-oxygen propylene aether and sulphate 4g thereof, xanthans 0.2g, ethylene glycol 10g, silica ethane 0.1g, aluminium-magnesium silicate 0.5g, water is supplied 100g, makes the clothianidin Nitenpyram suspending agent that main active ingredient weight percentage is 33% under the effect of sand mill.
Embodiment 11:
Take 5g clothianidin, 60g Nitenpyram, alkylphenol polyoxyethylene 14g, phenethyl phenol polyethenoxy ether 15g, dimethylbenzene to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 65%.
Embodiment 12:
Take 45g clothianidin, 5g Nitenpyram, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g, makes by the method for water dispersion granule the clothianidin Nitenpyram water dispersible granules that main active ingredient weight percentage is 50% by above raw material.
Embodiment 13:
Take 25g clothianidin, 25g Nitenpyram, alkylphenol polyoxyethylene 14g, phenethyl phenol polyethenoxy ether 15g, dimethylbenzene to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the clothianidin Nitenpyram missible oil that main active ingredient weight percentage is 50%.
Claims (10)
1. a Synergistic insecticidal compositions for clothianidin-containing and Nitenpyram, is characterized in that it is main active ingredient that this Synergistic insecticidal compositions be take clothianidin and Nitenpyram, and wherein, the weight ratio of clothianidin and Nitenpyram is 0.1 ~ 70:0.5 ~ 70.
2. the Synergistic insecticidal compositions of clothianidin-containing according to claim 1 and Nitenpyram, is characterized in that the effective ingredient clothianidin of this Pesticidal combination and the weight ratio of Nitenpyram are 1 ~ 60:1 ~ 70.
3. the Synergistic insecticidal compositions of clothianidin-containing according to claim 2 and Nitenpyram, is characterized in that the effective ingredient clothianidin of this Pesticidal combination and the weight ratio of Nitenpyram are 1 ~ 30:1 ~ 30.
4. the Synergistic insecticidal compositions of clothianidin-containing according to claim 3 and Nitenpyram, is characterized in that the effective ingredient clothianidin of this Pesticidal combination and the weight ratio of Nitenpyram are 1 ~ 10:1 ~ 10.
5. the Synergistic insecticidal compositions of clothianidin-containing according to claim 1 and Nitenpyram, is characterized in that the two weight percentage in this Synergistic insecticidal compositions of clothianidin and Nitenpyram is 2% ~ 80%.
6. the Synergistic insecticidal compositions of clothianidin-containing according to claim 5 and Nitenpyram, is characterized in that the two weight percentage in this Synergistic insecticidal compositions of clothianidin and Nitenpyram is 8% ~ 60%.
7. the Synergistic insecticidal compositions of clothianidin-containing according to claim 1 and Nitenpyram, is characterized in that this Synergistic insecticidal compositions take clothianidin and Nitenpyram and be mixed with any one formulation allowing on agricultural chemicals as main active ingredient and insecticides adjuvant, excipients.
8. the Synergistic insecticidal compositions of clothianidin-containing according to claim 7 and Nitenpyram, is characterized in that described formulation is missible oil, wetting powder, microemulsion, aqueous emulsion, suspending agent or water dispersion granule.
9. the application in the insecticidal materials of the Synergistic insecticidal compositions of clothianidin-containing claimed in claim 1 and Nitenpyram one or more insects in preparation control Semiptera, Lepidoptera, Hymenoptera or coleoptera.
10. application according to claim 9, the Synergistic insecticidal compositions that it is characterized in that clothianidin-containing and Nitenpyram is prevented and treated the application in the insecticidal materials of rice hoppers or vegetable aphid and thrips in preparation.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104286002A (en) * | 2014-10-15 | 2015-01-21 | 济南凯因生物科技有限公司 | Insecticidal composition for preventing and treating rice hoverflies |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102057940A (en) * | 2011-01-18 | 2011-05-18 | 青岛泰生生物科技有限公司 | Insecticidal composition containing clothianidin and nitenpyram |
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| CN102057940A (en) * | 2011-01-18 | 2011-05-18 | 青岛泰生生物科技有限公司 | Insecticidal composition containing clothianidin and nitenpyram |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104286002A (en) * | 2014-10-15 | 2015-01-21 | 济南凯因生物科技有限公司 | Insecticidal composition for preventing and treating rice hoverflies |
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Application publication date: 20140312 |