CN103611198A - Absorbable medical porous membrane and preparation method thereof - Google Patents
Absorbable medical porous membrane and preparation method thereof Download PDFInfo
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- CN103611198A CN103611198A CN201310641291.8A CN201310641291A CN103611198A CN 103611198 A CN103611198 A CN 103611198A CN 201310641291 A CN201310641291 A CN 201310641291A CN 103611198 A CN103611198 A CN 103611198A
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Abstract
The invention provides an absorbable medical porous membrane, comprising membrane matrix and an absorbable fiber doped into the membrane matrix. The absorbable medical porous membrane provided by the invention comprises the absorbable fiber; the absorbable fiber is doped into the membrane matrix. The one-way or two-way tensile strength of the absorbable medical porous membrane is enhanced by the absorbable fiber, so that the tear resistance and the flexibility are improved. In addition, the absorbable medical porous membrane provided by the invention has better tissue barrier effect and air permeability, so that tissue liquid at two sides of the membrane is smooth to circulate, and exchange of nutrient substances at two sides of the membrane is facilitated. An experiment result shows that the tensile strength of the absorbable medical porous membrane provided by the invention can be up to 22.8N/mm<2>, the aperture is 0.05-40 microns, and the porosity is 50-95%.
Description
Technical field
The invention belongs to technical field of biological materials, relate in particular to a kind of absorbable medical perforated membrane and preparation method thereof.
Background technology
Tissue adhesion refers to that connective fiber and adjacent tissue or organ combine and the anomalous structure that forms.In surgical operation, tissue adhesion is the common clinical picture of surgical field, is also the process that patient must experience in agglutination; Tissue adhesion usually causes serious clinical complication, comprises intestinal obstruction, chronic pelvic inflammatory disease etc., has increased again the difficulty of operation and the potentiality of complication.Absorbable medical film is a kind of macromolecule medical function material, is degraded within the scheduled time CO
2and H
2o, the surgical operation application such as absorbable medical film preventing tissue adhesion are after surgery wider.
In prior art, the Chinese patent that the patent No. is CN1331913C discloses a kind of medical films that there is no hole, and the component of this atresia medical films is poly-DL lactic acid-co-glycolic acid.Although this atresia medical films can play the effect that prevents tissue adhesion to a certain extent, yet this atresia medical films is unfavorable for tissue fluid exchange and wound healing, has limited its application.
As the succedaneum of above-mentioned atresia medical films, prior art has developed again medical films with holes.The patent No. is that the Chinese patent of CN101405038A discloses a kind of porose medical films, and the component of this medical films is biological absorbable polymer, and described polymer comprises the copolymer of lactide and caprolactone; The porosity of this medical films is 0.1%～82%, and average pore size is 9 μ m～34 μ m.Although this porose medical films can be beneficial to the exchange of tissue fluid and the healing of wound, the mechanical strength of this medical films is poor, in operation stitching process, easily tears, and affects its extensive use.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of absorbable medical perforated membrane and preparation method thereof, this absorbable medical perforated membrane has higher mechanical strength, has improved its tear resistance and pliability.
The invention provides a kind of absorbable medical perforated membrane, comprise membrane matrix and be entrained in the absorbable fibre in described membrane matrix.
Preferably, the content of described absorbable fibre is 20wt.%～80wt.%.
Preferably, the content of described absorbable fibre is 25wt.%～70wt.%.
Preferably, described absorbable fibre is homopolymer fibre and/or copolymer fibre;
Described homopolymer fibre comprises the homopolymer fibre that chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol or trimethylene carbonate homopolymerization obtain;
Described copolymer fibre comprises the copolymer fibre that in chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol and trimethylene carbonate, two or more copolymerization obtains arbitrarily.
Preferably, described absorbable fibre comprises one or more in poly-epsilon-caprolactone fiber, polylactide fiber, chitin fiber and polylactide Acetic acid, hydroxy-, bimol. cyclic ester fiber.
Preferably, the thickness of described absorbable medical perforated membrane is 0.01mm～0.15mm.
Preferably, the aperture of described absorbable medical perforated membrane is 0.05 μ m～40 μ m;
The porosity of absorbable medical perforated membrane is 50%～95%.
Preferably, also comprise the complementary component being entrained in described membrane matrix;
Described complementary component comprises medicine, can absorb one or more in inorganic matter and degradable metal.
The preparation method that the invention provides a kind of absorbable medical perforated membrane, comprises the following steps:
A) provide casting solution;
B) described step casting solution a) is mixed with absorbable fibre, masking obtains polymeric film;
C) by described step b) polymeric film that obtains carries out inversion of phases in solidification liquid, obtains absorbable medical perforated membrane.
Preferably, described step a) in casting solution the mass concentration of polymer be 0.05g/mL～1.0g/mL.
The invention provides a kind of absorbable medical perforated membrane, comprise membrane matrix and be entrained in the absorbable fibre in described membrane matrix.Absorbable medical perforated membrane provided by the invention comprises absorbable fibre, and described absorbable fibre is entrained in described membrane matrix, and absorbable fibre has strengthened the unidirectional or two-way hot strength of absorbable medical perforated membrane, has improved its tear resistance and pliability.In addition, medical porous film provided by the invention has organizes barriering effect and breathability preferably, makes the tissue fluid circulation of film both sides smooth and easy, facilitates the exchange of the nutrient substance of film both sides.Experimental result shows, the hot strength of absorbable medical film provided by the invention is up to 22.8N/mm
2, aperture is 0.05 μ m～40 μ m, porosity is 50%～95%.
The specific embodiment
The invention provides a kind of absorbable medical perforated membrane, comprise membrane matrix and be entrained in the absorbable fibre in described membrane matrix.
Absorbable medical perforated membrane provided by the invention comprises absorbable fibre, and described absorbable fibre is entrained in membrane matrix, and absorbable fibre has strengthened the unidirectional or two-way hot strength of absorbable medical perforated membrane, has improved its tear resistance and pliability.
Absorbable medical perforated membrane provided by the invention comprises membrane matrix.In the present invention, described membrane matrix is preferably obtained by the casting solution masking that comprises homopolymer and/or copolymer; Described homopolymer preferably includes the homopolymer that chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol or trimethylene carbonate homopolymerization obtain; Described copolymer preferably includes the copolymer that in chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol and trimethylene carbonate, two or more copolymerization obtains arbitrarily, described membrane matrix is more preferably by comprising that one or more the casting solution in polylactide, poly-epsilon-caprolactone, PGA and polylactide Acetic acid, hydroxy-, bimol. cyclic ester makes, most preferably by comprising that one or more the casting solution in PLLA, poly DL-lactide and PLGA makes; In the present invention, the number-average molecular weight of described PLLA is preferably 30,000～80,000, and more preferably 40,000～60,000, most preferably be 50,000; The number-average molecular weight of described poly DL-lactide is preferably 30,000～80,000, and more preferably 40,000～60,000, most preferably be 50,000; The viscosity of described PLGA is preferably 0.7dL/g～1.5dL/g, and more preferably 1.1dL/g～1.3dL/g, most preferably is 1.2dL/g.
The absorbable medical perforated membrane that invention provides comprises the absorbable fibre being entrained in described membrane matrix.In the present invention, described absorbable fibre preferably includes homopolymer fibre and/or copolymer fibre; Described homopolymer fibre preferably includes the homopolymer fibre that chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol or trimethylene carbonate homopolymerization obtain; Described copolymer fibre preferably includes the copolymer fibre that in chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol and trimethylene carbonate, two or more copolymerization obtains arbitrarily; Described absorbable fibre more preferably comprises one or more in poly-epsilon-caprolactone fiber, polylactide fiber, chitin fiber and polylactide Acetic acid, hydroxy-, bimol. cyclic ester fiber; Described absorbable fibre most preferably comprises one or more in poly-epsilon-caprolactone fiber, PLLA fiber, poly DL-lactide fiber, PLGA fiber and chitin fiber.
The present invention does not have special restriction to the form of described absorbable fibre, in an embodiment of the present invention, described absorbable fibre can have the structurally ordered braiding of longitude and latitude, as being the non-woven fabrics being obtained through electrostatic spinning by homopolymer fibre as described in technique scheme and/or copolymer fibre; Described absorbable fibre can be also unordered being entrained in described membrane matrix, as being the dispersion of homopolymer fibre as described in technique scheme and/or copolymer fibre.In the present invention, that described absorbable fibre is orderly braiding, while thering is longitude and latitude structure, preferably include one or more in PLLA electrostatic spinning non-woven fabrics, poly-epsilon-caprolactone fibre sheet material and chitosan electrostatic spinning non-woven fabrics.The present invention does not have special restriction to the diameter of described absorbable fibre, when the dispersion of homopolymer fibre and/or copolymer fibre described in described absorbable fibre is technique scheme, the diameter of described absorbable fibre is preferably less than or equal to the thickness of described membrane matrix, more preferably 0.01mm～0.14mm; When described absorbable fibre, be orderly braiding, while thering is longitude and latitude structure, as non-woven fabrics, the thickness of absorbable fibre described orderly braiding, that have longitude and latitude structure is preferably less than or equal to the thickness of described membrane matrix, more preferably 0.01mm～0.14mm.In the present invention, the content of described absorbable fibre in described medical porous film is preferably 20wt.%～80wt.%, more preferably 25wt.%～70wt.%.
Absorbable medical perforated membrane provided by the invention preferably also comprises the complementary component being entrained in described membrane matrix.To described complementary composition and absorbable fibre, the relative position in described membrane matrix does not have special restriction in the present invention, and described complementary composition and described absorbable fibre are entrained in described membrane matrix.In the present invention, described complementary component preferably includes medicine, can absorb one or more in inorganic matter and degradable metal; More preferably comprise one or more in medicine, bioceramic, bio-vitric, sodium, calcium, zinc, magnesium and the aluminum of anti-inflammation drugs, analgesic, growth-factor medication, cancer therapy drug, promotion tissue growth, most preferably comprise one or more in ibuprofen, calcium and zinc.The present invention can be according to actual using part need to add complementary component, prepare absorbable medical perforated membrane, as actual using part needs antiinflammatory, those skilled in the art, by adding anti-inflammation drugs, prepare the absorbable medical perforated membrane with antiinflammation.In the present invention, the content of described complementary component in described absorbable medical perforated membrane is preferably 0.001wt.%～5wt.%, more preferably 0.01wt.%～3wt.%.
The thickness of absorbable medical perforated membrane provided by the invention is preferably 0.01mm～0.15mm, more preferably 0.02mm～0.13mm; The aperture of described absorbable medical perforated membrane is preferably 0.05 μ m～40 μ m, more preferably 0.08 μ m～30 μ m; The porosity of described absorbable medical perforated membrane is preferably 50%～95%, and more preferably 55%～90%.
The preparation method that the invention provides a kind of absorbable medical perforated membrane, comprises the following steps:
A) provide casting solution;
B) described step casting solution a) is mixed with absorbable fibre, masking obtains polymeric film;
C) by described step b) polymeric film that obtains carries out inversion of phases in solidification liquid, obtains absorbable medical perforated membrane.
The invention provides casting solution.In the present invention, described casting solution comprises polymer and casting solvent.The present invention when preparing casting solution described in the addition sequence of polymer and casting solvent there is no special restriction, preferably described polymer is joined in described casting solvent, obtain casting solution.In the present invention, described polymer is consistent with the kind of homopolymer described in technique scheme and/or copolymer, and the kind at this to described polymer repeats no more.In the present invention, described casting solvent preferably includes one or more in dichloromethane, chloroform, oxolane, dioxane, acetone and DMF; More preferably comprise one or more in chloroform, oxolane and dioxane.In the present invention, in described casting solution, the mass concentration of polymer is preferably 0.05g/mL～1.0g/mL, more preferably 0.1g/mL～0.8g/mL.
Particularly, in an embodiment of the present invention, when described polymer is PLLA, described casting solvent can be one or both in dichloromethane and chloroform; When described polymer is poly DL-lactide, described casting solvent can be one or more in dichloromethane, chloroform, oxolane, dioxane, acetone and DMF.
In the present invention, described casting solution preferably also comprises porogen.In the present invention, described porogen is preferably Polyethylene Glycol, carbamide and is dissolved in one or more in the liquid flux of described casting solvent; One or both in ethanol and Polyethylene Glycol more preferably.The present invention does not have special restriction to the consumption of described porogen, and the consumption of porogen is adjusted in the aperture requirement that those skilled in the art can be according to actual needs, obtains the absorbable medical perforated membrane in required aperture.In the present invention, the aperture of described absorbable medical perforated membrane is preferably 0.05 μ m～40 μ m, more preferably 0.1 μ m～30 μ m; The porosity of described absorbable medical perforated membrane is preferably 50%～95%, and more preferably 55%～80%.
In the present invention, described casting solution preferably also comprises complementary component.In the present invention, the kind of described complementary component is consistent with the kind of complementary component described in technique scheme, does not repeat them here.
Obtain after casting solution, the present invention mixes masking by described casting solution with absorbable fibre, obtains polymeric film.The present invention preferably, before described casting solution is mixed to masking with absorbable fibre, carries out de-bubble by described casting solution.The present invention does not have special restriction to the method for described de-bubble, adopts de-bubble technical scheme well known to those skilled in the art.
Obtain the casting solution after de-bubble, the present invention preferably mixes the casting solution after described de-bubble with absorbable fibre, and masking obtains polymeric film.The present invention preferably mixes with absorbable fibre the casting solution after described de-bubble in substrate mould, and masking obtains polymeric film; More preferably described absorbable fibre is placed in to substrate mould, then casting solution is mixed with absorbable fibre, masking obtains polymeric film.The present invention does not have special restriction to described substrate mould, adopts substrate mould well known to those skilled in the art, is preferably one or both in glass plate and polyester material, more preferably glass plate.In the present invention, the kind of described absorbable fibre and form are consistent with kind and the form of absorbable fibre described in technique scheme, do not repeat them here.In the present invention, the mass ratio of described absorbable fibre and casting solution is preferably 1:(3～12), 1:(5～10 more preferably).In the present invention, the mass ratio of described complementary component and absorbable fibre is preferably 1:(4～80000), 1:(15～50000 more preferably), most preferably be 1:(20～20000).
The present invention does not have special restriction to the hybrid mode of described casting solution and described absorbable fibre, those skilled in the art can be different according to the form of the absorbable fibre described in technique scheme, select the hybrid mode of suitable casting solution and described absorbable fibre.In an embodiment of the present invention, when described absorbable fibre is the fiber dispersion disperseing, the absorbable fibre with disordered structure can be dipped in the casting solution after described de-bubble; When described absorbable fibre is, while having longitude and latitude structure by orderly braiding, the casting solution after described de-bubble can be placed on the absorbable fibre of orderly braiding.The present invention is not particularly limited the method for described casting solution and absorbable fibre masking, the method of described masking preferably includes one or more in blade coating, casting, curtain coating, spraying and roller coating, more preferably comprises one or more in blade coating, curtain coating and roller coating.
The present invention, preferably according to following principle, is mated the kind of the kind of absorbable fibre described in technique scheme and casting solvent: in the present invention, described casting solvent can not dissolve absorbable fibre before absorbable medical perforated membrane forms; Or described casting solvent dissolves the surface of absorbable fibre before absorbable medical perforated membrane forms; Or described casting solvent does not dissolve described absorbable fibre from start to finish.
Obtain after polymeric film, the present invention carries out described polymeric film inversion of phases in solidification liquid, obtains absorbable medical perforated membrane.The present invention preferably, after obtaining polymeric film, without standing, directly carries out described polymeric film inversion of phases in solidification liquid, more preferably, after obtaining polymeric film, without standing, directly together with substrate mould, in solidification liquid, carries out inversion of phases.In the present invention, described solidification liquid preferably includes one or more in ethanol, methanol, ice ether and water, more preferably one or both in water and ethanol.The present invention does not have special restriction to the consumption of described solidification liquid, preferably described casting solvent is fully cemented out.In the present invention, described solidification liquid does not dissolve absorbable fibre and membrane matrix, can casting solvent be cemented out, and the polymeric film obtaining is solidified with described casting solvent arbitrarily than dissolving each other, and obtains absorbable medical perforated membrane.
In an embodiment of the present invention, when described polymer is PLLA, described casting solvent can be one or both in dichloromethane and chloroform, and described solidification liquid can be one or more in ethanol, methanol and ice ether; When described polymer is poly DL-lactide, casting solvent can be one or more in oxolane, dioxane, acetone and DMF, and solidification liquid can be water.
The present invention, after completing described inversion of phases, obtains nascent film, preferably described nascent film is dried, and obtains absorbable medical perforated membrane.The present invention does not have special restriction to described being dried, and adopts dry technology scheme well known to those skilled in the art.
The present invention carries out the performance test of hot strength to prepared absorbable medical perforated membrane, and detailed process is as follows:
The present invention carries out tabletting by absorbable medical perforated membrane, makes dumbbell shape batten, is placed on universal testing machine and stretches, and writes down hot strength.
Experimental result shows, the hot strength of the absorbable medical perforated membrane that the present invention prepares is 14N/mm
2～23N/mm
2.
The present invention adopts micrometer caliper to carry out the test of film thickness to prepared absorbable medical perforated membrane, and result shows, the thickness of the absorbable medical perforated membrane that the present invention prepares is 0.01mm～0.15mm.
A kind of absorbable medical perforated membrane provided by the invention, comprises membrane matrix and is entrained in the absorbable fibre in described membrane matrix.Absorbable medical perforated membrane provided by the invention comprises absorbable fibre, and described absorbable fibre is entrained in membrane matrix, and absorbable fibre has strengthened the unidirectional or two-way hot strength of absorbable medical perforated membrane, has improved its tear resistance and pliability.In addition, absorbable medical perforated membrane provided by the invention has organizes barriering effect and breathability preferably, makes the tissue fluid circulation of film both sides smooth and easy, facilitates the exchange of the nutrient substance of film both sides.
Absorbable medical perforated membrane provided by the invention can provide a kind of nerve repair material for nerve reparation, and described nerve repair material is preferably the neural pipe of repairing, and the described neural pipe of repairing is for tubulose absorbable medical perforated membrane.In the present invention, described nerve repair material connects the neuronic broken ends of fractured bone far away and the nearly broken ends of fractured bone, for nerve growth provides a suitable microenvironment, promotes destroyed or undermined neuranagenesis reparation and reinvents, and finally realizes function of nervous system and repairs.The present invention does not have special restriction to the length of the tube chamber of described nerve repair material and diameter, and length and diameter that those skilled in the art can be are according to actual needs adjusted length and the diameter of the tube chamber of nerve repair material, obtain required nerve repair material.
In order to further illustrate the present invention, below in conjunction with embodiment, a kind of absorbable medical perforated membrane provided by the invention and preparation method thereof is described in detail, but they can not be interpreted as to limiting the scope of the present invention.
Embodiment 1
The PLLA that is 50,000 by 5g molecular weight is placed in 20g chloroform, drips wherein 5g ethanol and fully dissolves, and obtains casting solution after deaeration;
Substrate mould is placed on the platform of abswolute level, the electrostatic spinning non-woven fabrics that the PLLA that is 50,000 by 0.67g molecular weight is made is layered in substrate mould, then in mould, pours 10g casting solution into, and standing curtain coating 5min, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film immersed in ethanol and soaks 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Embodiment 2
The PLLA that is 50,000 by 5g molecular weight is placed in 25g dichloromethane, fully dissolves, and obtains casting solution after deaeration;
Substrate mould is placed on the platform of abswolute level, the poly-epsilon-caprolactone cellosilk that is 100,000 1g molecular weight is uniformly distributed and is distributed in substrate mould, with a flat plate mold, suppress and form fibre sheet material a night, then in mould, pour 10g casting solution into, then by casting method masking on the fibre plate of substrate mould, obtain polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film is immersed in ethanol, soak 5h, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Embodiment 3
The Polyethylene Glycol that the poly DL-lactide that is 60,000 by 5g molecular weight and 5% molecular weight are 2000 is placed in oxolane and the dioxane mixed liquor that 25g volume ratio is 1:1, fully dissolves, and obtains casting solution after deaeration;
The electrostatic spinning non-woven fabrics that the PLLA that is 50,000 by molecular weight is made is layered on substrate mould glass plate, the casting solution of falling 5g on non-woven fabrics then, and the method masking that twines the Glass rod roll-in of adhesive tape by both sides, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate glasses plate, then dry, obtain absorbable medical film.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Embodiment 4
The poly DL-lactide that is 60,000 by 5g molecular weight is placed in 25g oxolane and dioxane 1:1 mixed liquor, fully dissolves, and obtains casting solution after deaeration;
The electrostatic spinning non-woven fabrics that the PLLA that is 50,000 by molecular weight is made is layered on substrate mould glass plate, the casting solution of falling 5g on non-woven fabrics then, and the method masking that twines the Glass rod roll-in of adhesive tape by both sides, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film is immersed in the water together with substrate glasses plate, soak 5h, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Embodiment 5
The PLGA of 2.5g intrinsic viscosity 1.2dL/g (mol ratio of DL-lactide and Acetic acid, hydroxy-, bimol. cyclic ester is 75:25) is placed in to 12.5g oxolane and dioxane 1:1 mixed liquor, fully dissolves, after deaeration, obtain casting solution;
The PLLA fiber that is cut into 50,000 molecular weight of the long 0.5g of 2cm is joined in above-mentioned casting solution, and mix homogeneously after deaeration, falls the above-mentioned casting solution of 10g on substrate mould glass plate, uses the Glass rod knifing that twines adhesive tape by both sides, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate glasses plate, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Embodiment 6
The poly DL-lactide that is 60,000 5g molecular weight is placed in 25g oxolane and dioxane 1:1 mixed liquor, fully dissolves, and obtains casting solution after deaeration;
The electrostatic spinning non-woven fabrics that the chitosan that is 150,000 by molecular weight is made is layered on substrate mould glass plate, the casting solution of falling 5g on non-woven fabrics then, and the method masking that twines the Glass rod roll-in of adhesive tape by both sides, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate glasses plate, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Embodiment 7
The poly DL-lactide that is 60,000 5g molecular weight is placed in oxolane and the dioxane mixed liquor that 25g volume ratio is 1:1, then to the antibiotic medicine ibuprofen that adds 2wt.% in solution, fully dissolves, and obtains casting solution after deaeration;
The electrostatic spinning non-woven fabrics that the PLLA that is 50,000 by molecular weight is made is layered on substrate mould glass plate, the casting solution of falling 5g on non-woven fabrics then, and the method masking that twines the Glass rod roll-in of adhesive tape by both sides, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate glasses plate, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the absorbable medical perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Comparative example 1
This comparative example is prepared casting solution according to embodiment 1 technology of preparing scheme;
Substrate mould glass plate is placed on the platform of abswolute level, then in mould, pours the casting solution of the above-mentioned preparation of 10g into, standing curtain coating 5min masking, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film immersed in ethanol and soaks 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the reference perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Comparative example 2
This comparative example is prepared casting solution according to embodiment 2 technology of preparing schemes;
Substrate mould glass plate is placed on the platform of abswolute level, then in mould, pours the above-mentioned casting solution of 10g into, by standing curtain coating 5min masking, obtain polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film immersed in ethanol and soaks 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the reference perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Comparative example 3
This comparative example is prepared casting solution according to embodiment 3 technology of preparing schemes;
On substrate mould glass plate, fall the above-mentioned casting solution of 5g, the method masking by above-mentioned roll-in, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the reference perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Comparative example 4
This comparative example is prepared casting solution according to the technical scheme of embodiment 4;
On substrate mould glass plate, fall the above-mentioned casting solution of 5g, the method masking by above-mentioned roll-in, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the reference perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Comparative example 5
This comparative example is prepared casting solution according to the technical scheme of embodiment 5;
The PLGA that is 1.2dL/g by 2.5g intrinsic viscosity (75/25) joins in the oxolane and dioxane mixed liquor that 12.5g casting solvent volume ratio is 1:1, fully dissolve, after deaeration, scrape as stated above masking, obtain polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the reference perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
Comparative example 6
This comparative example is prepared casting solution according to the technical scheme of embodiment 6;
On substrate mould glass plate, fall the above-mentioned casting solution of 5g, the method masking by above-mentioned roll-in, obtains polymeric film;
Obtain after polymeric film, without standing, directly described polymeric film be immersed in the water and soak 5h together with substrate mould, obtain absorbable medical perforated membrane.
The present invention carries out the test of hot strength to the reference perforated membrane of gained according to the technical scheme of hot strength described above, test result is as shown in table 1, the performance test results of the absorbable medical perforated membrane that table 1 obtains for the embodiment of the present invention and comparative example.
The performance test results of the absorbable medical perforated membrane that table 1 embodiment of the present invention and comparative example obtain
As can be seen from Table 1, the hot strength of absorbable medical perforated membrane provided by the invention is up to 22.8N/mm
2, and the hot strength of the absorbable medical perforated membrane that comparative example obtains only has 5.6N/mm
2.
As seen from the above embodiment, the invention provides a kind of absorbable medical perforated membrane, comprise membrane matrix and be entrained in the absorbable fibre in described membrane matrix.Absorbable medical perforated membrane provided by the invention comprises absorbable fibre, and described absorbable fibre is entrained in membrane matrix, and absorbable fibre has strengthened the unidirectional or two-way hot strength of absorbable medical perforated membrane, has improved its tear resistance and pliability.In addition, medical porous film provided by the invention has organizes barriering effect and breathability preferably, can make the tissue fluid circulation of film both sides smooth and easy, facilitates the exchange of the nutrient substance of film both sides.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. an absorbable medical perforated membrane, comprises membrane matrix and is entrained in the absorbable fibre in described membrane matrix.
2. absorbable medical perforated membrane according to claim 1, is characterized in that, the content of described absorbable fibre is 20wt.%～80wt.%.
3. absorbable medical perforated membrane according to claim 2, is characterized in that, the content of described absorbable fibre is 25wt.%～70wt.%.
4. absorbable medical perforated membrane according to claim 1, is characterized in that, described absorbable fibre is homopolymer fibre and/or copolymer fibre;
Described homopolymer fibre comprises the homopolymer fibre that chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol or trimethylene carbonate homopolymerization obtain;
Described copolymer fibre comprises the copolymer fibre that in chitosan, chitin, collagen protein, lactide, Acetic acid, hydroxy-, bimol. cyclic ester, 6-caprolactone, lactic acid, ethylene glycol and trimethylene carbonate, two or more copolymerization obtains arbitrarily.
5. absorbable medical perforated membrane according to claim 4, is characterized in that, described absorbable fibre comprises one or more in poly-epsilon-caprolactone fiber, polylactide fiber, chitin fiber and polylactide Acetic acid, hydroxy-, bimol. cyclic ester fiber.
6. absorbable medical perforated membrane according to claim 1, is characterized in that, the thickness of described absorbable medical perforated membrane is 0.01mm～0.15mm.
7. absorbable medical perforated membrane according to claim 1, is characterized in that, the aperture of described absorbable medical perforated membrane is 0.05 μ m～40 μ m;
The porosity of absorbable medical perforated membrane is 50%～95%.
8. absorbable medical perforated membrane according to claim 1, is characterized in that, also comprises the complementary component being entrained in described membrane matrix;
Described complementary component comprises medicine, can absorb one or more in inorganic matter and degradable metal.
9. a preparation method for absorbable medical perforated membrane, comprises the following steps:
A) provide casting solution;
B) described step casting solution a) is mixed with absorbable fibre, masking obtains polymeric film;
C) by described step b) polymeric film that obtains carries out inversion of phases in solidification liquid, obtains absorbable medical perforated membrane.
10. preparation method according to claim 9, is characterized in that, described step a) in casting solution the mass concentration of polymer be 0.05g/mL～1.0g/mL.
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| CN108096642A (en) * | 2017-12-07 | 2018-06-01 | 中国纺织科学研究院 | Absorbable film layer, adsorbable hemostatic agents and preparation method thereof |
| CN110420351A (en) * | 2019-07-11 | 2019-11-08 | 中国科学院长春应用化学研究所 | A kind of 3D printing flexible, porous timbering material and preparation method thereof |
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| CN103611198B (en) | 2016-09-28 |
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