CN102433684B - Superfine composite fiber film, preparation method and use thereof - Google Patents
Superfine composite fiber film, preparation method and use thereof Download PDFInfo
- Publication number
- CN102433684B CN102433684B CN201110347268.9A CN201110347268A CN102433684B CN 102433684 B CN102433684 B CN 102433684B CN 201110347268 A CN201110347268 A CN 201110347268A CN 102433684 B CN102433684 B CN 102433684B
- Authority
- CN
- China
- Prior art keywords
- polyethylene glycol
- composite fiber
- poly
- glycolide
- lactide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Materials For Medical Uses (AREA)
- Nonwoven Fabrics (AREA)
Abstract
The invention relates to a biodegradable and bioabsorbable superfine composite fiber film, which consists of poly lactic-co-glycolic acid of the weight ratio ranging from 75wt% to 100wt% and poly latic acid-b-polyethylene glycol of the weight ratio ranging from 0wt% to 25wt%. The preparation method includes the following steps of mixing the poly lactic-co-glycolic acid and the poly latic acid-b-polyethylene glycol into N, N-dimethylformamide or acetone or mixture of the N-dimethylformamide and the acetone so as to obtain uniform polymer solution, then stirring the uniform polymer solution at room temperature to obtain uniform mixed liquid, and finally injecting the uniform mixed liquid into an electrostatic spinning device to conduct electrostatic spinning, and accordingly the poly lactic-co-glycolic acid and the poly lactic acid-b-polyethylene glycol superfine composite fiber film is obtained. The superfine composite fiber film has excellent biocompatibility and adjustable biodegradation, has the advantages of light and soft texture and fine permeability simultaneously, and can be used as excellent internal adhesion-proof materials.
Description
Technical field
The present invention relates to a kind of biodegradable and can superfine composite fiber film, the Its Preparation Method And Use of post-operation adhesion preventing of bio-absorbable, particularly relate to superfine composite fiber film, Its Preparation Method And Use prepared by a kind of poly (glycolide-lactide) (PLGA) and polylactide-b-polyethylene glycol (PELA).
Background technology
Post-operation adhesion is the sciences problems that surgical field has rate occurred frequently and recurrence rate.Complication caused by post-operation adhesion brings great misery not only to the daily life of patient, and makes large the increasing that have a big risk of second operation.Therefore, how to prevent post-operation adhesion, the misery reducing patient becomes the problem of medical domain research.For a long time, medical circle has done a large amount of work in the research preventing postoperative intestinal adhesion, and effect surely belongs to physical isolation method the most significantly.The product that prevents adhesion commercially available at present mainly occurs with the form of gel, solid film and nonwoven fabric etc.
Adherence preventing material is roughly divided into the material of non-absorbent material and absorption.
Non-absorbent material comprises silicon chip, GoreTex sheet, comprises anti-organ adhesion's film of the aquagel membrane of mixed polymer, the water-soluble polymer that described mixed polymer comprises polyvinyl alcohol and specifies.Although by being attached on damage location by sheet, these sheet energy physical separation damage locations thus make do not have adhesion, they can not be absorbed in vivo, therefore create artificial material and are detained problem in body.In addition, the not absorbing sheet pasted like this or film itself can cause dysfunction by adhering to organ.In this case, even also can not remove by again performing the operation the sheet adhered to like this on organ.Therefore, attempted develop can in vivo high safety absorb Absorbable rod base material.
CN 101056662B discloses a kind of adherence preventing material, and it comprises water-absorbent crosslinked poly-gamma-glutamic acid as active ingredient, wherein water-absorbent crosslinked poly-gamma-glutamic acid being cross-linked to form by poly-gamma-glutamic acid and another poly-gamma-glutamic acid.
CN 100525778C discloses a kind of novel post-operation adhesion preventing material and preparation method, and its component and content are as follows by weight percentage: shitosan 10-90, polyanion or polyethylene glycol 90-10; The preparation method of novel post-operation adhesion preventing material is 1) shitosan is dissolved in the acid solution of 0.1%-5%, be made into the chitosan solution that concentration is 0.5%-6%; Wherein: acid is hydrochloric acid, citric acid, acetic acid or tartaric acid; 2) solution concentration of polyanion and distilled water is made into 1%-15%; Or the solution concentration of polyethylene glycol and distilled water is made into 1%-30%.By above-mentioned 1) and 2) two solution mix, and namely obtain solution-type adherence preventing material.Adherence preventing material Anti Triplex can be film material, gel or solution.
CN 1876926A discloses a kind of preparation of nano-scale fiber bondedfibre fabric, and as the application of postoperative anti-adhesion membrane.This bondedfibre fabric adopts the preparation of the method for electrostatic spinning and obtains.First prepare spinning solution, aliphatic polyester is dissolved in solvent, stir obtained aliphatic polyester spinning solution.Spinning solution solvent for use is carrene, chloroform, acetone, tetrachloroethanes, one or both the compound system such as dimethylacetylamide.Secondly, on electrostatic spinning machine, obtain aliphatic polyester superfine fibre by spinning solution dress note, electrostatic spinning and collection superfine fibre two step, realize the bondedfibre fabric that electrospinning becomes nano-scale fiber, for post-operation adhesion preventing after sterilization process.
Clinical effectiveness shows, although these products can play certain preventing adhesiving effect, but also have a lot of problems demand to solve, as materials microstructure matching, degradability and operability etc., these all require further study and improve to reach the object improving preventing adhesiving effect.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of biodegradable and can the superfine fibre composite membrane of bio-absorbable and good biocompatibility.
Superfine composite fiber film of the present invention, is made up of the poly (glycolide-lactide) of 75wt% ~ 100wt% and the polylactide-b-polyethylene glycol of 0wt% ~ 25wt%.
As optimal technical scheme, superfine composite fiber film of the present invention, is made up of the poly (glycolide-lactide) of 85wt% ~ 95wt% and the polylactide-b-polyethylene glycol of 5wt% ~ 15wt%.
Poly (glycolide-lactide) is prepared by glycolide and lactide monomer ring opening copolymer, nontoxic, easily processes, and has good biological degradability and biocompatibility, but causes cellular affinity bad due to its hydrophobicity.Polylactide-b-polyethylene glycol is amphipathic nature block polymer, has good biocompatibility and hydrophily, but its biological degradability is bad.Two kinds of materials are all the use safety by FDA certification, the material of excellent performance.The present invention according to the characteristic of the two, in conjunction with both the chief, use rational mass distribution to obtain adhesiveness and be suitable for and the superfine composite fiber film of easily biological-degradable.
As optimal technical scheme, the weight average molecular weight of described poly (glycolide-lactide) is 40,000 ~ 200,000; Preferably, in poly (glycolide-lactide), the mol ratio of lactide and glycolide is 95:5 ~ 40:60.
As optimal technical scheme, the weight average molecular weight of described polylactide-b-polyethylene glycol is 2000 ~ 80,000; Preferably, in polylactide-b-polyethylene glycol, the mol ratio of polylactide and polyethylene glycol is 9:1 ~ 2:8.
As optimal technical scheme, the fibre diameter of described tunica fibrosa is 500nm ~ 5000nm, preferred 1000nm ~ 3000nm; The thickness of described tunica fibrosa is 100 μm ~ 180 μm, preferably 120 μm ~ 180 μm.
The superfine composite fiber film obtained can carry out vacuumize further under room temperature (as 25 DEG C).As desirable adherence preventing material, superfine composite fiber film provided by the present invention has good biocompatibility, suitable tissue adherence, can complete wound coverage surface and have retention time in enough bodies; Degraded can absorb and not need second operation to be taken out; Can effectively prevent Adhesion formation from not affecting again the normal healing of wound; Also there is certain mechanical strength and be convenient to implementation and operation etc.In addition, this film is prepared by electrostatic spinning technique, has light weight softness, the advantages such as high porosity, especially has suitable thickness, can be used as post-operation adhesion preventing material.
An object of the present invention is also the preparation method providing a kind of superfine composite fiber film.
The preparation method of superfine composite fiber film provided by the present invention comprises the steps: 1) poly (glycolide-lactide) and the mixing of polylactide-b-polyethylene glycol are dissolved in DMF or acetone or its mixture, obtain uniform polymer solution; 2) by step 1) the uniform polymer solution of gained at room temperature stirs, and obtains homogeneous mixed liquor; 3) by step 2) the homogeneous mixed liquor of gained injects electrostatic spinning apparatus and carries out electrostatic spinning, obtains the superfine composite fiber film of poly (glycolide-lactide) and polylactide-b-polyethylene glycol.
In recent years, along with the maturation of electrostatic spinning technique, the static spinning membrane selecting biocompatibility macromolecule to prepare is adapted at the application of biomedical material aspect owing to having the feature such as extra specific surface area and super large porosity.The structure of the class cytoskeleton matrix on static spinning membrane microcosmic not only has cell compatibility, and the structure of these porous has good gas permeability, is beneficial to exchange and the transmission of endotrophic material.Adopt static spinning membrane can reach the effect playing physical barrier as adherence preventing material, the circulation environment of nutriment and metabolite between tissue can also be ensured, thus while playing preventing adhesiving effect, also help normally carrying out of wound healing.
But, due to the appearance of three-dimensional pore space structure, make static spinning membrane face a lot of problem as in the research process of adherence preventing material.We are found by results of animal research: if material is too thin, cell can penetrate film and grow, and cannot play the effect prevented adhesion; And material is too thick, the increase due to implantation amount makes histocompatbility reduce and cause rejection, thus causes burden in body.Therefore, when static spinning membrane is used as adherence preventing material, how to determine that optimum thickness becomes a key breakthrough point of this technical field.The thickness of tunica fibrosa of the present invention is selected, between 100 μm ~ 180 μm, both can play the effect prevented adhesion, can not cause burden again to health during use.In the present invention, the condition of electrostatic spinning can adopt prior art, and voltage is 15 ~ 30kV, liquid inventory is 10 ~ 100L/min, receiving range is 5cm ~ 25cm.
Step 1) in poly (glycolide-lactide) and polylactide-b-polyethylene glycol mixture in poly (glycolide-lactide) account for 75wt% ~ 100wt% and polylactide-b-polyethylene glycol accounts for 0wt% ~ 25wt%.
As preferably, step 1) in the weight average molecular weight of poly (glycolide-lactide) be 40,000 ~ 200,000, in preferred poly (glycolide-lactide), the mol ratio of lactide and glycolide is 95:5 ~ 40:60.
As preferably, step 1) in the weight average molecular weight of polylactide-b-polyethylene glycol be 2000 ~ 80,000, in preferred polylactide-b-polyethylene glycol, the mol ratio of polylactide and polyethylene glycol is 9:1 ~ 2:8.
As preferably, step 1) in the volume ratio of DMF and acetone be 1:9 ~ 9:1.
As preferably, step 1) in polymer is total in polymer solution quality concentration expressed in percentage by volume be 25% ~ 70%, preferred mass concentration expressed in percentage by volume is 30% ~ 60%, and further preferred mass concentration expressed in percentage by volume is 30% ~ 50%.
An object of the present invention is also to provide a kind of superfine composite fiber film in body Resection, there is good material compatibility and structural compatibility, can self-retaining, promote wound healing and play good physical barrier effect, thus play good preventing adhesiving effect.
Accompanying drawing explanation
The surperficial SEM figure of the superfine fibre composite film material that in Fig. 1 embodiment 1, PLGA and PELA prepares.
In Fig. 2 embodiment 1, the section SEM of the superfine fibre composite film material that PLGA and PELA prepares schemes.
Detailed description of the invention
For ease of understanding the present invention, it is as follows that the present invention enumerates embodiment.Those skilled in the art should understand, described embodiment only understands the present invention for helping, and should not be considered as concrete restriction of the present invention.
Embodiment one
(1) preparation of solution: (molecular weight is 80,000 by PLGA, wherein the mol ratio of lactide and glycolide is 95:5) (molecular weight is 10,000 with PELA, wherein the mol ratio of polylactide and polyethylene glycol is 2:8) be dissolved in N, N-dimethylformamide (DMF), with the mixed solvent of acetone (volume ratio is 5:5), obtains the mixed solution that total polymer mass body volume concentrations is PLGA and PELA of 50%.In solution, the mass ratio of PLGA and PELA is 95:5.
(2) electrostatic spinning: the PLGA solution obtained in step (1) is placed in the feed injector of electrospinning device.Regulate the distance between spinning head and roller to be 12cm, the environment temperature of spinning is 25 DEG C, and the air velocity in environment controls at 0.5 ~ 0.8m
3/ hr, open high voltage source and feed injector pump, regulation voltage is to 20kV, and the delivery rate of solution is 20 μ l/min, carries out spinning, and spinning time 100min obtains electrostatic spinning superfine fibre composite membrane on a rotating drum.
(3) by the tunica fibrosa collected in step (2) repeatedly with after deionized water rinsing, in 20 DEG C of vacuum drying chambers, vacuumize is after 24 hours, obtains superfine fibre composite film material that is biodegradable and that absorb.Superfine fibre composite film material is nonwoven fabric construct, and superfine fibre diameter is between 1 ~ 3 μm, as shown in Figure 1; There is three-dimensional loose loose structure, as shown in Figure 2.Fibrage thickness is 100 ~ 180 μm.
Embodiment two
(1) preparation of solution: (molecular weight is 200,000 by PLGA, wherein the mol ratio of lactide and glycolide is 3:1) (molecular weight is 10,000 with PELA, wherein the mol ratio of polylactide and polyethylene glycol is 50:50) be dissolved in N, N-dimethylformamide (DMF), with the mixed solvent of acetone (volume ratio is 9:1), obtains the mixed solution that total polymer mass body volume concentrations is PLGA and PELA of 35%.In solution, the mass ratio of PLGA and PELA is 80:20.
(2) electrostatic spinning: the PLGA solution obtained in step (1) is placed in the feed injector of electrospinning device.Regulate the distance between spinning head and roller to be 12cm, the environment temperature of spinning is 25 DEG C, and the air velocity in environment controls at 0.5 ~ 0.8m
3/ hr, open high voltage source and feed injector pump, regulation voltage is to 20kV, and the delivery rate of solution is 20 μ l/min, carries out spinning, and spinning time 150min obtains electrostatic spinning superfine fibre composite membrane on a rotating drum.
(3) by the tunica fibrosa collected in step (2) repeatedly with after deionized water rinsing, in 20 DEG C of vacuum drying chambers, vacuumize is after 24 hours, obtains superfine fibre composite film material that is biodegradable and that absorb.Superfine fibre composite film material is nonwoven fabric construct, and superfine fibre diameter is between 1 ~ 3 μm; There is three-dimensional loose network-like structure.Fibrage thickness is 100 ~ 150 μm.
Embodiment three
(1) preparation of solution: (molecular weight is 40,000 by PLGA, wherein the mol ratio of lactide and glycolide is 3:1) (molecular weight is 80,000 with PELA, wherein the mol ratio of polylactide and polyethylene glycol is 9:1) be dissolved in N, N-dimethylformamide (DMF), with the mixed solvent of acetone (volume ratio is 1:9), obtains the mixed solution that total polymer mass body volume concentrations is PLGA and PELA of 45wt%.In solution, the mass ratio of PLGA and PELA is 75:25.
(2) electrostatic spinning: the PLGA solution obtained in step (1) is placed in the feed injector of electrospinning device.Regulate the distance between spinning head and roller to be 12cm, the environment temperature of spinning is 25 DEG C, and the air velocity in environment controls at 0.5 ~ 0.8m
3/ hr, open high voltage source and feed injector pump, regulation voltage is to 20kV, and the delivery rate of solution is 20 μ l/min, carries out spinning, and spinning time 120min obtains electrostatic spinning superfine fibre composite membrane on a rotating drum.
(3) by the tunica fibrosa collected in step (2) repeatedly with after deionized water rinsing, in 20 DEG C of vacuum drying chambers, vacuumize is after 24 hours, obtains superfine fibre composite film material that is biodegradable and that absorb.Superfine fibre composite film material is nonwoven fabric construct, and superfine fibre diameter is between 1 ~ 5 μm; There is three-dimensional loose loose structure.Fibrage thickness is 100 ~ 150 μm.
Applicant states, the present invention illustrates detailed process equipment and process flow process of the present invention by above-described embodiment, but the present invention is not limited to above-mentioned detailed process equipment and process flow process, namely do not mean that the present invention must rely on above-mentioned detailed process equipment and process flow process and could implement.Person of ordinary skill in the field should understand, any improvement in the present invention, to equivalence replacement and the interpolation of auxiliary element, the concrete way choice etc. of each raw material of product of the present invention, all drops within protection scope of the present invention and open scope.
Claims (11)
1. a superfine composite fiber film, is characterized in that, is made up of the poly (glycolide-lactide) of 75wt% ~ 95wt% and the polylactide-b-polyethylene glycol of 5wt% ~ 25wt%;
The weight average molecular weight of described polylactide-b-polyethylene glycol is 2000 ~ 80,000;
In polylactide-b-polyethylene glycol, the mol ratio of polylactide and polyethylene glycol is 9:1 ~ 2:8;
The weight average molecular weight of described poly (glycolide-lactide) is 40,000 ~ 200,000;
In poly (glycolide-lactide), the mol ratio of lactide and glycolide is 95:5 ~ 40:60;
The fibre diameter of described tunica fibrosa is 1000nm ~ 5000nm.
2. superfine composite fiber film according to claim 1, is characterized in that, is made up of the poly (glycolide-lactide) of 85wt% ~ 95wt% and the polylactide-b-polyethylene glycol of 5wt% ~ 15wt%.
3. superfine composite fiber film according to claim 1 and 2, is characterized in that, the fibre diameter of described tunica fibrosa is 1000nm ~ 3000nm.
4. superfine composite fiber film according to claim 1 and 2, is characterized in that, the thickness of described tunica fibrosa is 100 μm ~ 180 μm.
5. superfine composite fiber film according to claim 4, is characterized in that, the thickness of described tunica fibrosa is 100 μm ~ 150 μm.
6. the preparation method of the superfine composite fiber film according to any one of Claims 1 to 5, comprise the steps: 1) poly (glycolide-lactide) and the mixing of polylactide-b-polyethylene glycol are dissolved in N, in dinethylformamide or acetone or its mixture, obtain uniform polymer solution; 2) by step 1) the uniform polymer solution of gained at room temperature stirs, and obtains homogeneous mixed liquor; 3) by step 2) the homogeneous mixed liquor of gained injects electrostatic spinning apparatus and carries out electrostatic spinning, obtains the superfine composite fiber film of poly (glycolide-lactide) and polylactide-b-polyethylene glycol;
Step 1) in the weight average molecular weight of polylactide-b-polyethylene glycol be 2000 ~ 80,000, in polylactide-b-polyethylene glycol, the mol ratio of polylactide and polyethylene glycol is 9:1 ~ 2:8;
Step 1) in the weight average molecular weight of poly (glycolide-lactide) be 40,000 ~ 200,000; In poly (glycolide-lactide), the mol ratio of lactide and glycolide is 95:5 ~ 40:60.
7. method according to claim 6, is characterized in that, step 1) in the volume ratio of DMF and acetone be 1:9 ~ 9:1.
8. method according to claim 6, is characterized in that, step 1) in polymer is total in polymer solution quality concentration expressed in percentage by volume be 30% ~ 70%.
9. method according to claim 8, is characterized in that, described quality concentration expressed in percentage by volume is 35% ~ 60%.
10. method according to claim 9, is characterized in that, described quality concentration expressed in percentage by volume is 35% ~ 50%.
The purposes of 11. superfine composite fiber films according to any one of Claims 1 to 5, is characterized in that, described superfine composite fiber film is used in body Resection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110347268.9A CN102433684B (en) | 2011-11-04 | 2011-11-04 | Superfine composite fiber film, preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110347268.9A CN102433684B (en) | 2011-11-04 | 2011-11-04 | Superfine composite fiber film, preparation method and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102433684A CN102433684A (en) | 2012-05-02 |
| CN102433684B true CN102433684B (en) | 2015-06-10 |
Family
ID=45982026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110347268.9A Active CN102433684B (en) | 2011-11-04 | 2011-11-04 | Superfine composite fiber film, preparation method and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102433684B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007363A (en) * | 2012-12-19 | 2013-04-03 | 浙江微度医疗器械有限公司 | Degradable anti-adhesion compound membrane and preparation method thereof |
| CN103768662B (en) * | 2014-02-26 | 2016-06-01 | 中国科学院长春应用化学研究所 | The preparation method of a kind of biodegradable medical surgery anti-adhesion membrane |
| CN107747165B (en) * | 2017-10-16 | 2019-06-25 | 苏州大学 | A kind of super hydrophilic polyester nano tunica fibrosa and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314187A (en) * | 2000-03-22 | 2001-09-26 | 四川迪康集团股份有限公司 | Medical anti-adhesive film |
| CN1837274A (en) * | 2005-03-21 | 2006-09-27 | 中国科学院化学研究所 | Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof |
| CN1994476A (en) * | 2006-08-29 | 2007-07-11 | 北京华世本全科技有限公司 | Degradable compound biomaterial membrane for medical purpose |
| CN101029143A (en) * | 2007-03-06 | 2007-09-05 | 天津大学 | Controllable biological degradable polyester superfine fibrous film material |
| CN101257935A (en) * | 2005-09-05 | 2008-09-03 | 百润生物技术公司 | Multi-layered antiadhesion barrier |
| CN101274104A (en) * | 2007-03-27 | 2008-10-01 | 上海鼎华医械有限责任公司 | Preparation of absorbable medical membrane |
| CN101623517A (en) * | 2009-08-11 | 2010-01-13 | 广州迈普再生医学科技有限公司 | Medical anti-sticking membrane and preparation method thereof |
| CN102107018A (en) * | 2011-01-11 | 2011-06-29 | 上海鼎华医械有限责任公司 | Postoperative anti-adhesion membrane and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1305064B1 (en) * | 2000-07-28 | 2008-04-23 | Anika Therapeutics Inc. | Bioabsorbable composites of derivatized hyaluronic acid |
| US9649331B2 (en) * | 2009-08-27 | 2017-05-16 | Ara Medical Llc | Sprayable polymers as adhesion barriers |
-
2011
- 2011-11-04 CN CN201110347268.9A patent/CN102433684B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314187A (en) * | 2000-03-22 | 2001-09-26 | 四川迪康集团股份有限公司 | Medical anti-adhesive film |
| CN1837274A (en) * | 2005-03-21 | 2006-09-27 | 中国科学院化学研究所 | Degradable and absorbable polymer nano fibrous membrane materials and preparation process and use thereof |
| CN101257935A (en) * | 2005-09-05 | 2008-09-03 | 百润生物技术公司 | Multi-layered antiadhesion barrier |
| CN1994476A (en) * | 2006-08-29 | 2007-07-11 | 北京华世本全科技有限公司 | Degradable compound biomaterial membrane for medical purpose |
| CN101029143A (en) * | 2007-03-06 | 2007-09-05 | 天津大学 | Controllable biological degradable polyester superfine fibrous film material |
| CN101274104A (en) * | 2007-03-27 | 2008-10-01 | 上海鼎华医械有限责任公司 | Preparation of absorbable medical membrane |
| CN101623517A (en) * | 2009-08-11 | 2010-01-13 | 广州迈普再生医学科技有限公司 | Medical anti-sticking membrane and preparation method thereof |
| CN102107018A (en) * | 2011-01-11 | 2011-06-29 | 上海鼎华医械有限责任公司 | Postoperative anti-adhesion membrane and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| Fabrication and characterization of hydrophilic electrospun membranes made from the block copolymer of poly(ethylene glycol-co-lactide);De-Juan Yang等;《Journal of Biomedical Materials Research Part A》;20070901;第82A卷(第3期);第680-688页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102433684A (en) | 2012-05-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101623517B (en) | Medical anti-sticking membrane and preparation method thereof | |
| US9101508B2 (en) | Electro spun nanofibrous wound dressing and a method of synthesizing the same | |
| US10022477B2 (en) | Composition for anti-adhesion, surgical mesh composite with anti-adhesion property comprising the same and method for producing thereof | |
| CN110665061A (en) | Acellular scaffold solution-GelMA hydrogel composite material and preparation method thereof | |
| CN104096272A (en) | Postoperation anti-infectious composite electrostatic-spinning nanometer fiber-film sheet for repairing hernia and preparation method thereof | |
| MX2011009282A (en) | Artificial dura mater and manufacturing method thereof. | |
| CN111840649A (en) | Composite tissue repair patch prepared by coating process and preparation method thereof | |
| IL193640A (en) | Biodegradable foam | |
| KR20090004027A (en) | Method for the preparation of tube-type porous biodegradable scaffold having a double-layered structure for vascular graft | |
| CN103083735A (en) | Composite membrane for guiding bone tissue regeneration and preparation method thereof | |
| CN102397580A (en) | Anti-adhesion fiber membrane with hemostasis and antibiosis functions and preparation method thereof | |
| CN102657898A (en) | Degradable nanofiber anti-adhesive membrane with double-release performance and preparation method of same | |
| Zhu et al. | An injectable hydroxyapatite/poly (lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly (glycolide) fibers for bone repair | |
| CN109876186A (en) | A kind of biological medical degradable double-layer scaffold and preparation method thereof for neural restoration | |
| CN104353128A (en) | Degradable intravascular stent and preparation method and application thereof | |
| CN102433684B (en) | Superfine composite fiber film, preparation method and use thereof | |
| Shi et al. | Preparation of porous polylactide microspheres and their application in tissue engineering | |
| US20090220577A1 (en) | Moulded body for medically treating wounds | |
| CN102908649A (en) | Anti-adhesion fibrous membrane with hematostatic function | |
| CN107596455A (en) | Preparation method of the netted sacculus of antibiotic property degradable macromolecule and products thereof and application | |
| KR100464930B1 (en) | Barrier membrance for guided tissue regeneration and the preparation thereof | |
| Nicolae et al. | Polymer fibers in biomedical engineering | |
| CN109943974B (en) | Preparation method of nerve conduit material based on polyhydroxyalkanoate/gelatin electrospun nanofiber | |
| JP2009513290A (en) | Scleral buckling band and manufacturing method thereof | |
| WO2020077551A1 (en) | Composite barrier film and preparation method therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |