CN103610977B - The poultry preparation method of efficient eliminating pestilence and relieving toxicity medicine - Google Patents
The poultry preparation method of efficient eliminating pestilence and relieving toxicity medicine Download PDFInfo
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- CN103610977B CN103610977B CN201310641727.3A CN201310641727A CN103610977B CN 103610977 B CN103610977 B CN 103610977B CN 201310641727 A CN201310641727 A CN 201310641727A CN 103610977 B CN103610977 B CN 103610977B
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- medicine
- radix
- relieving toxicity
- eliminating pestilence
- gypsum fibrosum
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Abstract
The present invention relates to veterinary drug, be specifically related to a kind of eliminating pestilence and relieving toxicity medicine.Main purpose is to provide the eliminating pestilence and relieving toxicity process for preparing medicine that a kind of side effect is little.Eliminating pestilence and relieving toxicity medicine, formula is: Gypsum Fibrosum 60g, Radix Rehmanniae 30 45g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 35 45g, Cortex Moutan 20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g, Herba Lophatheri 25g；Said medicine is pulverized to obtain powder；Or be prepared as tablet after pulverizing further or pulverize as superfine powder.The present invention substantially reduces Gypsum Fibrosum consumption, reduces medicine cold, alleviates animal bodies infringement and side effect；But by suitably adjusting of other amounts of components is kept original efficacy of drugs；Determined curative effect, significantly, property of medicine milder.Eliminate Radix Scrophulariae, simplify pharmaceutical formulation；Reduce medicine material and processing cost.
Description
Technical field
The present invention relates to veterinary drug, be specifically related to a kind of eliminating pestilence and relieving toxicity medicine.
Background technology
Antipyretic and antitoxic powder is stupid the formulated recipe of teacher more than the Qing Dynasty famous epidemic febrile disease scholar, is loaded in written by it
" A View of Epidemic Febrile Diseases with Rashes " book.By Gypsum Fibrosum, Radix Rehmanniae, Cornu rhinocerotis, Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, know
Mother, Radix Paeoniae Rubra, Radix Platycodonis, Radix Scrophulariae, Cortex Moutan, Fructus Forsythiae, Folium Bambusae, Radix Glycyrrhizae composition, we by Baihu Tang,
Xijiao Dihuang Tang, Rhizoma Coptidis toxic materials clearing away decoction tripartite's addition or subtraction of changes form, and have clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body
Effect.Clinic is rather benefited from.
The party slightly adjusts through development and evolution, such as, substitute Cornu rhinocerotis with Cornu Bubali.2005 editions beasts
Antipyretic and antitoxic powder or the formula of tablet described in pharmacopeia be: Gypsum Fibrosum 120g, Radix Rehmanniae 30g, water
Cornu Bovis seu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 30g, Cortex Moutan 20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 25g, profound
Ginseng 25g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g, Herba Lophatheri 25g.By rule
Method of determining is pulverized as powder or is prepared as tablet further.
This medicine heat-clearing and toxic substances removing, purging fire and cooling blood, inhibitory anti-virus, can quickly kill pathogen, drug effect
Persistently, drug resistance strain it is not likely to produce.Improving immunity of organisms, induction body produces interferon, carries
High cytophagous phagocytic function.There is relieving diarrhea with astringents, bactericidal antiphlogistic, reparation intestinal, strengthen food
The function such as it is intended to.Play eliminating fire and detoxication, the effect of removing heat from blood effect；Cure mainly pyretic toxicity ecchymosis, unconsciousness due to high fever.
The most antipyretic removing heat from blood, treatment discharge function are obvious.It is particularly suited for: duck infectious slurry
Film inflammation, pig hyperpyrexia syndrome, pig streptococcicosis, swine eperythrozoonosis, bovine influenza,
Canine distemper etc..But, medicine is the most just put down except Radix Platycodonis, Radix Glycyrrhizae property, and remaining is all bitter cold Chinese medicine.Monarch
First of medical gypsum Great Cold especially.Though therefore the heat clearing away of this medicine, detoxify, treat warm discharge function obvious.
But it is three points of poison of medicine, the thing of still more complete anti-almost bitter cold, necessarily causes one to animal bodies
Fixed infringement and adverse effect.Mainly damage yang-energy, the impairment of QI-blood.And because medication is total with drug effect
It is to there is time difference, so drug dose always can be more than expense during clinical treatment warm disease,
So it is further exacerbated by side effect.After clinical manifestation mainly warm disease recovery from illness, animal shape disappears
Thin, inappetence, growth promoter slow down；Have with indigestion symptom.Have a strong impact on cultivation
Benefit.
Summary of the invention
The main object of the present invention is to provide the system of the little efficient eliminating pestilence and relieving toxicity medicine of a kind of side effect
Preparation Method.
The technical solution adopted in the present invention is: the preparation method of a kind of eliminating pestilence and relieving toxicity medicine, and it is special
Levy and be: formula is:
Gypsum Fibrosum 60g, Radix Rehmanniae 30-45g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 35-45g,
Cortex Moutan 20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, sweet
Grass 15g, Herba Lophatheri 25g.Get the raw materials ready the most according to the above ratio.
Then described medicine material is pulverized, sieves, is mixed to obtain powder.Smashing fineness, method etc.
Index is pressed the powder preparation method of States Pharmacopoeia specifications and is implemented.Or it is prepared as sheet by States Pharmacopoeia specifications method
Agent.Or pulverize further as superfine powder.Obviously, the formula of said medicine is pro rata,
Rather than it is only capable of the drug manufacture by this weight and use every time.
Usage and dosage: consumption per day: the 1g/kg such as horse, cattle, sheep, pig, rabbit, fowl every day.It is used in conjunction
3-5 day.
The Advantageous Effects of the present invention:
Substantially reduce Gypsum Fibrosum consumption, reduce medicine cold, alleviate animal bodies infringement and side effect；
But by suitably adjusting of other amounts of components is kept original efficacy of drugs；Determined curative effect, significantly,
Property of medicine milder.
Eliminate Radix Scrophulariae, simplify pharmaceutical formulation；Reduce medicine material and processing cost.
Detailed description of the invention
Provide below preferred embodiment so that those skilled in the art more clear and clear and definite this
Bright technical scheme and Advantageous Effects.But the enforcement of the present invention is not limited in following enforcement
Example.The formula simultaneously the most not proving the present invention is unique particular requirement, but allows reasonably etc.
With replacing and commercial production, the error of clinical practice.
Embodiment one
Formula:
Gypsum Fibrosum 60g, Radix Rehmanniae 30g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 45g, Cortex Moutan
20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g,
Herba Lophatheri 25g.
Medicine material is pulverized jointly, No. two excessively sieves, further micronizing are that superfine powder both obtains.
Embodiment two
Formula:
Gypsum Fibrosum 60g, Radix Rehmanniae 35g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 40g, Cortex Moutan
20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g,
Herba Lophatheri 25g.
Medicine material is jointly pulverized, crosses No. two sieves, is mixed to obtain powder.
Embodiment three
Formula:
Gypsum Fibrosum 60g, Radix Rehmanniae 45g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 35g, Cortex Moutan
20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g,
Herba Lophatheri 25g.
Medicine material is jointly pulverized, crosses No. two sieves, is mixed to obtain powder.
Embodiment four
Formula:
Gypsum Fibrosum 60g, Radix Rehmanniae 45g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 45g, Cortex Moutan
20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g,
Herba Lophatheri 25g.
Medicine material is jointly pulverized, crosses No. two sieves, is mixed to obtain powder.
Embodiment five
Formula:
Gypsum Fibrosum 60g, Radix Rehmanniae 45g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 45g, Cortex Moutan
20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g, Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g,
Herba Lophatheri 25g.
Medicine material pulverizes jointly, sieve, mix and be mixed together tabletting with excipient and obtain tablet.
Stability test
Materials and methods: the eliminating pestilence and relieving toxicity medicine of Example 1-5, according to " Chinese veterinary pharmacopoeia "
One annex medicine stability experimental technique of version in 2010 carries out hot and humid high light Acceleration study, presses
Commercially available back, at temperature 40 ± 2 DEG C, relative humidity 75 ± 5%, illumination 4500 ± 500LX
Medicine stability experimental box (Chongqing immortality experimental apparatus factory) is placed 6 months, during testing
1st, 2,3,6 the end of month are separately sampled once, carry out the indexs such as the character of medicine, content
Corresponding investigation.
Result: the eliminating pestilence and relieving toxicity medicine of the present invention after accelerated test 6 months, character, moisture content,
Contents of Main Components has no significant change, and has good stability, and complies fully with " Chinese veterinary pharmacopoeia " 2010
The year version quality index requirement to powder or tablet.Because of the improvement kind of the most existing medicine, therefore not
Verbose Listing shows stability experiment data again.
Eliminating pestilence and relieving toxicity is in veterinary clinic application effect
1. materials and methods
1.1 medicine
The eliminating pestilence and relieving toxicity medicine of the embodiment of the present invention 2,4,5.
Comparative example 1: commercially available antipyretic and antitoxic powder, purchased from animal pharmaceutical factory of Chongqing City.
1.2 case sources: technical staff gathers clinical because of pig popularity in the area such as Hechuan, Jiangjin
Cold, fever 368 example, infectious serositis in duck 200 example, chicken intestinal diorder are had loose bowels case 156 example, dog
Distemper 1080 example.Stochastic averagina is divided into four groups, and often group case load is identical；Respectively use embodiment 2,
4,5 and the Drug therapy of comparative example 1, other condition is identical.
1.3 case diagnosis: with natural cases according to epidemiology, clinical symptoms, pathological change,
Laboratory Diagnosed.
1.4 implementation processes: carried out case treatment by this seminar technical staff, and record test knot
Really.
Usage and dosage: natural cases is puddled nursing by feedstuff, use for oral administration；Every 1kg body weight 1g
Every day, disposably feed；Pig, dog are used in conjunction 5；Chicken, duck are used in conjunction 4.Observe after one week,
Pay a return visit and record the state of an illness.
1.5 results judge
Cure: be wholly absent by poultry disease after prescriptive procedure, number of times medication, spirit, body temperature,
Appetite recovers normal, and urine feces is normal.
Effective: substantially to disappear by poultry disease after prescriptive procedure, number of times medication, spirit, body temperature,
Appetite makes moderate progress, and urine feces is normal.
Invalid: not disappear by poultry disease after prescriptive procedure, number of times medication, sb.'s illness took a turn for the worse or death,
Body temperature, spirit, urine stool colour, character are abnormal.
Effective case statistical data includes the case cured, and effective percentage is the percentage ratio of effective case.
2. result:
The eliminating pestilence and relieving toxicity medicine of 2.1 present invention as can be seen from Table 1 has good therapeutic effect, right
Swine influenza heating, infectious serositis in duck, etc. effective percentage reach more than 95.0%, cure
Rate is all more than 90%.
Table 1: the eliminating pestilence and relieving toxicity clinical drug therapeutic effect statistical table of the present invention
Side effect and impact on animal are followed the trail of
The animal their early stage verifying above-mentioned clinical effectiveness starts until the bimestrial body weight of prognosis
The change that change is tracked, it is seen that the medicine of the present invention subtracts while effectively curing Animal diseases
Light side effect, beneficially animal recover and growth.
Claims (1)
1. the preparation method of an eliminating pestilence and relieving toxicity medicine, it is characterised in that: formula is:
Gypsum Fibrosum 60g, Radix Rehmanniae 45g, Cornu Bubali 60g, Rhizoma Coptidis 20g, Fructus Gardeniae 45g, Cortex Moutan 20g, Radix Scutellariae 25g, Radix Paeoniae Rubra 30g,
Rhizoma Anemarrhenae 30g, Fructus Forsythiae 30g, Radix Platycodonis 25g, Radix Glycyrrhizae 15g, Herba Lophatheri 25g；Said medicine is pulverized to obtain powder；Or after pulverizing
It is prepared as tablet further or pulverizes as superfine powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310641727.3A CN103610977B (en) | 2013-12-03 | 2013-12-03 | The poultry preparation method of efficient eliminating pestilence and relieving toxicity medicine |
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| CN201310641727.3A CN103610977B (en) | 2013-12-03 | 2013-12-03 | The poultry preparation method of efficient eliminating pestilence and relieving toxicity medicine |
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| CN103610977A CN103610977A (en) | 2014-03-05 |
| CN103610977B true CN103610977B (en) | 2016-08-17 |
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| CN201310641727.3A Expired - Fee Related CN103610977B (en) | 2013-12-03 | 2013-12-03 | The poultry preparation method of efficient eliminating pestilence and relieving toxicity medicine |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258019A (en) * | 2014-10-17 | 2015-01-07 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine composition for treating swine high fever syndromes and preparation method of composition |
| CN104352875A (en) * | 2014-12-03 | 2015-02-18 | 浙江汇特动物药业有限公司 | Scourge-clearing and toxin-vanquishing powder formula for veterinary use and process flow thereof |
| CN105148125A (en) * | 2015-08-26 | 2015-12-16 | 安徽天安动物药业有限公司 | Xiehuo Jiedu herbal medicament for livestock |
| CN107095046A (en) * | 2017-03-24 | 2017-08-29 | 合肥慧谷农业科技有限公司 | A kind of feed addictive for preventing and treating pig erythroderma and preparation method thereof |
| CN110448649A (en) * | 2019-08-13 | 2019-11-15 | 河南普华基因科技有限公司 | The preparation process of eliminating pestilence and relieving toxicity particle |
Citations (3)
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|---|---|---|---|---|
| CN101810791A (en) * | 2009-12-17 | 2010-08-25 | 河南省康星药业有限公司 | Preparation method of ultrafine powder for eliminating pestilence and relieving toxicity at normal temperature |
| CN102885992A (en) * | 2012-09-28 | 2013-01-23 | 河南亚卫动物药业有限公司 | Qingwen Baidu San solid dispersion and preparation method thereof |
| CN103202963A (en) * | 2013-04-11 | 2013-07-17 | 山东谊源动物药业有限公司 | Antipyretic and toxin removing powder for livestock |
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2013
- 2013-12-03 CN CN201310641727.3A patent/CN103610977B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810791A (en) * | 2009-12-17 | 2010-08-25 | 河南省康星药业有限公司 | Preparation method of ultrafine powder for eliminating pestilence and relieving toxicity at normal temperature |
| CN102885992A (en) * | 2012-09-28 | 2013-01-23 | 河南亚卫动物药业有限公司 | Qingwen Baidu San solid dispersion and preparation method thereof |
| CN103202963A (en) * | 2013-04-11 | 2013-07-17 | 山东谊源动物药业有限公司 | Antipyretic and toxin removing powder for livestock |
Non-Patent Citations (1)
| Title |
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| 清瘟败毒散;袁宗辉;《吉林畜牧兽医》;20030815(第07期);全文 * |
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Granted publication date: 20160817 Termination date: 20181203 |