CN103585255B - A kind of extraction separation method of Radix Astragali - Google Patents
A kind of extraction separation method of Radix Astragali Download PDFInfo
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Abstract
The present invention provides a kind of extraction separation methods of Radix Astragali, including：Step 1, Radix Astragali is taken, is decocted with water, filtering, collects filtrate；Step 2, alcohol precipitation after the filtrate concentration, is suspension, detaches liquid phase and solid phase, collect liquid phase and solid phase respectively；Step 3, the liquid phase is concentrated to give Radix Astragali extractum after further refining, and the solid phase is refined to be drying to obtain astragalus polyose, wherein the step 2 is using centrifuge separation liquid phase and solid phase.Centrifuge used is Horizontal spiral discharging centrifuge.Preparation method separating effect provided by the invention is high, can shorten working hour, reduce cost, and the degree of automation is higher, is suitable for the big production of industry.
Description
Technical field
The present invention relates to Chinese medicines, and in particular to a kind of extraction separation method of Radix Astragali.
Background technology
Radix Astragali is the root of leguminous herbaceous plant's astragalus mongolicus, Astragalus membranacus, has invigorating qi for strengthening superficies, profit water detumescence, eliminating toxic row
Purulence, myogenic and other effects.The medicinal of Radix Astragali has more than 2000 years history so far, modern study, Radix Astragali containing saponin, sucrose, polysaccharide,
The various trace elements such as a variety of amino acid, folic acid and selenium, zinc, copper.Have enhancing body's immunity, liver protection, diuresis, anti-aging,
Resisting stress, decompression and wide antibacterial action.
The compound Chinese medicinal preparation that QISHEN YIQI DIWAN (QSYQ) is made of Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng and dalbergia heartwood oil.In 2003
Year is ratified through state food and drug administration for treating coronary heart diseases and angina pectoris, small, convenient to take with dosage,
Dissolution rate is fast, can directly transmucosal absorbed into serum, bioavilability are high, curative effect is high and make without gastrointestinal irritation, without apparent poison is secondary
The characteristics of using.
Medicinal extract (hereinafter referred to as Radix Astragali extractum) obtained by Radix Astragali water extract-alcohol precipitation is the important component of QISHEN YIQI DIWAN,
Production technology is：It is decocted using water, after liquid is concentrated, high concentration ethanol is added and carries out alcohol precipitation, separation supernatant and precipitation, institute
It obtaining supernatant and is concentrated to give Radix Astragali extractum after further refining, what is be precipitated during alcohol precipitation is precipitated as astragalus polyose constituents,
It is needed to detach removal according to technological requirement, but since the precipitation particle size distribution range that alcohol precipitation is precipitated is wider, and high sugared high viscosity, because
How precipitation is effectively become the key for being related to Radix Astragali extractum quality by this with separation of the supernatant.
Currently, the common solid-liquid separating method in laboratory is mainly the following：
Gravitational settling：By the effect of earth gravitational field, using the density variation of particle and fluid, it is allowed to that opposite transport occurs
It moves and settles, is i.e. gravitational settling.
It is separated by filtration：Separation of solid and liquid is handled by way of filtering and intercepting.
It centrifuges：The method detached by means of centrifugal force, the substance for keeping proportion different.Since centrifuge can generate
Quite high angular speed makes centrifugal force be much larger than gravity, and then the suspended matter in solution is convenient to heavy drop.
But in the big production of actual industry, it has been found that：The heavy shallow lake particle size of Astragenol is smaller, after measured its
Grain size is mainly 10-100mm, and it is smaller with the density contrast of supernatant, therefore effect of settling is undesirable, stands 36 hours naturally
Afterwards, supernatant still cannot be separated effectively with precipitation, and supernatant accounts for total volume ratio less than 40%.Therefore natural subsidence separation method
It takes longer, and is unfavorable for supernatant liquid yield and supernatant quality control, method are infeasible.It was carried out using plate and frame filter press
Filter, it is mainly some monosaccharide and polysaccharide constituents to form sediment because Astragenol is heavy, and viscosity is higher, and quality is softer, with the progress of filtering,
Precipitation is gradually gathered on filter cloth, causes filter cloth to block quickly, and the rate of filtration slows down, and causes to take longer (about 13-15hr).Plate
Frame filter press cannot replace filter cloth in time, therefore this method is infeasible.
Invention content
The technical issues of to solve to encounter in actual industrialization, the present invention provides a kind of extraction separation sides of Radix Astragali
Method, including：
Step 1, Radix Astragali is taken, is decocted with water, filtering, collects filtrate；Step 2, alcohol precipitation after the filtrate concentration, to be suspended
Liquid detaches liquid phase and solid phase, collects liquid phase and solid phase respectively；Step 3, the liquid phase is concentrated to give Radix Astragali after further refining
Medicinal extract, the solid phase is refined to be drying to obtain astragalus polyose, wherein the step 2 is using centrifuge separation liquid phase and solid phase.
According to the present invention, the step 2 includes using Horizontal spiral discharging centrifuge, the Horizontal spiral discharging centrifuge
Solid phase in the suspension is deposited to the drum inner wall, institute by rotary drum and auger conveyor, the rotary drum by running at high speed
It is different from the rotary drum identical and rotating speed of steering to state auger conveyor, thus generates relative motion, drum inner wall will be deposited in
Solid phase and liquid phase separation.
Horizontal spiral discharging centrifuge is also known as horizontal spiral automatic discharge centrifuge, Horizontal settling screw discharging centrifugation
Machine, horizontal type screw settling centrifuge.Mainly by components groups such as rotary drum, auger conveyor (also known as screw feeder) and differential mechanisms
At.Rotary drum high speed rotation generates centrifugal force, the suspension in rotary drum is divided into two-phase, heavier solid phase is deposited in drum inner wall.
Auger conveyor is identical as rotary drum steering, and differential mechanism is used to control the speed discrepancy of auger conveyor and rotary drum, thus generates opposite
Movement, will be deposited in the solid phase and liquid phase separation of drum inner wall.
According to one of embodiment of the present invention, Horizontal spiral discharging centrifuge rotating speed is more than 2500r/min.
Preferably, Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4000r/min.
It is furthermore preferred that Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4800r/min.
According to one of embodiment of the present invention, the Horizontal spiral discharging centrifuge separation factor is more than 1200.
Preferably, the Horizontal spiral discharging centrifuge separation factor is more than or equal to 2800.
It is furthermore preferred that the Horizontal spiral discharging centrifuge separation factor is more than or equal to 3100.
The separation factor of centrifuge refer to suspension in bowl or emulsion in centrifugal force field it is suffered from
The ratio of the ratio of mental and physical efforts and its gravity, i.e. centrifugal acceleration and acceleration of gravity.Separation factor is indicated with Fr：
In formula：
N is centrifuge speed (r/min)
R is bowl radius (m)
G is acceleration of gravity (9.81m/s2)
Experiment shows：Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4000r/min or separation factor is more than or equal to
When 2800, the granule materials of 5 μ or more can be detached, meet the separation of solid and liquid requirement of Radix Astragali alcohol precipitation liquid, separating effect is ideal.
The method of the invention is in preparing pharmaceutical composition or the health products containing the Radix Astragali extractum and/or astragalus polyose
Application.
Radix Astragali extractum and/or astragalus polyose prepared by the extraction separation method of the present invention can be used as raw material more for preparing
Kind different pharmaceutical composition or health products.Described pharmaceutical composition or the dosage form of health products are selected from：It is tablet, sugar coated tablet, thin
Film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral solution, mouth containing agent, granule, electuary, pill,
Powder, paste, sublimed preparation, suspension, pulvis, solution, injection, suppository, ointment, emplastrum, creme, spray, drops
Or patch.
Application of the method for the invention in preparing QISHEN YIQI DIWAN.
Radix Astragali extractum prepared by the method for the invention is successfully used for the industrialized production of QISHEN YIQI DIWAN, automation
Degree is high, and good separating effect is at low cost, solves the problems, such as to shift from laboratory small-scale production to industrial big production.
Horizontal spiral discharge sedimentation centrifuge is particularly suitable for Radix Astragali and precipitates this high solid content high-viscosity material, solves more
Difficult problem is detached over year.
Preparation method separating effect provided by the invention is ideal, effectively removes impurity, improves product quality separating effect
It is high.This method the degree of automation is higher, and material need not replace the complex operations such as filter bag, and easy to clean, greatly with into going out
Reduce labor intensity, working hour can be shortened, reduce cost, be suitable for the big production of industry.
The additional aspect of the present invention and advantage will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Description of the drawings
The above-mentioned and/or additional aspect and advantage of the present invention will become from the following description of the accompanying drawings of embodiments
Obviously and it is readily appreciated that, wherein：
Fig. 1 Horizontal spiral discharging centrifuge structural schematic diagrams, wherein 1 being belt pulley, 2 being differential mechanism, 3 be rotary drum, 4 being spiral shell
Rotation conveyer, 5 be shell, 6 be belt pulley, 7 be feed pipe, 8 be engine base.
Specific implementation mode
Embodiments of the present invention are described below in detail, the embodiment is exemplary, and is only used for explaining the present invention,
And it is not construed as limiting the claims.
Test example difference centrifuge separating effect compares
We investigate centrifugal separation method, and according to factors such as separating effect, processing capacity, the degree of automation
Different centrifuges are evaluated.
1, tube centrifuge
Material：Radix Astragali precipitation solution about 5000L.
Experiment：After confirming that centrifuge instrument is normal, equipment is opened, after equipment stabilization, register instrument rotating speed (rotating speed
16000r/min) separation factor 15050, material are injected by bottom liquid inlet mouth, and centrifugal force forces feed liquid along drum inner wall to upstream
It is dynamic, and be layered because of the density contrast of feed liquid different component, supernatant is flowed out by upper part discharge port, and sampling carries out turbidimetric analysis turbidimetry.It is heavy
Starch is since centrifugation force effect is deposited on drum inner wall, and when object to be precipitated reaches certain thickness, arrestment removes the gred, and it is heavy to take
Shallow lake sample carries out determination of moisture.
As a result：
(1) separating effect：The turbidity of centrifugate is 80ntu after separation of solid and liquid, and the solid after equipment centrifugation is more dry, contains
Water is 25%, and supernatant accounting is reached for 58%, and separating effect is preferable.
(2) processing capacity and the degree of automation：Due to higher (the Solid content 20- of Radix Astragali precipitation solution solids content
30%), tube centrifuge rotary drum volume is small, after material enters rotary drum, is largely deposited on rotary drum in the short time, therefore needs
It wants frequent shutdown to remove the gred, increases the complexity of operation, influence production efficiency.In addition, Radix Astragali precipitation is relatively viscous, cleaning when ratio
It is more difficult.Therefore, tube centrifuge processing capacity and the degree of automation are poor.
2, disk centrifugal separator
Material：Radix Astragali precipitation solution about 4500L.
Experiment：After confirming that centrifuge instrument is normal, equipment is opened, after equipment stabilization, register instrument rotating speed (rotating speed
8000r/min) separation factor 6000, feed liquid flow to bottom of the drum by central upper portion feed inlet through charge pipe, by under disc base
Edge outflow tends to rotary drum space, and under effect of centrifugal force, the larger solid phase particles of proportion sink to rotatory drum wall in feed liquid, are sliding
Under rotary drum control, can be discharged through slag notch, liquid phase it is mobile to center after disk fully settle and by centripetal discharge pump discharge machine outside, tune
Whole charging, discharging speed make supernatant reach clarification, and supernatant is taken to measure turbidity, and precipitation is taken to measure moisture.
As a result：
(1) separating effect：Rotating speed 8000r/min, separation factor 6000, the turbidity 100ntu of centrifugate is left after separation of solid and liquid
The right side, separating effect are preferable.
(2) processing capacity and the degree of automation：Precipitation after centrifugation, water content are up to 60%, and supernatant accounting is only
45%, reason is the settling height that disk shortens solid particle, and the liquid in precipitation cannot be squeezed out fully, lead to supernatant liquid yield
It is smaller.Reduction of speed need to be carried out when discharging, due to levels of precipitate height, cause discharging frequent, it can not continuous production.In addition, Radix Astragali alcohol precipitation
Precipitation is relatively viscous, not easy cleaning.Therefore, disk centrifugal separator detach Astragalus Root P.E alcohol precipitation precipitation with supernatant when processing capacity and
The degree of automation is relatively low.
3, perforated wall centrifuge
Material：Radix Astragali precipitation solution about 4750L.
Experiment：After confirming that centrifuge instrument is normal, equipment is opened, after equipment stabilization, register instrument rotating speed, feed liquid is by upper
Portion is added, and under effect of centrifugal force, liquid phase passes through outside filter medium (filter bag) discharge machine, and solid formation is trapped in rotary drum, turns
It is scraped from centrifuge lower part and is discharged with material scraper after drum reduction of speed, replaced different pore size filter bag, carry out separating experiment respectively, take supernatant
Liquid measures turbidity, and precipitation is taken to measure moisture.
As a result：
The separating effect of 1 perforated wall centrifuge of table compares
(1) separating effect：Using 200 mesh (74 μm of aperture) filter bag carry out centrifugal filtration, centrifuge speed 1000r/min,
Separation factor 698, the precipitation water content after centrifugation are 30%, centrifugate turbidity 257ntu, and centrifugate turbidity is higher.Replace 600
Mesh filter bag (25 μm of aperture), centrifugate turbidity is declined (190ntu).Precipitation water content after centrifugation is 30% or so.It replaces
After 1000 mesh filter bags, centrifugate turbidity is 170ntu, still slightly higher；Precipitation water content after centrifugation is 30% or so.Therefore, it filters
Formula centrifuge, which uses, is more than or equal to 600 mesh filter bags, and when being especially greater than equal to 1000 mesh filter bag, separating effect is higher.But it is yellow
Stilbene precipitation particle size distribution range is looser (1.259~831.764mm), and filter bag can only intercept partly precipitated, unavoidably there is part
Particle penetrates, and influences separating effect.
(2) the degree of automation：Centrifugal process can realize continuous feed, automatic discharging, so as to continuous production.But
It needs manually to be cleaned after filter bag use, is unfavorable for realizing automation control.
(3) processing capacity：Since to sink precipitation capacity more for Astragenol, the very thick beds of precipitation are quickly formed on filter cloth, are needed timely
Carry out slagging-off discharging；After automatic discharging, fine and close sedimentary is formed on filter bag since precipitation is relatively sticked to, causes filter cloth to block, mistake
Filtering velocity degree slows down.
4, horizontal spiral discharge sedimentation centrifuge
Material：Radix Astragali precipitation solution about 5200L.
Experiment：After confirming that centrifuge instrument is normal, equipment is opened, after equipment stabilization, material is added, using spiral and is turned
The solid phase for being deposited on drum inner wall is pushed to the discharge of rotary drum small end exit by bulging relative motion, and clear liquid after separation is from centrifuge
The other end is discharged.Adjustment equipment rotating speed and charging rate, take supernatant to measure turbidity respectively, and precipitation measures moisture, observation separation
Effect.
As a result：
The separating effect of 2 horizontal spiral discharge sedimentation centrifuge of table compares
(1) separating effect：When rotating speed is more than 2500r/min, separation factor is more than or equal to more than 1200, especially rotating speed
When 4000r/min or separation factor are more than or equal to 2800, the granule materials of 5 μ or more can be detached, Radix Astragali alcohol precipitation liquid is met
Separation of solid and liquid requirement, separating effect is more satisfactory.
(2) processing capacity and the degree of automation：The degree of automation is higher, it can be achieved that continuous feed, continuous discharge.Instrument is just
In cleaning, automatic on-line cleaning can be carried out.
Embodiment one
The Radix Astragali 2400kg for taking crushing is decocted 2 times with water, and every time plus 6 times are measured water, are extracted 2 hours, 1 hour, are merged successively
Filtrate is collected in extracting solution, filtering；Filtrate is concentrated into 2000L, adds 95% ethyl alcohol that determining alcohol is made to be 60%, is unloaded using horizontal spiral
Expect sedimentation centrifuge (roller diameter 350mm, rotary drum length 1460, rotating speed 2500r/min, separation factor 1225), separating liquid
Phase and solid phase；Gained liquid phase is concentrated to give Radix Astragali extractum after further refining, and gained solid phase is further dried more up to Radix Astragali
Sugar.
Embodiment two
The Radix Astragali 2400kg for taking crushing is decocted 2 times with water, and every time plus 6 times are measured water, are extracted 2 hours, 1 hour, are merged successively
Filtrate is collected in extracting solution, filtering；Filtrate is concentrated into 2500L, adds 95% ethyl alcohol that determining alcohol is made to be 60%, is unloaded using horizontal spiral
Expect sedimentation centrifuge (roller diameter 350mm, rotary drum length 1460, rotating speed 2700r/min, separation factor 1428), separating liquid
Phase and solid phase；Gained liquid phase is concentrated to give Radix Astragali extractum after further refining, and gained solid phase is further dried more up to Radix Astragali
Sugar.
Embodiment three
The Radix Astragali 2400kg for taking crushing is decocted 2 times with water, and every time plus 6 times are measured water, are extracted 2 hours, 1 hour, are merged successively
Filtrate is collected in extracting solution, filtering；Filtrate is concentrated into 2500L, adds 95% ethyl alcohol that determining alcohol is made to be 60%, is unloaded using horizontal spiral
Expect sedimentation centrifuge (roller diameter 220mm, rotary drum length 930, rotating speed 4800r/min, separation factor 2833), detaches liquid phase
With solid phase；Gained liquid phase is concentrated to give Radix Astragali extractum after further refining, and gained solid phase is further dried up to astragalus polyose.
Example IV
The Radix Astragali 2400kg for taking crushing is decocted 2 times with water, and respectively plus 6 times are measured water, are extracted 2 hours, 1 hour, are merged successively
Filtrate is collected in extracting solution, filtering；Filtrate is concentrated into 2500L, adds 95% ethyl alcohol that determining alcohol is made to be 60%, is unloaded using horizontal spiral
Expect sedimentation centrifuge (roller diameter 350mm, rotary drum length 1460, rotating speed 4000r/min, separation factor 3136), separating liquid
Phase and solid phase；Gained liquid phase is concentrated to give Radix Astragali extractum after further refining, and gained solid phase is further dried more up to Radix Astragali
Sugar.
Embodiment five
The Radix Astragali 1200kg for taking crushing is decocted 2 times with water, and every time plus 6 times are measured water, are extracted 2 hours, 1 hour, are merged successively
Filtrate is collected in extracting solution, filtering；Filtrate is concentrated into 1250L, adds 95% ethyl alcohol that determining alcohol is made to be 60%, is unloaded using horizontal spiral
Expect sedimentation centrifuge (roller diameter 200mm, rotary drum length 600, rotating speed 5800r/min, separation factor 3760), detaches liquid phase
With solid phase；Gained liquid phase is concentrated to give Radix Astragali extractum after further refining, and gained solid phase is further dried up to astragalus polyose.
Embodiment six
The Radix Astragali 2400kg for taking crushing is decocted 2 times with water, and every time plus 6 times are measured water, are extracted 2 hours, 1 hour, are merged successively
Filtrate is collected in extracting solution, filtering；Filtrate is concentrated into 2500L, adds 95% ethyl alcohol that determining alcohol is made to be 60%, is unloaded using horizontal spiral
Expect sedimentation centrifuge (roller diameter 350mm, rotary drum length 1460, rotating speed 4000r/min, separation factor 3136), separating liquid
Phase and solid phase；Gained liquid phase is concentrated to give Radix Astragali extractum after further refining, and gained solid phase is further dried more up to Radix Astragali
Sugar.
Embodiment seven
Take Radix Astragali 1800kg, Radix Salviae Miltiorrhizae 900kg, Radix Notoginseng 180kg, dalbergia heartwood oil 12kg, auxiliary material polyethylene glycol-6000 760kg.It will
Radix Salviae Miltiorrhizae, Radix Notoginseng through crushing, water decoct 2 times, and every time plus 7 times are measured water, 2 hours every time, merge decoction liquor, filtration, filtrate concentration
To 900ml, 95% ethyl alcohol is added, determining alcohol is made to reach 70%, stands 12~24 hours, filtration recycles ethyl alcohol, is condensed into Radix Salviae Miltiorrhizae
Radix Notoginseng medicinal extract；It by the Radix Astragali through crushing, adds water to cook 2 times, every time plus 6 times are measured water, are extracted 2 hours, 1 hour successively, are merged filter
Liquid when being concentrated into 1500L or so, adds 95% ethyl alcohol that determining alcohol is made to be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotary drum
Diameter 350mm, rotary drum length 1460, rotating speed 3500-4000r/min, separation factor 2401-3136) liquid phase and solid phase are detached,
Gained liquid phase is concentrated to give Radix Astragali extractum after further refining (drying of gained solid phase is another to be used)；Dalbergia wood is taken, adds 5 times of amount water, returns
Stream extraction 5 hours, collects volatile oil；It takes above-mentioned Salvia miltiorrhiza and Panax notoginseng medicinal extract, Radix Astragali extractum and polyethylene glycol-6000, water-bath to dissolve, changes
After even, dalbergia wood volatile oil is added, mixing moves in pill dripping machine, and 2,100,000 bags of dripping pills are made.
Embodiment eight
Take Radix Astragali 1800kg, Radix Salviae Miltiorrhizae 900kg, Radix Notoginseng 180kg, dalbergia heartwood oil 12kg, auxiliary material polyethylene glycol-6000 760kg.It will
Radix Notoginseng, Radix Salviae Miltiorrhizae through crushing, water decoct 2 times, and every time plus 7 times are measured water, 2 hours every time, merge decoction liquor, filtration, filtrate concentration
To 900ml, 95% ethyl alcohol is added, determining alcohol is made to reach 70%, stands 12~24 hours, filtration recycles ethyl alcohol, is condensed into Radix Salviae Miltiorrhizae
Radix Notoginseng medicinal extract；It by Radix Astragali, adds water to cook 2 times, every time plus 6 times are measured water, are extracted 2 hours, 1 hour successively, merging filtrate is concentrated into
When 1500L or so, adds 95% ethyl alcohol that determining alcohol is made to be 60%, use horizontal spiral discharge sedimentation centrifuge (roller diameter
220mm, rotary drum length 930, rotating speed 4000-4800r/min, separation factor 1971-2833) detach liquid phase and solid phase, gained
Liquid phase is concentrated to give Radix Astragali extractum after further refining (drying of gained solid phase is another to be used)；Dalbergia wood is taken, 5 times of amount water, reflux is added to carry
It takes 5 hours, collects volatile oil；It takes above-mentioned Salvia miltiorrhiza and Panax notoginseng medicinal extract, Radix Astragali extractum and polyethylene glycol-6000, water-bath to dissolve, changes even
Afterwards, dalbergia wood volatile oil is added, mixing moves in pill dripping machine, and 2,100,000 bags of dripping pills are made.
Embodiment nine
Six gained Radix Astragali extractum 450g of Example and different malt 670g, glucose 200g, strawberry fruit powder 40g, strawberry are fragrant
Smart 10g, crospovidone 10g, magnesium stearate 10g, the above raw material is sufficiently mixed softwood is made with ethanol in proper amount solution after, system
Grain, 60 DEG C of forced air dryings make 1000, and whole grain is tabletted to get oral disnitegration tablet.
Embodiment ten
Six gained astragalus polyose 25% of Example, xylitol 48%, maltose 6%, 14% cyclodextrin, 7% calcium lactate
Radix Astragali soft capsule is prepared according to soft capsule common process.
Embodiment 11
Six gained astragalus polyose 5.0g of embodiment and 10g xylitols, 0.8g oligoisomaltoses, 10g antierythrites, 0.05
Aspartame, remaining is water, and astragalus oral liquid is made.
Embodiment 12
Four gained astragalus polyose 99.9% of Example, is added 0.1% dextrin after mixing wherein, pelletizes, dry
Up to Astragalus granules or electuary.
Embodiment 13
Example four gained Radix Astragali extractum 58g, lotus leaf 29g, Siraitia grosvenorii 13g, which are uniformly mixed, is made composition, respectively mistake
16 mesh sieve, 22 mesh sieve, take middle section to dispense.Add outer packing to get tea bag.
Embodiment 14
Example four gained astragalus polyose 58g, mulberry leaf 28g, fruit of Chinese wolfberry 13g, which are uniformly mixed, is made composition, respectively mistake
16 mesh sieve, 22 mesh sieve, take middle section to dispense.Add outer packing to get tea bag.
Embodiment 15
Four gained astragalus polyose 58g of Example, flour 180g, butter 90g are uniformly mixed and are divided into fritter, round as a ball,
By flat, decoration, it is baked biscuit to obtain the final product.
Embodiment 16
Four gained Radix Astragali extractum 58g of Example, flour 180g, butter 90g, white granulated sugar 30g, milk 25g are uniformly mixed,
Mold is added, toasts up to cake.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. a kind of extraction separation method of Radix Astragali, including：
Step 1, Radix Astragali is taken, is decocted with water, filtering, collects filtrate；Step 2, alcohol precipitation after the filtrate concentration, is suspension, point
Chaotropic phase and solid phase collect liquid phase and solid phase respectively；Step 3, the liquid phase is concentrated to give Radix Astragali extractum after further refining,
The solid phase is refined to be drying to obtain astragalus polyose, wherein described
For step 2 using Horizontal spiral discharging centrifuge separation liquid phase and solid phase, centrifuge speed is more than 4000r/min, separation because
Number is more than 2800.
2. method according to claim 1, which is characterized in that the Horizontal spiral discharging centrifuge rotating speed is more than or equal to
4800r/min。
3. method according to claim 1, which is characterized in that the Horizontal spiral discharging centrifuge separation factor is more than or equal to
3100。
4. claims 1 to 3 any one the method is preparing the pharmaceutical composition containing the Radix Astragali extractum and/or astragalus polyose
Application in object or health products.
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