CN103585255A - Extracting and separating method of radix astragali - Google Patents
Extracting and separating method of radix astragali Download PDFInfo
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Abstract
The invention discloses an extracting and separating method of radix astragali. The method comprises a step 1 of decocting and boiling the radix astragali with water, filtering and collecting filtrate; a step 2 of concentrating the filtrate, precipitating by using an alcohol to form a suspension, separating a liquid phase and a solid phase, and collecting the liquid phase and the solid phase separately; and a step 3 of concentrating the liquid phase after the liquid phase is further purified to obtain radix astragali extract, and purifying and drying the solid phase to obtain radix astragali polysaccharides, wherein the step 2 adopts a centrifuge to separate the liquid phase and the solid phase. The centrifuge is a horizontal type helical-conveyer centrifugal. The method has high separating effects, and is capable of shortening labor-hour and reducing the cost. The method is high in automation degree and suitable for industrial production in a large scale.
Description
Technical field
The present invention relates to Chinese medicine, be specifically related to a kind of extraction separation method of the Radix Astragali.
Background technology
The Radix Astragali is the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali, has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The medicinal history of existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
The compound Chinese medicinal preparation that QISHEN YIQI DIWAN (QSYQ) is comprised of the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng and Lignum Dalbergiae Odoriferae oil.In 2003 Nian Jing state food and drug administration approvals, be used for the treatment of coronary heart diseases and angina pectoris, have that dosage is little, taking convenience, dissolution rate are fast, directly through mucous membrane absorbed into serum, bioavailability is high, curative effect is high and without gastrointestinal irritation, without the feature of obvious toxic-side effects.
The important component part that Radix Astragali water extract-alcohol precipitation gained extractum (hereinafter referred to as Radix Astragali extractum) is QISHEN YIQI DIWAN, its production technology is: adopt decocting to boil, medicinal liquid is after concentrated, add high concentration ethanol to carry out precipitate with ethanol, separation of supernatant and precipitation, gained supernatant is the concentrated Radix Astragali extractum that obtains after further refining, that in precipitate with ethanol process, separates out is precipitated as astragalus polysaccharides constituents, according to technological requirement, need separated removal, but because the precipitation particle size distribution range that precipitate with ethanol is separated out is wider, and high sugared high viscosity, therefore how effectively precipitation and supernatant to be separated into the key that is related to Radix Astragali extractum quality.
At present, the solid-liquid separating method that laboratory is conventional mainly contains following several:
Gravitational settling: rely on the effect of earth gravitational field, utilize the density variation of granule and fluid, make it to occur relative motion and sedimentation, i.e. gravitational settling.
Isolated by filtration: the mode of tackling by filtration is processed solid-liquid separation.
Centrifugalize: by means of centrifugal force, make the different material of proportion carry out separated method.Because centrifuge can produce quite high angular velocity, make centrifugal force much larger than gravity, so the float in solution is convenient to heavy falling.
But in the large production of actual industry, we find: the heavy shallow lake of (+)-Astragenol particulate matter particle diameter is less, its particle diameter is mainly 10-100mm after measured, and the density contrast of itself and supernatant is less, therefore effect of settling is undesirable, naturally after standing 36 hours, supernatant still can not effectively separate with precipitation, and supernatant accounts for cumulative volume ratio less than 40%.Therefore natural subsidence separation method is consuming time longer, and is unfavorable for supernatant yield and supernatant quality control, and method is infeasible.Adopt filter press to filter, because the heavy shallow lake of (+)-Astragenol is mainly some monosaccharide and polysaccharide composition, viscosity is higher, quality is softer, and along with the carrying out of filtering, precipitation is gathered on filter cloth gradually, cause very soon filter cloth to stop up, the rate of filtration slows down, and causes grow (about 13-15hr) consuming time.Filter press can not be changed filter cloth in time, so this method is infeasible.
Summary of the invention
For solving the technical problem running in actual industrialization, the invention provides a kind of extraction separation method of the Radix Astragali, comprising:
Step 1, gets the Radix Astragali, and water decocts, filters, and collects filtrate; Step 2, precipitate with ethanol after described filtrate is concentrated, is suspension, separated liquid phase and solid phase, collect respectively liquid phase and solid phase; Step 3, described liquid phase is the concentrated Radix Astragali extractum that obtains after further refining, the refining astragalus polysaccharides that is drying to obtain of described solid phase, wherein said step 2 adopts the separated liquid phase of centrifuge and solid phase.
According to the present invention, described step 2 adopts Horizontal spiral discharging centrifuge, described Horizontal spiral discharging centrifuge comprises rotary drum and auger conveyor, described rotary drum is deposited to described drum inner wall by running up by solid phase in described suspension, described auger conveyor turns to identical from described rotary drum and rotating speed is different, produce thus relative motion, will be deposited in solid phase and the liquid phase separation of drum inner wall.
Horizontal spiral discharging centrifuge is called again horizontal spiral automatic discharge centrifuge, Horizontal settling screw conveyer centrifugal, horizontal type screw settling centrifuge.Mainly by parts such as rotary drum, auger conveyor (being called again screw feeder) and differential mechanisms, formed.Rotary drum high speed rotating produces centrifugal force, the suspension in rotary drum is divided into biphase, heavier solid phase and is deposited in drum inner wall.It is identical that auger conveyor and rotary drum turn to, and differential mechanism, for controlling the speed discrepancy of auger conveyor and rotary drum, produces relative motion thus, will be deposited in solid phase and the liquid phase separation of drum inner wall.
According to one of embodiment of the present invention, Horizontal spiral discharging centrifuge rotating speed is greater than 2500r/min.
Preferably, Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4000r/min.
Preferred, Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4800r/min.
According to one of embodiment of the present invention, described Horizontal spiral discharging centrifuge separation factor is greater than 1200.
Preferably, described Horizontal spiral discharging centrifuge separation factor is more than or equal to 2800.
Preferred, described Horizontal spiral discharging centrifuge separation factor is more than or equal to 3100.
The separation factor of centrifuge refers to suspension in bowl or emulsion suffered centrifugal force and the ratio of its gravity, the i.e. ratio of centrifugal acceleration and acceleration of gravity in centrifugal force field.Separation factor represents with Fr:
In formula:
N is centrifuge speed (r/min)
R is bowl radius (m)
G is acceleration of gravity (9.81m/s
2)
Experiment shows: Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4000r/min, or separation factor is more than or equal at 2800 o'clock, and granule materials that can be more than separated 5 μ, meets the solid-liquid separation requirement of Radix Astragali precipitate with ethanol medicinal liquid, and separating effect is desirable.
The method of the invention contains described Radix Astragali extractum and/or the pharmaceutical composition of astragalus polysaccharides or the application in health product in preparation.
Radix Astragali extractum prepared by extraction separation method of the present invention and/or astragalus polysaccharides can be used as raw material and are used for preparing multiple different pharmaceutical composition or health product.The dosage form of described pharmaceutical composition or health product is selected from: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop or patch.
The application of the method for the invention in preparation QISHEN YIQI DIWAN.
Radix Astragali extractum prepared by the method for the invention is successfully for the suitability for industrialized production of QISHEN YIQI DIWAN, and automaticity is high, good separating effect, and cost is low, has solved and from laboratory small-scale production to industry, has produced greatly a difficult problem for transfer.
Horizontal spiral discharge sedimentation centrifuge is particularly suitable for this high solid content high-viscosity material of Radix Astragali precipitation, has solved a difficult problem for separation difficulty for many years.
Preparation method separating effect provided by the invention is desirable, effectively removes impurity, has improved product quality separating effect high.The method automaticity is higher, and material, with entering with going out, does not need to change the complex operations such as filter bag, and easy to clean, has reduced greatly labor intensity, can shorten man-hour, reduces costs, and is applicable to the large production of industry.
The aspect that the present invention is additional and advantage in the following description part provide, and part will become obviously from the following description, or recognize by practice of the present invention.
Accompanying drawing explanation
Above-mentioned and/or additional aspect of the present invention and advantage will become from the following description of the accompanying drawings of embodiments and obviously and easily understand, wherein:
Fig. 1 Horizontal spiral discharging centrifuge structural representation, wherein 1 is that belt pulley, 2 is that differential mechanism, 3 is that rotary drum, 4 is that auger conveyor, 5 is that shell, 6 is that belt pulley, 7 is that feed pipe, 8 is support.
The specific embodiment
Describe embodiments of the present invention below in detail, described embodiment is exemplary, only for explaining the present invention, and can not be interpreted as limitation of the present invention.
The different centrifuge separating effect comparisons of test example
We investigate centrifugal separation method, and evaluate according to the different centrifuges of the factors such as separating effect, disposal ability, automaticity.
1, tube centrifuge
Material: the about 5000L of Radix Astragali alcohol deposit fluid.
Experiment: after confirming that centrifuge instrument is normal, opening device, after equipment is stable, grapher rotating speed (rotating speed 16000r/min) separation factor 15050, material is injected by bottom liquid inlet mouth, and centrifugal force forces feed liquid upwards to flow along drum inner wall, and because of the density contrast layering of feed liquid different component, supernatant is flowed out by upper part discharge port, and turbidimetric analysis turbidimetry is carried out in sampling.Precipitate is because centrifugal action is deposited on drum inner wall, and when precipitate reaches certain thickness, arrestment removes the gred, and gets deposit sample and carries out determination of water.
Result:
(1) separating effect: after solid-liquid separation, the turbidity of centrifugal liquid is 80ntu, and the solid after this equipment is centrifugal is more dry, and water content is 25%, and supernatant accounting is reached for 58%, and separating effect is better.
(2) disposal ability and automaticity: because Radix Astragali precipitate with ethanol is liquid-solid containing thing content higher (admittedly being 20-30% containing thing); tube centrifuge rotary drum volume is little; material enters after rotary drum; in short time, be deposited on rotary drum in a large number; therefore need frequent shutdown to remove the gred; the complexity that has increased operation, affects production efficiency.In addition, Radix Astragali precipitation is more sticky, more difficult during cleaning.Therefore, tube centrifuge disposal ability and automaticity are poor.
2, disk centrifugal separator
Material: the about 4500L of Radix Astragali alcohol deposit fluid.
Experiment: after confirming that centrifuge instrument is normal, opening device, after equipment is stable, grapher rotating speed (rotating speed 8000r/min) separation factor 6000, feed liquid flow to bottom of the drum by central upper portion charging aperture through charge pipe, by disc base lower edge, flow out trend rotary drum space, under effect of centrifugal force, the solid phase particles that in feed liquid, proportion is larger sinks to rotatory drum wall, under slip rotary drum is controlled, can discharge through slag notch, liquid phase through the backward center of the abundant sedimentation of video disc move and by centripetal pump discharge machine outside, adjust charging, discharging speed, make supernatant reach clarification, get supernatant and measure turbidity, get precipitation and measure moisture.
Result:
(1) separating effect: rotating speed 8000r/min, separation factor 6000, the turbidity 100ntu of centrifugal liquid left and right after solid-liquid separation, separating effect is better.
(2) disposal ability and automaticity: the precipitation after centrifugal, water content is up to 60%, and supernatant accounting is only 45%, and former because video disc shortens the settling height of solid particle, the medicinal liquid in precipitation can not fully be extruded, and causes supernatant yield less.During discharging, need carry out reduction of speed, because levels of precipitate is high, cause discharging frequent, cannot produce continuously.In addition, the heavy shallow lake of (+)-Astragenol is more sticky, not easy cleaning.Therefore, disk centrifugal separator separated Radix Astragali extract precipitate with ethanol precipitation during with supernatant disposal ability and automaticity lower.
3, perforated wall centrifuge
Material: the about 4750L of Radix Astragali alcohol deposit fluid.
Experiment: after confirming that centrifuge instrument is normal, opening device, after equipment is stable, grapher rotating speed, feed liquid is added by top, and under effect of centrifugal force, liquid phase is through outside filter medium (filter bag) discharge machine, solid formation is trapped in rotary drum, after rotary drum reduction of speed, with material scraper, scrape from centrifuge bottom and discharge, change different pore size filter bag, carry out respectively separating experiment, get supernatant and measure turbidity, get precipitation and measure moisture.
Result:
The separating effect comparison of table 1 perforated wall centrifuge
(1) separating effect: adopt 200 orders (aperture 74 μ m) filter bag to carry out centrifugal filtration, centrifuge speed 1000r/min, separation factor 698, the precipitation water content after centrifugal is 30%, centrifugal liquid turbidity 257ntu, centrifugal liquid turbidity is higher.Change 600 order filter bags (aperture 25 μ m), centrifugal liquid turbidity decline to some extent (190ntu).Precipitation water content after centrifugal is 30% left and right.Change after 1000 order filter bags, centrifugal liquid turbidity is 170ntu, still slightly high; Precipitation water content after centrifugal is 30% left and right.Therefore, perforated wall centrifuge uses and is more than or equal to 600 order filter bags, and while being especially more than or equal to 1000 order filter bag, separating effect is higher.But, Radix Astragali precipitation particle size distribution range wider (1.259～831.764mm), filter bag can only be tackled partly precipitated, unavoidably has part granule to see through, and affects separating effect.
(2) automaticity: centrifugal process can be realized continuous feed, automatic discharging, thus can produce continuously.But filter bag needs manually to clean after using, be unfavorable for realizing automatization and control.
(3) disposal ability: because the heavy precipitation capacity of (+)-Astragenol is many, form very soon the very thick beds of precipitation on filter cloth, discharging in time need remove the gred; After automatic discharging, because precipitation is bonded on filter bag, form fine and close sedimentary deposit, cause filter cloth to stop up, the rate of filtration slows down.
4, horizontal spiral discharge sedimentation centrifuge
Material: the about 5200L of Radix Astragali alcohol deposit fluid.
Test: after confirming that centrifuge instrument is normal, opening device, after equipment is stable, adds material, utilize the relative motion of spiral and rotary drum that the solid phase that is deposited on drum inner wall is pushed to the discharge of rotary drum small end exit, the clear liquid after separation is discharged from the centrifuge other end.Conditioning equipment rotating speed and charging rate, get respectively supernatant and measure turbidity, and precipitation is measured moisture, observes separating effect.
Result:
The separating effect comparison of table 2 horizontal spiral discharge sedimentation centrifuge
(1) separating effect: when rotating speed is greater than 2500r/min, separation factor is greater than 1200, and especially rotating speed is more than or equal to 4000r/min, or separation factor is more than or equal at 2800 o'clock, granule materials that can be more than separated 5 μ, meets the solid-liquid separation requirement of Radix Astragali precipitate with ethanol medicinal liquid, and separating effect is more satisfactory.
(2) disposal ability and automaticity: automaticity is higher, can realize continuous feed, continuous discharge.Instrument is convenient to clean, and can carry out automatic on-line cleaning.
Embodiment mono-
Get the Radix Astragali 2400kg of pulverizing, water decocts 2 times, adds 6 times of water gagings at every turn, extracts successively 2 hours, 1 hour, and merge extractive liquid,, filters, and collects filtrate; Filtrate is concentrated into 2000L, and adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotating speed is 2500r/min, separation factor 1225 for roller diameter 350mm, rotary drum length 1460), separated liquid phase and solid phase; Gained liquid phase is concentrated after further refining obtains Radix Astragali extractum, and gained solid phase is further drying to obtain astragalus polysaccharides.
Embodiment bis-
Get the Radix Astragali 2400kg of pulverizing, water decocts 2 times, adds 6 times of water gagings at every turn, extracts successively 2 hours, 1 hour, and merge extractive liquid,, filters, and collects filtrate; Filtrate is concentrated into 2500L, and adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotating speed is 2700r/min, separation factor 1428 for roller diameter 350mm, rotary drum length 1460), separated liquid phase and solid phase; Gained liquid phase is concentrated after further refining obtains Radix Astragali extractum, and gained solid phase is further drying to obtain astragalus polysaccharides.
Embodiment tri-
Get the Radix Astragali 2400kg of pulverizing, water decocts 2 times, adds 6 times of water gagings at every turn, extracts successively 2 hours, 1 hour, and merge extractive liquid,, filters, and collects filtrate; Filtrate is concentrated into 2500L, and adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotating speed is 4800r/min, separation factor 2833 for roller diameter 220mm, rotary drum length 930), separated liquid phase and solid phase; Gained liquid phase is concentrated after further refining obtains Radix Astragali extractum, and gained solid phase is further drying to obtain astragalus polysaccharides.
Embodiment tetra-
Get the Radix Astragali 2400kg of pulverizing, water decocts 2 times, adds respectively 6 times of water gagings, extracts successively 2 hours, 1 hour, and merge extractive liquid,, filters, and collects filtrate; Filtrate is concentrated into 2500L, and adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotating speed is 4000r/min, separation factor 3136 for roller diameter 350mm, rotary drum length 1460), separated liquid phase and solid phase; Gained liquid phase is concentrated after further refining obtains Radix Astragali extractum, and gained solid phase is further drying to obtain astragalus polysaccharides.
Embodiment five
Get the Radix Astragali 1200kg of pulverizing, water decocts 2 times, adds 6 times of water gagings at every turn, extracts successively 2 hours, 1 hour, and merge extractive liquid,, filters, and collects filtrate; Filtrate is concentrated into 1250L, and adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotating speed is 5800r/min, separation factor 3760 for roller diameter 200mm, rotary drum length 600), separated liquid phase and solid phase; Gained liquid phase is concentrated after further refining obtains Radix Astragali extractum, and gained solid phase is further drying to obtain astragalus polysaccharides.
Embodiment six
Get the Radix Astragali 2400kg of pulverizing, water decocts 2 times, adds 6 times of water gagings at every turn, extracts successively 2 hours, 1 hour, and merge extractive liquid,, filters, and collects filtrate; Filtrate is concentrated into 2500L, and adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (rotating speed is 4000r/min, separation factor 3136 for roller diameter 350mm, rotary drum length 1460), separated liquid phase and solid phase; Gained liquid phase is concentrated after further refining obtains Radix Astragali extractum, and gained solid phase is further drying to obtain astragalus polysaccharides.
Embodiment seven
Get Radix Astragali 1800kg, Radix Salviae Miltiorrhizae 900kg, Radix Notoginseng 180kg, Lignum Dalbergiae Odoriferae oil 12kg, adjuvant PEG-4000 760kg.By Radix Salviae Miltiorrhizae, Radix Notoginseng through pulverizing, decocting boils 2 times, adds 7 times of water gagings at every turn, each 2 hours, merges decoction liquor, filter, filtrate is concentrated into 900ml, adds 95% ethanol, makes determining alcohol reach 70%, standing 12～24 hours, filter, reclaim ethanol, be condensed into Salvia miltiorrhiza and Panax notoginseng extractum; By the Radix Astragali through pulverizing, decoct with water 2 times, add 6 times of water gagings at every turn, extract successively 2 hours, 1 hour, merging filtrate, while being concentrated into 1500L left and right, adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (roller diameter 350mm, rotary drum length 1460, rotating speed is 3500-4000r/min, separation factor 2401-3136) separated liquid phase and solid phase, gained liquid phase is the concentrated Radix Astragali extractum (dry another the using of gained solid phase) that obtains after further refining; Get Lignum Dalbergiae Odoriferae, add 5 times of water gagings, reflux, extract, 5 hours, collects volatile oil; Get above-mentioned Salvia miltiorrhiza and Panax notoginseng extractum, Radix Astragali extractum and PEG-4000, water-bath is dissolved, change even after, add volatile oil of Lignum Dalbergiae Odoriferae, mix, move in pill dripping machine, make 2,100,000 bags of drop pill.
Embodiment eight
Get Radix Astragali 1800kg, Radix Salviae Miltiorrhizae 900kg, Radix Notoginseng 180kg, Lignum Dalbergiae Odoriferae oil 12kg, adjuvant PEG-4000 760kg.By Radix Notoginseng, Radix Salviae Miltiorrhizae through pulverizing, decocting boils 2 times, adds 7 times of water gagings at every turn, each 2 hours, merges decoction liquor, filter, filtrate is concentrated into 900ml, adds 95% ethanol, makes determining alcohol reach 70%, standing 12～24 hours, filter, reclaim ethanol, be condensed into Salvia miltiorrhiza and Panax notoginseng extractum; By the Radix Astragali, decoct with water 2 times, add 6 times of water gagings at every turn, extract successively 2 hours, 1 hour, merging filtrate, while being concentrated into 1500L left and right, adding 95% ethanol, to make determining alcohol be 60%, uses horizontal spiral discharge sedimentation centrifuge (roller diameter 220mm, rotary drum length 930, rotating speed is 4000-4800r/min, separation factor 1971-2833) separated liquid phase and solid phase, gained liquid phase is the concentrated Radix Astragali extractum (dry another the using of gained solid phase) that obtains after further refining; Get Lignum Dalbergiae Odoriferae, add 5 times of water gagings, reflux, extract, 5 hours, collects volatile oil; Get above-mentioned Salvia miltiorrhiza and Panax notoginseng extractum, Radix Astragali extractum and PEG-4000, water-bath is dissolved, change even after, add volatile oil of Lignum Dalbergiae Odoriferae, mix, move in pill dripping machine, make 2,100,000 bags of drop pill.
Embodiment nine
Get embodiment six gained Radix Astragali extractum 450g and different Fructus Hordei Germinatus 670g, glucose 200g, Fructus Fragariae Ananssae fruit powder 40g, strawberry essence 10g, polyvinylpolypyrrolidone 10g, magnesium stearate 10g, above raw material fully mixes with appropriate alcoholic solution to be made after soft material, granulate, 60 ℃ of forced air dryings, make 1000, granulate, compacting in flakes, obtains oral cavity disintegration tablet.
Embodiment ten
Get embodiment six gained astragalus polysaccharidess 25%, xylitol 48%, maltose 6%, 14% cyclodextrin, 7% calcium lactate is prepared Radix Astragali soft capsule according to soft capsule common process.
Embodiment 11
Embodiment six gained astragalus polysaccharides 5.0g and 10g xylitol, 0.8g oligomeric isomaltose, 10g erythritol, 0.05 aspartame, all the other are water, make Radix Astragali oral liquid.
Embodiment 12
Get embodiment tetra-gained astragalus polysaccharidess 99.9%, add therein after 0.1% dextrin mix homogeneously, granulate, be drying to obtain Astragalus granules or electuary.
Embodiment 13
Get embodiment tetra-gained Radix Astragali extractum 58g, Folium Nelumbinis 29g, Fructus Momordicae 13g mix homogeneously are made compositions, cross respectively 16 mesh sieves, 22 mesh sieves, get mid portion packing.Add outer package, obtain teabag.
Embodiment 14
Get embodiment tetra-gained astragalus polysaccharides 58g, Folium Mori 28g, Fructus Lycii 13g mix homogeneously are made compositions, cross respectively 16 mesh sieves, 22 mesh sieves, get mid portion packing.Add outer package, obtain teabag.
Embodiment 15
Get embodiment tetra-gained astragalus polysaccharides 58g, flour 180g, butter 90g mix homogeneously and be divided into fritter, round as a ball, by flat, to decorate, bake obtains cookies.
Embodiment 16
Get embodiment tetra-gained Radix Astragali extractum 58g, flour 180g, butter 90g, white sugar 30g, milk 25g mix homogeneously, add mould, toast and obtain cake.
Although illustrated and described embodiments of the invention, for the ordinary skill in the art, be appreciated that without departing from the principles and spirit of the present invention and can carry out multiple variation, modification, replacement and modification to these embodiment, scope of the present invention is limited by claims and equivalent thereof.
Claims (10)
1. an extraction separation method for the Radix Astragali, comprising:
Step 1, gets the Radix Astragali, and water decocts, filters, and collects filtrate; Step 2, precipitate with ethanol after described filtrate is concentrated, is suspension, separated liquid phase and solid phase, collect respectively liquid phase and solid phase; Step 3, described liquid phase is the concentrated Radix Astragali extractum that obtains after further refining, the refining astragalus polysaccharides that is drying to obtain of described solid phase, wherein said step 2 adopts the separated liquid phase of centrifuge and solid phase.
2. method according to claim 1, it is characterized in that described step 2 adopts Horizontal spiral discharging centrifuge, described Horizontal spiral discharging centrifuge comprises rotary drum and auger conveyor, described rotary drum is deposited to described drum inner wall by running up by solid phase in described suspension, described auger conveyor turns to identical from described rotary drum and rotating speed is different, produce thus relative motion, will be deposited in solid phase and the liquid phase separation of drum inner wall.
3. method according to claim 2, is characterized in that described Horizontal spiral discharging centrifuge rotating speed is greater than 2500r/min.
4. method according to claim 3, is characterized in that described Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4000r/min.
5. method according to claim 4, is characterized in that described Horizontal spiral discharging centrifuge rotating speed is more than or equal to 4800r/min.
6. method according to claim 2, is characterized in that described Horizontal spiral discharging centrifuge separation factor is greater than 1200.
7. method according to claim 6, is characterized in that described Horizontal spiral discharging centrifuge separation factor is more than or equal to 2800.
8. method according to claim 7, is characterized in that described Horizontal spiral discharging centrifuge separation factor is more than or equal to 3100.
9. described in claim 1 to 8 any one, method contains described Radix Astragali extractum and/or the pharmaceutical composition of astragalus polysaccharides or the application in health product in preparation.
10. the application of method in preparation QISHEN YIQI DIWAN described in claim 9.
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